Roland Fiskesund

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Team leader och forskningsspecialist med fokus på Transfusionsmedicin och
Stamcellsbiologi
Medicine Doktor och ST-läkare i Klinisk Immunologi och Transfusionsmedicin.

Forskningsbeskrivning

Transfusionsmedicin är en av hörnstenarna i modern medicin och
forskningfältet har stor translationell potential.
Transfusion av blodplättar och röda blodkroppar används dagligen på våra
svenska sjukhus. Vårt huvudsakliga forskningsintresse är att utforska
konceptet neutrofiltransfusion till neutropena patienter som saknar
egenproduktion av dessa vita blodkroppar.
Andra forskningsprojekt som vi arbetar med inkluderar enzymatisk konvertering
av blodgrupper, citratmetabolism vid aferes och processning av
stamcellsprodukter.

Artiklar

Article: CELL DEATH AND DIFFERENTIATION. 2022;29(1):246-261

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells.

Karsten S; Fiskesund R; Zhang X-M; Marttila P; Sanjiv K; Pham T; Rasti A; Bräutigam L; Almlöf I; Marcusson-Ståhl M; Sandman C; Platzack B; Harris RA; Kalderén C; Cederbrant K; Helleday T; Warpman Berglund U
Article: CANCER RESEARCH. 2021;81(2):476-488

Cell Softness Prevents Cytolytic T-cell Killing of Tumor-Repopulating Cells.

Liu Y; Zhang T; Zhang H; Li J; Zhou N; Fiskesund R; Chen J; Lv J; Ma J; Zhang H; Tang K; Cheng F; Zhou Y; Zhang X; Wang N; Huang B
Article: ACR OPEN RHEUMATOLOGY. 2020;2(6):344-356

Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms.

Thiagarajan D; Fiskesund R; Frostegård A; Steen J; Rahman M; Vikström M; Lundström S; Frostegård J
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(9):1057-1068

Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells.

Ma J; Wei K; Zhang H; Tang K; Li F; Zhang T; Liu J; Xu P; Yu Y; Sun W; Zhu L; Chen J; Zhou L; Liang X; Lv J; Fiskesund R; Liu Y; Huang B
Article: CANCER RESEARCH. 2018;78(14):3926-3937

Fibrin Stiffness Mediates Dormancy of Tumor-Repopulating Cells via a Cdc42-Driven Tet2 Epigenetic Program.

Liu Y; Lv J; Liang X; Yin X; Zhang L; Chen D; Jin X; Fiskesund R; Tang K; Ma J; Zhang H; Dong W; Mo S; Zhang T; Cheng F; Zhou Y; Xie J; Wang N; Huang B
Article: CANCER CELL. 2018;33(3):480-494.e7

Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation.

Liu Y; Liang X; Dong W; Fang Y; Lv J; Zhang T; Fiskesund R; Xie J; Liu J; Yin X; Jin X; Chen D; Tang K; Ma J; Zhang H; Yu J; Yan J; Liang H; Mo S; Cheng F; Zhou Y; Zhang H; Wang J; Li J; Chen Y; Cui B; Hu Z-W; Cao X; Xiao-Feng Qin F; Huang B
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(3):1057-1073

STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells.

Liu Y; Lv J; Liu J; Liang X; Jin X; Xie J; Zhang L; Chen D; Fiskesund R; Tang K; Ma J; Zhang H; Dong W; Mo S; Zhang T; Cheng F; Zhou Y; Jia Q; Zhu B; Kong Y; Guo J; Zhang H; Hu Z-W; Cao X; Qin FX-F; Huang B
Article: NATURE COMMUNICATIONS. 2018;9(1):873

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.

Chen D; Xie J; Fiskesund R; Dong W; Liang X; Lv J; Jin X; Liu J; Mo S; Zhang T; Cheng F; Zhou Y; Zhang H; Tang K; Ma J; Liu Y; Huang B
Article: CLINICAL IMMUNOLOGY. 2016;166-167:27-37

IgM antibodies against malondialdehyde and phosphorylcholine are together strong protection markers for atherosclerosis in systemic lupus erythematosus: Regulation and underlying mechanisms.

Rahman M; Sing S; Golabkesh Z; Fiskesund R; Gustafsson T; Jogestrand T; Frostegård AG; Hafström I; Liu A; Frostegård J
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(1):197-205

Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins.

Liu A; Ming JY; Fiskesund R; Ninio E; Karabina S-A; Bergmark C; Frostegård AG; Frostegård J
Article: JOURNAL OF IMMUNOLOGY. 2014;192(10):4551-4559

Naturally occurring human phosphorylcholine antibodies are predominantly products of affinity-matured B cells in the adult.

Fiskesund R; Steen J; Amara K; Murray F; Szwajda A; Liu A; Douagi I; Malmström V; Frostegård J
Article: JOURNAL OF MOLECULAR BIOLOGY. 2012;417(4):279-293

Crystal structure of bifunctional aldos-2-ulose dehydratase/isomerase from Phanerochaete chrysosporium with the reaction intermediate ascopyrone M.

Claesson M; Lindqvist Y; Madrid S; Sandalova T; Fiskesund R; Yu S; Schneider G
Article: RESULTS IN IMMUNOLOGY. 2012;2:13-18

IgM phosphorylcholine antibodies inhibit cell death and constitute a strong protection marker for atherosclerosis development, particularly in combination with other auto-antibodies against modified LDL.

Fiskesund R; Su J; Bulatovic I; Vikström M; de Faire U; Frostegård J
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2011;29(6):942-950

Effect of biological therapy on levels of atheroprotective antibodies against phosphorylcholine and apolipoproteins in rheumatoid arthritis - a one year study.

Ajeganova S; Fiskesund R; de Faire U; Hafström I; Frostegård J
Article: STROKE. 2010;41(4):607-612

Low levels of antibodies against phosphorylcholine predict development of stroke in a population-based study from northern Sweden.

Fiskesund R; Stegmayr B; Hallmans G; Vikström M; Weinehall L; de Faire U; Frostegård J
Article: JOURNAL OF APPLIED MICROBIOLOGY. 2009;106(2):624-633

Inhibition spectrum studies of microthecin and other anhydrofructose derivatives using selected strains of Gram-positive and -negative bacteria, yeasts and moulds, and investigation of the cytotoxicity of microthecin to malignant blood cell lines.

Fiskesund R; Thomas LV; Schobert M; Ernberg I; Lundt I; Yu S

Alla övriga publikationer

Review: PLANTA MEDICA. 2010;76(15):1635-1641

1,5-anhydro-D-fructose and its derivatives: biosynthesis, preparation and potential medical applications.

Fiskesund R; Abeyama K; Yoshinaga K; Abe J-I; Yuan Y; Yu S
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2006;1760(9):1314-1322

The anhydrofructose pathway and its possible role in stress response and signaling.

Yu S; Fiskesund R

Anställningar

Biträdande Lektor, Medicin, Huddinge, Karolinska Institutet, 2022-2028

Examina och utbildning

Medicine Doktorsexamen, Institutet för miljömedicin, Karolinska Institutet, 2014
Läkarexamen, Karolinska Institutet, 2009

Om mig

Forskningsbeskrivning

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI