Niklas Schultz

Article: NATURE COMMUNICATIONS. 2023;14(1):509

Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples.

Mirzazadeh R; Andrusivova Z; Larsson L; Newton PT; Galicia LA; Abalo XM; Avijgan M; Kvastad L; Denadai-Souza A; Stakenborg N; Firsova AB; Shamikh A; Jurek A; Schultz N; Nistér M; Samakovlis C; Boeckxstaens G; Lundeberg J

Article: NATURE COMMUNICATIONS. 2022;13(1):5475

Spatio-temporal analysis of prostate tumors in situ suggests pre-existence of treatment-resistant clones.

Marklund M; Schultz N; Friedrich S; Berglund E; Tarish F; Tanoglidi A; Liu Y; Bergenstråhle L; Erickson A; Helleday T; Lamb AD; Sonnhammer E; Lundeberg J

Article: NATURE. 2022;608(7922):360-367

Spatially resolved clonal copy number alterations in benign and malignant tissue.

Erickson A; He M; Berglund E; Marklund M; Mirzazadeh R; Schultz N; Kvastad L; Andersson A; Bergenstråhle L; Bergenstråhle J; Larsson L; Alonso Galicia L; Shamikh A; Basmaci E; Díaz De Ståhl T; Rajakumar T; Doultsinos D; Thrane K; Ji AL; Khavari PA; Tarish F; Tanoglidi A; Maaskola J; Colling R; Mirtti T; Hamdy FC; Woodcock DJ; Helleday T; Mills IG; Lamb AD; Lundeberg J

Article: CELL GENOMICS. 2021;1(3):100065

Genome-wide spatial expression profiling in formalin-fixed tissues.

Gracia Villacampa E; Larsson L; Mirzazadeh R; Kvastad L; Andersson A; Mollbrink A; Kokaraki G; Monteil V; Schultz N; Appelberg KS; Montserrat N; Zhang H; Penninger JM; Miesbach W; Mirazimi A; Carlson J; Lundeberg J

Article: NATURE COMMUNICATIONS. 2018;9(1):2419

Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity.

Berglund E; Maaskola J; Schultz N; Friedrich S; Marklund M; Bergenstråhle J; Tarish F; Tanoglidi A; Vickovic S; Larsson L; Salmén F; Ogris C; Wallenborg K; Lagergren J; Ståhl P; Sonnhammer E; Helleday T; Lundeberg J

Article: NATURE COMMUNICATIONS. 2017;8(1):374

Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer.

Asim M; Tarish F; Zecchini HI; Sanjiv K; Gelali E; Massie CE; Baridi A; Warren AY; Zhao W; Ogris C; McDuffus L-A; Mascalchi P; Shaw G; Dev H; Wadhwa K; Wijnhoven P; Forment JV; Lyons SR; Lynch AG; O'Neill C; Zecchini VR; Rennie PS; Baniahmad A; Tavaré S; Mills IG; Galanty Y; Crosetto N; Schultz N; Neal D; Helleday T

Article: CELL REPORTS. 2016;14(2):298-309

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.

Sanjiv K; Hagenkort A; Calderón-Montaño JM; Koolmeister T; Reaper PM; Mortusewicz O; Jacques SA; Kuiper RV; Schultz N; Scobie M; Charlton PA; Pollard JR; Berglund UW; Altun M; Helleday T

Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(312):312re11

Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair.

Tarish FL; Schultz N; Tanoglidi A; Hamberg H; Letocha H; Karaszi K; Hamdy FC; Granfors T; Helleday T

Article: NATURE. 2014;508(7495):215-221

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

Gad H; Koolmeister T; Jemth A-S; Eshtad S; Jacques SA; Ström CE; Svensson LM; Schultz N; Lundbäck T; Einarsdottir BO; Saleh A; Göktürk C; Baranczewski P; Svensson R; Berntsson RP-A; Gustafsson R; Strömberg K; Sanjiv K; Jacques-Cordonnier M-C; Desroses M; Gustavsson A-L; Olofsson R; Johansson F; Homan EJ; Loseva O; Bräutigam L; Johansson L; Höglund A; Hagenkort A; Pham T; Altun M; Gaugaz FZ; Vikingsson S; Evers B; Henriksson M; Vallin KSA; Wallner OA; Hammarström LGJ; Wiita E; Almlöf I; Kalderén C; Axelsson H; Djureinovic T; Puigvert JC; Häggblad M; Jeppsson F; Martens U; Lundin C; Lundgren B; Granelli I; Jensen AJ; Artursson P; Nilsson JA; Stenmark P; Scobie M; Berglund UW; Helleday T

Article: CLINICAL CANCER RESEARCH. 2013;19(6):1547-1556

Castration therapy results in decreased Ku70 levels in prostate cancer.

Al-Ubaidi FLT; Schultz N; Loseva O; Egevad L; Granfors T; Helleday T

Article: CARCINOGENESIS. 2013;34(2):325-330

Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair.

Kotova N; Vare D; Schultz N; Gradecka Meesters D; Stepnik M; Grawé J; Helleday T; Jenssen D

Article: CARCINOGENESIS. 2012;33(11):2026-2034

Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.

Nicolay NH; Carter R; Hatch SB; Schultz N; Prevo R; McKenna WG; Helleday T; Sharma RA

Article: NUCLEIC ACIDS RESEARCH. 2012;40(17):8440-8448

CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation.

Elvers I; Hagenkort A; Johansson F; Djureinovic T; Lagerqvist A; Schultz N; Stoimenov I; Erixon K; Helleday T

Article: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. 2012;82(3):1243-1248

Castration therapy of prostate cancer results in downregulation of HIF-1α levels.

Al-Ubaidi FLT; Schultz N; Egevad L; Granfors T; Helleday T

Article: DNA REPAIR. 2011;10(9):961-969

CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.

Ström CE; Mortusewicz O; Finch D; Parsons JL; Lagerqvist A; Johansson F; Schultz N; Erixon K; Dianov GL; Helleday T

Article: PLOS ONE. 2011;6(5):e19492

Transcription inhibition by DRB potentiates recombinational repair of UV lesions in mammalian cells.

Stoimenov I; Schultz N; Gottipati P; Helleday T

Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2011;706(1-2):1-6

Transcription inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) causes DNA damage and triggers homologous recombination repair in mammalian cells.

Stoimenov I; Gottipati P; Schultz N; Helleday T

Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;402(1):70-82

Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage.

Groth P; Ausländer S; Majumder MM; Schultz N; Johansson F; Petermann E; Helleday T

Article: FASEB JOURNAL. 2010;24(8):2795-2803

Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans.

Waluk DP; Schultz N; Hunt MC

Article: CANCER RESEARCH. 2010;70(13):5389-5398

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.

Gottipati P; Vischioni B; Schultz N; Solomons J; Bryant HE; Djureinovic T; Issaeva N; Sleeth K; Sharma RA; Helleday T

Article: MOLECULAR CELL. 2010;37(4):492-502

Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.

Petermann E; Orta ML; Issaeva N; Schultz N; Helleday T

Article: NUCLEIC ACIDS RESEARCH. 2009;37(19):6400-6413

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.

Al-Minawi AZ; Lee Y-F; Håkansson D; Johansson F; Lundin C; Saleh-Gohari N; Schultz N; Jenssen D; Bryant HE; Meuth M; Hinz JM; Helleday T

Article: EMBO JOURNAL. 2009;28(17):2601-2615

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

Bryant HE; Petermann E; Schultz N; Jemth A-S; Loseva O; Issaeva N; Johansson F; Fernandez S; McGlynn P; Helleday T

Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2007;83(5):319-329

Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: co-localization, relationship with DSB repair and clonogenic survival.

Marková E; Schultz N; Belyaev IY

Article: CYTOGENETIC AND GENOME RESEARCH. 2007;116(1-2):38-45

RAD51C (RAD51L2) is involved in maintaining centrosome number in mitosis.

Renglin Lindh A; Schultz N; Saleh-Gohari N; Helleday T

Article: HUMAN MOLECULAR GENETICS. 2006;15(7):1217-1224

Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility.

Lindh AR; Rafii S; Schultz N; Cox A; Helleday T

Article: CELL CYCLE. 2005;4(9):1176-1178

Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy.

Helleday T; Bryant HE; Schultz N

Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(16):7158-7169

Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks.

Saleh-Gohari N; Bryant HE; Schultz N; Parker KM; Cassel TN; Helleday T

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(18):6455-6460

Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro.

Mellroth P; Karlsson J; Håkansson J; Schultz N; Goldman WE; Steiner H

Article: NATURE. 2005;434(7035):913-917

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

Bryant HE; Schultz N; Thomas HD; Parker KM; Flower D; Lopez E; Kyle S; Meuth M; Curtin NJ; Helleday T

Article: ONCOGENE. 2004;23(13):2324-2329

p53 protects from replication-associated DNA double-strand breaks in mammalian cells.

Kumari A; Schultz N; Helleday T

Article: NUCLEIC ACIDS RESEARCH. 2003;31(17):4959-4964

Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination.

Schultz N; Lopez E; Saleh-Gohari N; Helleday T

Article: JOURNAL OF MOLECULAR BIOLOGY. 2003;328(3):521-535

RAD51 is involved in repair of damage associated with DNA replication in mammalian cells.

Lundin C; Schultz N; Arnaudeau C; Mohindra A; Hansen LT; Helleday T

Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(16):5869-5878

Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells.

Lundin C; Erixon K; Arnaudeau C; Schultz N; Jenssen D; Meuth M; Helleday T

Article: CELL MOTILITY AND THE CYTOSKELETON. 2001;50(2):69-88

Spindle positioning in fibroblasts supports an astral microtubule length dependent force generation at the basal membrane.

Schultz N; Onfelt A

Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2000;126(2):97-123

Sensitivity of cytokinesis to hydrophobic interactions. Chemical induction of bi-and multinucleated cells.

Schultz N; Onfelt A

Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1996;353(1-2):11-46

The detection and evaluation of aneugenic chemicals.

Parry JM; Parry EM; Bourner R; Doherty A; Ellard S; O'Donovan J; Hoebee B; de Stoppelaar JM; Mohn GR; Onfelt A; Renglin A; Schultz N; Söderpalm-Berndes C; Jensen KG; Kirsch-Volders M; Elhajouji A; Van Hummelen P; Degrassi F; Antoccia A; Cimini D; Izzo M; Tanzarella C; Adler ID; Kliesch U; Hess P

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