Karl-Johan Malmberg

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: TRANSPLANTATION AND CELLULAR THERAPY. 2023;29(6):376.e1-376.e11

Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation.

Haroun-Izquierdo A; Lanuza PM; Pfefferle A; Netskar H; Ask EH; Törlén J; Björklund A; Sohlberg E; Malmberg K-J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(12):e2220320120

Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age.

Humbert M; Olofsson A; Wullimann D; Niessl J; Hodcroft EB; Cai C; Gao Y; Sohlberg E; Dyrdak R; Mikaeloff F; Neogi U; Albert J; Malmberg K-J; Lund-Johansen F; Aleman S; Björkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: RESPIRATORY RESEARCH. 2023;24(1):62

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.

Palma Medina LM; Babačić H; Dzidic M; Parke Å; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgård J; Moll K; Karolinska K. I./K. COVID-19 Study Group; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Gredmark-Russ S; Rooyackers O; Svensson M; Chambers BJ; Eriksson LI; Pernemalm M; Björkström NK; Aleman S; Ljunggren H-G; Klingström J; Strålin K; Norrby-Teglund A
Article: CURRENT PROTOCOLS. 2022;2(11):e613

Small Interfering RNA Delivery Into Primary Human Natural Killer Cells for Functional Gene Analyses.

Momayyezi P; Malmberg K-J; Hammer Q
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(11):e005577

Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia.

Haroun-Izquierdo A; Vincenti M; Netskar H; van Ooijen H; Zhang B; Bendzick L; Kanaya M; Momayyezi P; Li S; Wiiger MT; Hoel HJ; Krokeide SZ; Kremer V; Tjonnfjord G; Berggren S; Wikström K; Blomberg P; Alici E; Felices M; Önfelt B; Höglund P; Valamehr B; Ljunggren H-G; Björklund A; Hammer Q; Kveberg L; Cichocki F; Miller JS; Malmberg K-J; Sohlberg E
Article: CANCER CELL. 2022;40(9):1027-1043.e9

NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.

Salomé B; Sfakianos JP; Ranti D; Daza J; Bieber C; Charap A; Hammer C; Banchereau R; Farkas AM; Ruan DF; Izadmehr S; Geanon D; Kelly G; de Real RM; Lee B; Beaumont KG; Shroff S; Wang YA; Wang Y-C; Thin TH; Garcia-Barros M; Hegewisch-Solloa E; Mace EM; Wang L; O'Donnell T; Chowell D; Fernandez-Rodriguez R; Skobe M; Taylor N; Kim-Schulze S; Sebra RP; Palmer D; Clancy-Thompson E; Hammond S; Kamphorst AO; Malmberg K-J; Marcenaro E; Romero P; Brody R; Viard M; Yuki Y; Martin M; Carrington M; Mehrazin R; Wiklund P; Mellman I; Mariathasan S; Zhu J; Galsky MD; Bhardwaj N; Horowitz A
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(7):1190-1193

An optimized platform for efficient siRNA delivery into human NK cells.

Palacios D; Momayyezi P; Huhn O; Ask EH; Dunst J; Malmberg K-J; Hammer Q
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195

The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.

Ljunggren H-G; Ask EH; Cornillet M; Strunz B; Chen P; Rao Muvva J; Akber M; Buggert M; Chambers BJ; Cuapio A; Dzidic M; Filipovic I; Flodström-Tullberg M; Garcia M; Gorin J-B; Gredmark-Russ S; Hertwig L; Klingström J; Kokkinou E; Kvedaraite E; Lourda M; Mjösberg J; Maucourant C; Norrby-Teglund A; Palma Medina LM; Parrot T; Perez-Potti A; Ponzetta A; Ringqvist E; Rivera-Ballesteros O; Rooyackers O; Sandberg JK; Sandberg JT; Sekine T; Svensson M; Varnaite R; Wullimann D; Karolinska KI/K COVID-19 Study Group; Eriksson LI; Aleman S; Malmberg K-J; Strålin K; Björkström NK
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(11):e154334

Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse.

Shapiro RM; Birch GC; Hu G; Vergara Cadavid J; Nikiforow S; Baginska J; Ali AK; Tarannum M; Sheffer M; Abdulhamid YZ; Rambaldi B; Arihara Y; Reynolds C; Halpern MS; Rodig SJ; Cullen N; Wolff JO; Pfaff KL; Lane AA; Lindsley RC; Cutler CS; Antin JH; Ho VT; Koreth J; Gooptu M; Kim HT; Malmberg K-J; Wu CJ; Chen J; Soiffer RJ; Ritz J; Romee R
Article: CELL REPORTS. 2022;38(10):110503

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells.

Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; García M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Karolinska COVID-19 Study Group; Severe COVID-19 GWAS Group; Degenhardt F; Franke A; Spallotta F; Mori M; Michaëlsson J; Björkström NK; Rückert T; Romagnani C; Horowitz A; Klingström J; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2022;139(5):704-716

Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia.

Sohlberg E; Pfefferle A; Heggernes Ask E; Tschan-Plessl A; Jacobs B; Netskar H; Lorenz S; Kanaya M; Kosugi-Kanaya M; Meinke S; Mörtberg A; Höglund P; Sundin M; Carlsson G; Palmblad J; Malmberg K-J
Article: CELL STEM CELL. 2021;28(12):2062-2075.e5

Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy.

Woan KV; Kim H; Bjordahl R; Davis ZB; Gaidarova S; Goulding J; Hancock B; Mahmood S; Abujarour R; Wang H; Tuininga K; Zhang B; Wu C-Y; Kodal B; Khaw M; Bendzick L; Rogers P; Ge MQ; Bonello G; Meza M; Felices M; Huffman J; Dailey T; Lee TT; Walcheck B; Malmberg KJ; Blazar BR; Bryceson YT; Valamehr B; Miller JS; Cichocki F
Article: MOLECULAR THERAPY. 2021;29(12):3410-3421

Anti-NKG2C/IL-15/anti-CD33 killer engager directs primary and iPSC-derived NKG2C+ NK cells to target myeloid leukemia.

Chiu E; Felices M; Cichocki F; Davis Z; Wang H; Tuninga K; Vallera DA; Lee T; Bjordahl R; Malmberg KJ; Valamehr B; Miller JS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.

Lourda M; Dzidic M; Hertwig L; Bergsten H; Palma Medina LM; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki KT; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ; Karolinska KI/K COVID-19 Study Group
Article: JOURNAL OF IMMUNOLOGY RESEARCH. 2021;2021:9920234-18

Bioinformatic Analysis Reveals Central Role for Tumor-Infiltrating Immune Cells in Uveal Melanoma Progression.

Lachota M; Lennikov A; Malmberg K-J; Zagozdzon R
Article: SCIENCE IMMUNOLOGY. 2021;6(58):eabe9057

Natural killer cell receptors regulate responses of HLA-E-restricted T cells.

Sullivan LC; Nguyen THO; Harpur CM; Stankovic S; Kanagarajah AR; Koutsakos M; Saunders PM; Cai Z; Gray JA; Widjaja JML; Lin J; Pietra G; Mingari MC; Moretta L; Samir J; Luciani F; Westall GP; Malmberg KJ; Kedzierska K; Brooks AG
Article: CYTOTHERAPY. 2021;23(4):329-338

Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma.

Tschan-Plessl A; Kalberer CP; Wieboldt R; Stern M; Siegler U; Wodnar-Filipowicz A; Gerull S; Halter J; Heim D; Tichelli A; Tsakiris DA; Malmberg K-J; Passweg JR; Bottos A
Article: MED. 2021;2(2):180-195.e5

A Systemic Protein Deviation Score Linked to PD-1+ CD8+ T Cell Expansion That Predicts Overall Survival in Diffuse Large B Cell Lymphoma.

Ask EH; Tschan-Plessl A; Gjerdingen TJ; Sætersmoen ML; Hoel HJ; Wiiger MT; Olweus J; Wahlin BE; Lingjærde OC; Horowitz A; Cashen AF; Watkins M; Fehniger TA; Holte H; Kolstad A; Malmberg K-J
Article: CELL. 2020;183(1):158-168.e14

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.

Sekine T; Perez-Potti A; Rivera-Ballesteros O; Strålin K; Gorin J-B; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgård J; Parrot T; Folkesson E; Karolinska COVID-19 Study Group; Rooyackers O; Eriksson LI; Henter J-I; Sönnerborg A; Allander T; Albert J; Nielsen M; Klingström J; Gredmark-Russ S; Björkström NK; Sandberg JK; Price DA; Ljunggren H-G; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670

MAIT cell activation and dynamics associated with COVID-19 disease severity.

Parrot T; Gorin J-B; Ponzetta A; Maleki KT; Kammann T; Emgård J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren H-G; Björkström NK; Aleman S; Buggert M; Klingström J; Strålin K; Sandberg JK
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström NK; Karolinska COVID-19 Study Group
Article: CELL STEM CELL. 2020;27(2):224-237.e6

Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity.

Zhu H; Blum RH; Bernareggi D; Ask EH; Wu Z; Hoel HJ; Meng Z; Wu C; Guan K-L; Malmberg K-J; Kaufman DS
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:561553

Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles.

Goldenson BH; Zhu H; Wang YM; Heragu N; Bernareggi D; Ruiz-Cisneros A; Bahena A; Ask EH; Hoel HJ; Malmberg K-J; Kaufman DS
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:2128

The Oncometabolite 5'-Deoxy-5'-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation.

Jacobs B; Schlögl S; Strobl CD; Völkl S; Stoll A; Mougiakakos D; Malmberg K-J; Mackensen A; Aigner M
Article: CELL REPORTS. 2019;29(8):2284-2294.e4

Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity.

Pfefferle A; Jacobs B; Netskar H; Ask EH; Lorenz S; Clancy T; Goodridge JP; Sohlberg E; Malmberg K-J
Article: GASTROENTEROLOGY. 2019;157(4):1067-1080.e9

Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer.

Cornillet M; Jansson H; Schaffer M; Hertwig L; Berglin L; Zimmer CL; Johansson H; Ellis E; Isaksson B; Gonzalez-Galarza FF; Middleton D; Malmberg K-J; Sparrelid E; Björkström NK
Article: JOURNAL OF IMMUNOLOGY. 2019;202(3):736-746

Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal.

Jacobs B; Pfefferle A; Clement D; Berg-Larsen A; Saetersmoen ML; Lorenz S; Wiiger MT; Goodridge JP; Malmberg K-J
Article: NATURE COMMUNICATIONS. 2019;10(1):514

Remodeling of secretory lysosomes during education tunes functional potential in NK cells.

Goodridge JP; Jacobs B; Saetersmoen ML; Clement D; Hammer Q; Clancy T; Skarpen E; Brech A; Landskron J; Grimm C; Pfefferle A; Meza-Zepeda L; Lorenz S; Wiiger MT; Louch WE; Ask EH; Liu LL; Oei VYS; Kjällquist U; Linnarsson S; Patel S; Taskén K; Stenmark H; Malmberg K-J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2085

Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma.

Enqvist M; Jacobs B; Junlén HR; Schaffer M; Melén CM; Friberg D; Wahlin BE; Malmberg K-J
Article: CLINICAL CANCER RESEARCH. 2018;24(8):1834-1844

Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML.

Björklund AT; Carlsten M; Sohlberg E; Liu LL; Clancy T; Karimi M; Cooley S; Miller JS; Klimkowska M; Schaffer M; Watz E; Wikström K; Blomberg P; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellström-Lindberg E; Ljunggren H-G; Malmberg K-J
Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(4):467-480

Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors.

Oei VYS; Siernicka M; Graczyk-Jarzynka A; Hoel HJ; Yang W; Palacios D; Almåsbak H; Bajor M; Clement D; Brandt L; Önfelt B; Goodridge J; Winiarska M; Zagozdzon R; Olweus J; Kyte J-A; Malmberg K-J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(11):4042-4058

CD56bright NK cells exhibit potent antitumor responses following IL-15 priming.

Wagner JA; Rosario M; Romee R; Berrien-Elliott MM; Schneider SE; Leong JW; Sullivan RP; Jewell BA; Becker-Hapak M; Schappe T; Abdel-Latif S; Ireland AR; Jaishankar D; King JA; Vij R; Clement D; Goodridge J; Malmberg K-J; Wong HC; Fehniger TA
Article: CANCER IMMUNOLOGY RESEARCH. 2017;5(8):654-665

Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells.

Liu LL; Béziat V; Oei VYS; Pfefferle A; Schaffer M; Lehmann S; Hellström-Lindberg E; Söderhäll S; Heyman M; Grandér D; Malmberg K-J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2016;126(10):3772-3782

Cognate HLA absence in trans diminishes human NK cell education.

Landtwing V; Raykova A; Pezzino G; Béziat V; Marcenaro E; Graf C; Moretta A; Capaul R; Zbinden A; Ferlazzo G; Malmberg K-J; Chijioke O; Münz C
Article: SCIENCE IMMUNOLOGY. 2016;1(3):eaag1672

Class I HLA haplotypes form two schools that educate NK cells in different ways.

Horowitz A; Djaoud Z; Nemat-Gorgani N; Blokhuis J; Hilton HG; Béziat V; Malmberg K-J; Norman PJ; Guethlein LA; Parham P
Article: ONCOIMMUNOLOGY. 2016;5(5):e1138199

Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.

Mensali N; Ying F; Sheng VOY; Yang W; Walseng E; Kumari S; Fallang L-E; Kolstad A; Uckert W; Malmberg KJ; Wälchli S; Olweus J
Article: CELL REPORTS. 2016;15(5):1088-1099

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.

Liu LL; Landskron J; Ask EH; Enqvist M; Sohlberg E; Traherne JA; Hammer Q; Goodridge JP; Larsson S; Jayaraman J; Oei VYS; Schaffer M; Taskén K; Ljunggren H-G; Romagnani C; Trowsdale J; Malmberg K-J; Béziat V
Article: JOURNAL OF IMMUNOLOGY. 2016;196(3):1400-1411

Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

Björklund AT; Clancy T; Goodridge JP; Béziat V; Schaffer M; Hovig E; Ljunggren H-G; Ljungman PT; Malmberg K-J
Article: ONCOTARGET. 2015;6(33):34178-34190

Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome.

Sohlberg E; Pfefferle A; Andersson S; Baumann BC; Hellström-Lindberg E; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3374-3381

Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells.

Forslund E; Sohlberg E; Enqvist M; Olofsson PE; Malmberg K-J; Önfelt B
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2015;21(9):1589-1596

Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation.

Sobecks RM; Wang T; Askar M; Gallagher MM; Haagenson M; Spellman S; Fernandez-Vina M; Malmberg K-J; Müller C; Battiwalla M; Gajewski J; Verneris MR; Ringdén O; Marino S; Davies S; Dehn J; Bornhäuser M; Inamoto Y; Woolfrey A; Shaw P; Pollack M; Weisdorf D; Milller J; Hurley C; Lee SJ; Hsu K
Article: BONE MARROW TRANSPLANTATION. 2015;50(9):1217-1223

Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation.

von Bahr L; Blennow O; Alm J; Björklund A; Malmberg K-J; Mougiakakos D; Le Blanc A; Oefner PJ; Labopin M; Ljungman P; Le Blanc K
Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4518-4527

Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.

Enqvist M; Ask EH; Forslund E; Carlsten M; Abrahamsen G; Béziat V; Andersson S; Schaffer M; Spurkland A; Bryceson Y; Önfelt B; Malmberg K-J
Article: IMMUNITY. 2015;42(3):443-456

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.

Schlums H; Cichocki F; Tesi B; Theorell J; Beziat V; Holmes TD; Han H; Chiang SCC; Foley B; Mattsson K; Larsson S; Schaffer M; Malmberg K-J; Ljunggren H-G; Miller JS; Bryceson YT
Article: GUT. 2015;64(3):469-482

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals.

Lunemann S; Malone DFG; Grabowski J; Port K; Béziat V; Bremer B; Malmberg K-J; Manns MP; Sandberg JK; Cornberg M; Ljunggren H-G; Wedemeyer H; Björkström NK
Article: FRONTIERS IN IMMUNOLOGY. 2015;6:507

Polyclonal Expansion of NKG2C(+) NK Cells in TAP-Deficient Patients.

Béziat V; Sleiman M; Goodridge JP; Kaarbø M; Liu LL; Rollag H; Ljunggren H-G; Zimmer J; Malmberg K-J
Article: BLOOD. 2014;124(16):2533-2543

Role for early-differentiated natural killer cells in infectious mononucleosis.

Azzi T; Lünemann A; Murer A; Ueda S; Béziat V; Malmberg K-J; Staubli G; Gysin C; Berger C; Münz C; Chijioke O; Nadal D
Article: BLOOD. 2014;124(5):812-821

Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.

Munneke JM; Björklund AT; Mjösberg JM; Garming-Legert K; Bernink JH; Blom B; Huisman C; van Oers MHJ; Spits H; Malmberg K-J; Hazenberg MD
Article: AGE. 2014;36(2):571-582

Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity.

Bengnér M; Béziat V; Ernerudh J; Nilsson B-O; Löfgren S; Wikby A; Malmberg KJ; Strindhall J
Article: BLOOD. 2013;121(23):4703-4707

Influence of KIR gene copy number on natural killer cell education.

Béziat V; Traherne JA; Liu LL; Jayaraman J; Enqvist M; Larsson S; Trowsdale J; Malmberg K-J
Article: BLOOD. 2013;121(14):2678-2688

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.

Béziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Björklund AT; Retière C; Sverremark-Ekström E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2013;121(8):1326-1334

Classification of human natural killer cells based on migration behavior and cytotoxic response.

Vanherberghen B; Olofsson PE; Forslund E; Sternberg-Simon M; Khorshidi MA; Pacouret S; Guldevall K; Enqvist M; Malmberg K-J; Mehr R; Önfelt B
Article: FRONTIERS IN IMMUNOLOGY. 2013;4:65

Natural killer cell inhibitory receptor expression in humans and mice: a closer look.

Sternberg-Simon M; Brodin P; Pickman Y; Onfelt B; Kärre K; Malmberg K-J; Höglund P; Mehr R
Article: BLOOD. 2012;120(17):3455-3465

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells.

Björkström NK; Béziat V; Cichocki F; Liu LL; Levine J; Larsson S; Koup RA; Anderson SK; Ljunggren H-G; Malmberg K-J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(2):447-457

CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients.

Béziat V; Dalgard O; Asselah T; Halfon P; Bedossa P; Boudifa A; Hervier B; Theodorou I; Martinot M; Debré P; Björkström NK; Malmberg K-J; Marcellin P; Vieillard V
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(11):1688-1697

Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study.

Remberger M; Ackefors M; Berglund S; Blennow O; Dahllöf G; Dlugosz A; Garming-Legert K; Gertow J; Gustafsson B; Hassan M; Hassan Z; Hauzenberger D; Hägglund H; Karlsson H; Klingspor L; Kumlien G; Le Blanc K; Ljungman P; Machaczka M; Malmberg K-J; Marschall H-U; Mattsson J; Olsson R; Omazic B; Sairafi D; Schaffer M; Svahn B-M; Svenberg P; Swartling L; Szakos A; Uhlin M; Uzunel M; Watz E; Wernerson A; Wikman A; Wikström A-C; Winiarski J; Ringdén O
Article: JOURNAL OF IMMUNOLOGY. 2011;187(7):3546-3554

Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells.

Enqvist M; Nilsonne G; Hammarfjord O; Wallin RPA; Björkström NK; Björnstedt M; Hjerpe A; Ljunggren H-G; Dobra K; Malmberg K-J; Carlsten M
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(7):1913-1923

NKG2D performs two functions in invariant NKT cells: direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d.

Kuylenstierna C; Björkström NK; Andersson SK; Sahlström P; Bosnjak L; Paquin-Proulx D; Malmberg K-J; Ljunggren H-G; Moll M; Sandberg JK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(1):13-21

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus.

Björkström NK; Lindgren T; Stoltz M; Fauriat C; Braun M; Evander M; Michaëlsson J; Malmberg K-J; Klingström J; Ahlm C; Ljunggren H-G
Article: PLOS ONE. 2011;6(11):e27664

Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection.

Björkström NK; Svensson A; Malmberg K-J; Eriksson K; Ljunggren H-G
Article: JOURNAL OF IMMUNOLOGY. 2011;186(1):62-72

Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention.

Taner SB; Pando MJ; Roberts A; Schellekens J; Marsh SGE; Malmberg K-J; Parham P; Brodsky FM
Article: BLOOD. 2010;116(19):3853-3864

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.

Björkström NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Björklund AT; Flodström-Tullberg M; Michaëlsson J; Rottenberg ME; Guzmán CA; Ljunggren H-G; Malmberg K-J
Article: LEUKEMIA. 2010;24(9):1607-1616

Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34+ blasts in myelodysplastic syndrome.

Carlsten M; Baumann BC; Simonsson M; Jädersten M; Forsblom A-M; Hammarstedt C; Bryceson YT; Ljunggren H-G; Hellström-Lindberg E; Malmberg K-J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;177(1):493-500

Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.

Rotzius P; Thams S; Soehnlein O; Kenne E; Tseng C-N; Björkström NK; Malmberg K-J; Lindbom L; Eriksson EE
Article: BLOOD. 2010;115(13):2686-2694

NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation.

Björklund AT; Schaffer M; Fauriat C; Ringdén O; Remberger M; Hammarstedt C; Barrett AJ; Ljungman P; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2010;115(6):1166-1174

Education of human natural killer cells by activating killer cell immunoglobulin-like receptors.

Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaëlsson J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(2):378-387

Activating NK-cell receptors co-stimulate CD4(+)CD28(-) T cells in patients with rheumatoid arthritis.

Fasth AER; Björkström NK; Anthoni M; Malmberg K-J; Malmström V
Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:353-364

Analysis of the KIR repertoire in human NK cells by flow cytometry.

Björkström NK; Fauriat C; Bryceson YT; Sandberg JK; Ljunggren H-G; Malmberg K-J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(4):1272-1277

Regulation of interleukin-4 signaling by extracellular reduction of intramolecular disulfides.

Curbo S; Gaudin R; Carlsten M; Malmberg K-J; Troye-Blomberg M; Ahlborg N; Karlsson A; Johansson M; Lundberg M
Article: JOURNAL OF IMMUNOLOGY. 2009;183(8):4921-4930

Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells.

Carlsten M; Norell H; Bryceson YT; Poschke I; Schedvins K; Ljunggren H-G; Kiessling R; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2009;183(7):4792-4799

T cell infiltrates in the muscles of patients with dermatomyositis and polymyositis are dominated by CD28null T cells.

Fasth AER; Dastmalchi M; Rahbar A; Salomonsson S; Pandya JM; Lindroos E; Nennesmo I; Malmberg K-J; Söderberg-Nauclér C; Trollmo C; Lundberg IE; Malmström V
Article: BLOOD. 2009;114(1):95-104

KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression.

Andersson S; Fauriat C; Malmberg J-A; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019

Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype.

Fauriat C; Andersson S; Björklund AT; Carlsten M; Schaffer M; Björkström NK; Baumann BC; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2008;181(6):4219-4228

Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection.

Björkström NK; Gonzalez VD; Malmberg K-J; Falconer K; Alaeus A; Nowak G; Jorns C; Ericzon B-G; Weiland O; Sandberg JK; Ljunggren H-G
Article: CELLULAR MICROBIOLOGY. 2008;10(2):426-436

IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection.

Hühn MH; Hultcrantz M; Lind K; Ljunggren H-G; Malmberg K-J; Flodström-Tullberg M
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74

Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets.

Gonzalez VD; Björkström NK; Malmberg K-J; Moll M; Kuylenstierna C; Michaëlsson J; Ljunggren H-G; Sandberg JK
Article: JOURNAL OF IMMUNOLOGY. 2007;179(7):4513-4519

The CD16- CD56(bright) NK cell subset is resistant to reactive oxygen species produced by activated granulocytes and has higher antioxidative capacity than the CD16+ CD56(dim) subset.

Harlin H; Hanson M; Johansson CC; Sakurai D; Poschke I; Norell H; Malmberg K-J; Kiessling R
Article: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2007;56(7):973-984

A short-term dietary supplementation with high doses of vitamin E increases NK cell cytolytic activity in advanced colorectal cancer patients.

Hanson MGV; Ozenci V; Carlsten MCV; Glimelius BL; Frödin J-EA; Masucci G; Malmberg K-J; Kiessling RVR
Article: CANCER RESEARCH. 2007;67(3):1317-1325

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.

Carlsten M; Björkström NK; Norell H; Bryceson Y; van Hall T; Baumann BC; Hanson M; Schedvins K; Kiessling R; Ljunggren H-G; Malmberg K-J
Article: CANCER RESEARCH. 2006;66(12):6387-6394

Frequent loss of HLA-A2 expression in metastasizing ovarian carcinomas associated with genomic haplotype loss and HLA-A2-restricted HER-2/neu-specific immunity.

Norell H; Carlsten M; Ohlum T; Malmberg K-J; Masucci G; Schedvins K; Altermann W; Handke D; Atkins D; Seliger B; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 2005;174(10):6080-6087

Preferential cell death of CD8+ effector memory (CCR7-CD45RA-) T cells by hydrogen peroxide-induced oxidative stress.

Takahashi A; Hanson MGV; Norell HR; Havelka AM; Kono K; Malmberg K-J; Kiessling RVR
Article: TRANSPLANTATION. 2004;78(7):1081-1085

Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation.

Schaffer M; Malmberg K-J; Ringdén O; Ljunggren H-G; Remberger M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2002;110(10):1515-1523

IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.

Malmberg K-J; Levitsky V; Norell H; de Matos CT; Carlsten M; Schedvins K; Rabbani H; Moretta A; Söderström K; Levitskaya J; Kiessling R
Article: CLINICAL CANCER RESEARCH. 2002;8(6):1772-1778

A short-term dietary supplementation of high doses of vitamin E increases T helper 1 cytokine production in patients with advanced colorectal cancer.

Malmberg K-J; Lenkei R; Petersson M; Ohlum T; Ichihara F; Glimelius B; Frödin J-E; Masucci G; Kiessling R
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(12):3602-3611

The identification of a common pathogen-specific HLA class I A*0201-restricted cytotoxic T cell epitope encoded within the heat shock protein 65.

Charo J; Geluk A; Sundbäck M; Mirzai B; Diehl AD; Malmberg KJ; Achour A; Huriguchi S; van Meijgaarden KE; Drijfhout JW; Beekman N; van Veelen P; Ossendorp F; Ottenhoff TH; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 2001;167(5):2595-2601

Inhibition of activated/memory (CD45RO(+)) T cells by oxidative stress associated with block of NF-kappaB activation.

Malmberg KJ; Arulampalam V; Ichihara F; Petersson M; Seki K; Andersson T; Lenkei R; Masucci G; Pettersson S; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 1999;163(2):1037-1044

Identification of new HER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas.

Rongcun Y; Salazar-Onfray F; Charo J; Malmberg KJ; Evrin K; Maes H; Kono K; Hising C; Petersson M; Larsson O; Lan L; Appella E; Sette A; Celis E; Kiessling R
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Review: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):205-220

Advances in immune therapies in hematological malignancies.

Mazzarella L; Enblad G; Olweus J; Malmberg K-J; Jerkeman M
Review: CANCERS. 2020;12(12):E3719-3719

Prospects for NK Cell Therapy of Sarcoma.

Lachota M; Vincenti M; Winiarska M; Boye K; Zagożdżon R; Malmberg K-J
Editorial comment: CELL CALCIUM. 2020;92:102289

Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis.

Patel S; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:812

Deciphering Natural Killer Cell Homeostasis.

Pfefferle A; Jacobs B; Haroun-Izquierdo A; Kveberg L; Sohlberg E; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:753

TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells.

Clement D; Goodridge JP; Grimm C; Patel S; Malmberg K-J
Review: SEMINARS IN IMMUNOPATHOLOGY. 2019;41(1):59-68

Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells.

Saetersmoen ML; Hammer Q; Valamehr B; Kaufman DS; Malmberg K-J
Review: CYTOKINE & GROWTH FACTOR REVIEWS. 2018;44:1-10

Innovative therapy, monoclonal antibodies, and beyond: Highlights from the eighth annual meeting.

De Santis F; Del Vecchio M; Castagnoli L; De Braud F; Di Cosimo S; Franceschini D; Fucà G; Hiscott J; Malmberg KJ; McGranahan N; Pietrantonio F; Rivoltini L; Sangaletti S; Tagliabue E; Tripodo C; Vernieri C; Zitvogel L; Pupa SM; Di Nicola M
Review: CURRENT PHARMACEUTICAL DESIGN. 2017;23(32):4716-4725

Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery.

Clancy T; Dannenfelser R; Troyanskaya O; Malmberg KJ; Hovig E; Kristensen V
Review: IMMUNOGENETICS. 2017;69(8-9):547-556

Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition.

Malmberg K-J; Sohlberg E; Goodridge JP; Ljunggren H-G
Review: SEMINARS IN IMMUNOLOGY. 2017;31:20-29

Natural killer cell-mediated immunosurveillance of human cancer.

Malmberg K-J; Carlsten M; Björklund A; Sohlberg E; Bryceson YT; Ljunggren H-G
Review: MOLECULAR ONCOLOGY. 2015;9(10):1904-1917

Harnessing adaptive natural killer cells in cancer immunotherapy.

Liu LL; Pfefferle A; Yi Sheng VO; Björklund AT; Béziat V; Goodridge JP; Malmberg K-J
Review: IMMUNOLOGICAL REVIEWS. 2015;267(1):197-213

Newtonian cell interactions shape natural killer cell education.

Goodridge JP; Önfelt B; Malmberg K-J
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196

Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation.

Béziat V; Traherne J; Malmberg J-A; Ivarsson MA; Björkström NK; Retière C; Ljunggren H-G; Michaëlsson J; Trowsdale J; Malmberg K-J
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(12):3141-3145

Spotlight on NKG2C and the human NK-cell response to CMV infection.

Malmberg K-J; Beziat V; Ljunggren H-G
Other: IMMUNITY. 2011;35(5):653-657

Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation.

Malmberg K-J; Michaëlsson J; Parham P; Ljunggren H-G
Editorial comment: HLA. 2010;76(1):74-75

Identification of a novel KIR3DL1*072 allele by sequence-based typing.

Schellekens J; Schaffer M; Malmberg K-J; Madrigal JA; Marsh SGE
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1309-1315

Tolerant and diverse natural killer cell repertoires in the absence of selection.

Andersson S; Malmberg J-A; Malmberg K-J
Review: INTERNATIONAL JOURNAL OF CANCER. 2009;124(4):757-762

Natural killer cell-mediated lysis of freshly isolated human tumor cells.

Carlsten M; Malmberg K-J; Ljunggren H-G
Editorial comment: NATURE IMMUNOLOGY. 2009;10(1):11-12

Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes.

Malmberg K-J; Ljunggren H-G
Published conference paper: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2008;57(10):1541-1552

NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy.

Malmberg K-J; Bryceson YT; Carlsten M; Andersson S; Björklund A; Björkström NK; Baumann BC; Fauriat C; Alici E; Dilber MS; Ljunggren H-G
Review: NATURE REVIEWS IMMUNOLOGY. 2007;7(5):329-339

Prospects for the use of NK cells in immunotherapy of human cancer.

Ljunggren H-G; Malmberg K-J
Meeting abstract: HUMAN IMMUNOLOGY. 2006;67(10):S129

KIR-HLA mismatch in T-cell replete HLA-identical sibling hematopoietic stem cell transplantation for acute myelogenous leukemia

Schaffer M; Remberger M; Ringden O; Ljunggren H-G; Malmberg K-J
Review: SEMINARS IN CANCER BIOLOGY. 2006;16(1):16-31

Escape from immune- and nonimmune-mediated tumor surveillance.

Malmberg K-J; Ljunggren H-G
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):531-534

KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation.

Malmberg K-J; Schaffer M; Ringdén O; Remberger M; Ljunggren H-G
Review: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2004;53(10):879-892

Effective immunotherapy against cancer: a question of overcoming immune suppression and immune escape?

Malmberg K-J
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Anställningar

Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-

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Docent, Experimentell hematologi, Karolinska Institutet, 2009
MEDICINE DOKTORSEXAMEN, Institutionen för onkologi-patologi, Karolinska Institutet, 2003
Läkarexamen, Karolinska Institutet, 2000

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