Om mig
Jag är professor i klinisk immunologi vid Institutionen för medicinsk biokemi och biofysik, Karolinska Institutet.
Jag utbildades som läkare och tog examen från Sun Yat-Sen Medical University i Kina 1993. Under 1993 och 1994 arbetade jag som läkare vid Guangzhou Respiratory Disease Research Institute. Jag fick doktorsexamen i klinisk immunologi vid Karolinska Institutet 1999 och genomförde sedan postdocutbildning på Harvard Medical School 2000. Under 2001 kom jag tillbaka till Karolinska Institutet där jag blev docent och gruppledare 2004. Jag blev utnämnd till professor i klinisk immunologi vid Karolinska Institutet 2011.
Forskningsbeskrivning
Utvalda publikationer
Mesoscale DNA feature in antibody-coding sequence facilitates somatic hypermutation. Wang Y, Zhang S, Yang X, Hwang JK, Zhan C, Lian C, et al. Cell. 2023 May 11;186(10):2193-2207.e19.
Heterologous inactivated virus/mRNA vaccination response to BF.7, BQ.1.1, and XBB.1. Zuo F, Sun R, Abolhassani H, Du L, Wang Y, Vlachiotis S, et al. Lancet Reg Health West Pac. 2023 Apr;33:100762.
DNA repair mechanisms that promote insertion-deletion events during immunoglobulin gene diversification. Hao Q, Zhan C, Lian C, Luo S, Cao W, Wang B, Xie X, Ye X, et al. Sci Immunol. 2023 Mar 31;8(81):eade1167.
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein. Bianchini F, Crivelli V, Abernathy ME, Guerra C, Palus M, er al. Sci Immunol. 2023 Mar 17;8(81):eade0958.
Inherited IFNAR1 Deficiency in a Child with Both Critical COVID-19 Pneumonia and Multisystem Inflammatory Syndrome. Abolhassani H, Landegren N, Bastard P, Materna M, Modaresi M, Du L, et al. J Clin Immunol 2022 Apr;42(3):471-483
A single-cell atlas of diffuse large B cell lymphoma. Ye X, Wang L, Nie M, Wang Y, Dong S, Ren W, Li G, Li ZM, Wu K, Pan-Hammarström Q Cell Rep 2022 Apr;39(3):110713
Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant. Zuo F, Abolhassani H, Du L, Piralla A, Bertoglio F, de Campos-Mata L, Wan H, et al. Nat Commun 2022 May;13(1):2670
Human T-bet governs the generation of a distinct subset of CD11chighCD21low B cells. Yang R, Avery DT, Jackson KJL, Ogishi M, Benhsaien I, Du L, Ye X, et al. Sci Immunol 2022 Jul;7(73):eabq3277
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia. Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, et al. J Exp Med 2022 Aug;219(8)
Limited cross-variant neutralization after primary Omicron infection: consideration for a variant-containing booster. Marcotte H, Hammarström L, Pan-Hammarström Q Signal Transduct Target Ther 2022 Aug;7(1):294
Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19. Abolhassani H, Delavari S, Landegren N, Shokri S, Bastard P, Du L, et al. J Allergy Clin Immunol 2022 Nov;150(5):1059-1073
Mucosal IgA against SARS-CoV-2 Omicron Infection. Zuo F, Marcotte H, Hammarström L, Pan-Hammarström Q N Engl J Med 2022 Nov;387(21):e55
The dual role of CD70 in B-cell lymphomagenesis. Nie M, Ren W, Ye X, Berglund M, Wang X, Fjordén K, Du L, et al. Clin Transl Med 2022 Dec;12(12):e1118
SARS-CoV-2 specific B- and T-cell immunity in a population-based study of young Swedish adults. Björkander S, Du L, Zuo F, Ekström S, Wang Y, Wan H, Sherina N, et al., J Allergy Clin Immunol 2021 Oct
X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia. Abolhassani H, Vosughimotlagh A, Asano T, Landegren N, Boisson B, Delavari S, et al., J Clin Immunol 2021 Oct
Antibody therapy for COVID-19. Hammarström L, Marcotte H, Piralla A, Baldanti F, Pan-Hammarström Q Curr Opin Allergy Clin Immunol 2021 Sep
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Asano T, Boisson B, Onodi F, Matuozzo D, Moncada-Velez M, Maglorius Renkilaraj MRL, et al. Sci Immunol 2021 08;6(62): eabl4348.
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, et al. Sci Immunol 2021 08;6(62): eabl4340.
Genetic mechanisms of HLA-I loss and immune escape in diffuse large B cell lymphoma. Fangazio M, Ladewig E, Gomez K, Garcia-Ibanez L, Kumar R, Teruya-Feldstein J, et al. Proc Natl Acad Sci U S A 2021 Jun;118(22)
Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection. Sherina N, Piralla A, Du L, Wan H, Kumagai-Braesch M, Andréll J, et al. Med (N Y) 2021 Mar;2(3):281-295.e4
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. De Gasparo R, Pedotti M, Simonelli L, Nickl P, et al Nature 2021 Mar; doi: 10.1038/s41586-021-03461-y.
Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas. Ye X, Ren W, Liu D, Li X, Li W, Wang X, et al J Exp Med 2021 Feb;218(2):e20200573. doi: 10.1084/jem.20200573.
Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria. Yang R, Mele F, Worley L, Langlais D, Rosain J, Benhsaien I, et al Cell 2020 Dec 3:S0092-8674(20)31453-7. doi: 10.1016/j.cell.2020.10.046.
Pan-cancer analysis of whole genomes. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium Nature 2020 02;578(7793):82-93
Genomic basis for RNA alterations in cancer PCAWG Transcriptome Core Group, et al Nature 2020 578(7793);129-136
Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma. Ren W, Ye X, Su H, Li W, Liu D, Pirmoradian M, et al Blood 2018 06;131(24):2670-2681
Reduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome. Björkman A, Du L, van der Burg M, Cormier-Daire V, Borck G, Pié J, et al J. Allergy Clin. Immunol. 2018 01;141(1):408-411.e8
Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. Abolhassani H, Edwards ES, Ikinciogullari A, Jing H, Borte S, Buggert M, et al J. Exp. Med. 2017 01;214(1):91-106
Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency. Bronson PG, Chang D, Bhangale T, Seldin MF, Ortmann W, Ferreira RC, et al Nat. Genet. 2016 11;48(11):1425-1429
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas. Georgiou K, Chen L, Berglund M, Ren W, de Miranda NF, Lisboa S, et al Blood 2016 06;127(24):3026-34
Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas. Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S, et al Nat Commun 2015 Dec;6():10131
Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells. Björkman A, Qvist P, Du L, Bartish M, Zaravinos A, Georgiou K, et al Proc. Natl. Acad. Sci. U.S.A. 2015 Feb;112(7):2157-62
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, et al Cell 2014 Dec;159(7):1524-37
Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients. de Miranda NF, Georgiou K, Chen L, Wu C, Gao Z, Zaravinos A, et al Blood 2014 Oct;124(16):2544-53
A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination. Enervald E, Du L, Visnes T, Björkman A, Lindgren E, Wincent J, et al J. Exp. Med. 2013 Nov;210(12):2503-13
DNA repair genes are selectively mutated in diffuse large B cell lymphomas. de Miranda NF, Peng R, Georgiou K, Wu C, Falk Sörqvist E, Berglund M, et al J. Exp. Med. 2013 Aug;210(9):1729-42
Nurture your scientific curiosity early in your research career. Jagodic M, Stridh P, Gad AK, Paine A, Udekwu KI, Sjöholm LK, et al Nat. Genet. 2013 Feb;45(2):116-8
Utbildning
MD, Sun Yat-Sen Universitetet 1993 PhD, Immunologi, KI 1999 Ledarskapsprogram vid Harvard Business School 2017-2019