Nicolas Ruffin

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: NATURE. 2023

Preprint clubs: why it takes a village to do peer review.

Richter FC; Gea-Mallorquí E; Mortha A; Ruffin N; Vabret N
Article: ISCIENCE. 2023;26(2):106019

Single-cell RNA-seq analysis reveals dual sensing of HIV-1 in blood Axl+ dendritic cells.

Brouiller F; Nadalin F; Bonté P-E; Ait-Mohamed O; Delaugerre C; Lelièvre J-D; Ginhoux F; Ruffin N; Benaroch P
Article: NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION. 2023;10(1):e200056

Sustained Low Relapse Rate With Highly Variable B-Cell Repopulation Dynamics With Extended Rituximab Dosing Intervals in Multiple Sclerosis.

Starvaggi Cucuzza C; Longinetti E; Ruffin N; Evertsson B; Kockum I; Jagodic M; Al Nimer F; Frisell T; Piehl F
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29(11):3317-3328

B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients.

Asplund Högelin K; Ruffin N; Pin E; Hober S; Nilsson P; Starvaggi Cucuzza C; Khademi M; Olsson T; Piehl F; Al Nimer F
Article: ELIFE. 2022;11:e74065

Correlation between leukocyte phenotypes and prognosis of amyotrophic lateral sclerosis.

Cui C; Ingre C; Yin L; Li X; Andersson J; Seitz C; Ruffin N; Pawitan Y; Piehl F; Fang F
Article: ISCIENCE. 2021;24(9):103078

Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis.

Asplund Högelin K; Ruffin N; Pin E; Månberg A; Hober S; Gafvelin G; Grönlund H; Nilsson P; Khademi M; Olsson T; Piehl F; Al Nimer F
Journal article: M S-MEDECINE SCIENCES. 2020;36(4):316-319

[A new population of blood precursors of dendritic cells endowed with specific properties regarding HIV-1].

Brouiller F; Ruffin N; Benaroch P
Journal article: FRONTIERS IN MICROBIOLOGY. 2020;11:1603

HIV-2-Infected Macrophages Produce and Accumulate Poorly Infectious Viral Particles.

Gea-Mallorquí E; Zablocki-Thomas L; Maurin M; Jouve M; Rodrigues V; Ruffin N; Benaroch P
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(43):21685-21693

Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors.

Ruffin N; Gea-Mallorquí E; Brouiller F; Jouve M; Silvin A; See P; Dutertre C-A; Ginhoux F; Benaroch P
Journal article: PLOS PATHOGENS. 2019;15(6):e1007868

Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations.

Hani L; Chaillon A; Nere M-L; Ruffin N; Alameddine J; Salmona M; Lopez Zaragoza J-L; Smith DM; Schwartz O; Lelièvre J-D; Delaugerre C; Lévy Y; Seddiki N
Journal article: SCIENCE. 2017;356(6342):eaag3009

Mapping the human DC lineage through the integration of high-dimensional techniques.

See P; Dutertre C-A; Chen J; Günther P; McGovern N; Irac SE; Gunawan M; Beyer M; Händler K; Duan K; Sumatoh HRB; Ruffin N; Jouve M; Gea-Mallorquí E; Hennekam RCM; Lim T; Yip CC; Wen M; Malleret B; Low I; Shadan NB; Fen CFS; Tay A; Lum J; Zolezzi F; Larbi A; Poidinger M; Chan JKY; Chen Q; Rénia L; Haniffa M; Benaroch P; Schlitzer A; Schultze JL; Newell EW; Ginhoux F
Journal article: IMMUNOLOGY. 2017;151(2):137-145

From dendritic cells to B cells dysfunctions during HIV-1 infection: T follicular helper cells at the crossroads.

Ruffin N; Hani L; Seddiki N
Journal article: FRONTIERS IN IMMUNOLOGY. 2017;8:1698

Myeloid Cell Interaction with HIV: A Complex Relationship.

Rodrigues V; Ruffin N; San-Roman M; Benaroch P
Journal article: AIDS. 2015;29(5):519-530

Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1.

Ruffin N; Brezar V; Ayinde D; Lefebvre C; Schulze Zur Wiesch J; van Lunzen J; Bockhorn M; Schwartz O; Hocini H; Lelievre J-D; Banchereau J; Levy Y; Seddiki N
Journal article: PLOS PATHOGENS. 2015;11(3):e1004752

Decreased HIV-specific T-regulatory responses are associated with effective DC-vaccine induced immunity.

Brezar V; Ruffin N; Richert L; Surenaud M; Lacabaratz C; Palucka K; Thiébaut R; Banchereau J; Levy Y; Seddiki N
Journal article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2014;30(S1):a173-a174

Regulatory T-cells Represent an Important Fraction of HIV-specific T-cells: What Is their Impact on Vaccination?

Brezar V; Ruffin N; Surenaud M; Lacabaratz C; Palucka K; Banchereau J; Lévy Y; Seddiki N
Journal article: JOURNAL OF IMMUNOLOGICAL METHODS. 2014;411:70-75

A highly relevant and efficient single step method for simultaneous depletion and isolation of human regulatory T cells in a clinical setting.

Brezar V; Ruffin N; Lévy Y; Seddiki N
Journal article: IMMUNOLOGY. 2014;142(1):32-38

Role of miR-155 in the regulation of lymphocyte immune function and disease.

Seddiki N; Brezar V; Ruffin N; Lévy Y; Swaminathan S
Article: AIDS. 2013;27(8):1209-1217

B-cell subset alterations and correlated factors in HIV-1 infection.

Pensieroso S; Galli L; Nozza S; Ruffin N; Castagna A; Tambussi G; Hejdeman B; Misciagna D; Riva A; Malnati M; Chiodi F; Scarlatti G
Article: VACCINE. 2013;31(18):2231-2237

Relation of activation-induced deaminase (AID) expression with antibody response to A(H1N1)pdm09 vaccination in HIV-1 infected patients.

Cagigi A; Pensieroso S; Ruffin N; Sammicheli S; Thorstensson R; Pan-Hammarström Q; Hejdeman B; Nilsson A; Chiodi F
Article: JOURNAL OF INTERNAL MEDICINE. 2012;272(5):492-503

Immune activation and increased IL-21R expression are associated with the loss of memory B cells during HIV-1 infection.

Ruffin N; Lantto R; Pensieroso S; Sammicheli S; Hejdeman B; Rethi B; Chiodi F
Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2012;10:144

Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011.

Ruffin N; Borggren M; Euler Z; Fiorino F; Grupping K; Hallengärd D; Javed A; Mendonca K; Pollard C; Reinhart D; Saba E; Sheik-Khalil E; Sköld A; Ziglio S; Scarlatti G; Gotch F; Wahren B; Shattock RJ
Article: JOURNAL OF AUTOIMMUNITY. 2012;38(4):304-314

IL-7 modulates B cells survival and activation by inducing BAFF and CD70 expression in T cells.

Sammicheli S; Ruffin N; Lantto R; Vivar N; Chiodi F; Rethi B
Article: JOURNAL OF INFECTIOUS DISEASES. 2011;203(11):1658-1667

Survival and proliferation of CD28- T cells during HIV-1 infection relate to the amplitude of viral replication.

Vivar N; Ruffin N; Sammicheli S; Hejdeman B; Rethi B; Chiodi F
Article: TRANSPLANTATION. 2011;91(9):946-951

The involvement of epithelial Fas in a human model of graft versus host disease.

Ruffin N; Ahmed SS; Osorio LM; Wang XN; Jackson GH; Collin MP; Ekre H-P; Chiodi F; Dickinson AM
Article: PLOS ONE. 2011;6(12):e28629

IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.

Sammicheli S; Dang VPL; Ruffin N; Pham HT; Lantto R; Vivar N; Chiodi F; Rethi B
Article: FRONTIERS IN IMMUNOLOGY. 2011;2:90

The impact of inflammation and immune activation on B cell differentiation during HIV-1 infection.

Ruffin N; Thang PH; Rethi B; Nilsson A; Chiodi F
Article: PLOS NEGLECTED TROPICAL DISEASES. 2010;4(10):e844

Systemic FasL and TRAIL neutralisation reduce leishmaniasis induced skin ulceration.

Tasew G; Nylén S; Lieke T; Lemu B; Meless H; Ruffin N; Wolday D; Asseffa A; Yagita H; Britton S; Akuffo H; Chiodi F; Eidsmo L
Article: JOURNAL OF INTERNAL MEDICINE. 2010;268(2):181-193

The role of IL-1beta in reduced IL-7 production by stromal and epithelial cells: a model for impaired T-cell numbers in the gut during HIV-1 infection.

Thang PH; Ruffin N; Brodin D; Rethi B; Cam PD; Hien NT; Lopalco L; Vivar N; Chiodi F
Article: BLOOD. 2008;112(4):1195-1204

Priming of T cells to Fas-mediated proliferative signals by interleukin-7.

Rethi B; Vivar N; Sammicheli S; Fluur C; Ruffin N; Atlas A; Rajnavolgyi E; Chiodi F
Article: AMERICAN JOURNAL OF PATHOLOGY. 2007;170(1):227-239

FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major.

Eidsmo L; Fluur C; Rethi B; Eriksson Ygberg S; Ruffin N; De Milito A; Akuffo H; Chiodi F
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Alla övriga publikationer

Editorial comment: EMBO REPORTS. 2023;24(6):e57258

The Preprint Club: A blueprint for community-based peer review: A blueprint for community-based peer review.

Richter FC; Gea-Mallorquí E; Mortha A; Ruffin N; Vabret N
Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2022;22(12):715

Dynamics of antigen retention by follicular dendritic cells.

Ruffin N; Gea-Mallorquí E
Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2022;22(2):74

A pan-cancer signature for dysfunctional T cells.

Ruffin N; Guerreiro-Cacais AO
Review: AIDS. 2013;27(15):2323-2334

Impairment of B-cell functions during HIV-1 infection.

Amu S; Ruffin N; Rethi B; Chiodi F
Review: JOURNAL OF TRANSLATIONAL MEDICINE. 2011;9:40

Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010.

Brinckmann S; da Costa K; van Gils MJ; Hallengärd D; Klein K; Madeira L; Mainetti L; Palma P; Raue K; Reinhart D; Reudelsterz M; Ruffin N; Seifried J; Schäfer K; Sheik-Khalil E; Sköld A; Uchtenhagen H; Vabret N; Ziglio S; Scarlatti G; Shattock R; Wahren B; Gotch F

Anställningar

Senior Forskningsspecialist, Klinisk neurovetenskap, Karolinska Institutet, 2022-

Examina och utbildning

Docent, Immunologi, Karolinska Institutet, 2023
Medicine Doktorsexamen, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2012

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

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