Lukas Graetz

Article: CELL REPORTS. 2024;43(2):113727

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7.

Kinsolving J; Bous J; Kozielewicz P; Košenina S; Shekhani R; Grätz L; Masuyer G; Wang Y; Stenmark P; Dong M; Schulte G

Article: HEPATOLOGY. 2023

Wnt/β-catenin and NFκB signaling synergize to trigger growth factor-free regeneration of adult primary human hepatocytes.

Oliva-Vilarnau N; Beusch CM; Sabatier P; Sakaraki E; Tjaden A; Graetz L; Büttner FA; Dorotea D; Nguyen M; Bergqvist F; Sundström Y; Müller S; Zubarev RA; Schulte G; Tredup C; Gramignoli R; Tietge UJF; Lauschke VM

Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180 Suppl 2:S23-S144

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie AA; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Davies JA; Abbracchio MP; Abraham G; Agoulnik A; Alexander W; Al-Hosaini K; Bäck M; Baker JG; Barnes NM; Bathgate R; Beaulieu J-M; Beck-Sickinger AG; Behrens M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Bräuner-Osborne H; Burnstock G; Caló G; Castaño JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Cox HM; Csaba Z; Dahlgren C; Dent G; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; Garelja ML; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Grätz L; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Herr D; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Larhammar D; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Lolait SJ; Lupp A; Macrae R; Maguire J; Malfacini D; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Müller CE; Murphy PM; Nahon J-L; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schöneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Singh KD; Smith CM; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PBMWM; Tirupula K; Toll L; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Yao C; Ye RD

Article: NATURE COMMUNICATIONS. 2023;14(1):4573

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.

Grätz L; Kowalski-Jahn M; Scharf MM; Kozielewicz P; Jahn M; Bous J; Lambert NA; Gloriam DE; Schulte G

Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model.

Grätz L; Sajkowska-Kozielewicz JJ; Wesslowski J; Kinsolving J; Bridge LJ; Petzold K; Davidson G; Schulte G; Kozielewicz P

Article: SCIENCE SIGNALING. 2023;16(779):eabo4974

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.

Bowin C-F; Kozielewicz P; Grätz L; Kowalski-Jahn M; Schihada H; Schulte G

Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2022;5(11):1142-1155

Insertion of Nanoluc into the Extracellular Loops as a Complementary Method To Establish BRET-Based Binding Assays for GPCRs.

Grätz L; Müller C; Pegoli A; Schindler L; Bernhardt G; Littmann T