Renhai Cao

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627

Pericyte-fibroblast transition promotes tumor growth and metastasis.

Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:12680

Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism.

Yang Y; Zhang Y; Iwamoto H; Hosaka K; Seki T; Andersson P; Lim S; Fischer C; Nakamura M; Abe M; Cao R; Skov PV; Chen F; Chen X; Lu Y; Nie G; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:11385

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.

Yang Y; Andersson P; Hosaka K; Zhang Y; Cao R; Iwamoto H; Yang X; Nakamura M; Wang J; Zhuang R; Morikawa H; Xue Y; Braun H; Beyaert R; Samani N; Nakae S; Hams E; Dissing S; Fallon PG; Langer R; Cao Y
Article: NATURE COMMUNICATIONS. 2016;7:10824

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis.

Wong HLX; Jin G; Cao R; Zhang S; Cao Y; Zhou Z
Article: NATURE COMMUNICATIONS. 2014;5:4944

TNFR1 mediates TNF-α-induced tumour lymphangiogenesis and metastasis by modulating VEGF-C-VEGFR3 signalling.

Ji H; Cao R; Yang Y; Zhang Y; Iwamoto H; Lim S; Nakamura M; Andersson P; Wang J; Sun Y; Dissing S; He X; Yang X; Cao Y
Article: SCIENTIFIC REPORTS. 2013;3:2053

VEGF significantly restores impaired memory behavior in Alzheimer's mice by improvement of vascular survival.

Religa P; Cao R; Religa D; Xue Y; Bogdanovic N; Westaway D; Marti HH; Winblad B; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(39):15894-15899

Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis.

Cao R; Ji H; Feng N; Zhang Y; Yang X; Andersson P; Sun Y; Tritsaris K; Hansen AJ; Dissing S; Cao Y
Article: CELL CYCLE. 2012;11(15):2793-2798

When MT1-MMP meets ADAMs.

Wong HLX; Cao R; Jin G; Chan KM; Cao Y; Zhou Z
Article: DEVELOPMENTAL CELL. 2012;22(6):1176-1190

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.

Chan KM; Wong HLX; Jin G; Liu B; Cao R; Cao Y; Lehti K; Tryggvason K; Zhou Z
Article: NATURE MEDICINE. 2011;18(1):100-110

PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells.

Xue Y; Lim S; Yang Y; Wang Z; Jensen LDE; Hedlund E-M; Andersson P; Sasahara M; Larsson O; Galter D; Cao R; Hosaka K; Cao Y
Article: CIRCULATION. 2011;124(9):1059-U170

Arteriogenic therapy by intramyocardial sustained delivery of a novel growth factor combination prevents chronic heart failure.

Banquet S; Gomez E; Nicol L; Edwards-Lévy F; Henry J-P; Cao R; Schapman D; Dautreaux B; Lallemand F; Bauer F; Cao Y; Thuillez C; Mulder P; Richard V; Brakenhielm E
Article: NATURE PROTOCOLS. 2011;6(6):817-826

Mouse corneal lymphangiogenesis model.

Cao R; Lim S; Ji H; Zhang Y; Yang Y; Honek J; Hedlund E-M; Cao Y
Article: CELL CYCLE. 2010;9(10):1882-1885

Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling.

Cao R; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(2):856-861

VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy.

Cao R; Xue Y; Hedlund E-M; Zhong Z; Tritsaris K; Tondelli B; Lucchini F; Zhu Z; Dissing S; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(43):18408-18413

Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass catfish.

Dahl Ejby Jensen L; Cao R; Hedlund E-M; Söll I; Lundberg JO; Hauptmann G; Steffensen JF; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(41):17505-17510

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature.

Hedlund E-M; Hosaka K; Zhong Z; Cao R; Cao Y
Article: CELL METABOLISM. 2009;9(1):99-109

Hypoxia-independent angiogenesis in adipose tissues during cold acclimation.

Xue Y; Petrovic N; Cao R; Larsson O; Lim S; Chen S; Feldmann HM; Liang Z; Zhu Z; Nedergaard J; Cannon B; Cao Y
Article: FASEB JOURNAL. 2009;23(1):153-163

Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability.

Zhang J; Cao R; Zhang Y; Jia T; Cao Y; Wahlberg E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(47):18513-18518

Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome.

Xue Y; Religa P; Cao R; Hansen AJ; Lucchini F; Jones B; Wu Y; Zhu Z; Pytowski B; Liang Y; Zhong W; Vezzoni P; Rozell B; Cao Y
Article: PLOS ONE. 2008;3(7):e2748

Hypoxia-induced retinal angiogenesis in zebrafish as a model to study retinopathy.

Cao R; Jensen LDE; Söll I; Hauptmann G; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(29):10167-10172

FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue.

Xue Y; Cao R; Nilsson D; Chen S; Westergren R; Hedlund E-M; Martijn C; Rondahl L; Krauli P; Walum E; Enerbäck S; Cao Y
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(10):2766-2777

Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis.

Nissen LJ; Cao R; Hedlund E-M; Wang Z; Zhao X; Wetterskog D; Funa K; Bråkenhielm E; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(39):15364-15369

IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs.

Tritsaris K; Myren M; Ditlev SB; Hübschmann MV; van der Blom I; Hansen AJ; Olsen UB; Cao R; Zhang J; Jia T; Wahlberg E; Dissing S; Cao Y
Article: EXPERIMENTAL CELL RESEARCH. 2007;313(13):2896-2909

Intra- and extracellular signaling by endothelial neuregulin-1.

Iivanainen E; Paatero I; Heikkinen S-M; Junttila TT; Cao R; Klint P; Jaakkola PM; Cao Y; Elenius K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(29):12140-12145

Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs.

Lu H; Xu X; Zhang M; Cao R; Bråkenhielm E; Li C; Lin H; Yao G; Sun H; Qi L; Tang M; Dai H; Zhang Y; Su R; Bi Y; Zhang Y; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(10):3919-3924

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.

Zhou X; Tian F; Sandzén J; Cao R; Flaberg E; Szekely L; Cao Y; Ohlsson C; Bergo MO; Borén J; Akyürek LM
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641

Cell-type-specific regulation of degradation of hypoxia-inducible factor 1 alpha: role of subcellular compartmentalization.

Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: BLOOD. 2006;107(9):3531-3536

Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action.

Cao R; Björndahl MA; Gallego MI; Chen S; Religa P; Hansen AJ; Cao Y
Article: BLOOD. 2005;106(13):4184-4190

Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels.

Religa P; Cao R; Bjorndahl M; Zhou Z; Zhu Z; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(43):15593-15598

Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo.

Björndahl M; Cao R; Nissen LJ; Clasper S; Johnson LA; Xue Y; Zhou Z; Jackson D; Hansen AJ; Cao Y
Article: CANCER RESEARCH. 2005;65(20):9261-9268

Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis.

Björndahl MA; Cao R; Burton JB; Brakenhielm E; Religa P; Galter D; Wu L; Cao Y
Article: CANCER CELL. 2004;6(4):333-345

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.

Cao R; Björndahl MA; Religa P; Clasper S; Garvin S; Galter D; Meister B; Ikomi F; Tritsaris K; Dissing S; Ohhashi T; Jackson DG; Cao Y
Article: CANCER RESEARCH. 2004;64(14):4699-4702

Impaired angiogenesis, delayed wound healing and retarded tumor growth in perlecan heparan sulfate-deficient mice.

Zhou Z; Wang J; Cao R; Morita H; Soininen R; Chan KM; Liu B; Cao Y; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(12):1579-1588

Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice.

Bråkenhielm E; Cao R; Gao B; Angelin B; Cannon B; Parini P; Cao Y
Article: CANCER RESEARCH. 2004;64(12):4059-4063

Deletion of laminin-8 results in increased tumor neovascularization and metastasis in mice.

Zhou Z; Doi M; Wang J; Cao R; Liu B; Chan KM; Kortesmaa J; Sorokin L; Cao Y; Tryggvason K
Article: CIRCULATION RESEARCH. 2004;94(11):1443-1450

Blockage of VEGF-induced angiogenesis by preventing VEGF secretion.

Björndahl M; Cao R; Eriksson A; Cao Y
Article: CANCER RESEARCH. 2004;64(10):3679-3686

Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis.

Veitonmäki N; Cao R; Wu L-H; Moser TL; Li B; Pizzo SV; Zhivotovsky B; Cao Y
Article: CIRCULATION RESEARCH. 2004;94(5):664-670

Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability.

Cao R; Eriksson A; Kubo H; Alitalo K; Cao Y; Thyberg J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(8):2476-2481

Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.

Bråkenhielm E; Veitonmäki N; Cao R; Kihara S; Matsuzawa Y; Zhivotovsky B; Funahashi T; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(10):6033-6038

Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing.

Ekstrand AJ; Cao R; Bjorndahl M; Nystrom S; Jonsson-Rylander A-C; Hassani H; Hallberg B; Nordlander M; Cao Y
Article: NATURE MEDICINE. 2003;9(5):604-613

Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2.

Cao R; Bråkenhielm E; Pawliuk R; Wariaro D; Post MJ; Wahlberg E; Leboulch P; Cao Y
Article: CIRCULATION. 2003;107(11):1532-1538

Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability.

Eriksson A; Cao R; Roy J; Tritsaris K; Wahlestedt C; Dissing S; Thyberg J; Cao Y
Article: FASEB JOURNAL. 2002;16(12):1575-1583

Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFR-alphaalpha and -alphabeta receptors.

Cao R; Bråkenhielm E; Li X; Pietras K; Widenfalk J; Ostman A; Eriksson U; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8868-8873

Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.

Kubo H; Cao R; Brakenhielm E; Mäkinen T; Cao Y; Alitalo K
Article: CANCER CELL. 2002;1(1):99-108

Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.

Eriksson A; Cao R; Pawliuk R; Berg SM; Tsang M; Zhou D; Fleet C; Tritsaris K; Dissing S; Leboulch P; Cao Y
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(4):1194-1202

Deletion of the laminin alpha4 chain leads to impaired microvessel maturation.

Thyboll J; Kortesmaa J; Cao R; Soininen R; Wang L; Iivanainen A; Sorokin L; Risling M; Cao Y; Tryggvason K
Article: NATURE. 2001;414(6863):550-554

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression.

Makino Y; Cao R; Svensson K; Bertilsson G; Asman M; Tanaka H; Cao Y; Berkenstam A; Poellinger L
Article: ONCOGENE. 2001;20(34):4685-4695

The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor.

Ambartsumian N; Klingelhöfer J; Grigorian M; Christensen C; Kriajevska M; Tulchinsky E; Georgiev G; Berezin V; Bock E; Rygaard J; Cao R; Cao Y; Lukanidin E
Article: FASEB JOURNAL. 2001;15(10):1798-1800

Suppression of angiogenesis, tumor growth, and wound healing by resveratrol, a natural compound in red wine and grapes.

Bråkenhielm E; Cao R; Cao Y
Article: CIRCULATION. 2001;104(3):358-364

Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect.

Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(11):6390-6395

Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF.

Cao R; Brakenhielm E; Wahlestedt C; Thyberg J; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(8):4052-4057

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.

Zhou Z; Apte SS; Soininen R; Cao R; Baaklini GY; Rauser RW; Wang J; Cao Y; Tryggvason K
Article: FASEB JOURNAL. 1999;13(15):2195-2202

Interleukin-18 acts as an angiogenesis and tumor suppressor.

Cao R; Farnebo J; Kurimoto M; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(10):5728-5733

Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis.

Cao R; Wu HL; Veitonmäki N; Linden P; Farnebo J; Shi GY; Cao Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(24):14389-14394

Vascular endothelial growth factor C induces angiogenesis in vivo.

Cao Y; Linden P; Farnebo J; Cao R; Eriksson A; Kumar V; Qi JH; Claesson-Welsh L; Alitalo K
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Editorial comment: ONCOIMMUNOLOGY. 2015;4(3):e989777

Collaborative effects between the TNFα-TNFR1-macrophage axis and the VEGF-C-VEGFR3 signaling in lymphangiogenesis and metastasis.

Cao R; Ji H; Yang Y; Cao Y
Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):982-991

In vivo angiogenesis and lymphangiogenesis models.

Jensen LD; Cao R; Cao Y
Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2008;86(7):785-789

R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways.

Cao Y; Cao R; Hedlund E-M
Review: CLINICAL LIPIDOLOGY. 2008;3(2):153-162

Therapeutic potential of antiangiogenic agents for prevention and treatment of obesity

Cao Y; Cao R; Xue Y
Corrigendum: CANCER CELL. 2006;9(3):239

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004)

Cao RH; Björndahl MA; Religa P; Clasper S; Garvin S; Gaiter D; Meister B; Ikomi F; Tritsoris K; Dissing S; Ohhashi T; Jackson DG; Cao YH
Review: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY. 2002;2(6):667-681

Kringle structures and antiangiogenesis.

Cao Y; Cao R; Veitonmäki N
Review: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2002;13(7):380-390

Antiangiogenic mechanisms of diet-derived polyphenols.

Cao Y; Cao R; Bråkenhielm E
Letter: NATURE. 1999;398(6726):381

Angiogenesis inhibited by drinking tea.

Cao Y; Cao R

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