Karima Chergui

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About me

Karima Chergui is a University lecturer and research group leader for Molecular neurophysiology [1]. [1] http://ki.se/en/fyfa/molecular-neurophysiology

Articles

Article: NATURE COMMUNICATIONS. 2023;14(1):5804

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y; Kaya I; Shariatgorji R; Lundkvist J; Wahlberg LU; Nilsson A; Mamula D; Kehr J; Zareba-Paslawska J; Biverstål H; Chergui K; Zhang X; Andren PE; Svenningsson P
Article: NPJ PARKINSONS DISEASE. 2023;9(1):56

Aberrant somatic calcium channel function in cNurr1 and LRRK2-G2019S mice.

Skiteva O; Yao N; Mantas I; Zhang X; Perlmann T; Svenningsson P; Chergui K
Article: BIOMOLECULES. 2022;13(1):51

Age- and Sex-Dependent Behavioral and Neurochemical Alterations in hLRRK2-G2019S BAC Mice.

Yao N; Skiteva O; Chergui K
Article: BIOMOLECULES. 2022;12(11):1635

Neuronal Firing and Glutamatergic Synapses in the Substantia Nigra Pars Reticulata of LRRK2-G2019S Mice.

Sitzia G; Skiteva O; Chergui K
Article: SCIENCE ADVANCES. 2022;8(34):eabo1543

PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons.

Toskas K; Yaghmaeian-Salmani B; Skiteva O; Paslawski W; Gillberg L; Skara V; Antoniou I; Södersten E; Svenningsson P; Chergui K; Ringnér M; Perlmann T; Holmberg J
Article: JOURNAL OF NEUROCHEMISTRY. 2022;161(2):158-172

LRRK2-G2019S mice display alterations in glutamatergic synaptic transmission in midbrain dopamine neurons.

Skiteva O; Yao N; Sitzia G; Chergui K
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):530

Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens.

Skiteva O; Yao N; Chergui K
Article: NEUROPHARMACOLOGY. 2020;174:108136

NMDA receptors are altered in the substantia nigra pars reticulata and their blockade ameliorates motor deficits in experimental parkinsonism.

Sitzia G; Mantas I; Zhang X; Svenningsson P; Chergui K
Article: FRONTIERS IN AGING NEUROSCIENCE. 2020;12:84

Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37.

Zhang X; Mantas I; Fridjonsdottir E; Andrén PE; Chergui K; Svenningsson P
Article: MOLECULAR PSYCHIATRY. 2018;23(10):2066-2077

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit.

Yao N; Skiteva O; Zhang X; Svenningsson P; Chergui K
Article: NEUROSCIENCE LETTERS. 2018;666:11-16

High frequency stimulation induces LTD of AMPA receptor-mediated postsynaptic responses and LTP of synaptically-evoked firing in the dorsolateral striatum.

Skiteva O; Yao N; Nouhi M; Chergui K
Article: CNS NEUROSCIENCE & THERAPEUTICS. 2018;24(2):144-153

CIQ, a positive allosteric modulator of GluN2C/D-containing N-methyl-d-aspartate receptors, rescues striatal synaptic plasticity deficit in a mouse model of Parkinson's disease.

Nouhi M; Zhang X; Yao N; Chergui K
Article: FRONTIERS IN PHARMACOLOGY. 2018;9:166

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine.

Zhang X; Mantas I; Alvarsson A; Yoshitake T; Shariatgorji M; Pereira M; Nilsson A; Kehr J; Andrén PE; Millan MJ; Chergui K; Svenningsson P
Article: LEARNING & MEMORY. 2016;23(9):479-485

The GABAA receptor agonist muscimol induces an age- and region-dependent form of long-term depression in the mouse striatum.

Zhang X; Yao N; Chergui K
Article: NEUROPHARMACOLOGY. 2015;92:108-115

Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B- and GluN2D-containing NMDA receptors.

Zhang X; Chergui K
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2015;18(4):pyu052

Induction of cannabinoid- and N-methyl-D-aspartate receptor-mediated long-term depression in the nucleus accumbens and dorsolateral striatum is region and age dependent.

Zhang X; Feng Z-J; Chergui K
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2014;171(16):3938-3945

Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson's disease.

Zhang X; Feng Z-J; Chergui K
Article: EXPERIMENTAL NEUROLOGY. 2014;255:154-160

Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease.

Feng Z-J; Zhang X; Chergui K
Article: JOURNAL OF NEUROCHEMISTRY. 2014;129(4):581-590

GluN2D-containing NMDA receptors inhibit neurotransmission in the mouse striatum through a cholinergic mechanism: implication for Parkinson's disease.

Zhang X; Feng Z-J; Chergui K
Article: ADDICTION BIOLOGY. 2013;18(4):605-613

Ethanol inhibits excitatory neurotransmission in the nucleus accumbens of adolescent mice through GABAA and GABAB receptors.

Mishra D; Chergui K
Article: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2012;36(12):2117-2125

Ethanol disrupts the mechanisms of induction of long-term potentiation in the mouse nucleus accumbens.

Mishra D; Zhang X; Chergui K
Article: NEUROPHARMACOLOGY. 2011;60(6):975-981

Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens.

Chergui K
Article: JOURNAL OF NEUROSCIENCE. 2009;29(7):2238-2251

Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function.

Wallén-Mackenzie A; Nordenankar K; Fejgin K; Lagerström MC; Emilsson L; Fredriksson R; Wass C; Andersson D; Egecioglu E; Andersson M; Strandberg J; Lindhe O; Schiöth HB; Chergui K; Hanse E; Långström B; Fredriksson A; Svensson L; Roman E; Kullander K
Article: JOURNAL OF NEUROCHEMISTRY. 2008;106(4):1758-1765

NR2A-containing NMDA receptors depress glutamatergic synaptic transmission and evoked-dopamine release in the mouse striatum.

Schotanus SM; Chergui K
Article: NEUROPHARMACOLOGY. 2008;54(7):1143-1152

Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease.

Zhang X; Andren PE; Chergui K; Svenningsson P
Article: NEUROPHARMACOLOGY. 2008;54(5):837-844

Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens.

Schotanus SM; Chergui K
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2008;27(8):1957-1964

Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors.

Schotanus SM; Chergui K
Article: NEUROPHARMACOLOGY. 2006;51(2):272-282

NMDA depresses glutamatergic synaptic transmission in the striatum through the activation of adenosine A1 receptors: evidence from knockout mice.

Schotanus SM; Fredholm BB; Chergui K
Article: SCIENCE. 2006;311(5757):77-80

Alterations in 5-HT1B receptor function by p11 in depression-like states.

Svenningsson P; Chergui K; Rachleff I; Flajolet M; Zhang X; El Yacoubi M; Vaugeois J-M; Nomikos GG; Greengard P
Article: JOURNAL OF NEUROSCIENCE. 2005;25(28):6601-6609

Physiological role for casein kinase 1 in glutamatergic synaptic transmission.

Chergui K; Svenningsson P; Greengard P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(7):2191-2196

Cyclin-dependent kinase 5 regulates dopaminergic and glutamatergic transmission in the striatum.

Chergui K; Svenningsson P; Greengard P
Article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2002;365(3):173-180

GABA(B) receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo.

Erhardt S; Mathé JM; Chergui K; Engberg G; Svensson TH
Article: JOURNAL OF NEUROSCIENCE. 2000;20(22):8443-8451

Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity.

Calabresi P; Gubellini P; Centonze D; Picconi B; Bernardi G; Chergui K; Svenningsson P; Fienberg AA; Greengard P
Article: JOURNAL OF NEUROSCIENCE. 2000;20(6):2175-2182

Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission.

Chergui K; Bouron A; Normand E; Mulle C
Article: NEUROPHARMACOLOGY. 1999;38(2):223-231

Modulation by dopamine D1-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432.

Chergui K; Lacey MG
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(11):2370-2382

Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle.

Chergui K; Svenningsson P; Nomikos GG; Gonon F; Fredholm BB; Svennson TH
Article: NEUROPSYCHOPHARMACOLOGY. 1997;17(3):151-161

Chronic nicotine enhances basal and nicotine-induced Fos immunoreactivity preferentially in the medial prefrontal cortex of the rat.

Nisell M; Nomikos GG; Chergui K; Grillner P; Svensson TH
Article: NEUROSCIENCE. 1997;77(1):175-186

Ventral pallidum self-stimulation induces stimulus dependent increase in c-fos expression in reward-related brain regions.

Panagis G; Nomikos GG; Miliaressis E; Chergui K; Kastellakis A; Svensson TH; Spyraki C
Article: BRAIN RESEARCH. 1996;730(1-2):133-142

Nicotine injections into the ventral tegmental area increase locomotion and Fos-like immunoreactivity in the nucleus accumbens of the rat.

Panagis G; Nisell M; Nomikos GG; Chergui K; Svensson TH
Journal article: BEHAVIOURAL PHARMACOLOGY. 1996;7(Supplement 1):76

CHRONIC NICOTINE SELECTIVELY ENHANCES BASAL AND NICOTINE INDUCED FOS IMMUNOREACTIVITY IN THE MEDIAL PREFRONTAL CORTEX

G NG; M N; K C; P G; H ST
Journal article: BEHAVIOURAL PHARMACOLOGY. 1996;7(Supplement 1):82

VENTRAL PALLIDUM SELF-STIMULATION INCREASES C-FOS EXPRESSION IN REWARD-RELATED BRAIN REGIONS

G P; G NG; E M; K C; A K; H ST; C S
Article: JOURNAL OF NEUROCHEMISTRY. 1995;65(6):2603-2611

Uptake of dopamine released by impulse flow in the rat mesolimbic and striatal systems in vivo.

Suaud-Chagny MF; Dugast C; Chergui K; Msghina M; Gonon F
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 1995;5(3):405

P-11-4 Pattern of presynaptic activity in the mesolimbic dopamine system determines postsynaptic events

Svensson TH; Chergui K; Nomikos GG; Gonor F; Mathé JM
Journal article: NEUROSCIENCE. 1994;62(3):641-645

Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brain in vivo.

Chergui K; Suaud-Chagny MF; Gonon F
Journal article: NEUROREPORT. 1994;5(10):1185-1188

Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors.

Chergui K; Akaoka H; Charléty PJ; Saunier CF; Buda M; Chouvet G
Journal article: ANESTHESIOLOGY. 1993;79(5):1072-1082

Activation of brain noradrenergic neurons during recovery from halothane anesthesia. Persistence of phasic activation after clonidine.

Saunier CF; Akaoka H; de La Chapelle B; Charléty PJ; Chergui K; Chouvet G; Buda M; Quintin L
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1993;5(8):1024-1028

Serotonin differentially modulates responses mediated by specific excitatory amino acid receptors in the rat locus coeruleus.

Charléty PJ; Chergui K; Akaoka H; Saunier CF; Buda M; Aston-Jones G; Chouvet G
Journal article: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1993;347(4):353-362

The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons.

Arborelius L; Chergui K; Murase S; Nomikos GG; Höök BB; Chouvet G; Hacksell U; Svensson TH
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1993;5(2):137-144

Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo.

Chergui K; Charléty PJ; Akaoka H; Saunier CF; Brunet JL; Buda M; Svensson TH; Chouvet G
Journal article: EUROPEAN JOURNAL OF PHARMACOLOGY. 1992;219(1):169-172

Inhibition of locus coeruleus neurons by the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine: evidence for potent indirect adrenoceptor agonist properties.

Chergui K; Akaoka H; Brunet JL; Charléty PJ; Saunier CF; Buda M; Privat A; Vignon J; Kamenka JM; Chouvet G
Journal article: NEUROSCIENCE. 1992;49(1):63-72

Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area.

Suaud-Chagny MF; Chergui K; Chouvet G; Gonon F
Journal article: JOURNAL OF NEUROSCIENCE METHODS. 1992;42(1-2):119-128

Combining in vivo volume-controlled pressure microejection with extracellular unit recording.

Akaoka H; Saunier CF; Chergui K; Charléty P; Buda M; Chouvet G
Journal article: ACTA PHYSIOLOGICA. 1991;142(1):105-112

Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurenate.

Charlety PJ; Grenhoff J; Chergui K; De la Chapelle B; Buda M; Svensson TH; Chouvet G
Journal article: COMPTES RENDUS BIOLOGIES. 1991;313(2):139-144

[Participation of NMDA receptors in spontaneous burst firing of dopaminergic mesencephalic neurons].

Chergui K; Charléty PJ; Akaoka H; Brunet JL; Saunier CF; Buda M; Svensson TH; Chouvet G
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All other publications

Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S14-S15

GluN2D-containing NMDA receptors in cholinergic interneurons control dopamine release in the mouse striatum

Zhang X; Chergui K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20:S576-S577

Ethanol inhibits neurotransmission in the nucleus accumbens of juvenile mice through the activation of GABA receptors

Mishra D; Chergui K
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S26-S27

Gender-related differences in synaptic transmission and plasticity in the mouse striatum and nucleus accumbens

Schotanus SM; Chergui K
Editorial comment: CURRENT OPINION IN PHARMACOLOGY. 2007;7(1):1-2

Many ways to Rome - multiple approaches to novel drugs

Chergui K; Fredholm BB; Svenningsson P
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2006;16:S17

Role of dopamine and NMDA receptor subunits in the induction of long term potentiation in the nucleus accumbens

Schotanus SM; Chergui K
Published paper: JOURNAL OF MOLECULAR NEUROSCIENCE. 2005;26(2-3):239-244

Adenosine-dopamine interactions revealed in knockout mice.

Salmi P; Chergui K; Fredholm BB
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2005;15:S15-S16

Regulation of synaptic transmission in the striatum by protein kinases

Chergui K
Review: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1997;280(1):83-97

Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.

Schoemaker H; Claustre Y; Fage D; Rouquier L; Chergui K; Curet O; Oblin A; Gonon F; Carter C; Benavides J; Scatton B
Review: NEUROSCIENCE. 1996;72(1):141-156

Burst stimulation of the medial forebrain bundle selectively increase Fos-like immunoreactivity in the limbic forebrain of the rat.

Chergui K; Nomikos GG; Mathé JM; Gonon F; Svensson TH

Employments

Senior Lecturer, Department of Physiology and Pharmacology, Karolinska Institutet, 2010-

Degrees and Education

Docent, Karolinska Institutet, 2006

About me

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