zhao_pian_fan_rong_rong_.jpg

Rongrong Fan

Forskarassistent

 

Om mig

Lab page: 

https://ki.se/en/bionut/liver-and-monocyte-remodelling-in-non-alcoholic…

Forskningsbeskrivning

My research combines the phenotypic/clinical analysis with multi-OMICs approaches to understand the fundamental question of how over-nutritional signals alter chromatin remodelling to promote metabolic disease development.

We have so far analyzed different patient samples in the transcriptomic, cistromic and epigenomic levels and identified a group of interesting candidates involved in species-conserved and disease-relevant regulation of glucose and lipid metabolism. Of particular interest is the transcription factor coregulator GPS2, the dysregulation of which is associated with de-repressed inflammation and impaired lipid oxidation pathways, leading to type 2 diabetes and liver disease progression.

The ongoing research activity involves further investigation of the coregulator-based mechanisms in the genomic and epigenomic level in various disease contexts. Understanding such pathways is crucial for better deciphering disease mechanisms which is ultimately required for identifying novel targets with diagnostic and intervention potential. 

Pedagogiska meriter

Main supervisor of 1 ongoing PhD student Cosupervisor of 1 ongoing PhD student and 2 completed PhD students Project supervisor of 3 bachelor students and 1 Master student Evaluation of 4 Master theses Half-time committee of 1 PhD student Mentor of 1 PhD student More than 120 teaching hours in Bachelor, Master and PhD courses Professional university pedagogy training (equivalent to more than 5 weeks)

Utbildning

2018 to now: Assistant professor at the Department of Biosciences and Nutrition, Karolinska Institute, Fleminsberg. 2012 to 2017: Postdoctoral Study at the Department of Biosciences and Nutrition, Karolinska Institute, Fleminsberg. 2012: PhD in Medical Sciences, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong.

Akademiska priser och utmärkelser

Research grants:

EFSD / Novo Nordisk Future Leaders Award 2021 Cancerfonden Swedish research council (Vetenskapsrådet) CIMED Novo Nordisk Foundation KI Doctoral funding Åke Wibergs Stiftelse Diabetes Wellness Sverige Foundation EFSD / Lilly research fellowship KI foundation

Commission of trust:

Editorial board: Frontiers in Endocrinology  2021-. Guest editor: Frontiers in Endocrinology 2020. Steering Committee: lipoprotein research networks in KI south campus (supported by CIMED). Grant review task for: French National Research Agency (ANR) Grant review panel: Cancerfonden, KID Invited reviewer in: Nature Communications, eLife, JBC, FASEB J, Diabetologia, Diabetes, obesity and metabolism, PLoS One, Journal of cellular and molecular medicine, etc. Poster assesment committee: Epigenomics, nuclear receptor and diseases summer school. Spetses, 2019. Poster assesment committee: 7th Endometrial SRP Diabetes Joint Retreat. Stockholm, 2017. Poster assesment committee: Epigenomics, nuclear receptor and diseases summer school. Spetses, 2017.

Selected publications:

1) Huang, Z., Liang, N., Goni, S., Damdimopoulos, A., Wang, C., Ballaire, R., Jager, J., Niskanen, H., Jakobsson., Han, H., Bracken, A., Aouadi, M., Venteclef, N., Kaikkonen, M., Fan, RR# (co-corresponding author)., Treuter, E#. The corepressors GPS2 and SMRT control enhancer and silencer remodelling linked to eRNA transcription during inflammatory activation of macrophages. Molecular Cell 2021 (Featured article) DOI:https://doi.org/10.1016/j.molcel.2020.12.040.

2) Kang, ZF., Fan, RR. PPARα and NCOR / SMRT corepressor network in liver metabolic regulation. FASEB J 2020. doi: 10.1096/fj.202000055RR.

3) Liang, N., Damdimopoulos, A., Goñi, S., Huang, ZQ., Vedin, L., Jakobsson, T., Giudici, M., Ahmed, O., Pedrelli, M., Barilla, S., Alzaid, F., Mendoza, A., Schröder, T., Kuiper, R., Parini, P., Hollenberg, A., Lefebvre, P., Francque, S., Gaal, LV., Staels, B., Venteclef, N., Treuter, E#., and Fan, RR#Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα. Nature Communications 2019. 10:1684.

4) Huang, ZQ., Liang, N., Damdimopoulos, T., Fan, RR# (co-corresponding author) and Treuter, E#. G-protein pathway suppressor 2 links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. FASEB J (Cover story) 2018. doi: 10.1096/fj.201801123R.

5) Fan, R.R., Toubal, A., Goñi, S., Drareni, K., Huang, ZQ., Alzaid, F., Ballaire, R., Ancel,P., Liang, N., Damdimopoulos, A., Hainault, I., Soprani, A., Wisnewsky, JA., Foufelle, F., Lawrence, T., Gautier, JF., Venteclef, N & Treuter, E. Loss of the corepressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nature Medicine 2016. doi:10.1038/nm.4114.

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