Mariette Lengquist

Article: VASCULAR PHARMACOLOGY. 2023;150:107167

Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification.

Skenteris NT; Hemme E; Delfos L; Karadimou G; Karlöf E; Lengquist M; Kronqvist M; Zhang X; Maegdefessel L; Schurgers LJ; Arnardottir H; Biessen EAL; Bot I; Matic L

Article: BIOMOLECULES. 2023;13(6):882

Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.

Chemaly M; Marlevi D; Iglesias M-J; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; de Vries MR; Kooi ME; Hedin U

Article: ATHEROSCLEROSIS. 2023;371:41-53

Interleukin-6 trans-signaling induced laminin switch contributes to reduced trans-endothelial migration of granulocytic cells.

Zegeye MM; Matic L; Lengquist M; Hayderi A; Grenegård M; Hedin U; Sirsjö A; Ljungberg LU; Kumawat AK

Article: COMPUTERS IN BIOLOGY AND MEDICINE. 2023;152:106364

In silico model of atherosclerosis with individual patient calibration to enable precision medicine for cardiovascular disease.

Buckler AJ; Marlevi D; Skenteris NT; Lengquist M; Kronqvist M; Matic L; Hedin U

Article: JVS-VASCULAR SCIENCE. 2023;4:100111

Transcriptomic and physiological analyses reveal temporal changes contributing to the delayed healing response to arterial injury in diabetic rats.

Narayanan S; Röhl S; Lengquist M; Kronqvist M; Matic L; Razuvaev A

Article: ISCIENCE. 2022;25(5):104219

Clinical risk scores for stroke correlate with molecular signatures of vulnerability in symptomatic carotid patients.

Wadén K; Karlöf E; Narayanan S; Lengquist M; Hansson GK; Hedin U; Roy J; Matic L

Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2022;42(5):659-676

Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis.

Rykaczewska U; Zhao Q; Saliba-Gustafsson P; Lengquist M; Kronqvist M; Bergman O; Huang Z; Lund K; Waden K; Pons Vila Z; Caidahl K; Skogsberg J; Vukojevic V; Lindeman JHN; Roy J; Hansson GK; Treuter E; Leeper NJ; Eriksson P; Ehrenborg E; Razuvaev A; Hedin U; Matic L

Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(2):e682

Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.

Skenteris NT; Seime T; Witasp A; Karlöf E; Wasilewski GB; Heuschkel MA; Jaminon AMG; Oduor L; Dzhanaev R; Kronqvist M; Lengquist M; Peeters FECM; Söderberg M; Hultgren R; Roy J; Maegdefessel L; Arnardottir H; Bengtsson E; Goncalves I; Quertermous T; Goettsch C; Stenvinkel P; Schurgers LJ; Matic L

Article: FRONTIERS IN PHARMACOLOGY. 2022;13:988561

Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease.

Suur BE; Chemaly M; Lindquist Liljeqvist M; Djordjevic D; Stenemo M; Bergman O; Karlöf E; Lengquist M; Odeberg J; Hurt-Camejo E; Eriksson P; Ketelhuth DFJ; Roy J; Hedin U; Nyberg M; Matic L

Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2021;62(5):716-726

Carotid Plaque Phenotyping by Correlating Plaque Morphology from Computed Tomography Angiography with Transcriptional Profiling.

Karlöf E; Buckler A; Liljeqvist ML; Lengquist M; Kronqvist M; Toonsi MA; Maegdefessel L; Matic LP; Hedin U

Article: CELLS. 2021;10(6):1276

Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification.

Seime T; Akbulut AC; Liljeqvist ML; Siika A; Jin H; Winski G; van Gorp RH; Karlöf E; Lengquist M; Buckler AJ; Kronqvist M; Waring OJ; Lindeman JHN; Biessen EAL; Maegdefessel L; Razuvaev A; Schurgers LJ; Hedin U; Matic L

Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41(5):1738-1750

Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.

Buckler AJ; Karlöf E; Lengquist M; Gasser TC; Maegdefessel L; Perisic Matic L; Hedin U

Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:655869

AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury.

Gallina AL; Rykaczewska U; Wirka RC; Caravaca AS; Shavva VS; Youness M; Karadimou G; Lengquist M; Razuvaev A; Paulsson-Berne G; Quertermous T; Gisterå A; Malin SG; Tarnawski L; Matic L; Olofsson PS

Article: ATHEROSCLEROSIS. 2020;314:1-9

A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?

Rakipovski G; Rolin B; Barascuk N; Lund HE; Bjørn Bonde MF; Djordjevic D; Wulff-Larsen PG; Petersen M; Kirk RK; Hultman K; Manfe V; Blume N; Zahn S; Lengquist M; Maegdefessel L; Hovingh GK; Conde-Knape K; Hedin U; Matic L; Nyberg M

Article: CELLS. 2020;9(4):E1009-1009

Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice.

Röhl S; Suur BE; Lengquist M; Seime T; Caidahl K; Hedin U; Arner A; Matic L; Razuvaev A

Article: CIRCULATION RESEARCH. 2020;126(5):571-585

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.

Rykaczewska U; Suur BE; Röhl S; Razuvaev A; Lengquist M; Sabater-Lleal M; van der Laan SW; Miller CL; Wirka RC; Kronqvist M; Gonzalez Diez M; Vesterlund M; Gillgren P; Odeberg J; Lindeman JH; Veglia F; Humphries SE; de Faire U; Baldassarre D; Tremoli E; IMPROVE study group; Lehtiö J; Hansson GK; Paulsson-Berne G; Pasterkamp G; Quertermous T; Hamsten A; Eriksson P; Hedin U; Matic L

Article: ATHEROSCLEROSIS. 2020;292:215-223

Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques.

Rafnsson A; Matic LP; Lengquist M; Mahdi A; Shemyakin A; Paulsson-Berne G; Hansson GK; Gabrielsen A; Hedin U; Yang J; Pernow J

Article: PLOS ONE. 2020;15(1):e0227889

Dipeptidyl peptidase-4 is increased in the abdominal aortic aneurysm vessel wall and is associated with aneurysm disease processes.

Lindquist Liljeqvist M; Eriksson L; Villard C; Lengquist M; Kronqvist M; Hultgren R; Roy J

Article: JVS-VASCULAR SCIENCE. 2020;1:13-27

Transcriptomic profiling of experimental arterial injury reveals new mechanisms and temporal dynamics in vascular healing response.

Röhl S; Rykaczewska U; Seime T; Suur BE; Diez MG; Gådin JR; Gainullina A; Sergushichev AA; Wirka R; Lengquist M; Kronqvist M; Bergman O; Odeberg J; Lindeman JHN; Quertermous T; Hamsten A; Eriksson P; Hedin U; Razuvaev A; Matic LP

Article: THROMBOSIS AND HAEMOSTASIS. 2019;119(12):2014-2024

Early Inhibition of P-Selectin/P-Selectin Glycoprotein Ligand-1 Reduces Intimal Hyperplasia in Murine Vein Grafts through Platelet Adhesion.

Tseng C-N; Chang Y-T; Yen C-Y; Lengquist M; Kronqvist M; Eriksson EE; Hedin U

Article: ATHEROSCLEROSIS. 2019;288:175-185

Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization.

Karlöf E; Seime T; Dias N; Lengquist M; Witasp A; Almqvist H; Kronqvist M; Gådin JR; Odeberg J; Maegdefessel L; Stenvinkel P; Matic LP; Hedin U

Article: JOURNAL OF ULTRASOUND IN MEDICINE. 2019;38(7):1723-1731

Noninvasive in vivo Assessment of the Re-endothelialization Process Using Ultrasound Biomicroscopy in the Rat Carotid Artery Balloon Injury Model.

Röhl S; Eriksson L; Saxelin R; Lengquist M; Östenson C-G; Hedin U; Caidahl K; Razuvaev A

Article: ATHEROSCLEROSIS. 2019;283:127-136

Dual roles of heparanase in human carotid plaque calcification.

Aldi S; Eriksson L; Kronqvist M; Lengquist M; Löfling M; Folkersen L; Matic LP; Maegdefessel L; Grinnemo K-H; Li J-P; Österholm C; Hedin U

Article: MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT. 2018;10:17-28

Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis.

Aldi S; Matic LP; Hamm G; van Keulen D; Tempel D; Holmstrøm K; Szwajda A; Nielsen BS; Emilsson V; Ait-Belkacem R; Lengquist M; Paulsson-Berne G; Eriksson P; Lindeman JHN; Gool AJ; Stauber J; Hedin U; Hurt-Camejo E

Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):464-480

Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage.

Matic LP; Jesus Iglesias M; Vesterlund M; Lengquist M; Hong M-G; Saieed S; Sanchez-Rivera L; Berg M; Razuvaev A; Kronqvist M; Lund K; Caidahl K; Gillgren P; Pontén F; Uhlén M; Schwenk JM; Hansson GK; Paulsson-Berne G; Fagman E; Roy J; Hultgren R; Bergström G; Lehtiö J; Odeberg J; Hedin U

Article: THROMBOSIS AND HAEMOSTASIS. 2018;118(2):329-339

Neutrophil Elastase-Derived Fibrin Degradation Products Indicate Presence of Abdominal Aortic Aneurysms and Correlate with Intraluminal Thrombus Volume.

Lindquist Liljeqvist M; Silveira A; Hultgren R; Frebelius S; Lengquist M; Engström J; Gasser TC; Eriksson P; Roy J

Article: JOURNAL OF INTERNAL MEDICINE. 2017;282(5):429-444

Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke.

Mahdessian H; Perisic Matic L; Lengquist M; Gertow K; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Tremoli E; Hamsten A; Eriksson P; Hedin U; Mälarstig A; IMPROVE study group

Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2017;148(4):425-433

Vessel wall morphology is equivalent for different artery types and localizations of advanced human aneurysms.

Busch A; Grimm C; Hartmann E; Paloschi V; Kickuth R; Lengquist M; Otto C; Eriksson P; Kellersmann R; Lorenz U; Maegdefessel L

Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(4):1546-1560

Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques.

Langley SR; Willeit K; Didangelos A; Matic LP; Skroblin P; Barallobre-Barreiro J; Lengquist M; Rungger G; Kapustin A; Kedenko L; Molenaar C; Lu R; Barwari T; Suna G; Yin X; Iglseder B; Paulweber B; Willeit P; Shalhoub J; Pasterkamp G; Davies AH; Monaco C; Hedin U; Shanahan CM; Willeit J; Kiechl S; Mayr M

Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2017;69(2):101-109

Effects of Linagliptin on Vessel Wall Healing in the Rat Model of Arterial Injury Under Normal and Diabetic Conditions.

Eriksson L; Röhl S; Saxelin R; Lengquist M; Kronqvist M; Caidahl K; Östenson C-G; Razuvaev A

Article: MATURITAS. 2017;96:39-44

Differential expression of sex hormone receptors in abdominal aortic aneurysms.

Villard C; Eriksson P; Kronqvist M; Lengquist M; Jorns C; Hartman J; Roy J; Hultgren R

Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(9):1947-1961

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.

Perisic Matic L; Rykaczewska U; Razuvaev A; Sabater-Lleal M; Lengquist M; Miller CL; Ericsson I; Röhl S; Kronqvist M; Aldi S; Magné J; Paloschi V; Vesterlund M; Li Y; Jin H; Diez MG; Roy J; Baldassarre D; Veglia F; Humphries SE; de Faire U; Tremoli E; Odeberg J; Vukojević V; Lehtiö J; Maegdefessel L; Ehrenborg E; Paulsson-Berne G; Hansson GK; Lindeman JHN; Eriksson P; Quertermous T; Hamsten A; Hedin U

Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(5):e003031

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis.

Paramel Varghese G; Folkersen L; Strawbridge RJ; Halvorsen B; Yndestad A; Ranheim T; Krohg-Sørensen K; Skjelland M; Espevik T; Aukrust P; Lengquist M; Hedin U; Jansson J-H; Fransén K; Hansson GK; Eriksson P; Sirsjö A

Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2016;51(4):579-586

The Receptor for Advanced Glycation End Products (Rage) and Its Ligands in Plasma and Infrainguinal Bypass Vein.

Malmstedt J; Frebelius S; Lengquist M; Jörneskog G; Wang J; Swedenborg J

Article: JOURNAL OF INTERNAL MEDICINE. 2016;279(3):293-308

Gene expression signatures, pathways and networks in carotid atherosclerosis.

Perisic L; Aldi S; Sun Y; Folkersen L; Razuvaev A; Roy J; Lengquist M; Åkesson S; Wheelock CE; Maegdefessel L; Gabrielsen A; Odeberg J; Hansson GK; Paulsson-Berne G; Hedin U

Article: CARDIOVASCULAR RESEARCH. 2015;107(1):20-31

Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension.

Chang Y-T; Tseng C-N; Tannenberg P; Eriksson L; Yuan K; de Jesus Perez VA; Lundberg J; Lengquist M; Botusan IR; Catrina S-B; Tran P-K; Hedin U; Tran-Lundmark K

Article: THROMBOSIS AND HAEMOSTASIS. 2015;113(4):813-825

Platelet adhesion on endothelium early after vein grafting mediates leukocyte recruitment and intimal hyperplasia in a murine model.

Tseng C-N; Chang Y-T; Lengquist M; Kronqvist M; Hedin U; Eriksson EE

Article: PLOS ONE. 2014;9(6):e98904

Contribution of endothelial injury and inflammation in early phase to vein graft failure: the causal factors impact on the development of intimal hyperplasia in murine models.

Tseng C-N; Karlöf E; Chang Y-T; Lengquist M; Rotzius P; Berggren P-O; Hedin U; Eriksson EE

Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(10):2432-2443

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis.

Perisic L; Hedin E; Razuvaev A; Lengquist M; Osterholm C; Folkersen L; Gillgren P; Paulsson-Berne G; Ponten F; Odeberg J; Hedin U

Article: ATHEROSCLEROSIS. 2013;226(1):67-73

Increased expression of heparanase in symptomatic carotid atherosclerosis.

Osterholm C; Folkersen L; Lengquist M; Pontén F; Renné T; Li J; Hedin U

Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;302(11):L1159-L1166

Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia.

Chang Y-T; Ringman Uggla A; Osterholm C; Tran P-K; Eklöf A-C; Lengquist M; Hedin U; Tran-Lundmark K; Frenckner B

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