Niklas Mejhert

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Populärvetenskap och samverkan

Om mig

Forskargruppledare vid Avdelningen för Endokrinologi, Institutionen för Medicin i Huddinge.
För mer information, besök: https://ki.se/medh/mikael-ryden-niklas-mejhert-lab

Artiklar

Article: NATURE METABOLISM. 2024;:1-19

A spatiotemporal proteomic map of human adipogenesis.

Klingelhuber F; Frendo-Cumbo S; Omar-Hmeadi M; Massier L; Kakimoto P; Taylor AJ; Couchet M; Ribicic S; Wabitsch M; Messias AC; Iuso A; Müller TD; Rydén M; Mejhert N; Krahmer N
Article: SCIENCE ADVANCES. 2024;10(1):eadi2689

Transcriptional determinants of lipid mobilization in human adipocytes.

Ludzki AC; Hansen M; Zareifi D; Jalkanen J; Huang Z; Omar-Hmeadi M; Renzi G; Klingelhuber F; Boland S; Ambaw YA; Wang N; Damdimopoulos A; Liu J; Jernberg T; Petrus P; Arner P; Krahmer N; Fan R; Treuter E; Gao H; Rydén M; Mejhert N
Article: ADIPOCYTE. 2023;:2283213

Adipogenic characterization of immortalized CD55+ progenitor cells from human white adipose tissue.

Couchet M; Gao H; Klingelhuber F; Jalkanen J; De Castro Barbosa T; Omar-Hmeadi M; Massier L; Krahmer N; Mejhert N; Rydén M
Article: NATURE COMMUNICATIONS. 2023;14(1):1438

An integrated single cell and spatial transcriptomic map of human white adipose tissue.

Massier L; Jalkanen J; Elmastas M; Zhong J; Wang T; Nono Nankam PA; Frendo-Cumbo S; Bäckdahl J; Subramanian N; Sekine T; Kerr AG; Tseng BTP; Laurencikiene J; Buggert M; Lourda M; Kublickiene K; Bhalla N; Andersson A; Valsesia A; Astrup A; Blaak EE; Ståhl PL; Viguerie N; Langin D; Wolfrum C; Blüher M; Rydén M; Mejhert N
Article: MOLECULAR METABOLISM. 2022;64:101556

Tryptophan metabolism is a physiological integrator regulating circadian rhythms.

Petrus P; Cervantes M; Samad M; Sato T; Chao A; Sato S; Koronowski KB; Park G; Alam Y; Mejhert N; Seldin MM; Monroy Kuhn JM; Dyar KA; Lutter D; Baldi P; Kaiser P; Jang C; Sassone-Corsi P
Article: DEVELOPMENTAL CELL. 2022;57(3):387-397.e4

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.

Mejhert N; Gabriel KR; Frendo-Cumbo S; Krahmer N; Song J; Kuruvilla L; Chitraju C; Boland S; Jang D-K; von Grotthuss M; Costanzo MC; Rydén M; Olzmann JA; Flannick J; Burtt NP; Farese RV; Walther TC
Article: NATURE METABOLISM. 2022;4(2):190-202

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation.

Maqdasy S; Lecoutre S; Renzi G; Frendo-Cumbo S; Rizo-Roca D; Moritz T; Juvany M; Hodek O; Gao H; Couchet M; Witting M; Kerr A; Bergo MO; Choudhury RP; Aouadi M; Zierath JR; Krook A; Mejhert N; Rydén M
Article: CELL METABOLISM. 2021;33(9):1869-1882.e6

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin.

Bäckdahl J; Franzén L; Massier L; Li Q; Jalkanen J; Gao H; Andersson A; Bhalla N; Thorell A; Rydén M; Ståhl PL; Mejhert N
Article: ADVANCED SCIENCE. 2021;8(16):e2100106

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis.

Shen JX; Couchet M; Dufau J; de Castro Barbosa T; Ulbrich MH; Helmstädter M; Kemas AM; Zandi Shafagh R; Marques M-A; Hansen JB; Mejhert N; Langin D; Rydén M; Lauschke VM
Article: DIABETES. 2021;70(7):1486-1497

Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State.

Mileti E; Kwok KHM; Andersson DP; Mathelier A; Raman A; Bäckdahl J; Jalkanen J; Massier L; Thorell A; Gao H; Arner P; Mejhert N; Daub CO; Rydén M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2021;320(5):C822-C841

In vitro and ex vivo models of adipocytes.

Dufau J; Shen JX; Couchet M; De Castro Barbosa T; Mejhert N; Massier L; Griseti E; Mouisel E; Amri E-Z; Lauschke VM; Rydén M; Langin D
Journal article: CELL REPORTS. 2020;33(6):108378

A Systematic Protein Turnover Map for Decoding Protein Degradation.

Christiano R; Arlt H; Kabatnik S; Mejhert N; Lai ZW; Farese RV; Walther TC
Journal article: JOURNAL OF CELL BIOLOGY. 2020;219(10):e202006111

FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.

Becuwe M; Bond LM; Pinto AFM; Boland S; Mejhert N; Elliott SD; Cicconet M; Graham MM; Liu XN; Ilkayeva O; Saghatelian A; Walther TC; Farese RV
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(19):10565-10574

Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.

Petit CS; Lee JJ; Boland S; Swarup S; Christiano R; Lai ZW; Mejhert N; Elliott SD; McFall D; Haque S; Huang EJ; Bronson RT; Harper JW; Farese RV; Walther TC
Journal article: MOLECULAR CELL. 2020;77(6):1251-1264.e9

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.

Mejhert N; Kuruvilla L; Gabriel KR; Elliott SD; Guie M-A; Wang H; Lai ZW; Lane EA; Christiano R; Danial NN; Farese RV; Walther TC
Journal article: HEPATOLOGY. 2019;70(6):1972-1985

Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.

Gluchowski NL; Gabriel KR; Chitraju C; Bronson RT; Mejhert N; Boland S; Wang K; Lai ZW; Farese RV; Walther TC
Article: CELL REPORTS. 2018;25(3):551-560.e5

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.

Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyté A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martínez-Álvarez C; Hedén P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Rydén M
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2018;472:50-56

MicroRNAs-361-5p and miR-574-5p associate with human adipose morphology and regulate EBF1 expression in white adipose tissue.

Belarbi Y; Mejhert N; Gao H; Arner P; Rydén M; Kulyté A
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2018;103(2):710-721

Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance.

Petrus P; Bialesova L; Checa A; Kerr A; Naz S; Bäckdahl J; Gracia A; Toft S; Dahlman-Wright K; Hedén P; Dahlman I; Wheelock CE; Arner P; Mejhert N; Gao H; Rydén M
Article: INTERNATIONAL JOURNAL OF OBESITY. 2017;41(12):1815-1823

Repin1 deficiency in adipose tissue improves whole-body insulin sensitivity, and lipid metabolism.

Hesselbarth N; Kunath A; Kern M; Gericke M; Mejhert N; Rydén M; Stumvoll M; Blüher M; Klöting N
Article: NATURE BIOTECHNOLOGY. 2017;35(9):872-878

An integrated expression atlas of miRNAs and their promoters in human and mouse.

de Rie D; Abugessaisa I; Alam T; Arner E; Arner P; Ashoor H; Åström G; Babina M; Bertin N; Burroughs AM; Carlisle AJ; Daub CO; Detmar M; Deviatiiarov R; Fort A; Gebhard C; Goldowitz D; Guhl S; Ha TJ; Harshbarger J; Hasegawa A; Hashimoto K; Herlyn M; Heutink P; Hitchens KJ; Hon CC; Huang E; Ishizu Y; Kai C; Kasukawa T; Klinken P; Lassmann T; Lecellier C-H; Lee W; Lizio M; Makeev V; Mathelier A; Medvedeva YA; Mejhert N; Mungall CJ; Noma S; Ohshima M; Okada-Hatakeyama M; Persson H; Rizzu P; Roudnicky F; Sætrom P; Sato H; Severin J; Shin JW; Swoboda RK; Tarui H; Toyoda H; Vitting-Seerup K; Winteringham L; Yamaguchi Y; Yasuzawa K; Yoneda M; Yumoto N; Zabierowski S; Zhang PG; Wells CA; Summers KM; Kawaji H; Sandelin A; Rehli M; FANTOM Consortium; Hayashizaki Y; Carninci P; Forrest ARR; de Hoon MJL
Article: SCIENTIFIC DATA. 2017;4:170112

FANTOM5 CAGE profiles of human and mouse samples.

Noguchi S; Arakawa T; Fukuda S; Furuno M; Hasegawa A; Hori F; Ishikawa-Kato S; Kaida K; Kaiho A; Kanamori-Katayama M; Kawashima T; Kojima M; Kubosaki A; Manabe R-I; Murata M; Nagao-Sato S; Nakazato K; Ninomiya N; Nishiyori-Sueki H; Noma S; Saijyo E; Saka A; Sakai M; Simon C; Suzuki N; Tagami M; Watanabe S; Yoshida S; Arner P; Axton RA; Babina M; Baillie JK; Barnett TC; Beckhouse AG; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Carlisle AJ; Clevers HC; Davis CA; Detmar M; Dohi T; Edge ASB; Edinger M; Ehrlund A; Ekwall K; Endoh M; Enomoto H; Eslami A; Fagiolini M; Fairbairn L; Farach-Carson MC; Faulkner GJ; Ferrai C; Fisher ME; Forrester LM; Fujita R; Furusawa J-I; Geijtenbeek TB; Gingeras T; Goldowitz D; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Hasegawa Y; Herlyn M; Heutink P; Hitchens KJ; Hume DA; Ikawa T; Ishizu Y; Kai C; Kawamoto H; Kawamura YI; Kempfle JS; Kenna TJ; Kere J; Khachigian LM; Kitamura T; Klein S; Klinken SP; Knox AJ; Kojima S; Koseki H; Koyasu S; Lee W; Lennartsson A; Mackay-Sim A; Mejhert N; Mizuno Y; Morikawa H; Morimoto M; Moro K; Morris KJ; Motohashi H; Mummery CL; Nakachi Y; Nakahara F; Nakamura T; Nakamura Y; Nozaki T; Ogishima S; Ohkura N; Ohno H; Ohshima M; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov DA; Passier R; Patrikakis M; Pombo A; Pradhan-Bhatt S; Qin X-Y; Rehli M; Rizzu P; Roy S; Sajantila A; Sakaguchi S; Sato H; Satoh H; Savvi S; Saxena A; Schmidl C; Schneider C; Schulze-Tanzil GG; Schwegmann A; Sheng G; Shin JW; Sugiyama D; Sugiyama T; Summers KM; Takahashi N; Takai J; Tanaka H; Tatsukawa H; Tomoiu A; Toyoda H; van de Wetering M; van den Berg LM; Verardo R; Vijayan D; Wells CA; Winteringham LN; Wolvetang E; Yamaguchi Y; Yamamoto M; Yanagi-Mizuochi C; Yoneda M; Yonekura Y; Zhang PG; Zucchelli S; Abugessaisa I; Arner E; Harshbarger J; Kondo A; Lassmann T; Lizio M; Sahin S; Sengstag T; Severin J; Shimoji H; Suzuki M; Suzuki H; Kawai J; Kondo N; Itoh M; Daub CO; Kasukawa T; Kawaji H; Carninci P; Forrest ARR; Hayashizaki Y
Journal article: CELL METABOLISM. 2017;26(2):407-418.e3

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Chitraju C; Mejhert N; Haas JT; Diaz-Ramirez LG; Grueter CA; Imbriglio JE; Pinto S; Koliwad SK; Walther TC; Farese RV
Article: STEM CELLS. 2017;35(7):1799-1814

CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential.

Gao H; Volat F; Sandhow L; Galitzky J; Nguyen T; Esteve D; Åström G; Mejhert N; Ledoux S; Thalamas C; Arner P; Guillemot J-C; Qian H; Rydén M; Bouloumié A
Journal article: JOURNAL OF LIPID RESEARCH. 2017;58(6):1230-1237

Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.

Gluchowski NL; Chitraju C; Picoraro JA; Mejhert N; Pinto S; Xin W; Kamin DS; Winter HS; Chung WK; Walther TC; Farese RV
Article: DIABETES. 2017;66(1):218-230

Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution.

Ehrlund A; Mejhert N; Björk C; Andersson R; Kulyté A; Åström G; Itoh M; Kawaji H; Lassmann T; Daub CO; Carninci P; Forrest ARR; Hayashizaki Y; Sandelin A; Ingelsson E; FANTOM Consortium; Rydén M; Laurencikiene J; Arner P; Arner E
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2016;101(11):4021-4029

Adipose and Circulating CCL18 Levels Associate With Metabolic Risk Factors in Women.

Eriksson Hogling D; Petrus P; Gao H; Bäckdahl J; Dahlman I; Laurencikiene J; Acosta J; Ehrlund A; Näslund E; Kulyte A; Mejhert N; Andersson DP; Arner P; Rydén M
Article: DIABETES & METABOLISM. 2015;41(6):509-512

Low early B-cell factor 1 (EBF1) activity in human subcutaneous adipose tissue is linked to a pernicious metabolic profile.

Petrus P; Mejhert N; Gao H; Bäckdahl J; Arner E; Arner P; Rydén M
Article: PLOS BIOLOGY. 2015;13(12):e1002315

The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome.

Hurst LD; Ghanbarian AT; Forrest ARR; FANTOM consortium; Huminiecki L
Article: CELL METABOLISM. 2015;22(3):408-417

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis.

Rydén M; Uzunel M; Hård JL; Borgström E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisén J; Bernard S; Mattsson J; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(8):E1084-E1088

MicroRNA-193b Controls Adiponectin Production in Human White Adipose Tissue.

Belarbi Y; Mejhert N; Lorente-Cebrián S; Dahlman I; Arner P; Rydén M; Kulyté A
Article: LIPIDS IN HEALTH AND DISEASE. 2015;14:42

Saturated fatty acids in human visceral adipose tissue are associated with increased 11- β-hydroxysteroid-dehydrogenase type 1 expression.

Petrus P; Rosqvist F; Edholm D; Mejhert N; Arner P; Dahlman I; Rydén M; Sundbom M; Risérus U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(14):4363-4368

Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue.

Minchin JEN; Dahlman I; Harvey CJ; Mejhert N; Singh MK; Epstein JA; Arner P; Torres-Vázquez J; Rawls JF
Article: SCIENCE. 2015;347(6225):1010-1014

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.

Arner E; Daub CO; Vitting-Seerup K; Andersson R; Lilje B; Drabløs F; Lennartsson A; Rönnerblad M; Hrydziuszko O; Vitezic M; Freeman TC; Alhendi AMN; Arner P; Axton R; Baillie JK; Beckhouse A; Bodega B; Briggs J; Brombacher F; Davis M; Detmar M; Ehrlund A; Endoh M; Eslami A; Fagiolini M; Fairbairn L; Faulkner GJ; Ferrai C; Fisher ME; Forrester L; Goldowitz D; Guler R; Ha T; Hara M; Herlyn M; Ikawa T; Kai C; Kawamoto H; Khachigian LM; Klinken SP; Kojima S; Koseki H; Klein S; Mejhert N; Miyaguchi K; Mizuno Y; Morimoto M; Morris KJ; Mummery C; Nakachi Y; Ogishima S; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov D; Passier R; Patrikakis M; Pombo A; Qin X-Y; Roy S; Sato H; Savvi S; Saxena A; Schwegmann A; Sugiyama D; Swoboda R; Tanaka H; Tomoiu A; Winteringham LN; Wolvetang E; Yanagi-Mizuochi C; Yoneda M; Zabierowski S; Zhang P; Abugessaisa I; Bertin N; Diehl AD; Fukuda S; Furuno M; Harshbarger J; Hasegawa A; Hori F; Ishikawa-Kato S; Ishizu Y; Itoh M; Kawashima T; Kojima M; Kondo N; Lizio M; Meehan TF; Mungall CJ; Murata M; Nishiyori-Sueki H; Sahin S; Nagao-Sato S; Severin J; de Hoon MJL; Kawai J; Kasukawa T; Lassmann T; Suzuki H; Kawaji H; Summers KM; Wells C; FANTOM Consortium; Hume DA; Forrest ARR; Sandelin A; Carninci P; Hayashizaki Y
Article: DIABETES CARE. 2014;37(7):1831-1836

Changes in subcutaneous fat cell volume and insulin sensitivity after weight loss.

Andersson DP; Eriksson Hogling D; Thorell A; Toft E; Qvisth V; Näslund E; Thörne A; Wirén M; Löfgren P; Hoffstedt J; Dahlman I; Mejhert N; Rydén M; Arner E; Arner P
Article: CELL METABOLISM. 2014;19(6):981-992

Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue.

Gao H; Mejhert N; Fretz JA; Arner E; Lorente-Cebrián S; Ehrlund A; Dahlman-Wright K; Gong X; Strömblad S; Douagi I; Laurencikiene J; Dahlman I; Daub CO; Rydén M; Horowitz MC; Arner P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(14):5289-5294

Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.

Morikawa H; Ohkura N; Vandenbon A; Itoh M; Nagao-Sato S; Kawaji H; Lassmann T; Carninci P; Hayashizaki Y; Forrest ARR; Standley DM; Date H; Sakaguchi S; FANTOM Consortium
Article: DIABETES. 2014;63(4):1248-1258

Additive effects of microRNAs and transcription factors on CCL2 production in human white adipose tissue.

Kulyté A; Belarbi Y; Lorente-Cebrián S; Bambace C; Arner E; Daub CO; Hedén P; Rydén M; Mejhert N; Arner P
Article: NATURE. 2014;507(7493):462-470

A promoter-level mammalian expression atlas.

FANTOM Consortium and the RIKEN PMI and CLST (DGT); Forrest ARR; Kawaji H; Rehli M; Baillie JK; de Hoon MJL; Haberle V; Lassmann T; Kulakovskiy IV; Lizio M; Itoh M; Andersson R; Mungall CJ; Meehan TF; Schmeier S; Bertin N; Jørgensen M; Dimont E; Arner E; Schmidl C; Schaefer U; Medvedeva YA; Plessy C; Vitezic M; Severin J; Semple CA; Ishizu Y; Young RS; Francescatto M; Alam I; Albanese D; Altschuler GM; Arakawa T; Archer JAC; Arner P; Babina M; Rennie S; Balwierz PJ; Beckhouse AG; Pradhan-Bhatt S; Blake JA; Blumenthal A; Bodega B; Bonetti A; Briggs J; Brombacher F; Burroughs AM; Califano A; Cannistraci CV; Carbajo D; Chen Y; Chierici M; Ciani Y; Clevers HC; Dalla E; Davis CA; Detmar M; Diehl AD; Dohi T; Drabløs F; Edge ASB; Edinger M; Ekwall K; Endoh M; Enomoto H; Fagiolini M; Fairbairn L; Fang H; Farach-Carson MC; Faulkner GJ; Favorov AV; Fisher ME; Frith MC; Fujita R; Fukuda S; Furlanello C; Furino M; Furusawa J-I; Geijtenbeek TB; Gibson AP; Gingeras T; Goldowitz D; Gough J; Guhl S; Guler R; Gustincich S; Ha TJ; Hamaguchi M; Hara M; Harbers M; Harshbarger J; Hasegawa A; Hasegawa Y; Hashimoto T; Herlyn M; Hitchens KJ; Ho Sui SJ; Hofmann OM; Hoof I; Hori F; Huminiecki L; Iida K; Ikawa T; Jankovic BR; Jia H; Joshi A; Jurman G; Kaczkowski B; Kai C; Kaida K; Kaiho A; Kajiyama K; Kanamori-Katayama M; Kasianov AS; Kasukawa T; Katayama S; Kato S; Kawaguchi S; Kawamoto H; Kawamura YI; Kawashima T; Kempfle JS; Kenna TJ; Kere J; Khachigian LM; Kitamura T; Klinken SP; Knox AJ; Kojima M; Kojima S; Kondo N; Koseki H; Koyasu S; Krampitz S; Kubosaki A; Kwon AT; Laros JFJ; Lee W; Lennartsson A; Li K; Lilje B; Lipovich L; Mackay-Sim A; Manabe R-I; Mar JC; Marchand B; Mathelier A; Mejhert N; Meynert A; Mizuno Y; de Lima Morais DA; Morikawa H; Morimoto M; Moro K; Motakis E; Motohashi H; Mummery CL; Murata M; Nagao-Sato S; Nakachi Y; Nakahara F; Nakamura T; Nakamura Y; Nakazato K; van Nimwegen E; Ninomiya N; Nishiyori H; Noma S; Noma S; Noazaki T; Ogishima S; Ohkura N; Ohimiya H; Ohno H; Ohshima M; Okada-Hatakeyama M; Okazaki Y; Orlando V; Ovchinnikov DA; Pain A; Passier R; Patrikakis M; Persson H; Piazza S; Prendergast JGD; Rackham OJL; Ramilowski JA; Rashid M; Ravasi T; Rizzu P; Roncador M; Roy S; Rye MB; Saijyo E; Sajantila A; Saka A; Sakaguchi S; Sakai M; Sato H; Savvi S; Saxena A; Schneider C; Schultes EA; Schulze-Tanzil GG; Schwegmann A; Sengstag T; Sheng G; Shimoji H; Shimoni Y; Shin JW; Simon C; Sugiyama D; Sugiyama T; Suzuki M; Suzuki N; Swoboda RK; 't Hoen PAC; Tagami M; Takahashi N; Takai J; Tanaka H; Tatsukawa H; Tatum Z; Thompson M; Toyodo H; Toyoda T; Valen E; van de Wetering M; van den Berg LM; Verado R; Vijayan D; Vorontsov IE; Wasserman WW; Watanabe S; Wells CA; Winteringham LN; Wolvetang E; Wood EJ; Yamaguchi Y; Yamamoto M; Yoneda M; Yonekura Y; Yoshida S; Zabierowski SE; Zhang PG; Zhao X; Zucchelli S; Summers KM; Suzuki H; Daub CO; Kawai J; Heutink P; Hide W; Freeman TC; Lenhard B; Bajic VB; Taylor MS; Makeev VJ; Sandelin A; Hume DA; Carninci P; Hayashizaki Y
Article: NATURE. 2014;507(7493):455-461

An atlas of active enhancers across human cell types and tissues.

Andersson R; Gebhard C; Miguel-Escalada I; Hoof I; Bornholdt J; Boyd M; Chen Y; Zhao X; Schmidl C; Suzuki T; Ntini E; Arner E; Valen E; Li K; Schwarzfischer L; Glatz D; Raithel J; Lilje B; Rapin N; Bagger FO; Jørgensen M; Andersen PR; Bertin N; Rackham O; Burroughs AM; Baillie JK; Ishizu Y; Shimizu Y; Furuhata E; Maeda S; Negishi Y; Mungall CJ; Meehan TF; Lassmann T; Itoh M; Kawaji H; Kondo N; Kawai J; Lennartsson A; Daub CO; Heutink P; Hume DA; Jensen TH; Suzuki H; Hayashizaki Y; Müller F; Forrest ARR; Carninci P; Rehli M; Sandelin A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(3):E267-E274

MicroRNA profiling links miR-378 to enhanced adipocyte lipolysis in human cancer cachexia.

Kulyté A; Lorente-Cebrián S; Gao H; Mejhert N; Agustsson T; Arner P; Rydén M; Dahlman I
Article: CELL. 2014;156(1-2):343-358

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

Claussnitzer M; Dankel SN; Klocke B; Grallert H; Glunk V; Berulava T; Lee H; Oskolkov N; Fadista J; Ehlers K; Wahl S; Hoffmann C; Qian K; Rönn T; Riess H; Müller-Nurasyid M; Bretschneider N; Schroeder T; Skurk T; Horsthemke B; DIAGRAM+Consortium; Spieler D; Klingenspor M; Seifert M; Kern MJ; Mejhert N; Dahlman I; Hansson O; Hauck SM; Blüher M; Arner P; Groop L; Illig T; Suhre K; Hsu Y-H; Mellgren G; Hauner H; Laumen H
Article: PLOS ONE. 2014;9(1):e86800

MicroRNAs regulate human adipocyte lipolysis: effects of miR-145 are linked to TNF-α.

Lorente-Cebrián S; Mejhert N; Kulyté A; Laurencikiene J; Åström G; Hedén P; Rydén M; Arner P
Article: PLOS ONE. 2014;9(3):e80274

Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells.

Arner E; Forrest ARR; Ehrlund A; Mejhert N; Itoh M; Kawaji H; Lassmann T; Laurencikiene J; Rydén M; Arner P; FANTOM Consortium
Article: DIABETOLOGIA. 2013;56(9):2044-2054

LXR is a negative regulator of glucose uptake in human adipocytes.

Pettersson AML; Stenson BM; Lorente-Cebrián S; Andersson DP; Mejhert N; Krätzel J; Aström G; Dahlman I; Chibalin AV; Arner P; Laurencikiene J
Article: DIABETOLOGIA. 2013;56(8):1792-1801

Semaphorin 3C is a novel adipokine linked to extracellular matrix composition.

Mejhert N; Wilfling F; Esteve D; Galitzky J; Pellegrinelli V; Kolditz C-I; Viguerie N; Tordjman J; Näslund E; Trayhurn P; Lacasa D; Dahlman I; Stich V; Lång P; Langin D; Bouloumié A; Clément K; Rydén M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2013;98(3):E503-E508

Characterization of the Wnt inhibitors secreted frizzled-related proteins (SFRPs) in human adipose tissue.

Ehrlund A; Mejhert N; Lorente-Cebrián S; Aström G; Dahlman I; Laurencikiene J; Rydén M
Article: PLOS BIOLOGY. 2013;11(2):e1001485

Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass.

Girousse A; Tavernier G; Valle C; Moro C; Mejhert N; Dinel A-L; Houssier M; Roussel B; Besse-Patin A; Combes M; Mir L; Monbrun L; Bézaire V; Prunet-Marcassus B; Waget A; Vila I; Caspar-Bauguil S; Louche K; Marques M-A; Mairal A; Renoud M-L; Galitzky J; Holm C; Mouisel E; Thalamas C; Viguerie N; Sulpice T; Burcelin R; Arner P; Langin D
Article: DIABETES. 2012;61(8):1986-1993

Adipose tissue microRNAs as regulators of CCL2 production in human obesity.

Arner E; Mejhert N; Kulyté A; Balwierz PJ; Pachkov M; Cormont M; Lorente-Cebrián S; Ehrlund A; Laurencikiene J; Hedén P; Dahlman-Wright K; Tanti J-F; Hayashizaki Y; Rydén M; Dahlman I; van Nimwegen E; Daub CO; Arner P
Article: OBESITY. 2012;20(4):708-714

ITIH-5 expression in human adipose tissue is increased in obesity.

Anveden Å; Sjöholm K; Jacobson P; Palsdottir V; Walley AJ; Froguel P; Al-Daghri N; McTernan PG; Mejhert N; Arner P; Sjöström L; Carlsson LMS; Svensson P-A
Article: EUROPEAN JOURNAL OF NUTRITION. 2012;51(3):335-342

Differential effects of 1α,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes.

Lorente-Cebrián S; Eriksson A; Dunlop T; Mejhert N; Dahlman I; Aström G; Sjölin E; Wåhlén K; Carlberg C; Laurencikiene J; Hedén P; Arner P; Rydén M
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(10):E1661-E1665

MTCH2 in human white adipose tissue and obesity.

Kulyté A; Rydén M; Mejhert N; Dungner E; Sjölin E; Arner P; Dahlman I
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(6):E962-E966

Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity.

Jiao H; Arner P; Dickson SL; Vidal H; Mejhert N; Henegar C; Taube M; Hansson C; Hinney A; Galan P; Simon C; Silveira A; Benrick A; Jansson J-O; Bouloumié A; Langin D; Laville M; Debard C; Axelsson T; Rydén M; Kere J; Dahlman-Wright K; Hamsten A; Clement K; Dahlman I
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2011;96(1):133-141

Twist1 in human white adipose tissue and obesity.

Pettersson AT; Mejhert N; Jernås M; Carlsson LMS; Dahlman I; Laurencikiene J; Arner P; Rydén M
Article: BRITISH JOURNAL OF CANCER. 2010;102(10):1541-1548

Adipose tissue pathways involved in weight loss of cancer cachexia.

Dahlman I; Mejhert N; Linder K; Agustsson T; Mutch DM; Kulyte A; Isaksson B; Permert J; Petrovic N; Nedergaard J; Sjölin E; Brodin D; Clement K; Dahlman-Wright K; Rydén M; Arner P
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2010;95(5):2451-2457

Mapping of the fibroblast growth factors in human white adipose tissue.

Mejhert N; Galitzky J; Pettersson AT; Bambace C; Blomqvist L; Bouloumié A; Frayn KN; Dahlman I; Arner P; Rydén M
Article: DIABETES. 2010;59(3):564-571

A possible inflammatory role of twist1 in human white adipocytes.

Pettersson AT; Laurencikiene J; Mejhert N; Näslund E; Bouloumié A; Dahlman I; Arner P; Rydén M
Article: BMC ENDOCRINE DISORDERS. 2010;10:1

Role of Receptor-Interacting Protein 140 in human fat cells.

Mejhert N; Laurencikiene J; Pettersson AT; Kaaman M; Stenson BM; Rydén M; Dahlman I
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2009;94(8):3003-3009

Role of follistatin in promoting adipogenesis in women.

Flanagan JN; Linder K; Mejhert N; Dungner E; Wahlen K; Decaunes P; Rydén M; Björklund P; Arver S; Bhasin S; Bouloumie A; Arner P; Dahlman I
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Preprint: BIORXIV. 2023

A Spatiotemporal Proteomic Map of Human Adipogenesis

Klingelhuber F; Frendo-Cumbo S; Omar-Hmeadi M; Taylor AJ; Kakimoto P; Couchet M; Ribicic S; Wabitsch M; Messias AC; Iuso A; Müller TD; Rydén M; Mejhert N; Krahmer N
Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(5):269-270

Understanding the complexity of insulin resistance.

Mejhert N; Rydén M
Review: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2022;274:131-144

Insights from Studies of White Adipose Tissue Using Single-Cell Approaches.

Mejhert N; Rydén M
Corrigendum: CELL METABOLISM. 2021;33(11):2301

Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin.

Bäckdahl J; Franzén L; Massier L; Li Q; Jalkanen J; Gao H; Andersson A; Bhalla N; Thorell A; Rydén M; Ståhl PL; Mejhert N
Review: CURRENT OPINION IN PHARMACOLOGY. 2020;55:47-52

Novel aspects on the role of white adipose tissue in type 2 diabetes.

Mejhert N; Rydén M
Letter: CELL METABOLISM. 2020;32(1):1-3

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation.

Gao H; Arner P; Beauchef G; Guéré C; Vie K; Dahlman I; Mejhert N; Rydén M
Review: ADIPOCYTE. 2020;9(1):620-625

Glutamine metabolism in adipocytes: a bona fide epigenetic modulator of inflammation.

Lecoutre S; Maqdasy S; Petrus P; Ludzki A; Couchet M; Mejhert N; Rydén M
Editorial comment: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2017;91(11):1068-1077

Quantitative high-content/high-throughput microscopy analysis of lipid droplets in subject-specific adipogenesis models.

Bombrun M; Gao H; Ranefall P; Mejhert N; Arner P; Wählby C
Thesis / dissertation: 2013

Characterization of adipose factors regulated by body weight

Mejhert, Niklas
Conference publication: JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS. 2010;3(2-3):97

An Inflammatory Role of Twist1 in Human White Adipocytes

Pettersson A; Mejhert N; Naslund E; Bouloumie A; Dahlman I; Laurencikiene J; Amer P; Ryden M

Anställningar

Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-

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Docent, Cell- och molekylärbiologi, Karolinska Institutet, 2022
Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2013

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