Leo Hanke

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: JCI INSIGHT. 2023;8(17):e167656

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Àdori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; McInerney G; Murrell B; Aoun M; Bäckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Karlsson Hedestam GB; Castro Dopico X; Rorbach J
Article: NATURE BIOTECHNOLOGY. 2023;:1-4

High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler.

Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Beklem Bostancioglu R; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Fürth D; Stevens MM; Sezgin E
Article: NANO LETTERS. 2023;23(9):3701-3707

A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens.

Schlegel J; Porebski B; Andronico L; Hanke L; Edwards S; Brismar H; Murrell B; McInerney GM; Fernandez-Capetillo O; Sezgin E
Article: OPEN BIOLOGY. 2023;13(5):220369

Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH.

Schulte T; Panas MD; Han X; Williams L; Kedersha N; Fleck JS; Tan TJC; Dopico XC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-Å; Anderson P; Achour A; McInerney GM
Article: EUROSURVEILLANCE. 2023;28(13):2200432

At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study.

Byström JW; Vikström L; Rosendal E; Gröning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Karlsson Hedestam GB; Thunberg T; Monsen T; Elgh F; Evander M; Johansson AF; Överby AK; Ahlm C; Normark J; Forsell MN
Article: IMMUNITY. 2023;56(1):193-206.e7

Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies.

Pushparaj P; Nicoletto A; Sheward DJ; Das H; Castro Dopico X; Perez Vidakovics L; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekström S; McInerney G; Hällberg BM; Murrell B; Corcoran M; Karlsson Hedestam GB
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:941281

SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses.

Christensen D; Polacek C; Sheward DJ; Hanke L; McInerney G; Murrell B; Hartmann KT; Jensen HE; Zimmermann J; Jungersen G; Illigen KE; Isling LK; Fernandez-Antunez C; Ramirez S; Bukh J; Pedersen GK
Article: EBIOMEDICINE. 2022;84:104248

Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy.

Christensen D; Polacek C; Sheward DJ; Hanke L; Moliner-Morro A; McInerney G; Murrell B; Hartmann KT; Jensen HE; Jungersen G; Illigen K; Isling LK; Jensen RF; Hansen JS; Rosenkrands I; Fernandez-Antunez C; Ramirez S; Follmann F; Bukh J; Pedersen GK
Article: SCIENCE ADVANCES. 2022;8(12):eabm0220

Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies.

Hanke L; Sheward DJ; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith NL; Astorga-Wells J; Ekström S; Coquet JM; McInerney GM; Murrell B
Article: NATURE COMMUNICATIONS. 2022;13(1):155

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo.

Hanke L; Das H; Sheward DJ; Perez Vidakovics L; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hällberg BM; Murrell B; McInerney GM
Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:1083232

Silver nanoparticles with excellent biocompatibility block pseudotyped SARS-CoV-2 in the presence of lung surfactant.

Gupta G; Hamawandi B; Sheward DJ; Murrell B; Hanke L; McInerney G; Blosi M; Costa AL; Toprak MS; Fadeel B
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379

Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates.

Castro Dopico X; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikström L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Karlsson Hedestam GB
Article: CELL REPORTS MEDICINE. 2021;2(11):100450

Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models.

Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Perez Vidakovics L; Pankow A; Smith NL; Castro Dopico X; McInerney GM; Coquet JM; Karlsson Hedestam GB; Murrell B
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676

Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden.

Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
Article: NATURE COMMUNICATIONS. 2021;12(1):3695

Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.

Roxhed N; Bendes A; Dale M; Mattsson C; Hanke L; Dodig-Crnković T; Christian M; Meineke B; Elsässer S; Andréll J; Havervall S; Thålin C; Eklund C; Dillner J; Beck O; Thomas CE; McInerney G; Hong M-G; Murrell B; Fredolini C; Schwenk JM
Article: CELL REPORTS MEDICINE. 2021;2(4):100252

SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses.

Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Perez Vidakovics L; Kim C; Àdori M; Lenart K; Loré K; Castro Dopico X; Coquet JM; McInerney GM; Karlsson Hedestam GB; Murrell B
Article: SCIENCE. 2021;371(6530):eabe6230

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.

Koenig P-A; Das H; Liu H; Kümmerer BM; Gohr FN; Jenster L-M; Schiffelers LDJ; Tesfamariam YM; Uchima M; Wuerth JD; Gatterdam K; Ruetalo N; Christensen MH; Fandrey CI; Normann S; Tödtmann JMP; Pritzl S; Hanke L; Boos J; Yuan M; Zhu X; Schmid-Burgk JL; Kato H; Schindler M; Wilson IA; Geyer M; Ludwig KU; Hällberg BM; Wu NC; Schmidt FI
Article: SCIENTIFIC REPORTS. 2021;11(1):3125

DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice.

Szurgot I; Hanke L; Sheward DJ; Vidakovics LP; Murrell B; McInerney GM; Liljeström P
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1312

Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.

Hober S; Hellström C; Olofsson J; Andersson E; Bergström S; Jernbom Falk A; Bayati S; Mravinacova S; Sjöberg R; Yousef J; Skoglund L; Kanje S; Berling A; Svensson A-S; Jensen G; Enstedt H; Afshari D; Xu LL; Zwahlen M; von Feilitzen K; Hanke L; Murrell B; McInerney G; Karlsson Hedestam GB; Lendel C; Roth RG; Skoog I; Svenungsson E; Olsson T; Fogdell-Hahn A; Lindroth Y; Lundgren M; Maleki KT; Lagerqvist N; Klingström J; Da Silva Rodrigues R; Muschiol S; Bogdanovic G; Arroyo Mühr LS; Eklund C; Lagheden C; Dillner J; Sivertsson Å; Havervall S; Thålin C; Tegel H; Pin E; Månberg A; Hedhammar M; Nilsson P
Article: EBIOMEDICINE. 2021;63:103197

Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice.

Wørzner K; Sheward DJ; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Karlsson Hedestam GB; Murrell B; Christensen D; Pedersen GK
Article: BIOMOLECULES. 2020;10(12):E1661-1661

Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs.

Moliner-Morro A; J Sheward D; Karl V; Perez Vidakovics L; Murrell B; McInerney GM; Hanke L
Article: NATURE COMMUNICATIONS. 2020;11(1):5588

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.

Custódio TF; Das H; Sheward DJ; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer MA; Gruzinov AY; Jeffries CM; Graewert MA; Svergun DI; Dobrev N; Remans K; Seeger MA; McInerney GM; Murrell B; Hällberg BM; Löw C
Article: NATURE COMMUNICATIONS. 2020;11(1):5064

SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.

Rudberg A-S; Havervall S; Månberg A; Jernbom Falk A; Aguilera K; Ng H; Gabrielsson L; Salomonsson A-C; Hanke L; Murrell B; McInerney G; Olofsson J; Andersson E; Hellström C; Bayati S; Bergström S; Pin E; Sjöberg R; Tegel H; Hedhammar M; Phillipson M; Nilsson P; Hober S; Thålin C
Article: NATURE COMMUNICATIONS. 2020;11(1):4420

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.

Hanke L; Vidakovics Perez L; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Karlsson Hedestam GB; Hällberg BM; Murrell B; McInerney GM
Article: EMBO REPORTS. 2017;18(6):1027-1037

Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.

Hanke L; Schmidt FI; Knockenhauer KE; Morin B; Whelan SP; Schwartz TU; Ploegh HL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(2):E152-E160

Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response.

Truttmann MC; Zheng X; Hanke L; Damon JR; Grootveld M; Krakowiak J; Pincus D; Ploegh HL
Article: JOURNAL OF IMMUNOLOGY. 2016;197(12):4838-4847

Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs.

Duarte JN; Cragnolini JJ; Swee LK; Bilate AM; Bader J; Ingram JR; Rashidfarrokhi A; Fang T; Schiepers A; Hanke L; Ploegh HL
Article: MBIO. 2016;7(6):e01569-e01516

The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.

Hanke L; Knockenhauer KE; Brewer RC; van Diest E; Schmidt FI; Schwartz TU; Ploegh HL
Article: NATURE MICROBIOLOGY. 2016;1(8):16080

Phenotypic lentivirus screens to identify functional single domain antibodies.

Schmidt FI; Hanke L; Morin B; Brewer R; Brusic V; Whelan SPJ; Ploegh HL
Article: JOURNAL OF VIROLOGY. 2015;89(5):2792-2800

Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization.

Ashour J; Schmidt FI; Hanke L; Cragnolini J; Cavallari M; Altenburg A; Brewer R; Ingram J; Shoemaker C; Ploegh HL
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Alla övriga publikationer

Review: JOURNAL OF GENERAL VIROLOGY. 2022;103(5)

Nanobodies in the limelight: Multifunctional tools in the fight against viruses.

Moliner-Morro A; McInerney GM; Hanke L
Preprint: MEDRXIV. 2022;MEDRXIV

Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions.

Byström JW; Vikström L; Rosendal E; Gröning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Karlsson Hedestam GB; Thunberg T; Monsen T; Elgh F; Evander M; Johansson A; Överby AK; Ahlm C; Normark J; Forsell MN

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