Veronica Höiom
Senior Forskningsspecialist
E-postadress: veronica.hoiom@ki.se
Besöksadress: J6:20 BioClinicum, Akademiska stråket 1, 17164 Solna
Postadress: K7 Onkologi-Patologi, K7 Forskning Helgadottir, 171 77 Stockholm
Om mig
- I have a PhD (faculty of medicine) in Medical Genetics and are working as a Research Scientist at the Dept. of Oncology & Pathology, Karolinska Institutet, and as a Genetic Counselor at the Hereditary Cancer Unit, Karolinska University Hospital.
Forskningsbeskrivning
- My research focus is to reveal genetic mechanisms behind melanoma susceptibility and response to novel treatments. One research project aiming at discovering novel melanoma susceptibility genes by next-generation sequencing of melanoma-prone families. Approximately, 5- 10 % of all melanoma patients belong to a family with an inherited predisposition for melanoma (and in some cases also other malignancies). The most common high-penetrance gene for melanoma is the tumor suppressor gene, /CDKN2A/. In Sweden, less than 10% of the melanoma families carries a pathogenic variant in the /CDKN2A/ gene. We have also a few families with a pathogenic variant in another tumor suppressor gene, /BAP1/. Pathogenic variants in /BAP1/ is correlated to uveal melanoma, skin melanoma, mesothelioma and renal cell carcinoma. Knowledge about the genetic background is important for identifying high-risk individuals and facilitates primary and secondary prevention of melanoma. By exome sequencing of melanoma families without a mutation in a known melanoma gene, we are now in the process of new gene discovery by further genetic analyses and functional investigations of candidate genes. The development of targeted therapies and immune checkpoint inhibitors have substantially improved the outcome for patients with metastatic melanoma. However, not all patients benefit from these therapies or do it only for a limited period of time. The identification of biomarkers that predicts the treatment response are important to improve and also personalize the treatment options for melanoma patients. We are interested in understanding how inherited genetic variation can affect/predict clinical outcome by correlating host genotypes to response and survival of patients with advanced melanoma, treated with immunotherapy and/or targeted therapy.
Artiklar
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Article: JCO PRECISION ONCOLOGY. 2022;6:e2200145
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Article: BIOMEDICINES. 2022;10(5):1004
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Article: CANCERS. 2022;14(3):702
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Article: ACTA ONCOLOGICA. 2022;61(1):14-21
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Article: GENETICS IN MEDICINE. 2022;24(1):157-169
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Article: GENETICS IN MEDICINE. 2021;23(11):2087-2095
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Article: ACTA ONCOLOGICA. 2021;60(7):888-896
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Article: CANCER RESEARCH. 2021;81(9):2545-2555
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Article: BMC PUBLIC HEALTH. 2021;21(1):692
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Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2021;113(3):318-328
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Article: MELANOMA RESEARCH. 2020;30(5):500-510
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Article: MELANOMA RESEARCH. 2020;30(5):443-454
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Article: CELL DEATH AND DIFFERENTIATION. 2020;27(7):2081-2098
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Article: JOURNAL OF MEDICAL GENETICS. 2020;57(5):316-321
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Article: NATURE GENETICS. 2020;52(5):494-504
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Article: ACTA NEUROPATHOLOGICA. 2020;139(2):347-364
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Article: MELANOMA RESEARCH. 2019;29(5):483-490
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Article: CELL DEATH & DISEASE. 2019;10(9):663
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Article: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2019;81(2):386-394
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Article: LANCET CHILD & ADOLESCENT HEALTH. 2019;3(5):332-342
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Article: JOURNAL OF MEDICAL GENETICS. 2018;55(10):661-668
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Article: GENETICS IN MEDICINE. 2018;20(9):1087-1090
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Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2606-2612
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Article: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2017;77(5):893-901
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Article: CELL DEATH & DISEASE. 2017;8(8):e3029
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Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2017;409(15):3749-3756
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Article: LAKARTIDNINGEN. 2017;114:ELAM
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Article: HUMAN GENETICS. 2016;135(11):1241-1249
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Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(11):djw135
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Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(9):1914-1917
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Article: BIOMEDICAL CHROMATOGRAPHY. 2016;30(8):1234-1239
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Article: GENES CHROMOSOMES & CANCER. 2016;55(7):601-611
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Article: INTERNATIONAL JOURNAL OF CANCER. 2015;137(9):2220-2226
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Article: NATURE GENETICS. 2015;47(9):987-995
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Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(6):1351-1360
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Article: INTERNATIONAL JOURNAL OF CANCER. 2014;135(7):1625-1633
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Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2014;106(10):dju267
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Article: JOURNAL OF MEDICAL GENETICS. 2014;51(8):545-552
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Article: CANCER GENETICS. 2014;207(3):70-74
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Article: PIGMENT CELL & MELANOMA RESEARCH. 2014;27(2):234-243
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Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 2013;72(3):284-289
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Article: GENES CHROMOSOMES & CANCER. 2013;52(4):378-384
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Article: NATURE GENETICS. 2013;45(4):428-432
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Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(15_suppl):8588
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Article: PIGMENT CELL & MELANOMA RESEARCH. 2012;25(3):384-394
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Article: GENES CHROMOSOMES & CANCER. 2011;50(12):1076-1084
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Article: NATURE GENETICS. 2011;43(11):1108-1U98
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Article: PLOS ONE. 2011;6(12):e29451
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Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2010;102(20):1568-1583
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Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2010;87(1):6-16
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Article: NATURE GENETICS. 2009;41(8):920-U85
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Article: NATURE GENETICS. 2009;41(8):909-914
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Article: PIGMENT CELL & MELANOMA RESEARCH. 2009;22(2):196-204
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Article: NATURE GENETICS. 2009;41(2):221-227
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Article: NATURE GENETICS. 2008;40(11):1313-1318
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Article: NATURE GENETICS. 2008;40(7):886-891
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Article: JOURNAL OF MEDICAL GENETICS. 2007;44(2):99-106
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Article: CANCER RESEARCH. 2006;66(20):9818-9828
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Article: CLINICAL CHEMISTRY. 2005;51(12):2388-2391
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Article: GENES AND IMMUNITY. 2004;5(2):130-137
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Article: NATURE GENETICS. 2002;32(4):666-669
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Article: GENOMICS. 2000;70(3):307-314
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Article: JOURNAL OF AUTOIMMUNITY. 2000;14(2):169-178
- Visa fler
Alla övriga publikationer
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Letter: ACTA ONCOLOGICA. 2023;62(12):1967-1972
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Letter: ACTA ONCOLOGICA. 2023;62(6):565-570
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Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2021;39(15):9556
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Meeting abstract: ANNALS OF ONCOLOGY. 2020;31:S759
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Corrigendum: NATURE COMMUNICATIONS. 2019;10(1):299
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Review: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2018;110(12):1328-1341
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Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(5):1066-1069
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Review: APPLICATION OF CLINICAL GENETICS. 2016;9:147-155
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Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(1):287-290
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Editorial comment: ARTHRITIS & RHEUMATOLOGY. 2004;50(4):1348-1350
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Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;54(1-2):55-61