Konstantinos Meletis

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About me

Konstantinos Meletis is Professor of Systems Neuroscience in the Department of Neuroscience.

Selected academic honours, awards and prizes

2024 – The Arvid Carlsson Foundation Prize
2015 – William K. Bowes Jr. Foundation Associate Professor Award

2013 – Framtidens Forskningsledare, FFL5, Stiftelsen för Strategisk Forskning

2011 – William K. Bowes Jr. Foundation Assistant Professor Award

2010 – Marie Curie Reintegration Grant FP7 (EU)

2010 – NARSAD Young Investigator Award (USA)

Research

Investigation of the organization and function of brain circuits and neuron types that regulate motivated behaviors and decision-making, including the circuit and cellular mechanisms underlying dysfunction in mouse models of stress or mood disorders.

Selected publications

Review: ANNUAL REVIEW OF NEUROSCIENCE. 2021;44:547-562

Spatial Transcriptomics: Molecular Maps of the Mammalian Brain.

Ortiz C; Carlén M; Meletis K
Article: SCIENCE ADVANCES. 2020;6(26):eabb3446

Molecular atlas of the adult mouse brain.

Ortiz C; Navarro JF; Jurek A; Märtin A; Lundeberg J; Meletis K
Article: CELL REPORTS. 2019;29(13):4320-4333.e5

A Spatiomolecular Map of the Striatum.

Märtin A; Calvigioni D; Tzortzi O; Fuzik J; Wärnberg E; Meletis K
Article: MOLECULAR PSYCHIATRY. 2019;24(9):1351-1368

A hypothalamus-habenula circuit controls aversion.

Lazaridis I; Tzortzi O; Weglage M; Märtin A; Xuan Y; Parent M; Johansson Y; Fuzik J; Fürth D; Fenno LE; Ramakrishnan C; Silberberg G; Deisseroth K; Carlén M; Meletis K
Article: NATURE NEUROSCIENCE. 2018;21(1):139-149

An interactive framework for whole-brain maps at cellular resolution.

Fürth D; Vaissière T; Tzortzi O; Xuan Y; Märtin A; Lazaridis I; Spigolon G; Fisone G; Tomer R; Deisseroth K; Carlén M; Miller CA; Rumbaugh G; Meletis K
Article: NEURON. 2014;83(3):663-678

A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei.

Pollak Dorocic I; Fürth D; Xuan Y; Johansson Y; Pozzi L; Silberberg G; Carlén M; Meletis K
Article: PLOS ONE. 2014;9(1):e83879

Mice lacking NMDA receptors in parvalbumin neurons display normal depression-related behavior and response to antidepressant action of NMDAR antagonists.

Pozzi L; Pollak Dorocic I; Wang X; Carlén M; Meletis K
Article: JOURNAL OF NEUROSCIENCE. 2013;33(4):1678-1683

Target selectivity of feedforward inhibition by striatal fast-spiking interneurons.

Szydlowski SN; Pollak Dorocic I; Planert H; Carlén M; Meletis K; Silberberg G

Articles

Journal article: BIORXIV. 2023;:2023.09.27.559787

Sensorimotor Integration Supporting Perception Requires Syngap1 Expression in Cortex.

Vaissiere T; Michaelson S; Creson T; Goins J; Fürth D; Balazsfi D; Rojas C; Golovin R; Meletis K; Miller CA; O'Connor D; Rumbaugh G
Journal article: ENEURO. 2023;10(7):1-20

A Selective Projection from the Subthalamic Nucleus to Parvalbumin-Expressing Interneurons of the Striatum.

Kondabolu K; Doig NM; Ayeko O; Khan B; Torres A; Calvigioni D; Meletis K; Koós T; Magill PJ
Article: NATURE NEUROSCIENCE. 2023;26(7):1245-1255

Esr1+ hypothalamic-habenula neurons shape aversive states.

Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlén M; Meletis K
Article: NUCLEIC ACIDS RESEARCH. 2023;51(8):e47

The spatial landscape of gene expression isoforms in tissue sections.

Lebrigand K; Bergenstråhle J; Thrane K; Mollbrink A; Meletis K; Barbry P; Waldmann R; Lundeberg J
Article: CELL REPORTS. 2021;36(4):109437

Complete representation of action space and value in all dorsal striatal pathways.

Weglage M; Wärnberg E; Lazaridis I; Calvigioni D; Tzortzi O; Meletis K
Article: PLOS BIOLOGY. 2021;19(7):e3001341

Assessing the replicability of spatial gene expression using atlas data from the adult mouse brain.

Lu S; Ortiz C; Fürth D; Fischer S; Meletis K; Zador A; Gillis J
Article: JOURNAL OF NEUROSCIENCE. 2021;41(14):3120-3141

Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics.

Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Article: NATURE COMMUNICATIONS. 2021;12(1):1026

Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice.

Wu H; Petitpré C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25958-25967

Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants.

Fuzik J; Rehman S; Girach F; Miklosi AG; Korchynska S; Arque G; Romanov RA; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs GG; Alpár A; Hökfelt TGM; Harkany T
Article: NATURE NEUROSCIENCE. 2019;22(4):657-668

A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.

Ährlund-Richter S; Xuan Y; van Lunteren JA; Kim H; Ortiz C; Pollak Dorocic I; Meletis K; Carlén M
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2017;525(15):3227-3250

Monosynaptic retrograde tracing of neurons expressing the G-protein coupled receptor Gpr151 in the mouse brain.

Broms J; Grahm M; Haugegaard L; Blom T; Meletis K; Tingström A
Article: CELL RESEARCH. 2016;26(9):1033-1047

Cortical neurons gradually attain a post-mitotic state.

Anda FCD; Madabhushi R; Rei D; Meng J; Gräff J; Durak O; Meletis K; Richter M; Schwanke B; Mungenast A; Tsai L-H
Article: NATURE. 2012;489(7414):150-154

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision.

Song J; Zhong C; Bonaguidi MA; Sun GJ; Hsu D; Gu Y; Meletis K; Huang ZJ; Ge S; Enikolopov G; Deisseroth K; Luscher B; Christian KM; Ming G-L; Song H
Article: NATURE NEUROSCIENCE. 2012;15(7):1022-1031

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

de Anda FC; Rosario AL; Durak O; Tran T; Gräff J; Meletis K; Rei D; Soda T; Madabhushi R; Ginty DD; Kolodkin AL; Tsai L-H
Article: MOLECULAR PSYCHIATRY. 2012;17(5):537-548

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior.

Carlén M; Meletis K; Siegle JH; Cardin JA; Futai K; Vierling-Claassen D; Rühlmann C; Jones SR; Deisseroth K; Sheng M; Moore CI; Tsai L-H
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2011;2011:7529-7532

Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice.

Siegle JH; Carlen M; Meletis K; Tsai L-H; Moore CI; Ritt J
Article: CELL STEM CELL. 2010;7(4):470-482

Origin of new glial cells in intact and injured adult spinal cord.

Barnabé-Heider F; Göritz C; Sabelström H; Takebayashi H; Pfrieger FW; Meletis K; Frisén J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14657-14661

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene.

Forsberg M; Carlén M; Meletis K; Yeung MSY; Barnabé-Heider F; Persson MAA; Aarum J; Frisén J
Article: JOURNAL OF NEUROSCIENCE. 2010;30(31):10391-10406

Centrosome motility is essential for initial axon formation in the neocortex.

de Anda FC; Meletis K; Ge X; Rei D; Tsai L-H
Article: NEURON. 2010;67(1):33-48

Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.

Singh KK; Ge X; Mao Y; Drane L; Meletis K; Samuels BA; Tsai L-H
Article: BRAIN. 2010;133(Pt 4):983-995

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha.

Seidel S; Garvalov BK; Wirta V; von Stechow L; Schänzer A; Meletis K; Wolter M; Sommerlad D; Henze A-T; Nistér M; Reifenberger G; Lundeberg J; Frisén J; Acker T
Article: NATURE PROTOCOLS. 2010;5(2):247-254

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.

Cardin JA; Carlén M; Meletis K; Knoblich U; Zhang F; Deisseroth K; Tsai L-H; Moore CI
Article: NATURE. 2009;459(7247):663-U63

Driving fast-spiking cells induces gamma rhythm and controls sensory responses.

Cardin JA; Carlén M; Meletis K; Knoblich U; Zhang F; Deisseroth K; Tsai L-H; Moore CI
Article: NATURE NEUROSCIENCE. 2009;12(3):259-267

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.

Carlén M; Meletis K; Göritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabé-Heider F; Yeung MSY; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisén J
Article: PLOS BIOLOGY. 2008;6(7):e182-1507

Spinal cord injury reveals multilineage differentiation of ependymal cells.

Meletis K; Barnabé-Heider F; Carlén M; Evergren E; Tomilin N; Shupliakov O; Frisén J
Article: NATURE METHODS. 2008;5(2):189-196

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation.

Barnabé-Heider F; Meletis K; Eriksson M; Bergmann O; Sabelström H; Harvey MA; Mikkers H; Frisén J
Article: DEVELOPMENTAL DYNAMICS. 2007;236(6):1663-1676

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan.

Nguyen S; Meletis K; Fu D; Jhaveri S; Jaenisch R
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(15):2851-2859

Genetic visualization of neurogenesis.

Carlén M; Meletis K; Barnabé-Heider F; Frisén J
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812

Catalog of gene expression in adult neural stem cells and their in vivo microenvironment.

Williams C; Wirta V; Meletis K; Wikström L; Carlsson L; Frisén J; Lundeberg J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(8):2976-2983

Suppression of intestinal neoplasia by deletion of Dnmt3b.

Lin H; Yamada Y; Nguyen S; Linhart H; Jackson-Grusby L; Meissner A; Meletis K; Lo G; Jaenisch R
Article: DEVELOPMENT. 2006;133(2):363-369

p53 suppresses the self-renewal of adult neural stem cells.

Meletis K; Wirta V; Hede S-M; Nistér M; Lundeberg J; Frisén J
Article: DEVELOPMENTAL NEUROSCIENCE. 2006;28(1-2):118-127

Recording Notch signaling in real time.

Hansson EM; Teixeira AI; Gustafsson MV; Dohda T; Chapman G; Meletis K; Muhr J; Lendahl U
Article: BMC NEUROSCIENCE. 2005;6:28

Transcriptome analysis in primary neural stem cells using a tag cDNA amplification method.

Sievertzon M; Wirta V; Mercer A; Meletis K; Erlandsson R; Wikström L; Frisén J; Lundeberg J
Show more

All other publications

Preprint: BIORXIV. 2023

Cell type-specific representation of spatial context in the rat prefrontal cortex

Brünner H; Kim H; Ährlund-Richter S; van Lunteren J; Crestani A; Meletis K; Carlén M
Preprint: BIORXIV. 2023

Recurrent circuits encode visual center-surround computations in the mouse superior colliculus

Cui P; Song K; Mariatos-Metaxas D; Isla A; Femenia T; Lazaridis I; Meletis K; Kumar A; Kardamakis A
Preprint: BIORXIV. 2022

Esr1+ hypothalamic-habenula neurons shape aversive states

Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlén M; Meletis K
Preprint: BIORXIV. 2022

Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility

Weglage M; Ährlund-Richter S; Fuzik J; Skara V; Lazaridis I; Meletis K
Preprint: BIORXIV. 2020

A selective projection from the subthalamic nucleus to parvalbumin-expressing interneurons of the striatum

Kondabolu K; Doig N; Ayeko O; Khan B; Torres A; Calvigioni D; Meletis K; Magill P; Koós T
Preprint: BIORXIV. 2020

Replicability of spatial gene expression atlas data from the adult mouse brain

Lu S; Ortiz C; Fürth D; Fischer S; Meletis K; Zador A; Gillis J
Preprint: BIORXIV. 2020

The spatial landscape of gene expression isoforms in tissue sections

Lebrigand K; Bergenstråhle J; Thrane K; Mollbrink A; Meletis K; Meletis K; Barbry P; Waldmann R; Lundeberg J
Preprint: BIORXIV. 2020

A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics

Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Preprint: BIORXIV. 2020

Complete representation of action space and value in all striatal pathways

Weglage M; Wärnberg E; Lazaridis I; Tzortzi O; Meletis K
Preprint: BIORXIV. 2019

Molecular Atlas of the Adult Mouse Brain

Ortiz C; Navarro JF; Jurek A; Märtin A; Lundeberg J; Meletis K
Preprint: BIORXIV. 2019

Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulants

Fuzik J; Rehman S; Girach F; Miklosi A; Korchynska S; Arque G; Romanov R; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs G; Alpár A; Hökfelt TGM; Harkany T
Corrigendum: NATURE NEUROSCIENCE. 2019;22(6):1037

Publisher Correction: A whole-brain atlas of monosynaptic input targeting four different cell types in the medial prefrontal cortex of the mouse.

Ährlund-Richter S; Xuan Y; van Lunteren JA; Kim H; Ortiz C; Dorocic IP; Meletis K; Carlén M
Preprint: BIORXIV. 2019

A Spatiomolecular Map of the Striatum

Märtin A; Calvigioni D; Tzortzi O; Fuzik J; Wärnberg E; Meletis K
Corrigendum: NATURE NEUROSCIENCE. 2018;21(6):895

Publisher Correction: An interactive framework for whole-brain maps at cellular resolution.

Fürth D; Vaissière T; Tzortzi O; Xuan Y; Märtin A; Lazaridis I; Spigolon G; Fisone G; Tomer R; Deisseroth K; Carlén M; Miller CA; Rumbaugh G; Meletis K
Corrigendum: NATURE NEUROSCIENCE. 2014;17(12):1840

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex (vol 15, pg 1022, 2012)

de Anda FC; Rosario AL; Durak O; Tran T; Graeff J; Meletis K; Rei D; Soda T; Madabhushi R; Ginty DD; Kolodkin AL; Tsai L-H
Corrigendum: PLOS ONE. 2014;9(2):e91486

Mice Lacking NMDA Receptors in Parvalbumin Neurons Display Normal Depression-Related Behavior and Response to Antidepressant Action of NMDAR Antagonists (vol 9, e83879, 2014)

Pozzi L; Dorocic PI; Wang X; Carlen M; Meletis K
Editorial comment: TRENDS IN NEUROSCIENCES. 2003;26(6):292-296

Blood on the tracks: a simple twist of fate?

Meletis K; Frisén J
Editorial comment: JOURNAL OF CELL BIOLOGY. 2001;155(5):699-702

Have the bloody cells gone to our heads?

Meletis K; Frisen J

Grants

Brain circuits in decision-making

Knut and Alice Wallenberg Foundation

1 January 2020 - 1 January 2025
The organization and function of striatal circuits.

Swedish Research Council

1 January 2019 - 31 December 2024
Brain circuits regulating reward, anhedonia and addiction.

Swedish Research Council

1 January 2018 - 31 December 2021
Development of a whole-brain cellular mapping approach in a genetic model of autism and intellectual disability

National Institute of Mental Health

15 April 2016 - 31 March 2018
Optogenetic dissection of limbic circuits

Swedish Foundation for Strategic Research

1 January 2014 - 31 December 2018
ERA-NET NEURON Mental Disorders RDmaria aDBS

Swedish Research Council

1 January 2014 - 31 December 2016
Optogenetic characterization of limbic circuits for reward and addiction.

Swedish Research Council

1 January 2013 - 31 December 2017

Employments

Professor, Department of Neuroscience, Karolinska Institutet, 2021-

Degrees and Education

Docent, Karolinska Institutet, 2015
Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2006
Master Of Medical Science, Karolinska Institutet, 2000

About me

Research

Selected publications

Articles

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