Xinsong Chen | Karolinska Institutet

Artiklar

Journal article: NATURE COMMUNICATIONS. 2025;16(1):2801
Author Correction: Integrative spatial and genomic analysis of tumor heterogeneity with Tumoroscope
Shafighi S; Geras A; Jurzysta B; Sahaf Naeini A; Filipiuk I; Rączkowska A; Toosi H; Koperski Ł; Thrane K; Engblom C; Mold JE; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
Article: NATURE COMMUNICATIONS. 2024;15(1):9343
Integrative spatial and genomic analysis of tumor heterogeneity with Tumoroscope
Shafighi S; Geras A; Jurzysta B; Sahaf Naeini A; Filipiuk I; Raczkowska A; Toosi H; Koperski L; Thrane K; Engblom C; Mold JE; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
Article: GENOME BIOLOGY. 2024;25(1):214
Inferring clonal somatic mutations directed by X chromosome inactivation status in single cells
Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J
Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis
Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Article: BIOINFORMATICS. 2024;40(5):btae284
CopyVAE: a variational autoencoder-based approach for copy number variation inference using single-cell transcriptomics
Kurt S; Chen M; Toosi H; Chen X; Engblom C; Mold J; Hartman J; Lagergren J
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2024;43(1):107
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
Article: BREAST CANCER RESEARCH. 2024;26(1):24
Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer
Ronnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
Article: SCIENCE. 2023;382(6675):eadf8486
Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics
Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J
Article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2023;8(5):e10537
Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells
Collodet C; Blust K; Gkouma S; Stahl E; Chen X; Hartman J; Hedhammar M
Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088
Solid-phase capture and profiling of open chromatin by spatial ATAC
Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisen J; Stahl PL
Article: NATURE COMMUNICATIONS. 2023;14(1):982
Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics
Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592
A_2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Tay AHM; Prieto-Diaz R; Neo S; Tong L; Chen X; Carannante V; Onfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354
The Importance of Sex in the Discovery of Colorectal Cancer Prognostic Biomarkers
Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
Article: BREAST CANCER RESEARCH. 2020;22(1):80
Identification and targeting of selective vulnerability rendered by tamoxifen resistance
Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arner ESJ; Hartman J; Selivanova G
Article: CANCER RESEARCH. 2020;80(7):1538-1550
Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindstrom MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198
CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment
Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
Article: ONCOGENE. 2016;35(29):3807-3816
Oxidative stress enables Epstein-Barr virus-induced B-cell transformation by posttranscriptional regulation of viral and cellular growth-promoting factors
Chen X; Kamranvar SA; Masucci MG
Article: ONCOGENE. 2013;32(49):5522-5530
Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein-Barr virus
Kamranvar SA; Chen X; Masucci MG
Article: PLOS PATHOGENS. 2013;9(10):e1003664
Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells
Gastaldello S; Chen X; Callegari S; Masucci MG

Alla övriga publikationer

Conference publication: CANCER RESEARCH. 2024;84(9):po4-01-05-po4-01-05
The prognostic importance of biological pathway enrichment patterns in trastuzumab-treated early HER2-positive breast cancer
Ronnlund C; Yang Q; Schagerholm C; Foukakis T; Fredriksson I; Chen X; Robertson S; Sifakis E; Hartman J
Conference publication: VIRCHOWS ARCHIV. 2024;485:S206
The analytical and clinical validity of the Nottingham histological grading system in neoadjuvant setting
Steen S; Karlsson E; Chen X; Acs B; Hartman J
Letter: CANCER COMMUNICATIONS. 2023;43(7):855-859
Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1
Tong L; Kremer V; Neo SY; Liu Y; Chen Y; Wagner AK; Yang Y; Chen Z; Seitz C; Tobin NP; Ligtenberg MA; Alici E; Chen X; Haglund F; Seliger B; Harmenberg U; Colon E; Plogell A-HS; Liu LL; Lundqvist A
Meeting abstract: CANCER RESEARCH. 2023;83(5):p2-21-02-p2-21-02
Longitudinal tumor-immune microenvironment changes in patients with clinical luminal A early breast cancer treated with neoadjuvant palbociclib and endocrine therapy: results from the Swedish randomized PREDIX Luminal A trial
Zerdes I; Salgkamis D; Matikas A; Selander L; Wang K; Tzoras E; Sifakis E; Agartz S; Chen X; Hellstrom M; Hartman J; Bergh J; Foukakis T; Hatschek T
Preprint: BIORXIV. 2022
Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells
Collodet C; Blust K; Gkouma S; Ståhl E; Chen X; Hartman J; Hedhammar M
Preprint: BIORXIV. 2022
Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissue
Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Mantovani G; Hagemann-Jensen M; Saarenpää S; Jangard M; Michaëlsson J; Hartman J; Lagergren J; Mold J; Lundeberg J; Frisén J
Preprint: BIORXIV. 2022
Tumoroscope: a probabilistic model for mapping cancer clones in tumor tissues
Shafighi SD; Geras A; Jurzysta B; Naeini AS; Filipiuk I; Rączkowski Ł; Toosi H; Koperski Ł; Thrane K; Engblom C; Mold J; Chen X; Hartman J; Nowis D; Carbone A; Lagergren J; Szczurek E
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S1306
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Lovrot J; Tay A; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Preprint: BIORXIV. 2022
Chromatin accessibility profiling in tissue sections by spatial ATAC
Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisén J; Ståhl PL
Preprint: BIORXIV. 2021
PhylEx: Accurate reconstruction of clonal structure via integrated analysis of bulk DNA-seq and single cell RNA-seq data
Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O’Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Conference publication: VIRCHOWS ARCHIV. 2018;473:S30
Transcriptional profiling of endocrine resistant versus sensitive breast cancer uncovers gene expression programmes associated with therapeutic response
Schagerholm C; Robertson S; Govindasamy-Muralidharan K; Lovrot J; Chen X; Hartman J
Doctoral thesis: 2015
Studies on early cellular responses during Epstein-Barr virus infection
Chen X
Review: SEMINARS IN CANCER BIOLOGY. 2014;26:43-51
Tumor viruses and replicative immortality - Avoiding the telomere hurdle
Chen X; Kamranvar SA; Masucci MG