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Mikael Lindström

Forskare

Institution och organisatorisk tillhörighet:

Om mig

Grundexamen i Biomedicin från KI 1999, doktorsexamen i onkologi och experimentell onkologi 2004, docent i experimentell patologi och senior forskare på institutionen för medicinsk biokemi och biofysik (MBB) inom onkologi-tumörbiologi, inklusive metabola aspekter och molekylär patologi f f a hjärntumörer, verksam på SciLifeLab i Solna, Karolinska Institutet i Stockholm.

Forskningsbeskrivning

Vår målsättning är att förstå ribosombiogenesen i normala och cancerceller, samt omsätta denna kunskap i nya terapier mot cancer. Speciellt focus ligger på p53 och nukleolära stressmekanismer.

Några selekterade nyckelreferenser nedan. För att se komplett lista > 45 arbeten hänvisas till ORCID eller RESEARCHGATE eller Pubmed: "Lindstrom MS" .

The antimalarial drug amodiaquine stabilizes p53 through ribosome biogenesis stress, independently of its autophagy-inhibitory activity. Espinoza JA, Zisi A, Kanellis DC, Carreras-Puigvert J, Henriksson M, Hühn D, et al Cell Death Differ. 2019 Jul;():

Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis. Lindström MS, Jurada D, Bursac S, Orsolic I, Bartek J, Volarevic S Oncogene 2018 05;37(18):2351-2366

Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype. Goudarzi KM, Espinoza JA, Guo M, Bartek J, Nistér M, Lindström MS, et al Cancer Res. 2018 10;78(20):5901-5916

Induction of the 5S RNP-Mdm2-p53 ribosomal stress pathway delays the initiation but fails to eradicate established murine acute myeloid leukemia. Jaako P, Ugale A, Wahlestedt M, Velasco-Hernandez T, Cammenga J, Lindström MS, et al Leukemia 2017 01;31(1):213-221

NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape. Holmberg Olausson K, Elsir T, Moazemi Goudarzi K, Nistér M, Lindström MS Sci Rep 2015 Nov;5():16495

Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia. Jaako P, Debnath S, Olsson K, Zhang Y, Flygare J, Lindström MS, et al Leukemia 2015 Nov;29(11):2221-9

mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels. Goudarzi KM, Nistér M, Lindström MS Cancer Biol. Ther. 2014 ;15(11):1499-514

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53. Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, et al Genes Dev. 2014 Jan;28(1):58-70

p53 -Dependent and -Independent Nucleolar Stress Responses. Holmberg Olausson K, Nistér M, Lindström MS Cells 2012 Oct;1(4):774-98

Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells. Nazarenko I, Hedrén A, Sjödin H, Orrego A, Andrae J, Afink GB, et al PLoS ONE 2011 Apr;6(4):e18303

An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Macias E, Jin A, Deisenroth C, Bhat K, Mao H, Lindström MS, et al Cancer Cell 2010 Sep;18(3):231-43

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lindström MS, et al Cancer Cell 2007 Oct;12(4):355-66

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Lindström MS, Jin A, Deisenroth C, White Wolf G, Zhang Y Mol. Cell. Biol. 2007 Feb;27(3):1056-68

Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. Enomoto T, Lindström MS, Jin A, Ke H, Zhang Y J. Biol. Chem. 2006 Jul;281(27):18463-72

Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts. Lindström MS, Wiman KG Oncogene 2003 Aug;22(32):4993-5005

p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53. Lindström MS, Klangby U, Wiman KG Oncogene 2001 Apr;20(17):2171-7

 

Granskare av manus

Oncogene, Nature, Nature Cell Biology, J Biol Chem, Mol Cell Biol, Proteins, J. of Clinical Investigation, Mol Cell, Intl. J of Cancer, Int J Mol Sciences, Cancer, J Cytology & Histology, J Mol Biol, PLoS One, FEBS Letters, FEBS J, Future Oncology, Cell Proliferation, Biochem J, Nature Scientific Reports, Tumor Biology, Current Drug Targets,  Cytotherapy, Nature Communications, J Cell Science, Cell Reports, Cell Cycle, Chemistry Biology (Cell press), Blood, Pharmaceuticals, Biochem Soc Trans, Cells, Oncotarget, Int J of Dev Neuroscience, Cellular Physiology and Biochemistry, BMC Biotechnology, BMC Molecular Biology, Bioscience Reports, Cancer Res, Elife, J Cellular Physiology, Metabolites, EBiomedicine, ACS Chemical Biology, BBA Molecular Res och många fler.

Granskare av projektansökningar med mera

NWO/Vidi Scheme for Innovational Research Incentives Scheme, Netherlands, 2009; AICR, Assoc International Cancer Res (UK), 2010-11; Cancer Research UK (2010); YRC, Yorkshire Cancer Res (UK), 2011; Semaphore FRS FNRS (BE), 2011- (regular grants); Romanian national development and innovation council, uefiscdi, (RO), 2011-2012; German-Israeli Foundation for Scientific Research and Development, 2013; Semaphore FRS FNRS (BE), 2014- (Post doc grants), 2015, and 2016; YRC, Yorkshire Cancer Res (UK), 2014 (Pump priming awards, x2); Czech Science Foundation GACR (2014), regular project; National Science Centre Poland (2014), PhD grants; German-Israeli Foundation for Scientific Research and Development, 2014/15; INCa -the French National Cancer Institute, France, 2016; Fondation contre le Cancer Grant, Belgian Foundation against Cancer, 2016; Croatian Science Foundation, Croatia, 2016; INCa -the French National Cancer Institute, France, 2017; Agence Nationale de la Recherche, France, 2017, regular grant; Evaluator of Baillet Latour Grant for Medical Research and Baillet Latour Prize (GMR), NL, 2017; National Science Centre Poland (2017), regular grant; Semaphore FRS FNRS (BE), 2018, equipment and project grants m fl.

Ad hoc internationell expertmedlem i LS3 panel National Science Centre Poland, 2019

Pedagogiska meriter

Handledning doktorander

Huvudhandledare: Dr Kaveh Moazemi Goudarzi, PhD 2018-04-27, KI; Huvudhandledare: (pågående) Asimina Zisi, MSc, 2017-09-, KI, Co-supervisor: Dr Tamador Elsir, PhD 2010-06-04, KI; Co-supervisor: Dr Inga Nazarenko, PhD 2011-09-30, KI; Co-supervisor: Dr Karl Holmberg-Olausson, PhD 2015-06-01, KI;

Kurser

Högskolepedagogisk grundkurs GHPH09, 2009, KI; Träningskurs för doktorandhandledare, KI; Ledarskapsutbildning “UGL”, KI

Undervisning

Omfattande, över 600 timmar, undervisning på läkarlinjen (biokemi intermediärmetabolism, digestion, DFM1 kursen term 1 seminarier, föreläsningar, projekt, projektexamination och tentamen), och biomedicinprogrammet (seminarier, PBL handledare, lab undervisning inom onkologi-tumörbiologi och cell biologi) samt  inbjuden föreläsare på ett stort antal doktorandkurser om cancercellers metabolism, cancer stamceller, cancer cell cykel, apoptosis och biobanker inom cancerforskningen.

Förhandsgranskare av doktorsavhandlingar (betygsnämndsledamot)

Dr Ivailo Simoff, PhD, SU, 2009; Dr Jitendra Badhai, PhD, UU, 2009; Dr Chiou-Nan Shiue, PhD, KI, 2010; Dr Ann Sofie Fröjmark, PhD, UU, 2010; Dr Jelena Polajeva, PhD, UU 2012; Dr Deniz Özata, PhD, KI, 2015; Anahita Hamadi, PhD, UU, 2015; Vasil Savov, PhD, UU 2016; Chang Liu, PhD, KI; 2016; Xianli Shen, KI, 2017; Fredrik Lackmann, SU, 2017; H.A. M. Sakil, KI, 2017, m fl

Halvtidsnämnd vid PhD

Erik Berglund KI, 2013; Lei Zhang, UU, 2012 Yuan Xie, UU 2013; Vasil Savov, UU 2014; Emarndeena Cheteh Haji, KI, 2014; Xianli Shen, KI 2014; Amir Mahani, KI, 2014; Anna Sjösten, UU 2015; Mohammed Mustaq, KI, 2014; Honglei Zhao, KI, 2016; Dalel Saidi, KI, 2016; Satendra Kumar, KI, 2016; Chiara Pederiva, KI, 2017; Patrick Sculicia, KI. 2017; Nadilly Bonagas KI 2019, m fl

Examinator eller handledare för ett stort antal master och bachelor studenters projekt.

Ordförande vid disputation

Cecilia Nordfors, PhD, KI, 2015; Michael Mints PhD, KI, 2015; Elin Sjöberg PhD, KI, 2015

Fakultetsopponent

Amir Nematollani Mahani, KI, Dept LabMed, 2018-06-20.

Utbildning

Magisterexamen, Biomedicin, Karolinska Institutet, 1999

Medicine Doktorsexamen, Onkologi-Exp Onkologi, Karolinska Institutet, 2004

Docent i Experimentell Patologi, Karolinska Institutet, 2012

Akademiska priser och utmärkelser

Researcher position (“FoAss” extension), KI, 2013-2015

Swedish Research Council (VR), Young Researcher award, 2012-2014

Postdoctoral fellowship awarded by the Swedish Cancer Society (Cancerfonden), 2007 - 2010.

Postdoctoral fellowship awarded by the Swedish Research Council (VR), 2005-2006.

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