Sara Gredmark Russ

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

I vår forskargrupp arbetar vi med att förstå hur akuta virusinfektioner påverkar och påverkas av immunförsvaret, med ett speciellt intresse för fästingburen encefalit (TBE-virus) och COVID-19.

Forskningsbeskrivning

Vi forskar för att bättre förstå vad som händer i immunförsvaret vid akuta virusinfektioner, med ett särskilt intresse för fästingburen encefalit (TBE-virus) och COVID-19. Bättre kunskap om det naturliga, samt skillnader i immunsvaret vid akuta virusinfektioner, kan leda till nya insikter om akuta virussjukdomars underliggande orsaker. Det kan även leda till utveckling av nya specifika behandlingsmetoder.

Utöver en direkt ökad förståelse för de specifika virusinfektioner som vi nu studerar, kommer våra metoder att kunna användas vid studier av andra virusinfektioner och vid eventuella framtida utbrott av nya virusinfektioner.

https://ki.se/forskning/medicinvetarna-44-hur-undviks-tbe

Artiklar

Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396

Dynamic MAIT Cell Recovery after Severe COVID-19 Is Transient with Signs of Heterogeneous Functional Anomalies.

Kammann T; Gorin J-B; Parrot T; Gao Y; Ponzetta A; Emgård J; Maleki KT; Sekine T; Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S; Rooyackers O; Skagerberg M; Eriksson LI; Norrby-Teglund A; Mak JYW; Fairlie DP; Björkström NK; Klingström J; Ljunggren H-G; Aleman S; Buggert M; Strålin K; Sandberg JK
Article: NATURE COMMUNICATIONS. 2023;14(1):5921

Comprehensive proteomics and meta-analysis of COVID-19 host response.

Babačić H; Christ W; Araújo JE; Mermelekas G; Sharma N; Tynell J; García M; Varnaite R; Asgeirsson H; Glans H; Lehtiö J; Gredmark-Russ S; Klingström J; Pernemalm M
Article: IMMUNITY. 2023;56(8):1955-1974.e10

Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation.

Zwijnenburg AJ; Pokharel J; Varnaitė R; Zheng W; Hoffer E; Shryki I; Comet NR; Ehrström M; Gredmark-Russ S; Eidsmo L; Gerlach C
Article: LAKARTIDNINGEN. 2023;120:23101

[Neoehrlichiosis has entered the Stockholm region].

Glans H; Gunnarsson K; Gredmark Russ S
Journal article: TICK-BORNE ENCEPHALITIS - THE BOOK. 2023

Chapter 9: Immunology of TBEV infection

Gredmark-Russ S; Varnaite R
Article: RESPIRATORY RESEARCH. 2023;24(1):62

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.

Palma Medina LM; Babačić H; Dzidic M; Parke Å; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgård J; Moll K; Karolinska K. I./K. COVID-19 Study Group; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Gredmark-Russ S; Rooyackers O; Svensson M; Chambers BJ; Eriksson LI; Pernemalm M; Björkström NK; Aleman S; Ljunggren H-G; Klingström J; Strålin K; Norrby-Teglund A
Article: PLOS NEGLECTED TROPICAL DISEASES. 2023;17(2):e0010616

Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial.

Sandberg JT; Löfling M; Varnaitė R; Emgård J; Al-Tawil N; Lindquist L; Gredmark-Russ S; Klingström J; Loré K; Blom K; Ljunggren H-G
Article: EMERGING INFECTIOUS DISEASES. 2022;28(10):2074-2077

Ten-Week Follow-Up of Monkeypox Case-Patient, Sweden, 2022.

Pettke A; Filén F; Widgren K; Jacks A; Glans H; Andreasson S; Muradrasoli S; Helgesson S; Hauzenberger E; Karlberg ML; Walai N; Bjerkner A; Gourlé H; Gredmark-Russ S; Lindsjö OK; Sondén K; Asgeirsson H
Article: EMERGING INFECTIOUS DISEASES. 2022;28(7):1471-1474

Deaths from Tick-Borne Encephalitis, Sweden.

Varnaitė R; Gredmark-Russ S; Klingström J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195

The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.

Ljunggren H-G; Ask EH; Cornillet M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio A; Dzidic M; Filipovic I; Flodström-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Malmberg K-J; Strålin K; Björkström NK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510

COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations.

Cornillet M; Strunz B; Rooyackers O; Ponzetta A; Chen P; Muvva JR; Akber M; Buggert M; Chambers BJ; Dzidic M; Filipovic I; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Parrot T; Perez-Potti A; Rivera-Ballesteros O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Strålin K; Ljunggren H-G; Björkström NK
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862

Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza.

Brownlie D; Rødahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaëlsson J; Gredmark-Russ S; Smed-Sörensen A; Marquardt N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.

Lourda M; Dzidic M; Hertwig L; Bergsten H; Palma Medina LM; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki KT; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ; Karolinska KI/K COVID-19 Study Group
Article: BMC INFECTIOUS DISEASES. 2021;21(1):494

Shedding of infectious SARS-CoV-2 by hospitalized COVID-19 patients in relation to serum antibody responses.

Glans H; Gredmark-Russ S; Olausson M; Falck-Jones S; Varnaite R; Christ W; Maleki KT; Karlberg ML; Broddesson S; Falck-Jones R; Bell M; Johansson N; Färnert A; Smed-Sörensen A; Klingström J; Bråve A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118

Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.

Kvedaraite E; Hertwig L; Sinha I; Ponzetta A; Hed Myrberg I; Lourda M; Dzidic M; Akber M; Klingström J; Folkesson E; Muvva JR; Chen P; Gredmark-Russ S; Brighenti S; Norrby-Teglund A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Ginhoux F; Björkström NK; Henter J-I; Svensson M; Karolinska KI/K COVID-19 Study Group
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306

SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.

Sandberg JT; Varnaitė R; Christ W; Chen P; Muvva JR; Maleki KT; García M; Dzidic M; Folkesson E; Skagerberg M; Ahlén G; Frelin L; Sällberg M; Eriksson LI; Rooyackers O; Sönnerborg A; Buggert M; Björkström NK; Aleman S; Strålin K; Klingström J; Ljunggren H-G; Blom K; Gredmark-Russ S; Karolinska COVID‐19 Study Group
Article: JOURNAL OF IMMUNOLOGY. 2020;205(9):2437-2446

Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.

Varnaitė R; García M; Glans H; Maleki KT; Sandberg JT; Tynell J; Christ W; Lagerqvist N; Asgeirsson H; Ljunggren H-G; Ahlén G; Frelin L; Sällberg M; Blom K; Klingström J; Gredmark-Russ S
Article: CELL. 2020;183(1):158-168.e14

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.

Sekine T; Perez-Potti A; Rivera-Ballesteros O; Strålin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgård J; Parrot T; Folkesson E; Karolinska COVID-19 Study Group; Rooyackers O; Eriksson LI; Henter J-I; Sönnerborg A; Allander T; Albert J; Nielsen M; Klingström J; Gredmark-Russ S; Björkström NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670

MAIT cell activation and dynamics associated with COVID-19 disease severity.

Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgård J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Björkström NK; Aleman S; Buggert M; Klingström J; Strålin K; Sandberg JK
Article: JOURNAL OF IMMUNOLOGY. 2020;204(4):914-922

Magnitude and Functional Profile of the Human CD4+ T Cell Response throughout Primary Immunization with Tick-Borne Encephalitis Virus Vaccine.

Varnaitė R; Blom K; Lampen MH; Vene S; Thunberg S; Lindquist L; Ljunggren H-G; Rombo L; Askling HH; Gredmark-Russ S
Article: CLINICAL INFECTIOUS DISEASES. 2020;70(2):245-251

Tick-borne Encephalitis Vaccine Failures: A 10-year Retrospective Study Supporting the Rationale for Adding an Extra Priming Dose in Individuals Starting at Age 50 Years.

Hansson KE; Rosdahl A; Insulander M; Vene S; Lindquist L; Gredmark-Russ S; Askling HH
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2020;9(12):e1224

Innate lymphoid cell composition associates with COVID-19 disease severity.

García M; Kokkinou E; Carrasco García A; Parrot T; Palma Medina LM; Maleki KT; Christ W; Varnaitė R; Filipovic I; Ljunggren H-G; Björkström NK; Folkesson E; Rooyackers O; Eriksson LI; Sönnerborg A; Aleman S; Strålin K; Gredmark-Russ S; Klingström J; Mjösberg J; Karolinska KI/K COVID‐19 Study Group
Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2020;10:386

Genetic and Functional Characterization of Toll-Like Receptor Responses in Immunocompetent Patients With CMV Mononucleosis.

Frascaroli G; Rossini G; Maltoni V; Bartoletti M; Ortolani P; Gredmark-Russ S; Gelsomino F; Moroni A; Silenzi S; Castellani G; Sambri V; Mastroianni A; Brune W; Varani S
Article: IMMUNOHORIZONS. 2018;2(6):172-184

Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.

Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771

NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection.

Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaëlsson J; Ljunggren H-G; Gredmark-Russ S
Article: PLOS PATHOGENS. 2015;11(1):e1004622

Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection.

Blom K; Braun M; Pakalniene J; Dailidyte L; Béziat V; Lampen MH; Klingström J; Lagerqvist N; Kjerstadius T; Michaëlsson J; Lindquist L; Ljunggren H-G; Sandberg JK; Mickiene A; Gredmark-Russ S
Article: VIRULENCE. 2012;3(7):621-634

Dendritic cell biology in human cytomegalovirus infection and the clinical consequences for host immunity and pathology.

Gredmark-Russ S; Söderberg-Nauclér C
Article: IMMUNOBIOLOGY. 2011;216(1-2):243-250

The novel anti-rheumatic compound Rabeximod impairs differentiation and function of human pro-inflammatory dendritic cells and macrophages.

Giusti P; Frascaroli G; Tammik C; Gredmark-Russ S; Söderberg-Nauclér C; Varani S
Article: JOURNAL OF VIROLOGY. 2009;83(20):10644-10652

A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection.

Gredmark-Russ S; Isaacson MK; Kattenhorn L; Cheung EJ; Watson N; Ploegh HL
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2009;87(4):347-356

Active cytomegalovirus infection in aortic smooth muscle cells from patients with abdominal aortic aneurysm.

Gredmark-Russ S; Dzabic M; Rahbar A; Wanhainen A; Björck M; Larsson E; Michel J-B; Söderberg-Nauclér C
Article: JOURNAL OF VIROLOGY. 2009;83(2):830-835

Infection with human cytomegalovirus alters the MMP-9/TIMP-1 balance in human macrophages.

Strååt K; de Klark R; Gredmark-Russ S; Eriksson P; Söderberg-Nauclér C
Article: JOURNAL OF VIROLOGY. 2008;82(24):12205-12212

The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens.

Gredmark-Russ S; Cheung EJ; Isaacson MK; Ploegh HL; Grotenbreg GM
Article: JOURNAL OF VIROLOGY. 2007;81(19):10300-10309

A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection.

Gredmark S; Schlieker C; Quesada V; Spooner E; Ploegh HL
Article: SCANDINAVIAN CARDIOVASCULAR JOURNAL. 2007;41(4):230-234

Active cytomegalovirus replication in patients with coronary disease.

Gredmark S; Jonasson L; Van Gosliga D; Ernerudh J; Söderberg-Nauclér C
Article: JOURNAL OF VIROLOGY. 2007;81(10):5112-5120

Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells.

Gredmark S; Strååt K; Homman-Loudiyi M; Kannisto K; Söderberg-Nauclér C
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2005;25(7):e113-e116

The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents.

Olofsson PS; Jatta K; Wågsäter D; Gredmark S; Hedin U; Paulsson-Berne G; Söderberg-Nauclér C; Hansson GK; Sirsjö A
Article: JOURNAL OF IMMUNOLOGY. 2004;173(8):4897-4907

Human cytomegalovirus induces inhibition of macrophage differentiation by binding to human aminopeptidase N/CD13.

Gredmark S; Britt WB; Xie X; Lindbom L; Söderberg-Nauclér C
Article: JOURNAL OF VIROLOGY. 2004;78(19):10378-10389

Human cytomegalovirus inhibits cytokine-induced macrophage differentiation.

Gredmark S; Tilburgs T; Söderberg-Nauclér C
Article: JOURNAL OF LIPID RESEARCH. 2004;45(9):1768-1776

Effect of macrophage differentiation and exposure to mildly oxidized LDL on the proteolytic repertoire of THP-1 monocytes.

Whatling C; Björk H; Gredmark S; Hamsten A; Eriksson P
Article: JOURNAL OF VIROLOGY. 2003;77(20):10943-10956

Human cytomegalovirus inhibits differentiation of monocytes into dendritic cells with the consequence of depressed immunological functions.

Gredmark S; Söderberg-Nauclér C
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Alla övriga publikationer

Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174

Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection.

Blom K; Cuapio A; Sandberg JT; Varnaite R; Michaëlsson J; Björkström NK; Sandberg JK; Klingström J; Lindquist L; Gredmark Russ S; Ljunggren H-G

Anställningar

Adjungerad Lektor, Medicin, Huddinge, Karolinska Institutet, 2021-2025

Examina och utbildning

Docent, Infektionssjukdomar, Karolinska Institutet, 2019
MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 2005
Läkarexamen, Karolinska Institutet, 2001

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