Vesna Munic Kos

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Main focus of my research are chemicals (pharmaceuticals and environmental
toxins) which accumulate in organisms, and the effects they have on cells.
During 13 years of my career in the research of pharmaceutical industry large
part of my research was dealing with highly accumulating pharmaceuticals,
especially of macrolide class. Now I am studying endocrine disrupting
chemicals and the mechanisms of their impact on metabolic disorders as well
as their toxicokinetic properties.
Read more about my research on this link [1].
[1] https://ki.se/en/people/vesmun

Artiklar

Journal article: CHEMOSPHERE. 2024;349:140852

Environmental chemicals change extracellular lipidome of mature human white adipocytes.

Burkhardt P; Palma-Duran SA; Tuck ARR; Norgren K; Li X; Nikiforova V; Griffin JL; Munic Kos V
Journal article: TOXICOLOGY LETTERS. 2023;384:s72-S74

OS04-07 Environmental chemicals change extracellular lipidome of mature human white adipocytes

Burkhardt P; Duran SAP; Tuck A; Norgren K; Li X; Nikiforova V; Griffin JL; Kos VM
Article: FOOD AND CHEMICAL TOXICOLOGY. 2022;161:112842

High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells (hMSCs).

Norgren K; Tuck A; Vieira Silva A; Burkhardt P; Öberg M; Munic Kos V
Article: ARCHIVES OF TOXICOLOGY. 2021;95(2):591-615

Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors.

Delp J; Cediel-Ulloa A; Suciu I; Kranaster P; van Vugt-Lussenburg BM; Munic Kos V; van der Stel W; Carta G; Bennekou SH; Jennings P; van de Water B; Forsby A; Leist M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(2):363-377

A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides.

Peric M; Pešić D; Alihodžić S; Fajdetić A; Herreros E; Gamo FJ; Angulo-Barturen I; Jiménez-Díaz MB; Ferrer-Bazaga S; Martínez MS; Gargallo-Viola D; Mathis A; Kessler A; Banjanac M; Padovan J; Bencetić Mihaljević V; Munic Kos V; Bukvić M; Eraković Haber V; Spaventi R
Article: BIOMEDICINE & PHARMACOTHERAPY. 2020;130:110582

Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19.

Norinder U; Tuck A; Norgren K; Munic Kos V
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(23):E5938-5938

QSAR Models for Predicting Five Levels of Cellular Accumulation of Lysosomotropic Macrocycles.

Norinder U; Munic Kos V
Article: JOURNAL OF PHARMACEUTICAL SCIENCES. 2019;108(1):652-660

Quantification of Intracellular Accumulation and Retention of Lysosomotropic Macrocyclic Compounds by High-Throughput Imaging of Lysosomal Changes.

Easwaranathan A; Inci B; Ulrich S; Brunken L; Nikiforova V; Norinder U; Swanson S; Munic Kos V
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2018;829:44-53

Lysosomotropic cationic amphiphilic drugs inhibit adipocyte differentiation in 3T3-L1K cells via accumulation in cells and phospholipid membranes, and inhibition of autophagy.

Kagebeck P; Nikiforova V; Brunken L; Easwaranathan A; Ruegg J; Cotgreave I; Munic Kos V
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2018;281:1-10

Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs.

Sanchez Garcia D; Sjödin M; Hellstrandh M; Norinder U; Nikiforova V; Lindberg J; Wincent E; Bergman Å; Cotgreave I; Munic Kos V
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2017;133:351-364

Around the macrolide - Impact of 3D structure of macrocycles on lipophilicity and cellular accumulation.

Koštrun S; Munic Kos V; Matanović Škugor M; Palej Jakopović I; Malnar I; Dragojević S; Ralić J; Alihodžić S
Article: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 2014;39(4):263-276

A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents.

Milić A; Mihaljević VB; Ralić J; Bokulić A; Nožinić D; Tavčar B; Mildner B; Munić V; Malnar I; Padovan J
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2013;49(2):206-219

Structure-property relationship for cellular accumulation of macrolones in human polymorphonuclear leukocytes (PMNs).

Munić Kos V; Koštrun S; Fajdetić A; Bosnar M; Kelnerić Ž; Stepanić V; Eraković Haber V
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2013;21(1):321-332

Macrolactonolides: a novel class of anti-inflammatory compounds.

Tomašković L; Komac M; Makaruha Stegić O; Munić V; Ralić J; Stanić B; Banjanac M; Marković S; Hrvačić B; Čipčić Paljetak H; Padovan J; Glojnarić I; Eraković Haber V; Mesić M; Merćep M
Article: PHARMACOLOGICAL RESEARCH. 2012;66(4):357-362

Anti-inflammatory mechanism of action of azithromycin in LPS-stimulated J774A.1 cells.

Banjanac M; Munić Kos V; Nujić K; Vrančić M; Belamarić D; Crnković S; Hlevnjak M; Eraković Haber V
Article: PHARMACOLOGICAL RESEARCH. 2012;66(4):332-342

Fluorescently labeled macrolides as a tool for monitoring cellular and tissue distribution of azithromycin.

Matijašić M; Munić Kos V; Nujić K; Cužić S; Padovan J; Kragol G; Alihodžić S; Mildner B; Verbanac D; Eraković Haber V
Article: CELLULAR IMMUNOLOGY. 2012;279(1):78-86

Impairment of lysosomal functions by azithromycin and chloroquine contributes to anti-inflammatory phenotype.

Nujić K; Banjanac M; Munić V; Polančec D; Eraković Haber V
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2012;165(5):1348-1360

Azithromycin distinctively modulates classical activation of human monocytes in vitro.

Vrančić M; Banjanac M; Nujić K; Bosnar M; Murati T; Munić V; Stupin Polančec D; Belamarić D; Parnham MJ; Eraković Haber V
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2011;91(2):229-243

Azithromycin drives in vitro GM-CSF/IL-4-induced differentiation of human blood monocytes toward dendritic-like cells with regulatory properties.

Polancec DS; Munic Kos V; Banjanac M; Vrancic M; Cuzic S; Belamaric D; Parnham MJ; Polancec D; Erakovic Haber V
Article: PHARMACOLOGICAL RESEARCH. 2011;64(3):298-307

Intensity of macrolide anti-inflammatory activity in J774A.1 cells positively correlates with cellular accumulation and phospholipidosis.

Munić V; Banjanac M; Koštrun S; Nujić K; Bosnar M; Marjanović N; Ralić J; Matijašić M; Hlevnjak M; Eraković Haber V
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2011;43(5):359-369

Characterization of rhodamine-123, calcein and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells.

Munić V; Hlevnjak M; Eraković Haber V
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2011;54(3):719-733

Modeling cellular pharmacokinetics of 14- and 15-membered macrolides with physicochemical properties.

Stepanić V; Koštrun S; Malnar I; Hlevnjak M; Butković K; Ćaleta I; Dukši M; Kragol G; Makaruha-Stegić O; Mikac L; Ralić J; Tatić I; Tavčar B; Valko K; Zulfikari S; Munić V
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2010;41(1):86-95

Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays.

Munić V; Kelnerić Z; Mikac L; Eraković Haber V
Article: AQUATIC TOXICOLOGY. 2008;90(4):322-332

Cloning and molecular characterization of apical efflux transporters (ABCB1, ABCB11 and ABCC2) in rainbow trout (Oncorhynchus mykiss) hepatocytes.

Zaja R; Munić V; Klobucar RS; Ambriović-Ristov A; Smital T
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2005;517(1-2):132-143

Modulation of neutrophil and inflammation markers in chronic obstructive pulmonary disease by short-term azithromycin treatment.

Parnham MJ; Culić O; Eraković V; Munić V; Popović-Grle S; Barisić K; Bosnar M; Brajsa K; Cepelak I; Cuzić S; Glojnarić I; Manojlović Z; Novak-Mircetić R; Oresković K; Pavicić-Beljak V; Radosević S; Sucić M
Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2005;49(6):2372-2377

Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin.

Bosnar M; Kelnerić Z; Munić V; Eraković V; Parnham MJ
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2002;450(3):277-289

Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects.

Culić O; Eraković V; Cepelak I; Barisić K; Brajsa K; Ferencić Z; Galović R; Glojnarić I; Manojlović Z; Munić V; Novak-Mircetić R; Pavicić-Beljak V; Sucić M; Veljaca M; Zanić-Grubisić T; Parnham MJ
Article: NEUROPEPTIDES. 2000;34(2):121-128

The link between met-enkephalin-induced down-regulation of APN activity and the release of superoxide anion.

Marotti T; Balog T; Munić V; Sobocanec S; Abramić M
Visa fler

Alla övriga publikationer

Corrigendum: BIOCHEMICAL PHARMACOLOGY. 2022;202:115145

Corrigendum to "Obesity III: Obesogen assays: Limitations, strengths, and new directions" [Biochem. Pharmacol. 199 (2022) 115014].

Kassotis CD; Vom Saal FS; Babin PJ; Lagadic-Gossmann D; Le Mentec H; Blumberg B; Mohajer N; Legrand A; Munic Kos V; Martin-Chouly C; Podechard N; Langouët S; Touma C; Barouki R; Kim MJ; Audouze K; Choudhury M; Shree N; Bansal A; Howard S; Heindel JJ
Corrigendum: BIOCHEMICAL PHARMACOLOGY. 2022;202:115144

Corrigendum to "Obesity II: Establishing causal links between chemical exposures and obesity" [Biochem. Pharmacol. 199 (2022) 115015].

Heindel JJ; Howard S; Agay-Shay K; Arrebola JP; Audouze K; Babin PJ; Barouki R; Bansal A; Blanc E; Cave MC; Chatterjee S; Chevalier N; Choudhury M; Collier D; Connolly L; Coumoul X; Garruti G; Gilbertson M; Hoepner LA; Holloway AC; Howell G; Kassotis CD; Kay MK; Kim MJ; Lagadic-Gossmann D; Langouet S; Legrand A; Li Z; Le Mentec H; Lind L; Lind PM; Lustig RH; Martin-Chouly C; Munic Kos V; Podechard N; Roepke TA; Sargis RM; Starling A; Tomlinson CR; Touma C; Vondracek J; Vom Saal F; Blumberg B
Review: BIOCHEMICAL PHARMACOLOGY. 2022;199:115015

Obesity II: Establishing causal links between chemical exposures and obesity.

Heindel JJ; Howard S; Agay-Shay K; Arrebola JP; Audouze K; Babin PJ; Barouki R; Bansal A; Blanc E; Cave MC; Chatterjee S; Chevalier N; Choudhury M; Collier D; Connolly L; Coumoul X; Garruti G; Gilbertson M; Hoepner LA; Holloway AC; Howell G; Kassotis CD; Kay MK; Kim MJ; Lagadic-Gossmann D; Langouet S; Legrand A; Li Z; Le Mentec H; Lind L; Monica Lind P; Lustig RH; Martin-Chouly C; Munic Kos V; Podechard N; Roepke TA; Sargis RM; Starling A; Tomlinson CR; Touma C; Vondracek J; Vom Saal F; Blumberg B
Review: BIOCHEMICAL PHARMACOLOGY. 2022;199:115014

Obesity III: Obesogen assays: Limitations, strengths, and new directions.

Kassotis CD; Vom Saal FS; Babin PJ; Lagadic-Gossmann D; Le Mentec H; Blumberg B; Mohajer N; Legrand A; Munic Kos V; Martin-Chouly C; Podechard N; Langouët S; Touma C; Barouki R; Kim MJ; Audouze K; Choudhury M; Shree N; Bansal A; Howard S; Heindel JJ
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(10):E3480-3480

The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds.

Legler J; Zalko D; Jourdan F; Jacobs M; Fromenty B; Balaguer P; Bourguet W; Munic Kos V; Nadal A; Beausoleil C; Cristobal S; Remy S; Ermler S; Margiotta-Casaluci L; Griffin JL; Blumberg B; Chesné C; Hoffmann S; Andersson PL; Kamstra JH
Published conference paper: MARINE ENVIRONMENTAL RESEARCH. 2008;66(1):77-79

Cloning and mRNA expression analysis of an ABCG2 (BCRP) efflux transporter in rainbow trout (Oncorhynchus mykiss) liver and primary hepatocytes.

Zaja R; Munić V; Smital T

Anställningar

Anknuten till Forskning, Fysiologi och farmakologi, Karolinska Institutet, 2024-2024
Forskare, Fysiologi och farmakologi, Karolinska Institutet, 2019-2024

Om mig

Artiklar

Alla övriga publikationer

Anställningar

Nyheter från KI

Kalenderhändelser från KI