Mattias Carlsten

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Se sidan på engelska [1]
Tema: Att delta i forskning [2]
[1] http://ki.se/en/people/mattca
[2] http://ki.se/forskning/tema-att-delta-i-forskning

Artiklar

Article: MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2024;32(2):101225

Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart.

Al-Saadi J; Waldén M; Sandell M; Sohlmér J; Grankvist R; Friberger I; Andersson A; Carlsten M; Chien K; Lundberg J; Witman N; Holmin S
Article: LEUKEMIA. 2024;38(3):579-589

Harnessing upregulated E-selectin while enhancing SDF-1α sensing redirects infused NK cells to the AML-perturbed bone marrow.

Sanz-Ortega L; Andersson A; Carlsten M
Article: JOURNAL OF IMMUNOLOGY. 2024;212(5):868-880

KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.

Leijonhufvud C; Sanz-Ortega L; Schlums H; Gaballa A; Andersson A; Eriksson C; Segerberg F; Uhlin M; Bryceson YT; Carlsten M
Article: LEUKEMIA. 2023;37(9):1830-1841

Perturbed epigenetic transcriptional regulation in AML with IDH mutations causes increased susceptibility to NK cells.

Palau A; Segerberg F; Lidschreiber M; Lidschreiber K; Naughton AJ; Needhamsen M; Jung LA; Jagodic M; Cramer P; Lehmann S; Carlsten M; Lennartsson A
Article: EJNMMI RESEARCH. 2023;13(1):73

Comparative in vivo biodistribution of cells labelled with [89Zr]Zr-(oxinate)4 or [89Zr]Zr-DFO-NCS using PET.

Friberger I; Nilsson JN; Lu L; Siikanen J; Ardenfors O; Milton S; Samén E; Goos JACM; Carlsten M; Holmin S; Tran TA
Article: HAEMATOLOGICA. 2022;107(8):1786-1795

A novel CD34-specific T-cell engager efficiently depletes acute myeloid leukemia and leukemic stem cells in vitro and in vivo.

Arruda LCM; Stikvoort A; Lambert M; Jin L; Rivera LS; Alves RMP; De Moura TR; Mim C; Lehmann S; Axelsson-Robertson R; Dick JE; Mattsson J; Önfelt B; Carlsten M; Uhlin M
Article: BLOOD ADVANCES. 2022;6(11):3352-3366

Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses.

Daly J; Sarkar S; Natoni A; Stark JC; Riley NM; Bertozzi CR; Carlsten M; O'Dwyer ME
Article: VIRCHOWS ARCHIV. 2022;480(3):655-666

Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma.

Merrien M; Wasik AM; Ljung E; Morsy MHA; de Matos Rodrigues J; Carlsten M; Rassidakis GZ; Christensson B; Kolstad A; Jerkeman M; Ek S; Herold N; Wahlin BE; Sander B
Article: MOLECULAR IMAGING AND BIOLOGY. 2021;23(6):952-962

Optimisation of the Synthesis and Cell Labelling Conditions for [89Zr]Zr-oxine and [89Zr]Zr-DFO-NCS: a Direct In Vitro Comparison in Cell Types with Distinct Therapeutic Applications.

Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samén E; Carlsten M; Holmin S; Tran TA
Article: BMC CANCER. 2021;21(1):500

The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome.

Noring K; Carlsten M; Sonnevi K; Wahlin BE
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(10):e1346

LIR-1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody-dependent cellular cytotoxicity.

Leijonhufvud C; Reger R; Segerberg F; Theorell J; Schlums H; Bryceson YT; Childs RW; Carlsten M
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2121:213-239

CRISPR/Cas9-Based Gene Engineering of Human Natural Killer Cells: Protocols for Knockout and Readouts to Evaluate Their Efficacy.

Lambert M; Leijonhufvud C; Segerberg F; Melenhorst JJ; Carlsten M
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2164

Autoantibodies to Killer Cell Immunoglobulin-Like Receptors in Patients With Systemic Lupus Erythematosus Induce Natural Killer Cell Hyporesponsiveness.

Segerberg F; Lundtoft C; Reid S; Hjorton K; Leonard D; Nordmark G; Carlsten M; Hagberg N
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1262

Enhanced Bone Marrow Homing of Natural Killer Cells Following mRNA Transfection With Gain-of-Function Variant CXCR4R334X.

Levy E; Reger R; Segerberg F; Lambert M; Leijonhufvud C; Baumer Y; Carlsten M; Childs R
Article: ONCOIMMUNOLOGY. 2019;8(2):e1534664

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5.

Carlsten M; Namazi A; Reger R; Levy E; Berg M; St Hilaire C; Childs RW
Article: EXPERIMENTAL HEMATOLOGY & ONCOLOGY. 2019;8:7

The Karolinska experience of autologous stem-cell transplantation for lymphoma: a population-based study of all 433 patients 1994-2016.

Carlsten M; Jädersten M; Hellström A; Littmann K; Melén CM; Junlén HR; Sonnevi K; Ljungman P; Björkstrand B; Wahlin BE
Article: CLINICAL CANCER RESEARCH. 2018;24(8):1834-1844

Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML.

Björklund AT; Carlsten M; Sohlberg E; Liu LL; Clancy T; Karimi M; Cooley S; Miller JS; Klimkowska M; Schaffer M; Watz E; Wikström K; Blomberg P; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellström-Lindberg E; Ljunggren H-G; Malmberg K-J
Article: PLOS ONE. 2018;13(8):e0202651

Body composition measurements and risk of hematological malignancies: A population-based cohort study during 20 years of follow-up.

Hagström H; Andreasson A; Carlsson AC; Jerkeman M; Carlsten M
Article: CLINICAL CANCER RESEARCH. 2016;22(21):5211-5222

Checkpoint Inhibition of KIR2D with the Monoclonal Antibody IPH2101 Induces Contraction and Hyporesponsiveness of NK Cells in Patients with Myeloma.

Carlsten M; Korde N; Kotecha R; Reger R; Bor S; Kazandjian D; Landgren O; Childs RW
Article: METHODS IN MOLECULAR BIOLOGY. 2016;1441:231-240

mRNA Transfection to Improve NK Cell Homing to Tumors.

Levy ER; Carlsten M; Childs RW
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:105

Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-Induced ADCC against Lymphoma and Targets NK Cell Migration toward the Lymph Node-Associated Chemokine CCL19.

Carlsten M; Levy E; Karambelkar A; Li L; Reger R; Berg M; Peshwa MV; Childs RW
Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4518-4527

Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.

Enqvist M; Ask EH; Forslund E; Carlsten M; Abrahamsen G; Béziat V; Andersson S; Schaffer M; Spurkland A; Bryceson Y; Önfelt B; Malmberg K-J
Article: MOLECULAR THERAPY. 2014;22(7):1388-1395

Ultra-low dose interleukin-2 promotes immune-modulating function of regulatory T cells and natural killer cells in healthy volunteers.

Ito S; Bollard CM; Carlsten M; Melenhorst JJ; Biancotto A; Wang E; Chen J; Kotliarov Y; Cheung F; Xie Z; Marincola F; Tanimoto K; Battiwalla M; Olnes MJ; Perl S; Schum P; Hughes TE; Keyvanfar K; Hensel N; Muranski P; Young NS; Barrett AJ
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(7):1643-1652

Doxorubicin sensitizes human tumor cells to NK cell- and T-cell-mediated killing by augmented TRAIL receptor signaling.

Wennerberg E; Sarhan D; Carlsten M; Kaminskyy VO; D'Arcy P; Zhivotovsky B; Childs R; Lundqvist A
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554

Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells.

Enqvist M; Nilsonne G; Hammarfjord O; Wallin RPA; Björkström NK; Björnstedt M; Hjerpe A; Ljunggren H-G; Dobra K; Malmberg K-J; Carlsten M
Article: LEUKEMIA. 2010;24(9):1607-1616

Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome.

Carlsten M; Baumann BC; Simonsson M; Jädersten M; Forsblom A-M; Hammarstedt C; Bryceson YT; Ljunggren H-G; Hellström-Lindberg E; Malmberg K-J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(4):1272-1277

Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides.

Curbo S; Gaudin R; Carlsten M; Malmberg K-J; Troye-Blomberg M; Ahlborg N; Karlsson A; Johansson M; Lundberg M
Article: JOURNAL OF IMMUNOLOGY. 2009;183(8):4921-4930

Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells.

Carlsten M; Norell H; Bryceson YT; Poschke I; Schedvins K; Ljunggren H-G; Kiessling R; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019

Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype.

Fauriat C; Andersson S; Björklund AT; Carlsten M; Schaffer M; Björkström NK; Baumann BC; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2007;56(7):973-984

A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients.

Hanson MGV; Ozenci V; Carlsten MCV; Glimelius BL; Frödin J-EA; Masucci G; Malmberg K-J; Kiessling RVR
Article: CANCER RESEARCH. 2007;67(3):1317-1325

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.

Carlsten M; Björkström NK; Norell H; Bryceson Y; van Hall T; Baumann BC; Hanson M; Schedvins K; Kiessling R; Ljunggren H-G; Malmberg K-J
Article: CANCER RESEARCH. 2006;66(12):6387-6394

Frequent loss of HLA-A2 expression in metastasizing ovarian carcinomas associated with genomic haplotype loss and HLA-A2-restricted HER-2/neu-specific immunity.

Norell H; Carlsten M; Ohlum T; Malmberg K-J; Masucci G; Schedvins K; Altermann W; Handke D; Atkins D; Seliger B; Kiessling R
Article: JOURNAL OF CLINICAL INVESTIGATION. 2002;110(10):1515-1523

IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.

Malmberg K-J; Levitsky V; Norell H; de Matos CT; Carlsten M; Schedvins K; Rabbani H; Moretta A; Söderström K; Levitskaya J; Kiessling R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(32):30542-30551

The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1, and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene.

Rundlöf AK; Carlsten M; Arnér ES
Article: BIOCHEMICAL JOURNAL. 2000;347 Pt 3(Pt 3):661-668

Prominent expression of the selenoprotein thioredoxin reductase in the medullary rays of the rat kidney and thioredoxin reductase mRNA variants differing at the 5' untranslated region.

Rundlöf AK; Carlsten M; Giacobini MM; Arnér ES
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Alla övriga publikationer

Letter: HEMASPHERE. 2023;7(11):e974

Improved Leukemia Clearance After Adoptive Transfer of NK Cells Expressing the Bone Marrow Homing Receptor CXCR4R334X.

Segerberg F; Lambert M; Sanz-Ortega L; Andersson A; Childs RW; Carlsten M
Editorial comment: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):316

Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer.

Carlsten M; Bryceson YT
Corrigendum: MOLECULAR IMAGING AND BIOLOGY. 2022;24(3):510

Correction: Optimisation of the Synthesis and Cell Labelling Conditions for [89Zr]Zr-oxine and [89Zr]Zr-DFO-NCS: a Direct In Vitro Comparison in Cell Types with Distinct Therapeutic Applications.

Friberger I; Jussing E; Han J; Goos JACM; Siikanen J; Kaipe H; Lambert M; Harris RA; Samén E; Carlsten M; Holmin S; Tran TA
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:621225

Cytokines Orchestrating the Natural Killer-Myeloid Cell Crosstalk in the Tumor Microenvironment: Implications for Natural Killer Cell-Based Cancer Immunotherapy.

Gaggero S; Witt K; Carlsten M; Mitra S
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:2357

Natural Killer Cells in Myeloid Malignancies: Immune Surveillance, NK Cell Dysfunction, and Pharmacological Opportunities to Bolster the Endogenous NK Cells.

Carlsten M; Järås M
Review: FRONTIERS IN IMMUNOLOGY. 2019;10:1047

Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer.

Daly J; Carlsten M; O'Dwyer M
Review: SEMINARS IN IMMUNOLOGY. 2017;31:20-29

Natural killer cell-mediated immunosurveillance of human cancer.

Malmberg K-J; Carlsten M; Björklund A; Sohlberg E; Bryceson YT; Ljunggren H-G
Corrigendum: BLOOD CANCER JOURNAL. 2015;5(7):e321

The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies.

Dosani T; Carlsten M; Maric I; Landgren O
Review: NATURE REVIEWS DRUG DISCOVERY. 2015;14(7):487-498

Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens.

Childs RW; Carlsten M
Review: FRONTIERS IN IMMUNOLOGY. 2015;6:266

Genetic Manipulation of NK Cells for Cancer Immunotherapy: Techniques and Clinical Implications.

Carlsten M; Childs RW
Letter: HAEMATOLOGICA. 2014;99(6):e81-e83

A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma.

Korde N; Carlsten M; Lee M-J; Minter A; Tan E; Kwok M; Manasanch E; Bhutani M; Tageja N; Roschewski M; Zingone A; Costello R; Mulquin M; Zuchlinski D; Maric I; Calvo KR; Braylan R; Tembhare P; Yuan C; Stetler-Stevenson M; Trepel J; Childs R; Landgren O
Review: INTERNATIONAL JOURNAL OF CANCER. 2009;124(4):757-762

Natural killer cell-mediated lysis of freshly isolated human tumor cells.

Carlsten M; Malmberg K-J; Ljunggren H-G
Published paper: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2008;57(10):1541-1552

NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy.

Malmberg K-J; Bryceson YT; Carlsten M; Andersson S; Björklund A; Björkström NK; Baumann BC; Fauriat C; Alici E; Dilber MS; Ljunggren H-G

Anställningar

Anknuten till Forskning, Laboratoriemedicin, Karolinska Institutet, 2024-2027
Anknuten till Forskning, Medicin, Huddinge, Karolinska Institutet, 2023-2026

Examina och utbildning

Docent, hematologi, Karolinska Institutet, 2022
Medicine Doktorsexamen, Institutionen för medicin, Huddinge, Karolinska Institutet, 2010
Läkarexamen, Karolinska Institutet, 2007

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Anställningar

Examina och utbildning

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