Thomas Perlmann

Om mig
Publikationer
Populärvetenskap och samverkan

Om mig

Professor i molekylär utvecklingsbiologi.

Forskningsbeskrivning

Läs om min forskargrupp [1] (på engelska). [1] http://ki.se/en/cmb/thomas-perlmanns-group

Utvalda publikationer

Article: NATURE NEUROSCIENCE. 2015;18(6):826-835

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gómez-Galán M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
Article: CELL REPORTS. 2014;8(4):1018-1025

Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons.

Panman L; Papathanou M; Laguna A; Oosterveen T; Volakakis N; Acampora D; Kurtsdotter I; Yoshitake T; Kehr J; Joodmardi E; Muhr J; Simeone A; Ericson J; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2360-2365

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.

Kadkhodaei B; Alvarsson A; Schintu N; Ramsköld D; Volakakis N; Joodmardi E; Yoshitake T; Kehr J; Decressac M; Björklund A; Sandberg R; Svenningsson P; Perlmann T
Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(163):163ra156

α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.

Decressac M; Kadkhodaei B; Mattsson B; Laguna A; Perlmann T; Björklund A
Review: NATURE REVIEWS GENETICS. 2012;13(6):429-439

Maintaining differentiated cellular identity.

Holmberg J; Perlmann T
Article: GENES & DEVELOPMENT. 2011;25(19):2031-2040

Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.

Malewicz M; Kadkhodaei B; Kee N; Volakakis N; Hellman U; Viktorsson K; Leung CY; Chen B; Lewensohn R; van Gent DC; Chen DJ; Perlmann T
Article: CELL STEM CELL. 2011;8(6):663-675

Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells.

Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T

Artiklar

Article: EMBO JOURNAL. 2022;41(17):e108780

Schwann cell precursors represent a neural crest-like state with biased multipotency.

Kastriti ME; Faure L; Von Ahsen D; Bouderlique TG; Boström J; Solovieva T; Jackson C; Bronner M; Meijer D; Hadjab S; Lallemend F; Erickson A; Kaucka M; Dyachuk V; Perlmann T; Lahti L; Krivanek J; Brunet J-F; Fried K; Adameyko I
Article: SCIENCE ADVANCES. 2022;8(34):eabo1543

PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons.

Toskas K; Yaghmaeian-Salmani B; Skiteva O; Paslawski W; Gillberg L; Skara V; Antoniou I; Södersten E; Svenningsson P; Chergui K; Ringnér M; Perlmann T; Holmberg J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(13):6961

Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation.

Pulcrano S; De Gregorio R; De Sanctis C; Lahti L; Perrone-Capano C; Ponti D; di Porzio U; Perlmann T; Caiazzo M; Volpicelli F; Bellenchi GC
Article: DEVELOPMENT. 2022;149(5):dev200076

Selective requirement for polycomb repressor complex 2 in the generation of specific hypothalamic neuronal subtypes.

Yaghmaeian Salmani B; Balderson B; Bauer S; Ekman H; Starkenberg A; Perlmann T; Piper M; Bodén M; Thor S
Article: PLOS GENETICS. 2021;17(9):e1009822

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

Filograna R; Lee S; Tiklová K; Mennuni M; Jonsson V; Ringnér M; Gillberg L; Sopova E; Shupliakov O; Koolmeister C; Olson L; Perlmann T; Larsson N-G
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021;14:763777

Disease Duration Influences Gene Expression in Neuromelanin-Positive Cells From Parkinson's Disease Patients.

Tiklová K; Gillberg L; Volakakis N; Lundén-Miguel H; Dahl L; Serrano GE; Adler CH; Beach TG; Perlmann T
Article: NATURE COMMUNICATIONS. 2020;11(1):2898

CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.

Hagey DW; Topcic D; Kee N; Reynaud F; Bergsland M; Perlmann T; Muhr J
Article: NATURE COMMUNICATIONS. 2020;11(1):2434

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.

Tiklová K; Nolbrant S; Fiorenzano A; Björklund ÅK; Sharma Y; Heuer A; Gillberg L; Hoban DB; Cardoso T; Adler AF; Birtele M; Lundén-Miguel H; Volakakis N; Kirkeby A; Perlmann T; Parmar M
Article: NATURE COMMUNICATIONS. 2019;10(1):581

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.

Tiklová K; Björklund ÅK; Lahti L; Fiorenzano A; Nolbrant S; Gillberg L; Volakakis N; Yokota C; Hilscher MM; Hauling T; Holmström F; Joodmardi E; Nilsson M; Parmar M; Perlmann T
Article: NATURE COMMUNICATIONS. 2018;9(1):1226

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.

Södersten E; Toskas K; Rraklli V; Tiklova K; Björklund ÅK; Ringnér M; Perlmann T; Holmberg J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(10):2735-2740

Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.

Green H; Zhang X; Tiklova K; Volakakis N; Brodin L; Berg L; Greengard P; Perlmann T; Svenningsson P
Article: CELL STEM CELL. 2017;20(1):29-40

Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

Kee N; Volakakis N; Kirkeby A; Dahl L; Storvall H; Nolbrant S; Lahti L; Björklund ÅK; Gillberg L; Joodmardi E; Sandberg R; Parmar M; Perlmann T
Article: CELL STEM CELL. 2017;20(1):135-148

Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

Kirkeby A; Nolbrant S; Tiklova K; Heuer A; Kee N; Cardoso T; Ottosson DR; Lelos MJ; Rifes P; Dunnett SB; Grealish S; Perlmann T; Parmar M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(30):E4387-E4396

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.

Doucet-Beaupré H; Gilbert C; Profes MS; Chabrat A; Pacelli C; Giguère N; Rioux V; Charest J; Deng Q; Laguna A; Ericson J; Perlmann T; Ang S-L; Cicchetti F; Parent M; Trudeau L-E; Lévesque M
Article: DEVELOPMENT. 2016;143(14):2616-2628

The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.

Gross S; Garofalo DC; Balderes DA; Mastracci TL; Dias JM; Perlmann T; Ericson J; Sussel L
Article: SCIENTIFIC REPORTS. 2016;6:26448

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.

Hedlund E; Belnoue L; Theofilopoulos S; Salto C; Bye C; Parish C; Deng Q; Kadkhodaei B; Ericson J; Arenas E; Perlmann T; Simon A
Article: JOURNAL OF NEUROSCIENCE. 2015;35(42):14370-14385

Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression.

Volakakis N; Tiklova K; Decressac M; Papathanou M; Mattsson B; Gillberg L; Nobre A; Björklund A; Perlmann T
Article: JOURNAL OF NEUROSCIENCE. 2015;35(41):14057-14069

Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission.

Alvarsson A; Zhang X; Stan TL; Schintu N; Kadkhodaei B; Millan MJ; Perlmann T; Svenningsson P
Article: STEM CELLS. 2014;32(3):609-622

Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells.

Mong J; Panman L; Alekseenko Z; Kee N; Stanton LW; Ericson J; Perlmann T
Article: STEM CELLS AND DEVELOPMENT. 2014;23(1):5-15

Detailed expression analysis of regulatory genes in the early developing human neural tube.

Marklund U; Alekseenko Z; Andersson E; Falci S; Westgren M; Perlmann T; Graham A; Sundström E; Ericson J
Article: DEVELOPMENT. 2012;139(14):2625-2634

Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors.

Metzakopian E; Lin W; Salmon-Divon M; Dvinge H; Andersson E; Ericson J; Perlmann T; Whitsett JA; Bertone P; Ang S-L
Article: JOURNAL OF NEUROSCIENCE. 2012;32(2):436-451

Prenatal immune activation interacts with genetic Nurr1 deficiency in the development of attentional impairments.

Vuillermot S; Joodmardi E; Perlmann T; Ögren SO; Feldon J; Meyer U
Article: DEVELOPMENT. 2011;138(16):3399-3408

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.

Deng Q; Andersson E; Hedlund E; Alekseenko Z; Coppola E; Panman L; Millonig JH; Brunet J-F; Ericson J; Perlmann T
Article: GENES BRAIN AND BEHAVIOR. 2011;10(5):589-603

Schizophrenia-relevant behaviors in a genetic mouse model of constitutive Nurr1 deficiency.

Vuillermot S; Joodmardi E; Perlmann T; Ove Ögren S; Feldon J; Meyer U
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2010;88(10):2284-2293

Rapid increase of Nurr1 mRNA expression in limbic and cortical brain structures related to coping with depression-like behavior in mice.

Rojas P; Joodmardi E; Perlmann T; Ogren SO
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(27):12317-12322

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.

Volakakis N; Kadkhodaei B; Joodmardi E; Wallis K; Panman L; Silvaggi J; Spiegelman BM; Perlmann T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(4):1186-1191

NR4A orphan nuclear receptors influence retinoic acid and docosahexaenoic acid signaling via up-regulation of fatty acid binding protein 5.

Volakakis N; Joodmardi E; Perlmann T
Article: JOURNAL OF NEUROSCIENCE. 2009;29(50):15923-15932

Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons.

Kadkhodaei B; Ito T; Joodmardi E; Mattsson B; Rouillard C; Carta M; Muramatsu S-I; Sumi-Ichinose C; Nomura T; Metzger D; Chambon P; Lindqvist E; Larsson N-G; Olson L; Björklund A; Ichinose H; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(18):7613-7618

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells.

Friling S; Andersson E; Thompson LH; Jönsson ME; Hebsgaard JB; Nanou E; Alekseenko Z; Marklund U; Kjellander S; Volakakis N; Hovatta O; El Manira A; Björklund A; Perlmann T; Ericson J
Article: DEVELOPMENT. 2008;135(10):1843-1851

SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation.

Holmberg J; Hansson E; Malewicz M; Sandberg M; Perlmann T; Lendahl U; Muhr J
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2008;472(2):105-114

Corepressor interaction differentiates the permissive and non-permissive retinoid X receptor heterodimers.

Lammi J; Perlmann T; Aarnisalo P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2008;38(1):147-155

Retinoid receptor-activating ligands are produced within the mouse thymus during postnatal development.

Kiss I; Rühl R; Szegezdi E; Fritzsche B; Tóth B; Pongrácz J; Perlmann T; Fésüs L; Szondy Z
Article: HIPPOCAMPUS. 2008;18(8):785-792

Running increases neurogenesis without retinoic acid receptor activation in the adult mouse dentate gyrus.

Aberg E; Perlmann T; Olson L; Brené S
Article: MOLECULAR PSYCHIATRY. 2007;12(8):756-766

Adult mice with reduced Nurr1 expression: an animal model for schizophrenia.

Rojas P; Joodmardi E; Hong Y; Perlmann T; Ogren SO
Article: GENES & DEVELOPMENT. 2006;20(24):3475-3486

The establishment of neuronal properties is controlled by Sox4 and Sox11.

Bergsland M; Werme M; Malewicz M; Perlmann T; Muhr J
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2006;37(2):317-326

Characterization of the Nurr1 ligand-binding domain co-activator interaction surface.

Volakakis N; Malewicz M; Kadkhodai B; Perlmann T; Benoit G
Article: JOURNAL OF NEUROCHEMISTRY. 2006;97(5):1403-1411

Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem.

Hermanson E; Borgius L; Bergsland M; Joodmardi E; Perlmann T
Article: CELL. 2006;124(2):393-405

Identification of intrinsic determinants of midbrain dopamine neurons.

Andersson E; Tryggvason U; Deng Q; Friling S; Alekseenko Z; Robert B; Perlmann T; Ericson J
Article: JOURNAL OF MASS SPECTROMETRY. 2005;40(11):1448-1461

Specificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha.

Lengqvist J; Mata de Urquiza A; Perlmann T; Sjövall J; Griffiths WJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(40):34159-34169

Full-length p73alpha represses drug-induced apoptosis in small cell lung carcinoma cells.

Nyman U; Sobczak-Pluta A; Vlachos P; Perlmann T; Zhivotovsky B; Joseph B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(51):53338-53345

Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.

Codina A; Benoit G; Gooch JT; Neuhaus D; Perlmann T; Schwabe JWR
Article: MOLECULAR & CELLULAR PROTEOMICS. 2004;3(7):692-703

Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.

Lengqvist J; Mata De Urquiza A; Bergman A-C; Willson TM; Sjövall J; Perlmann T; Griffiths WJ
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2004;556(Pt 1):43-59

Congenital hypoventilation and impaired hypoxic response in Nurr1 mutant mice.

Nsegbe E; Wallén-Mackenzie A; Dauger S; Roux J-C; Shvarev Y; Lagercrantz H; Perlmann T; Herlenius E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;313(1):205-211

Defining an N-terminal activation domain of the orphan nuclear receptor Nurr1.

Nordzell M; Aarnisalo P; Benoit G; Castro DS; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(26):15619-15624

p57(Kip2) cooperates with Nurr1 in developing dopamine cells.

Joseph B; Wallén-Mackenzie A; Benoit G; Murata T; Joodmardi E; Okret S; Perlmann T
Article: GENES & DEVELOPMENT. 2003;17(24):3036-3047

Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cells.

Wallen-Mackenzie A; Mata de Urquiza A; Petersson S; Rodriguez FJ; Friling S; Wagner J; Ordentlich P; Lengqvist J; Heyman RA; Arenas E; Perlmann T
Article: NEURON. 2003;40(1):97-111

Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern.

Sockanathan S; Perlmann T; Jessell TM
Article: EXPERIMENTAL CELL RESEARCH. 2003;288(2):324-334

Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells.

Hermanson E; Joseph B; Castro D; Lindqvist E; Aarnisalo P; Wallén A; Benoit G; Hengerer B; Olson L; Perlmann T
Article: BEHAVIOURAL BRAIN RESEARCH. 2003;143(1):95-100

Elevated locomotor activity without altered striatal dopamine contents in Nurr1 heterozygous mice after acute exposure to methamphetamine.

Bäckman C; You ZB; Perlmann T; Hoffer BJ
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2003;17(11):2418-2424

Decreased ethanol preference and wheel running in Nurr1-deficient mice.

Werme M; Hermanson E; Carmine A; Buervenich S; Zetterström RH; Thorén P; Ogren SO; Olson L; Perlmann T; Brené S
Article: NATURE. 2003;423(6939):555-560

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors.

Wang Z; Benoit G; Liu J; Prasad S; Aarnisalo P; Liu X; Xu H; Walker NPC; Perlmann T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(38):35118-35123

Defining requirements for heterodimerization between the retinoid X receptor and the orphan nuclear receptor Nurr1.

Aarnisalo P; Kim C-H; Lee JW; Perlmann T
Article: DEVELOPMENTAL BRAIN RESEARCH. 2002;133(1):37-47

Generation of tyrosine hydroxylase-immunoreactive neurons in ventral mesencephalic tissue of Nurr1 deficient mice.

Tornqvist N; Hermanson E; Perlmann T; Stromberg I
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2001;18(6):649-663

Orphan nuclear receptor Nurr1 is essential for Ret expression in midbrain dopamine neurons and in the brain stem.

Wallén A A; Castro DS; Zetterström RH; Karlén M; Olson L; Ericson J; Perlmann T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(46):43277-43284

Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells.

Castro DS; Hermanson E; Joseph B; Wallén A; Aarnisalo P; Heller A; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(20):11714-11719

Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity.

Misner DL; Jacobs S; Shimizu Y; de Urquiza AM; Solomin L; Perlmann T; De Luca LM; Stevens CF; Evans RM
Article: SCIENCE. 2000;290(5499):2140-2144

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain.

de Urquiza AM; Liu S; Sjöberg M; Zetterström RH; Griffiths W; Sjövall J; Perlmann T
Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2000;96(6):808-813

NURR1 mutations in cases of schizophrenia and manic-depressive disorder.

Buervenich S; Carmine A; Arvidsson M; Xiang F; Zhang Z; Sydow O; Jönsson EG; Sedvall GC; Leonard S; Ross RG; Freedman R; Chowdari KV; Nimgaonkar VL; Perlmann T; Anvret M; Olson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(52):37483-37490

Activity of the Nurr1 carboxyl-terminal domain depends on cell type and integrity of the activation function 2.

Castro DS; Arvidsson M; Bondesson Bolin M; Perlmann T
Article: BRAIN RESEARCH. 1999;851(1-2):125-132

A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain.

Bäckman C; Perlmann T; Wallén A; Hoffer BJ; Morales M
Article: EXPERIMENTAL CELL RESEARCH. 1999;253(2):737-746

Fate of mesencephalic AHD2-expressing dopamine progenitor cells in NURR1 mutant mice.

Wallén A; Zetterström RH; Solomin L; Arvidsson M; Olson L; Perlmann T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(23):13270-13275

Feedback-inducible nuclear-receptor-driven reporter gene expression in transgenic mice.

Mata De Urquiza A; Solomin L; Perlmann T
Article: NATURE BIOTECHNOLOGY. 1999;17(7):653-659

Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes.

Wagner J; Akerud P; Castro DS; Holm PC; Canals JM; Snyder EY; Perlmann T; Arenas E
Article: JOURNAL OF CELL BIOLOGY. 1999;145(3):503-514

Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin.

Pekny M; Johansson CB; Eliasson C; Stakeberg J; Wallén A; Perlmann T; Lendahl U; Betsholtz C; Berthold CH; Frisén J
Article: DEVELOPMENT. 1999;126(6):1317-1326

Retinoids are produced by glia in the lateral ganglionic eminence and regulate striatal neuron differentiation.

Toresson H; Mata de Urquiza A; Fagerström C; Perlmann T; Campbell K
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(2):407-416

Role of retinoids in the CNS: differential expression of retinoid binding proteins and receptors and evidence for presence of retinoic acid.

Zetterström RH; Lindqvist E; Mata de Urquiza A; Tomac A; Eriksson U; Perlmann T; Olson L
Article: NATURE. 1998;395(6700):398-402

Retinoid-X receptor signalling in the developing spinal cord.

Solomin L; Johansson CB; Zetterström RH; Bissonnette RP; Heyman RA; Olson L; Lendahl U; Frisén J; Perlmann T
Article: CELL. 1998;92(1):73-82

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

Kliewer SA; Moore JT; Wade L; Staudinger JL; Watson MA; Jones SA; McKee DD; Oliver BB; Willson TM; Zetterström RH; Perlmann T; Lehmann JM
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(8):2048-2056

Positive and negative thymic selection in T cell receptor-transgenic mice correlate with Nur77 mRNA expression.

Xue Y; Chomez P; Castanos-Velez E; Biberfeld P; Perlmann T; Jondal M
Article: SCIENCE. 1997;276(5310):248-250

Dopamine neuron agenesis in Nurr1-deficient mice.

Zetterström RH; Solomin L; Jansson L; Hoffer BJ; Olson L; Perlmann T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(14):9443-9449

Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation.

Botling J; Castro DS; Oberg F; Nilsson K; Perlmann T
Article: MOLECULAR ENDOCRINOLOGY. 1996;10(12):1656-1666

Retinoid X receptor heterodimerization and developmental expression distinguish the orphan nuclear receptors NGFI-B, Nurr1, and Nor1.

Zetterström RH; Solomin L; Mitsiadis T; Olson L; Perlmann T
Article: BRAIN RESEARCH. 1996;41(1-2):111-120

Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system.

Zetterström RH; Williams R; Perlmann T; Olson L
Article: GENES & DEVELOPMENT. 1995;9(7):769-782

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

Perlmann T; Jansson L
Visa fler

Alla övriga publikationer

Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):3630

Author Correction: Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.

Tiklová K; Nolbrant S; Fiorenzano A; Björklund ÅK; Sharma Y; Heuer A; Gillberg L; Hoban DB; Cardoso T; Adler AF; Birtele M; Lundén-Miguel H; Volakakis N; Kirkeby A; Perlmann T; Parmar M
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):4639

Author Correction: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.

Södersten E; Toskas K; Rraklli V; Tiklova K; Björklund ÅK; Ringnér M; Perlmann T; Holmberg J
Editorial comment: DEVELOPMENT. 2016;143(16):2877-2881

The stem cell niche finds its true north.

Kirkeby A; Perlmann T; Pereira C-F
Review: EXPERIMENTAL CELL RESEARCH. 2014;329(1):94-100

Function of transcription factors at DNA lesions in DNA repair.

Malewicz M; Perlmann T
Review: NATURE REVIEWS NEUROLOGY. 2013;9(11):629-636

NURR1 in Parkinson disease--from pathogenesis to therapeutic potential.

Decressac M; Volakakis N; Björklund A; Perlmann T
Editorial comment: BMC BIOLOGY. 2011;9:51

Tracing lineages to uncover neuronal identity.

Panman L; Perlmann T
Review: JOURNAL OF INTERNAL MEDICINE. 2009;266(4):358-371

Neuronal cell replacement in Parkinson's disease.

Hedlund E; Perlmann T
Meeting abstract: DEVELOPMENTAL BIOLOGY. 2007;306(1):430

Temporal patterning determines visceral motoneuron subtypes generated from Nkx2.2⁺ progenitors in the hindbrain

Applequist JM; Karlen M; Jordi E; Perlmann T; Ericson J
Review: PHARMACOLOGICAL REVIEWS. 2006;58(4):798-836

International Union of Pharmacology. LXVI. Orphan nuclear receptors.

Benoit G; Cooney A; Giguere V; Ingraham H; Lazar M; Muscat G; Perlmann T; Renaud J-P; Schwabe J; Sladek F; Tsai M-J; Laudet V
Published paper: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. 2005;16(10):1631-1640

Electrospray mass spectrometry for the direct accurate mass measurement of ligands in complex with the retinoid X receptor alpha ligand binding domain.

Lengqvist J; Alvélius G; Jörnvall H; Sjövall J; Perlmann T; Griffiths WJ
Review: CELL AND TISSUE RESEARCH. 2004;318(1):45-52

Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells.

Perlmann T; Wallén-Mackenzie A
Review: TRENDS IN CELL BIOLOGY. 2004;14(7):369-376

Digging deep into the pockets of orphan nuclear receptors: insights from structural studies.

Benoit G; Malewicz M; Perlmann T
Published paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;991:48-60

Transcriptional control of dopamine neuron development.

Wallén A; Perlmann T
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2003;364:463-475

In vivo and in vitro reporter systems for studying nuclear receptor and ligand activities.

Mata de Urquiza A; Perlmann T
Letter: RAPID COMMUNICATIONS IN MASS SPECTROMETRY. 2002;16(20):2003-2006

Detection of a receptor-ligand non-covalent complex using a triple quadrupole mass spectrometer.

Lengqvist J; Griffiths WJ; Perlmann T; Sjövall J
Editorial comment: NATURE GENETICS. 2002;31(1):7-8

Retinoid metabolism: a balancing act.

Perlmann T
Letter: CELL. 1999;97(2):161-163

A unified nomenclature system for the nuclear receptor superfamily.

Nuclear Receptors Nomenclature Committee
Published paper: BRAIN RESEARCH REVIEWS. 1998;26(2-3):302-305

On CNS repair and protection strategies: novel approaches with implications for spinal cord injury and Parkinson's disease.

Olson L; Cheng H; Zetterström RH; Solomin L; Jansson L; Giménez-Llort L; Hoffer BJ; Perlmann T
Review: CELL. 1997;90(3):391-397

Nuclear receptors in Sicily: all in the famiglia.

Perlmann T; Evans RM
Editorial comment: NATURE. 1995;377(6548):387-388

The sound of silence.

Perlmann T; Vennström B

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