Radosveta Gencheva

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;208:S102-S103

The anticancer compounds auranofin, TRi-1 and TRi-2 have distinct cytotoxicity profiles with regards to thioredoxin reductase inhibition

Gencheva R; Cheng Q; Arner E
Article: REDOX BIOLOGY. 2023;62:102703

The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1.

Cheff DM; Huang C; Scholzen KC; Gencheva R; Ronzetti MH; Cheng Q; Hall MD; Arnér ESJ
Article: TRANSLATIONAL LUNG CANCER RESEARCH. 2022;11(10):2064-2078

Plasma RNA profiling unveils transcriptional signatures associated with resistance to osimertinib in EGFR T790M positive non-small cell lung cancer patients.

Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
Journal article: JOURNAL OF THORACIC ONCOLOGY. 2022;17(9):s156

P2.13-03 Plasma Profiling Unveils Transcriptional Signatures Associated with Resistance to Osimertinib in Non-Small Cell Lung Cancer

Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
Article: REDOX BIOLOGY. 2022;51:102278

Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus.

Fata F; Gencheva R; Cheng Q; Lullo R; Ardini M; Silvestri I; Gabriele F; Ippoliti R; Bulman CA; Sakanari JA; Williams DL; Arnér ESJ; Angelucci F
Article: TRANSLATIONAL LUNG CANCER RESEARCH. 2022;11(5):722-734

Elevated expression of miR-494-3p is associated with resistance to osimertinib in EGFR T790M-positive non-small cell lung cancer.

Kaźmierczak D; Eide IJZ; Gencheva R; Lai Y; Lewensohn R; Tsakonas G; Grundberg O; de Petris L; McGowan M; Brustugun OT; Ekman S; Hydbring P
Article: REDOX BIOLOGY. 2021;48:102184

Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin.

Sabatier P; Beusch CM; Gencheva R; Cheng Q; Zubarev R; Arnér ESJ

Alla övriga publikationer

Conference publication: FREE RADICAL BIOLOGY AND MEDICINE. 2023;201:39

THE ANTICANCER COMPOUNDS AURANOFIN, TRI-1 AND TRI-2 HAVE DISTINCT CYTOTOXICITY PROFILES WITH REGARDS TO THIOREDOXIN REDUCTASE INHIBITION

Gencheva R; Cheng Q; Arner E
Review: FREE RADICAL BIOLOGY AND MEDICINE. 2022;190:320-338

Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases.

Gencheva R; Cheng Q; Arnér ESJ
Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2022;62:177-196

Thioredoxin Reductase Inhibition for Cancer Therapy.

Gencheva R; Arnér ESJ
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2022;17(9):S156

Plasma Profiling Unveils Transcriptional Signatures Associated with Resistance to Osimertinib in Non-Small Cell Lung Cancer

Alexeyenko A; Brustugun OT; Eide IJZ; Gencheva R; Kosibaty Z; Lai Y; de Petris L; Tsakonas G; Grundberg O; Franzen B; Viktorsson K; Lewensohn R; Hydbring P; Ekman S
Published conference paper: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2018;1862(11):2511-2517

Efficient selenocysteine-dependent reduction of toxoflavin by mammalian thioredoxin reductase.

Gencheva R; Cheng Q; Arnér ESJ

Anställningar

Doktorand, Redox biokemi, Medicinsk biokemi och biofysik, Karolinska Institutet, 2020-2024

Examina och utbildning

Medicine Masterexamen, The Chemotherapeutic Potential of TRi-1: Biochemical Mechanisms of Cytotoxicity, Karolinska Institutet, 2020
Medicine Kandidatexamen, O.volvolus and B.malayi Thioredoxin Reductases As Therapeutic Targets for Lymphatic Filariasis, Karolinska Institutet, 2018

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI