Lars Tjernberg

Lars Tjernberg

Lektor/Funktionsenhetschef | Docent
E-postadress: lars.tjernberg@ki.se
Telefon: +46852483408
Besöksadress: BioClinicum J9:20, Visionsgatan 4, 17164 Huddinge
Postadress: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Tjernberg, 171 77 Stockholm

Om mig

  • Group leader at NVS. Research on Alzheimer disease using cutting edge techniques including mass spectrometry and nanoscopy.I have dedicated my 24 years in scientific research to understand how the amyloid β-peptide (Aβ) is formed and how it polymerizes into fibrils, and how these processes can be studied and targeted. I have expertise in analytical chemistry with focus on chromatography and spectrometry and long track record as a project and group leader at Karolinska Institutet. Under my leadership, we have had a long-lasting industrial collaboration with a Japanese pharmaceutical company, resulting in several patent applications on Aβ related discoveries. Importantly, I have shown the motif most critical for Aβ polymerization (residues 16-20 in Aβ, also called the Tjernberg peptide), and that ligands binding to this motif can inhibit Aβ polymerization. Furthermore, I have developed strategies for single plaque core analysis, proteomics of selected cells, and studying Aβ polymerization at nanomolar concentrations. I use several different systems including in vitro, cell lines, primary neurons, mouse as well as human brain. I have been in the forefront of introducing and setting up new technology at the department, including nanoscale liquid chromatography, isotope-labeling proteomics, laser capture microdissection and proximity ligation interacting studies in neurons. More recently, my group have developed expertise in super-resolution microscopy and reported on the synaptic localization of the Aβ producing enzyme γ-secretase.

Artiklar

Alla övriga publikationer

Anställningar

  • Lektor/Funktionsenhetschef, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2018-

Examina och utbildning

  • Docent, Neurobiologi, Karolinska Institutet, 2008

Nyheter från KI

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