Outi Sareila

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(7):1110-1119

Autoantibodies to Disease-Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis.

Lönnblom E; Leu Agelii M; Sareila O; Cheng L; Xu B; Viljanen J; Hafström I; Andersson MLE; Bergström G; Hultgård Ekwall A-K; Rudin A; Kastbom A; Sjöwall C; Jacobsson LTH; Kihlberg J; Gjertsson I; Holmdahl R
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(6):799-808

Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage.

Li T; Ge C; Krämer A; Sareila O; Leu Agelii M; Johansson L; Forslind K; Lönnblom E; Yang M; Xu B; Li Q; Cheng L; Bergström G; Fernandez G; Kastbom A; Rantapää-Dahlqvist S; Gjertsson I; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(5):856-863

Early Increase of Circulating Transitional B Cells and Autoantibodies to Joint-Related Proteins in Patients With Metastatic Melanoma Developing Checkpoint Inhibitor-Induced Inflammatory Arthritis.

Gatto M; Bjursten S; Jonsson CA; Agelii ML; Jonell C; McGrath S; Lönnblom E; Sareila O; Holmdahl R; Rudin A; Levin M; Gjertsson I
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):449

Variants of beta-glucan polysaccharides downregulate autoimmune inflammation.

Fahlquist-Hagert C; Sareila O; Rosendahl S; Holmdahl R
Article: ARTHRITIS & RHEUMATOLOGY. 2018;70(8):1343-1353

Chronic Active Arthritis Driven by Macrophages Without Involvement of T Cells: A Novel Experimental Model of Rheumatoid Arthritis.

Hagert C; Sareila O; Kelkka T; Nandakumar KS; Collin M; Xu B; Guérard S; Bäcklund J; Jalkanen S; Holmdahl R
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:114

The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models.

Hagert C; Sareila O; Kelkka T; Jalkanen S; Holmdahl R
Article: ANTIOXIDANTS & REDOX SIGNALING. 2017;27(18):1473-1490

Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.

Sareila O; Hagert C; Kelkka T; Linja M; Xu B; Kihlberg J; Holmdahl R
Article: ACS MEDICINAL CHEMISTRY LETTERS. 2016;7(9):826-830

(18)F-Labeling of Mannan for Inflammation Research with Positron Emission Tomography.

Li X-G; Hagert C; Siitonen R; Virtanen H; Sareila O; Liljenbäck H; Tuisku J; Knuuti J; Bergman J; Holmdahl R; Roivainen A
Article: PLOS ONE. 2015;10(11):e0141974

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes.

Sareila O; Hagert C; Rantakari P; Poutanen M; Holmdahl R
Article: ANTIOXIDANTS & REDOX SIGNALING. 2014;21(16):2231-2245

Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.

Kelkka T; Kienhöfer D; Hoffmann M; Linja M; Wing K; Sareila O; Hultqvist M; Laajala E; Chen Z; Vasconcelos J; Neves E; Guedes M; Marques L; Krönke G; Helminen M; Kainulainen L; Olofsson P; Jalkanen S; Lahesmaa R; Souto-Carneiro MM; Holmdahl R
Article: INFLAMMATORY BOWEL DISEASES. 2014;20(8):1435-1447

In vivo imaging of reactive oxygen and nitrogen species in murine colitis.

Asghar MN; Emani R; Alam C; Helenius TO; Grönroos TJ; Sareila O; Din MU; Holmdahl R; Hänninen A; Toivola DM
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2012;93(3):427-435

Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation.

Sareila O; Jaakkola N; Olofsson P; Kelkka T; Holmdahl R
Article: MEDIATORS OF INFLAMMATION. 2012;2012:730469-9

Superoxide dismutase 3 limits collagen-induced arthritis in the absence of phagocyte oxidative burst.

Kelkka T; Laurila JP; Sareila O; Olofsson P; Laukkanen MO; Holmdahl R
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2011;46(9):3845-3850

Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives.

Timonen JM; Nieminen RM; Sareila O; Goulas A; Moilanen LJ; Haukka M; Vainiotalo P; Moilanen E; Aulaskari PH
Article: ANTIOXIDANTS & REDOX SIGNALING. 2011;14(12):2373-2383

Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats.

Hultqvist M; Sareila O; Vilhardt F; Norin U; Olsson LM; Olofsson P; Hellman U; Holmdahl R
Article: MEDIATORS OF INFLAMMATION. 2011;2011:127587-15

Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase.

Turpeinen T; Nieminen R; Taimi V; Heittola T; Sareila O; Clark AR; Moilanen E; Korhonen R
Article: PULMONARY PHARMACOLOGY & THERAPEUTICS. 2009;22(3):167-176

Bacterial DNA delays human eosinophil apoptosis.

Ilmarinen P; Hasala H; Sareila O; Moilanen E; Kankaanranta H
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;155(6):884-895

Effects of levo- and dextrosimendan on NF-kappaB-mediated transcription, iNOS expression and NO production in response to inflammatory stimuli.

Sareila O; Korhonen R; Auvinen H; Hämäläinen M; Kankaanranta H; Nissinen E; Moilanen E
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2008;324(2):858-866

Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli.

Sareila O; Hämäläinen M; Nissinen E; Kankaanranta H; Moilanen E
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2008;8(1):100-108

Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.

Sareila O; Korhonen R; Kärpänniemi O; Nieminen R; Kankaanranta H; Moilanen E
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2007;152(7):1081-1091

PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.

Paukkeri E-L; Leppänen T; Sareila O; Vuolteenaho K; Kankaanranta H; Moilanen E
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2006;147(7):790-799

Inhibition of classical PKC isoenzymes downregulates STAT1 activation and iNOS expression in LPS-treated murine J774 macrophages.

Salonen T; Sareila O; Jalonen U; Kankaanranta H; Tuominen R; Moilanen E
Article: BMC PHARMACOLOGY. 2006;6:5

Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: implication in inducible nitric oxide synthase expression.

Lahti A; Sareila O; Kankaanranta H; Moilanen E
Article: MEDIATORS OF INFLAMMATION. 2006;2006(2):16161-7

JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.

Sareila O; Korhonen R; Kärpänniemi O; Nieminen R; Kankaanranta H; Moilanen E
Article: JOURNAL OF PHYTOPATHOLOGY. 2004;152(11-12):622-629

Role of viral movement and coat proteins and RNA in phloem-dependent movement and phloem unloading of tobamoviruses

Sareila O; Hohkuri M; Wahlroos T; Susi P
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Review: IMMUNOLOGICAL REVIEWS. 2016;269(1):228-247

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation.

Holmdahl R; Sareila O; Olsson LM; Bäckdahl L; Wing K
Review: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(12):1463-1474

Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells.

Holmdahl R; Sareila O; Pizzolla A; Winter S; Hagert C; Jaakkola N; Kelkka T; Olsson LM; Wing K; Bäckdahl L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a83-A84

CONDITIONAL MODEL TO STUDY THE TISSUE- AND TIME SPECIFIC EFFECTS OF NADPH OXIDASE 2-DERIVED REACTIVE OXYGEN SPECIES DURING ARTHRITIS

Sareila O; Rantakari P; Poutanen M; Holmdahl R
Review: ANTIOXIDANTS & REDOX SIGNALING. 2011;15(8):2197-2208

NOX2 complex-derived ROS as immune regulators.

Sareila O; Kelkka T; Pizzolla A; Hultqvist M; Holmdahl R

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