Marcus Buggert, Group leader

Assistant Professor and group leader at KI. Research focus on human memory CD8+ T cell differentiation and function in health, viral infections and cancer.

Marcus Buggert

Lektor, biträdande

Assistant Professor and group leader at KI. Research focus on human memory CD8+ T cell differentiation and function in health, viral infections and cancer.

Om mig

Master in Biomedicine at KI, 2004-2009. PhD studies at KI, 2010-2014. Post doc at University of Pennsylvania, USA, 2014-2017. Assistant Professor at KI, 2018-. Group leader at KI, 2019-.

Forskningsbeskrivning

Our group conduct innovative human immunology to study recirculating and resident memory CD8+ T cells in health and disease. These immune cells are absolutely critical for immune control of multiple chronic viral infections, such as HIV, and also represent a major cellular target of immune checkpoint therapies that have entirely revolutionized the treatment outcome in cancer care. However, many still view CD8+ T cells solely as killer T cells eliminating HIV-infected or tumor cells based on concepts from studies of peripheral blood. With emerging data from us and others demonstrating that many CD8+ T cells in tissues are non-cytolytic resident cells expressing multiple checkpoint molecules, such as PD-1, also in healthy subjects, it is tempting to speculate that these cells are designed to contain rather than eliminate tumors and virus-infected cells. This could be an evolutionary conserved process of the human body to minimize collateral tissue damage. Our group focus its work on many of these concepts with the aim to i) study the heterogeneity of circulating and resident memory CD8+ T cells in human donors, ii) identify alternative functions of memory CD8+ T cell in human tissues, iii) understand how memory CD8+ T cells maintain tumor and HIV control. 

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