Mike Aoun

About me
Publications
CV
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About me

"If you really want to hear about it, the first thing you'll probably want to
know is where I was born, and what my lousy childhood was like, and how my
parents were occupied and all before they had me, and all that David
Copperfield kind of crap, but I don't feel like going into it, if you want to
know the truth."
-/Salinger/
PhD in *Immunology *at Karolinska Institute
M.Sc in *Immunology and Immunotherapies* at Pierre et Marie Curie
University-Paris 6
B.Sc in *Biology* at Lebanese American University-LAU

Research

Understanding the role of the innate immune system and B cells in regulating
rheumatoid arthritis

Selected publications

Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2023;220(11):e20230101

Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.

Aoun M; Coelho A; Krämer A; Saxena A; Sabatier P; Beusch CM; Lönnblom E; Geng M; Do N-N; Xu Z; Zhang J; He Y; Romero Castillo L; Abolhassani H; Xu B; Viljanen J; Rorbach J; Fernandez Lahore G; Gjertsson I; Kastbom A; Sjöwall C; Kihlberg J; Zubarev RA; Burkhardt H; Holmdahl R

Articles

Article: JCI INSIGHT. 2023;8(17):e167656

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; McInerney G; Murrell B; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam GB; Castro Dopico X; Rorbach J
Article: NATURE COMMUNICATIONS. 2023;14(1):691

A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.

He Y; Ge C; Moreno-Giró À; Xu B; Beusch CM; Sandor K; Su J; Cheng L; Lönnblom E; Lundqvist C; Slot LM; Tong D; Urbonaviciute V; Liang B; Li T; Lahore GF; Aoun M; Malmström V; Rispens T; Ernfors P; Svensson CI; Scherer HU; Toes REM; Gjertsson I; Ekwall O; Zubarev RA; Holmdahl R
Article: ANTIOXIDANTS. 2021;11(1):12

Glycan Activation of Clec4b Induces Reactive Oxygen Species Protecting against Neutrophilia and Arthritis.

Aoun M; Cai X; Xu B; Lahore GF; Bonner MY; He Y; Bäckdahl L; Holmdahl R
Article: NATURE COMMUNICATIONS. 2021;12(1):6558

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation.

Sabatier P; Beusch CM; Saei AA; Aoun M; Moruzzi N; Coelho A; Leijten N; Nordenskjöld M; Micke P; Maltseva D; Tonevitsky AG; Millischer V; Carlos Villaescusa J; Kadekar S; Gaetani M; Altynbekova K; Kel A; Berggren P-O; Simonson O; Grinnemo K-H; Holmdahl R; Rodin S; Zubarev RA
Article: NATURE COMMUNICATIONS. 2021;12(1):5565

Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases.

Fernandez Lahore G; Förster M; Johannesson M; Sabatier P; Lönnblom E; Aoun M; He Y; Nandakumar KS; Zubarev RA; Holmdahl R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(40):24986-24997

Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.

Fernandez Lahore G; Raposo B; Lagerquist M; Ohlsson C; Sabatier P; Xu B; Aoun M; James J; Cai X; Zubarev RA; Nandakumar KS; Holmdahl R
Article: PLOS GENETICS. 2020;16(6):e1008788

Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease.

Bäckdahl L; Aoun M; Norin U; Holmdahl R
Article: BONE MARROW TRANSPLANTATION. 2015;50(6):858-864

Evaluation of pretransplant influenza vaccination in hematopoietic SCT: a randomized prospective study.

Ambati A; Boas LSV; Ljungman P; Testa L; de Oliveira JF; Aoun M; Colturato V; Maeurer M; Machado CM

All other publications

Preprint: MEDRXIV. 2021

Antigen receptor stimulation drives selection against pathogenic mtDNA variants that dysregulate lymphocyte responses

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward D; Teifel S; Liu Y; Harris R; Murrell B; Mcinerney G; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam G; Dopico XC; Rorbach J
Thesis / dissertation: 2021

Positional cloning of polymorphic loci that control autoreactive T cells

Aoun, Mike
Preprint: RESEARCH SQUARE. 2021

Polymorphic estrogen receptor binding site causes CD2-dependent sex bias in the susceptibility to autoimmune diseases

Lahore GF; Förster M; Johannesson M; Sabatier P; Lönnblom E; Aoun M; He Y; Nandakumar K; Zubarev R; Holmdahl R
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):324

Non-coding variants promote vitamin D receptor expression in activated T cells and protect from GPI-induced arthritis

Fernandez-Lahore G; Raposo B; Marquina C; Aoun M; Lagerquist M; Holmdahl R
Conference publication: BONE MARROW TRANSPLANTATION. 2014;49:S330

PRE-TRANSPLANT DONOR AND RECIPIENT INFLUENZA VACCINATION ENHANCES SERO-RESPONSE RATES IN THE FIRST SIX MONTHS AFTER HSCT

Ambati A; Testa L; Ljungman P; Boas LSV; Aoun M; Maeurer M; Machado C

Employments

Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2022-2024

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2021

About me

Research

Selected publications

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI