Ning Xu Landén

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Docent i experimentell dermatologi och venereologi, 2017. Det finns mer
information som presenteras på sidan på engelska och
på http://www.xulandenlab.com [1]
[1] http://www.xulandenlab.com

Forskningsbeskrivning

Både kroniska svårläkta sår och psoriasis är utbredda sjukdomar som
medför stegrande hälso- och ekonomiska bördor över hela världen i brist
på effektiv behandling. Undersökning av rollen av regulatoriska RNA, till
exempel mikroRNA och långa icke-kodande RNA, utgör ett växande koncept och
ett lovande område för farmaceutiskt ingrepp. Målet för vårt
laboratorium är att fastställa hur regulatoriska RNA påverkar huden vid
sårläkning och vid psoriasis. Dessutom strävar vi efter att tillämpa
grundläggande vetenskapliga fynd som terapeutiska ingrepp för patienter.

Artiklar

Article: CELL DEATH AND DIFFERENTIATION. 2023;30(5):1334-1348

Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport.

Zhang L; Piipponen M; Liu Z; Li D; Bian X; Niu G; Geara J; Toma MA; Sommar P; Xu Landén N
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(10):2793-2804.e26

Circular RNA Signatures of Human Healing and Nonhealing Wounds.

Toma MA; Liu Z; Wang Q; Zhang L; Li D; Sommar P; Landén NX
Article: ELIFE. 2022;11:e80322

Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets.

Liu Z; Zhang L; Toma MA; Li D; Bian X; Pastar I; Tomic-Canic M; Sommar P; Xu Landén N
Article: SCIENCE. 2022;377(6602):eabg9302

Interleukin-17 governs hypoxic adaptation of injured epithelium.

Konieczny P; Xing Y; Sidhu I; Subudhi I; Mansfield KP; Hsieh B; Biancur DE; Larsen SB; Cammer M; Li D; Landén NX; Loomis C; Heguy A; Tikhonova AN; Tsirigos A; Naik S
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 Pt A):705-716

Single-Cell Analysis Reveals Major Histocompatibility Complex II‒Expressing Keratinocytes in Pressure Ulcers with Worse Healing Outcomes.

Li D; Cheng S; Pei Y; Sommar P; Kärner J; Herter EK; Toma MA; Zhang L; Pham K; Cheung YT; Liu Z; Chen X; Eidsmo L; Deng Q; Xu Landén N
Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2022;14(9):a041230

Beyond the Code: Noncoding RNAs in Skin Wound Healing.

Li D; Niu G; Landén NX
Article: CLINICAL EPIGENETICS. 2021;13(1):161

DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque.

Li J; Zhang X; Yang M; Yang H; Xu N; Fan X; Liu G; Jiang X; Fan J; Zhang L; Zhang H; Zhou Y; Li R; Gao S; Jin J; Jin Z; Zheng J; Tu Q; Ren J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(3):659-671

miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes.

Li D; Peng H; Qu L; Sommar P; Wang A; Chu T; Li X; Bi X; Liu Q; Gallais Sérézal I; Rollman O; Lohcharoenkal W; Zheng X; Eliasson Angelstig S; Grünler J; Pivarcsi A; Sonkoly E; Catrina S-B; Xiao C; Ståhle M; Mi Q-S; Zhou L; Xu Landén N
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2193:67-75

Evaluation of MicroRNA Therapeutic Potential Using the Mouse In Vivo and Human Ex Vivo Wound Models.

Li X; Xu Landén N
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):768

HypoxamiR-210 accelerates wound healing in diabetic mice by improving cellular metabolism.

Narayanan S; Eliasson Angelstig S; Xu C; Grünler J; Zhao A; Zhu W; Xu Landén N; Ståhle M; Zhang J; Ivan M; Maltesen RG; Botusan IR; Rajamand Ekberg N; Zheng X; Catrina S-B
Article: ADVANCES IN WOUND CARE. 2020;9(4):145-160

Circular RNA hsa_circ_0084443 Is Upregulated in Diabetic Foot Ulcer and Modulates Keratinocyte Migration and Proliferation.

Wang A; Toma MA; Ma J; Li D; Vij M; Chu T; Wang J; Li X; Xu Landén N
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(2):465-476.e11

MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4.

Wu J; Li X; Li D; Ren X; Li Y; Herter EK; Qian M; Toma M-A; Wintler A-M; Sérézal IG; Rollman O; Ståhle M; Wikstrom JD; Ye X; Landén NX
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2154:239-247

Investigation of Skin Wound Healing Using a Mouse Model.

Wu J; Landén NX
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(6):1373-1384

WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines.

Herter EK; Li D; Toma MA; Vij M; Li X; Visscher D; Wang A; Chu T; Sommar P; Blomqvist L; Berglund D; Ståhle M; Wikstrom JD; Xu Landén N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452

Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration.

Li D; Kular L; Vij M; Herter EK; Li X; Wang A; Chu T; Toma M-A; Zhang L; Liapi E; Mota A; Blomqvist L; Gallais Sérézal I; Rollman O; Wikstrom JD; Bienko M; Berglund D; Ståhle M; Sommar P; Jagodic M; Landén NX
Article: ACTA DERMATO-VENEREOLOGICA. 2019;99(2):196-205

The Keratinocyte Transcriptome in Psoriasis: Pathways Related to Immune Responses, Cell Cycle and Keratinization.

Pasquali L; Srivastava A; Meisgen F; Das Mahapatra K; Xia P; Xu Landén N; Pivarcsi A; Sonkoly E
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(8):1754-1763

Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical Outcome.

Gallais Sérézal I; Classon C; Cheuk S; Barrientos-Somarribas M; Wadman E; Martini E; Chang D; Xu Landén N; Ehrström M; Nylén S; Eidsmo L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892

Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis.

Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Akkaya Ulum YZ; Zhang L; Xu Landén N; Girnita L; Jagodic M; Ståhle M; Sonkoly E; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638

MicroRNA-132 with Therapeutic Potential in Chronic Wounds.

Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grünler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrström M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Ståhle M; Xu Landén N
Article: SCIENTIFIC REPORTS. 2017;7(1):7797

MicroRNA-132 promotes fibroblast migration via regulating RAS p21 protein activator 1 in skin wound healing.

Li X; Li D; Wikstrom JD; Pivarcsi A; Sonkoly E; Ståhle M; Landén NX
Article: BRITISH JOURNAL OF DERMATOLOGY. 2017;176(3):723-731

Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis.

Wei T; Folkersen L; Biskup E; Xu N; Manfe V; Niazi O; Gniadecki R
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):550-561

MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis.

Srivastava A; Nikamo P; Lohcharoenkal W; Li D; Meisgen F; Xu Landén N; Ståhle M; Pivarcsi A; Sonkoly E
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19(12):pyw069

MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.

Wei YB; Melas PA; Villaescusa JC; Liu JJ; Xu N; Christiansen SH; Elbrønd-Bek H; Woldbye DPD; Wegener G; Mathé AA; Lavebratt C
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(12):2485-2494

MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC.

Lohcharoenkal W; Harada M; Lovén J; Meisgen F; Landén NX; Zhang L; Lapins J; Mahapatra KD; Shi H; Nissinen L; Kähäri V-M; Ståhle M; Sonkoly E; Grandér D; Arsenian-Henriksson M; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(3):640-648

Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue.

Cheung L; Fisher RM; Kuzmina N; Li D; Li X; Werngren O; Blomqvist L; Ståhle M; Landén NX
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(8):3008-3026

MicroRNA-132 enhances transition from inflammation to proliferation during wound healing.

Li D; Wang A; Liu X; Meisgen F; Grünler J; Botusan IR; Narayanan S; Erikci E; Li X; Blomqvist L; Du L; Pivarcsi A; Sonkoly E; Chowdhury K; Catrina S-B; Ståhle M; Landén NX
Article: SCIENTIFIC REPORTS. 2015;5:12017

Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment.

Checa A; Xu N; Sar DG; Haeggström JZ; Ståhle M; Wheelock CE
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135(6):1676-1685

MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration.

Li D; Li XI; Wang A; Meisgen F; Pivarcsi A; Sonkoly E; Ståhle M; Landén NX
Article: BMC MEDICAL GENOMICS. 2015;8:12

Effects of statin on circulating microRNAome and predicted function regulatory network in patients with unstable angina.

Li J; Chen H; Ren J; Song J; Zhang F; Zhang J; Lee C; Li S; Geng Q; Cao C; Xu N
Article: JOURNAL OF PROTEOME RESEARCH. 2015;14(1):557-566

LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNFα treatment.

Kamleh MA; Snowden SG; Grapov D; Blackburn GJ; Watson DG; Xu N; Ståhle M; Wheelock CE
Article: ATHEROSCLEROSIS. 2014;237(2):514-520

MicroRNA-223 inhibits tissue factor expression in vascular endothelial cells.

Li S; Chen H; Ren J; Geng Q; Song J; Lee C; Cao C; Zhang J; Xu N
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2014;75:49-57

MicroRNA-19b functions as potential anti-thrombotic protector in patients with unstable angina by targeting tissue factor.

Li S; Ren J; Xu N; Zhang J; Geng Q; Cao C; Lee C; Song J; Li J; Chen H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(7):1931-1940

MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes.

Meisgen F; Xu Landén N; Wang A; Réthi B; Bouez C; Zuccolo M; Gueniche A; Ståhle M; Sonkoly E; Breton L; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(6):1535-1541

Genetic variants of the IL22 promoter associate to onset of psoriasis before puberty and increased IL-22 production in T cells.

Nikamo P; Cheuk S; Lysell J; Enerbäck C; Bergh K; Xu Landén N; Eidsmo L; Ståhle M
Article: CARCINOGENESIS. 2014;35(5):1110-1120

miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma.

Gastaldi C; Bertero T; Xu N; Bourget-Ponzio I; Lebrigand K; Fourre S; Popa A; Cardot-Leccia N; Meneguzzi G; Sonkoly E; Pivarcsi A; Mari B; Barbry P; Ponzio G; Rezzonico R
Article: EXPERIMENTAL DERMATOLOGY. 2014;23(4):281-283

Activation of toll-like receptors alters the microRNA expression profile of keratinocytes.

Meisgen F; Xu Landén N; Bouez C; Zuccolo M; Gueniche A; Ståhle M; Sonkoly E; Breton L; Pivarcsi A
Article: PLOS ONE. 2014;9(7):e103206

MicroRNA-31 is overexpressed in cutaneous squamous cell carcinoma and regulates cell motility and colony formation ability of tumor cells.

Wang A; Landén NX; Meisgen F; Lohcharoenkal W; Ståhle M; Sonkoly E; Pivarcsi A
Article: PLOS ONE. 2014;9(1):e87826

Therapeutic effect of intravenous infusion of perfluorocarbon emulsion on LPS-induced acute lung injury in rats.

Hou S; Ding H; Lv Q; Yin X; Song J; Landén NX; Fan H
Article: BRITISH JOURNAL OF DERMATOLOGY. 2013;169(3):563-570

Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor-α therapy.

Pivarcsi A; Meisgen F; Xu N; Ståhle M; Sonkoly E
Article: JOURNAL OF IMMUNOLOGY. 2013;190(2):678-688

MicroRNA-31 is overexpressed in psoriasis and modulates inflammatory cytokine and chemokine production in keratinocytes via targeting serine/threonine kinase 40.

Xu N; Meisgen F; Butler LM; Han G; Wang X-J; Söderberg-Nauclér C; Ståhle M; Pivarcsi A; Sonkoly E
Article: PLOS ONE. 2013;8(12):e80738

Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease.

Ren J; Zhang J; Xu N; Han G; Geng Q; Song J; Li S; Zhao J; Chen H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(35):29899-29908

MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion.

Xu N; Zhang L; Meisgen F; Harada M; Heilborn J; Homey B; Grandér D; Ståhle M; Sonkoly E; Pivarcsi A
Article: EXPERIMENTAL DERMATOLOGY. 2012;21(4):312-314

MiR-21 is up-regulated in psoriasis and suppresses T cell apoptosis.

Meisgen F; Xu N; Wei T; Janson PC; Obad S; Broom O; Nagy N; Kauppinen S; Kemény L; Ståhle M; Pivarcsi A; Sonkoly E
Article: ONCOGENESIS. 2012;1(3):e3

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma.

Sonkoly E; Lovén J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grandér D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Ståhle M; Pivarcsi A
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(7):1521-1529

MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.

Xu N; Brodin P; Wei T; Meisgen F; Eidsmo L; Nagy N; Kemeny L; Ståhle M; Sonkoly E; Pivarcsi A
Article: METHODS IN MOLECULAR BIOLOGY. 2011;721:183-198

Characterization of RISC-associated adenoviral small RNAs.

Xu N; Akusjärvi G
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(3):581-9.e1-20-U306

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4.

Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Ståhle M; Pivarcsi A
Article: NUCLEIC ACIDS RESEARCH. 2009;37(20):6950-6959

The 5'-end heterogeneity of adenovirus virus-associated RNAI contributes to the asymmetric guide strand incorporation into the RNA-induced silencing complex.

Xu N; Gkountela S; Saeed K; Akusjärvi G
Article: JOURNAL OF VIROLOGY. 2007;81(19):10540-10549

Adenovirus virus-associated RNAII-derived small RNAs are efficiently incorporated into the rna-induced silencing complex and associate with polyribosomes.

Xu N; Segerman B; Zhou X; Akusjärvi G
Article: METHODS IN MOLECULAR MEDICINE. 2007;131:47-61

In vitro methods to study RNA interference during an adenovirus infection.

Andersson G; Xu N; Akusjärvi G
Article: JOURNAL OF VIROLOGY. 2005;79(15):9556-9565

Suppression of RNA interference by adenovirus virus-associated RNA.

Andersson MG; Haasnoot PCJ; Xu N; Berenjian S; Berkhout B; Akusjärvi G
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Alla övriga publikationer

Review: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(9):1667-1677

A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization.

Almet AA; Yuan H; Annusver K; Ramos R; Liu Y; Wiedemann J; Sorkin DH; Landén NX; Sonkoly E; Haniffa M; Nie Q; Lichtenberger BM; Luecken MD; Andersen B; Tsoi LC; Watt FM; Gudjonsson JE; Plikus MV; Kasper M
Review: HEALTH SCIENCE REPORTS. 2021;4(4):e374

Targeting microRNA for improved skin health.

Li X; Ponandai-Srinivasan S; Nandakumar KS; Fabre S; Xu Landén N; Mavon A; Khmaladze I
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(22):E8790-8790

The Immune Functions of Keratinocytes in Skin Wound Healing.

Piipponen M; Li D; Landén NX
Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(12):2547-2550.e12

Next-Generation Sequencing Identifies the Keratinocyte-Specific miRNA Signature of Psoriasis.

Srivastava A; Meisgen F; Pasquali L; Munkhammar S; Xia P; Ståhle M; Landén NX; Pivarcsi A; Sonkoly E
Review: EUROPEAN JOURNAL OF DERMATOLOGY. 2017;27(S1):12-14

MicroRNAs in skin wound healing.

Li D; Landén NX
Review: ADVANCES IN WOUND CARE. 2017;6(3):93-107

Non-Coding RNAs: New Players in Skin Wound Healing.

Herter EK; Xu Landén N
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2016;73(20):3861-3885

Transition from inflammation to proliferation: a critical step during wound healing.

Landén NX; Li D; Ståhle M
Review: IUBMB LIFE. 2015;67(8):601-610

New insights into T cells and their signature cytokines in atopic dermatitis.

Wang A-X; Xu Landén N
Letter: ACTA DERMATO-VENEREOLOGICA. 2013;93(3):366-367

Are BIC (miR-155) polymorphisms associated with eczema susceptibility?

Sääf A; Kockum I; Wahlgren C-F; Xu N; Sonkoly E; Ståhle M; Nordenskjöld M; Bradley M; Pivarcsi A
Published conference paper: EUROPEAN JOURNAL OF DERMATOLOGY. 2013;:66-71

Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes.

Wei T; Xu N; Meisgen F; Ståhle M; Sonkoly E; Pivarcsi A
Review: YI CHUAN = HEREDITAS / ZHONGGUO YI CHUAN XUE HUI BIAN JI.. 2012;34(6):784-792

[Application of next generation sequencing in microRNA detection].

Tang H-M; Chen H; Zhang J; Ren J-Y; Xu N
Letter: EXPERIMENTAL DERMATOLOGY. 2010;19(9):854-856

The expression of microRNA-203 during human skin morphogenesis.

Wei T; Orfanidis K; Xu N; Janson P; Ståhle M; Pivarcsi A; Sonkoly E

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