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Arne Östman

Professor

Om mig

Professor, Dept of Oncology-Pathology, Karolinska Institutet, 2006-

Professor II, CCBIO, Bergen University, 2016-

Forskningsbeskrivning

The Östman research group performs translation studies on autocrine and paracrine growth factor signaling in the tumor microenvironment, with particular emphasis on regulation of cancer-associated fibroblasts.

Selected qualifications (2021)

Author of more than 160 original research articles and 45+ reviews (Nat Rev Can, Cancer Cell, Trends in Cell Biology and Trends in Cancer); h-factor 62 (web of Science).

Completed supervision of 14 PhD students and 19 post-doctoral fellows of which the majority continues academic research. Six of these are full professors and 8 have been promoted to PI or junior PI positions.

Coordinator STARGET – a Linnaeus center for translational studies on the tumor microenvironment with funding from VR 2006-16.

Co-director StratCan – the strategic research program in cancer at Karolinska Institutet, 2010-18.

Member of the Nobel assembly (2020-).

Ad-hoc reviewer for the Nobel Assembly and the Royal Academy of Science (Sjöberg Prize).

Member of the Editorial Board Cancer Research (2015-).

Member of the board of “Svenska Sällskapet för Medicinsk Forskning” (2020-).

Supported by research grants from Swedish Cancer Society, Swedish Research Council, “Kreftforeningen”, Stockholm City Council (ALF), “Radiumhemmets forskningsfonder”, KAW (E Arner PI) and Ipsen.

External grant reviewer for Cancerfonden, Barncancerfonden, SSMF, ERC and national European agencies including CRUK and Wellcome Trust. Reviewer for e.g.  Nature, Nature Medicine, Nature Comm., Nat Rev Cancer, Nat Rev Clin Onc, Cancer Cell, EMBO J.

Main- or co-organizer of UICC Advanced Course of Cell Signaling and Cancer, 1999; Nobel Conference on Breast Cancer, 2012 and Swedish Cancer Research Meeting 2014.

Ad hoc member of international scientific advisory boards for e.g. ImClone, Eli-Lilly and Novartis.

10 selected publications since 2010

Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer.  Saito RA, Micke P, Paulsson J, Augsten M, Peña C, Jönsson P, Botling J, Edlund K, Johansson L, Carlsson P, Jirström K, Miyazono K, Ostman A. Cancer Res. 2010 Apr 1;70(7):2644-54.

The tumor microenvironment controls drug sensitivity. Ostman A. Nat Med. 2012 Sep;18(9):1332-4.

STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer. Peña C, Céspedes MV, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist PH, Hägglöf C, Birgisson H, Bojmar L, Jirström K, Sandström P, Olsson E, Veerla S, Gallardo A, Sjöblom T, Chang AC, Reddel RR, Mangues R, Augsten M, Ostman A. Cancer Res. 2013 Feb 15;73(4):1287-97.

Distinct effects of ligand-induced PDGFRα and PDGFRβ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments. Ehnman M, Missiaglia E, Folestad E, Selfe J, Strell C, Thway K, Brodin B, Pietras K, Shipley J, Östman A, Eriksson U. Cancer Res. 2013 Apr 1;73(7):2139-49

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling. Dagnell M, Frijhoff J, Pader I, Augsten M, Boivin B, Xu J, Mandal PK, Tonks NK, Hellberg C, Conrad M, Arnér ES, Östman A. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13398-403.

Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties. Augsten M, Sjöberg E, Frings O, Vorrink SU, Frijhoff J, Olsson E, Borg Å, Östman A. Cancer Res. 2014 Jun 1;74(11):2999-3010.

Local and systemic protumorigenic effects of cancer-associated fibroblast-derived GDF15. Bruzzese F, Hägglöf C, Leone A, Sjöberg E, Roca MS, Kiflemariam S, Sjöblom T, Hammarsten P, Egevad L, Bergh A, Ostman A, Budillon A, Augsten M. Cancer Res. 2014 Jul 1;74(13):3408-17.

A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer. Sjöberg E, Meyrath M, Milde L, Herrera M, Lövrot J, Hägerstrand D, Frings O, Bartish M, Rolny C, Sonnhammer E, Chevigné A, Augsten M* and  Östman A.*  *equal contribution Clin Cancer Res. 2019 Jun 15;25(12):3702-3717.

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ. Strell C, Paulsson J, Jin SB, Tobin NP, Mezheyeuski A, Roswall P, Mutgan C, Mitsios N, Johansson H, Wickberg SM, Svedlund J, Nilsson M, Hall P, Mulder J, Radisky DC, Pietras K, Bergh J, Lendahl U, Wärnberg F, Östman A. J Natl Cancer Inst. 2019 Sep 1;111(9):983-995.

High stromal PDGFRb expression predicts lack of benefit from post-operative radiotherapy in ductal breast carcinoma in situ within the SwedDCIS randomized trialStrell, C., Folkvaljon, D., Holmberg, E., Karlsson, P., Bergh, J., Bremer, T., Akslen, L.A., Wärnberg, F.* and Östman, A.*  *equal contribution Clin. Can. Res. 2021 DOI:10.1158/1078-0432.CCR-20-4300 )

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