Rakesh Kumar

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE COMMUNICATIONS. 2024;15(1):965

Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511

Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone.

Kumar R; Arroyo-García LE; Manchanda S; Adam L; Pizzirusso G; Biverstål H; Nilsson P; Fisahn A; Johansson J; Abelein A
Article: JACS AU. 2022;2(11):2571-2584

Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.

Abelein A; Ciofi-Baffoni S; Mörman C; Kumar R; Giachetti A; Piccioli M; Biverstål H
Article: NANOSCALE. 2022;14(40):15021-15033

Charge and hydrophobicity of amyloidogenic protein/peptide templates regulate the growth and morphology of gold nanoparticles.

Kadu P; Gadhe L; Navalkar A; Patel K; Kumar R; Sastry M; Maji SK
Article: JOURNAL OF MOLECULAR BIOLOGY. 2022;434(19):167761

α-Synuclein Aggregation Intermediates form Fibril Polymorphs with Distinct Prion-like Properties.

Mehra S; Ahlawat S; Kumar H; Datta D; Navalkar A; Singh N; Patel K; Gadhe L; Kadu P; Kumar R; Jha NN; Sakunthala A; Sawner AS; Padinhateeri R; Udgaonkar JB; Agarwal V; Maji SK
Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211

Amyloid Fibril Formation of Arctic Amyloid-β 1-42 Peptide is Efficiently Inhibited by the BRICHOS Domain.

Zhong X; Kumar R; Wang Y; Biverstål H; Ingeborg Jegerschöld C; J B Koeck P; Johansson J; Abelein A; Chen G
Article: NATURE COMMUNICATIONS. 2022;13(1):4695

Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform.

Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Strömberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2022;13(28):6427-6438

Direct Demonstration of Seed Size-Dependent α-Synuclein Amyloid Amplification.

Sakunthala A; Datta D; Navalkar A; Gadhe L; Kadu P; Patel K; Mehra S; Kumar R; Chatterjee D; Devi J; Sengupta K; Padinhateeri R; Maji SK
Article: EMBO REPORTS. 2022;23(7):e54405

Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration.

Brackhan M; Calza G; Lundgren K; Bascuñana P; Brüning T; Soliymani R; Kumar R; Abelein A; Baumann M; Lalowski M; Pahnke J
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303

Autophagy Impairment in App Knock-in Alzheimer's Model Mice.

Jiang R; Shimozawa M; Mayer J; Tambaro S; Kumar R; Abelein A; Winblad B; Bogdanovic N; Nilsson P
Article: JOURNAL OF NEUROCHEMISTRY. 2021;156(6):1003-1019

Benzimidazole-based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin-T.

Pravin N; Kumar R; Tripathi S; Kumar P; Mohite GM; Navalkar A; Panigrahi R; Singh N; Gadhe LG; Manchanda S; Shimozawa M; Nilsson P; Johansson J; Kumar A; Maji SK; Shanmugam M
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2020;11(24):10489-10496

Machine-Free Polymerase Chain Reaction with Triangular Gold and Silver Nanoparticles.

Kadu P; Pandey S; Neekhra S; Kumar R; Gadhe L; Srivastava R; Sastry M; Maji SK
Article: SCIENTIFIC REPORTS. 2020;10(1):21765

Functionalization of amyloid fibrils via the Bri2 BRICHOS domain.

Biverstål H; Kumar R; Schellhaus AK; Sarr M; Dantuma NP; Abelein A; Johansson J
Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(18):2836-2848

Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation.

Sharma K; Mehra S; Sawner AS; Markam PS; Panigrahi R; Navalkar A; Chatterjee D; Kumar R; Kadu P; Patel K; Ray S; Kumar A; Maji SK
Article: NATURE CHEMISTRY. 2020;12(8):705-716

α-Synuclein aggregation nucleates through liquid-liquid phase separation.

Ray S; Singh N; Kumar R; Patel K; Pandey S; Datta D; Mahato J; Panigrahi R; Navalkar A; Mehra S; Gadhe L; Chatterjee D; Sawner AS; Maiti S; Bhatia S; Gerez JA; Chowdhury A; Kumar A; Padinhateeri R; Riek R; Krishnamoorthy G; Maji SK
Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(5):2229-2236

Lipopolysaccharide from Gut Microbiota Modulates α-Synuclein Aggregation and Alters Its Biological Function.

Bhattacharyya D; Mohite GM; Krishnamoorthy J; Gayen N; Mehra S; Navalkar A; Kotler SA; Ratha BN; Ghosh A; Kumar R; Garai K; Mandal AK; Maji SK; Bhunia A
Article: JOURNAL OF MATERIALS CHEMISTRY A. 2019;7(9):4486-4493

Fabrication of an amyloid fibril-palladium nanocomposite: a sustainable catalyst for C-H activation and the electrooxidation of ethanol

Jayarajan R; Kumar R; Gupta J; Dev G; Kadu P; Chatterjee D; Bahadur D; Maiti D; Maji SK
Article: ACS BIOMATERIALS SCIENCE & ENGINEERING. 2019;5(1):126-138

Amyloid Fibrils with Positive Charge Enhance Retroviral Transduction in Mammalian Cells.

Kirti S; Patel K; Das S; Shrimali P; Samanta S; Kumar R; Chatterjee D; Ghosh D; Kumar A; Tayalia P; Maji SK
Article: ACS CHEMICAL NEUROSCIENCE. 2018;9(11):2628-2638

Parkinson's Disease Associated α-Synuclein Familial Mutants Promote Dopaminergic Neuronal Death in Drosophila melanogaster.

Mohite GM; Dwivedi S; Das S; Kumar R; Paluri S; Mehra S; Ruhela N; S A; Jha NN; Maji SK
Article: BIOCHEMISTRY. 2018;57(35):5183-5187

Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α-Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation.

Mohite GM; Kumar R; Panigrahi R; Navalkar A; Singh N; Datta D; Mehra S; Ray S; Gadhe LG; Das S; Singh N; Chatterjee D; Kumar A; Maji SK
Article: ADVANCED MATERIALS INTERFACES. 2018;5(18)

Cell Alignment on Graphene-Amyloid Composites

Das S; Kumawat MK; Ranganathan S; Kumar R; Adamcik J; Kadu P; Padinhateeri R; Srivastava R; Mezzenga R; Maji SK
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(34):12975-12991

Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils.

Mehra S; Ghosh D; Kumar R; Mondal M; Gadhe LG; Das S; Anoop A; Jha NN; Jacob RS; Chatterjee D; Ray S; Singh N; Kumar A; Maji SK
Article: BIOCHEMISTRY. 2018;57(33):5014-5028

The Familial α-Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers.

Mohite GM; Navalkar A; Kumar R; Mehra S; Das S; Gadhe LG; Ghosh D; Alias B; Chandrawanshi V; Ramakrishnan A; Mehra S; Maji SK
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2018;57(19):5262-5266

Cytotoxic Oligomers and Fibrils Trapped in a Gel-like State of α-Synuclein Assemblies.

Kumar R; Das S; Mohite GM; Rout SK; Halder S; Jha NN; Ray S; Mehra S; Agarwal V; Maji SK
Article: CHEMICAL COMMUNICATIONS. 2018;54(29):3605-3608

Multitude NMR studies of α-synuclein familial mutants: probing their differential aggregation propensities.

Bhattacharyya D; Kumar R; Mehra S; Ghosh A; Maji SK; Bhunia A
Article: BIOCHEMISTRY. 2018;57(5):791-804

Complexation of NAC-Derived Peptide Ligands with the C-Terminus of α-Synuclein Accelerates Its Aggregation.

Jha NN; Ranganathan S; Kumar R; Mehra S; Panigrahi R; Navalkar A; Ghosh D; Kumar A; Padinhateeri R; Maji SK
Article: ACS CHEMICAL NEUROSCIENCE. 2017;8(12):2722-2733

Comparison of α-Synuclein Fibril Inhibition by Four Different Amyloid Inhibitors.

Jha NN; Kumar R; Panigrahi R; Navalkar A; Ghosh D; Sahay S; Mondal M; Kumar A; Maji SK
Article: CELL DEATH AND DIFFERENTIATION. 2017;24(10):1784-1798

p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis.

Ghosh S; Salot S; Sengupta S; Navalkar A; Ghosh D; Jacob R; Das S; Kumar R; Jha NN; Sahay S; Mehra S; Mohite GM; Ghosh SK; Kombrabail M; Krishnamoorthy G; Chaudhari P; Maji SK
Article: ADVANCED HEALTHCARE MATERIALS. 2017;6(18)

Controlled Exposure of Bioactive Growth Factor in 3D Amyloid Hydrogel for Stem Cells Differentiation.

Das S; Kumar R; Jha NN; Maji SK
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Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2023;10:1193458

Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis.

Peña-Bautista C; Kumar R; Baquero M; Johansson J; Cháfer-Pericás C; Abelein A; Ferreira D

Anställningar

Postdoktor, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2024-2025
Postdoktor, Biovetenskaper och näringslära, Karolinska Institutet, 2021-2023

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