Juleen Zierath

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About me

Research group leader for the group Integrative Physiology at the Department of Physiology and Pharmacology and at the Department of Molecular Medicine and Surgery.

Articles

Journal article: CELL METABOLISM. 2024;36(2):278-300

Exercise induces tissue-specific adaptations to enhance cardiometabolic health.

Ashcroft SP; Stocks B; Egan B; Zierath JR
Article: CELL METABOLISM. 2023;35(10):1722-1735.e5

Seasonal light hours modulate peripheral clocks and energy metabolism in mice.

Small L; Lundell LS; Iversen J; Ehrlich AM; Dall M; Basse AL; Dalbram E; Hansen AN; Treebak JT; Barrès R; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2220102120

NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner.

Basse AL; Nielsen KN; Karavaeva I; Ingerslev LR; Ma T; Havelund JF; Nielsen TS; Frost M; Peics J; Dalbram E; Dall M; Zierath JR; Barrès R; Færgeman NJ; Treebak JT; Gerhart-Hines Z
Article: STAR PROTOCOLS. 2023;4(1):101985

Protocol to assess arteriovenous differences across the liver and hindlimb muscles in mice following treadmill exercise.

Ashcroft SP; Jepsen SL; Ehrlich AM; Treebak JT; Holst JJ; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(8):e2218510120

Time of day determines postexercise metabolism in mouse adipose tissue.

Pendergrast LA; Lundell LS; Ehrlich AM; Ashcroft SP; Schönke M; Basse AL; Krook A; Treebak JT; Dollet L; Zierath JR
Article: GEROSCIENCE. 2023;45(1):569-589

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary.

Erickson ML; Allen JM; Beavers DP; Collins LM; Davidson KW; Erickson KI; Esser KA; Hesselink MKC; Moreau KL; Laber EB; Peterson CA; Peterson CM; Reusch JE; Thyfault JP; Youngstedt SD; Zierath JR; Goodpaster BH; LeBrasseur NK; Buford TW; Sparks LM
Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598

Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers.

Pillon NJ; Sardón Puig L; Altıntaş A; Kamble PG; Casaní-Galdón S; Gabriel BM; Barrès R; Conesa A; Chibalin AV; Näslund E; Krook A; Zierath JR
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2022;135:155268

Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial.

Savikj M; Stocks B; Sato S; Caidahl K; Krook A; Deshmukh AS; Zierath JR; Wallberg-Henriksson H
Article: SCIENCE ADVANCES. 2022;8(36):eabo3192

Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes.

Pillon NJ; Smith JAB; Alm PS; Chibalin AV; Alhusen J; Arner E; Carninci P; Fritz T; Otten J; Olsson T; van Doorslaer de Ten Ryen S; Deldicque L; Caidahl K; Wallberg-Henriksson H; Krook A; Zierath JR
Article: NATURE GENETICS. 2022;54(9):1332-1344

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Wang Z; Emmerich A; Pillon NJ; Moore T; Hemerich D; Cornelis MC; Mazzaferro E; Broos S; Ahluwalia TS; Bartz TM; Bentley AR; Bielak LF; Chong M; Chu AY; Berry D; Dorajoo R; Dueker ND; Kasbohm E; Feenstra B; Feitosa MF; Gieger C; Graff M; Hall LM; Haller T; Hartwig FP; Hillis DA; Huikari V; Heard-Costa N; Holzapfel C; Jackson AU; Johansson Å; Jørgensen AM; Kaakinen MA; Karlsson R; Kerr KF; Kim B; Koolhaas CM; Kutalik Z; Lagou V; Lind PA; Lorentzon M; Lyytikäinen L-P; Mangino M; Metzendorf C; Monroe KR; Pacolet A; Pérusse L; Pool R; Richmond RC; Rivera NV; Robiou-du-Pont S; Schraut KE; Schulz C-A; Stringham HM; Tanaka T; Teumer A; Turman C; van der Most PJ; Vanmunster M; van Rooij FJA; van Vliet-Ostaptchouk JV; Zhang X; Zhao J-H; Zhao W; Balkhiyarova Z; Balslev-Harder MN; Baumeister SE; Beilby J; Blangero J; Boomsma DI; Brage S; Braund PS; Brody JA; Bruinenberg M; Ekelund U; Liu C-T; Cole JW; Collins FS; Cupples LA; Esko T; Enroth S; Faul JD; Fernandez-Rhodes L; Fohner AE; Franco OH; Galesloot TE; Gordon SD; Grarup N; Hartman CA; Heiss G; Hui J; Illig T; Jago R; James A; Joshi PK; Jung T; Kähönen M; Kilpeläinen TO; Koh W-P; Kolcic I; Kraft PP; Kuusisto J; Launer LJ; Li A; Linneberg A; Luan J; Vidal PM; Medland SE; Milaneschi Y; Moscati A; Musk B; Nelson CP; Nolte IM; Pedersen NL; Peters A; Peyser PA; Power C; Raitakari OT; Reedik M; Reiner AP; Ridker PM; Rudan I; Ryan K; Sarzynski MA; Scott LJ; Scott RA; Sidney S; Siggeirsdottir K; Smith AV; Smith JA; Sonestedt E; Strøm M; Tai ES; Teo KK; Thorand B; Tönjes A; Tremblay A; Uitterlinden AG; Vangipurapu J; van Schoor N; Völker U; Willemsen G; Williams K; Wong Q; Xu H; Young KL; Yuan JM; Zillikens MC; Zonderman AB; Ameur A; Bandinelli S; Bis JC; Boehnke M; Bouchard C; Chasman DI; Smith GD; de Geus EJC; Deldicque L; Dörr M; Evans MK; Ferrucci L; Fornage M; Fox C; Garland T; Gudnason V; Gyllensten U; Hansen T; Hayward C; Horta BL; Hyppönen E; Jarvelin M-R; Johnson WC; Kardia SLR; Kiemeney LA; Laakso M; Langenberg C; Lehtimäki T; Marchand LL; Lifelines Cohort Study; Magnusson PKE; Martin NG; Melbye M; Metspalu A; Meyre D; North KE; Ohlsson C; Oldehinkel AJ; Orho-Melander M; Pare G; Park T; Pedersen O; Penninx BWJH; Pers TH; Polasek O; Prokopenko I; Rotimi CN; Samani NJ; Sim X; Snieder H; Sørensen TIA; Spector TD; Timpson NJ; van Dam RM; van der Velde N; van Duijn CM; Vollenweider P; Völzke H; Voortman T; Waeber G; Wareham NJ; Weir DR; Wichmann H-E; Wilson JF; Hevener AL; Krook A; Zierath JR; Thomis MAI; Loos RJF; Hoed MD
Article: DIABETES. 2022;71(4):624-636

Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes.

Dollet L; Kuefner M; Caria E; Rizo-Roca D; Pendergrast L; Abdelmoez AM; Karlsson HKR; Björnholm M; Dalbram E; Treebak JT; Harada J; Näslund E; Rydén M; Zierath JR; Pillon NJ; Krook A
Article: MOLECULAR & CELLULAR PROTEOMICS. 2022;21(3):100207

Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation.

Stocks B; Gonzalez-Franquesa A; Borg ML; Björnholm M; Niu L; Zierath JR; Deshmukh AS
Article: MOLECULAR METABOLISM. 2022;57:101440

Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice.

Small L; Ehrlich A; Iversen J; Ashcroft SP; Trošt K; Moritz T; Hartmann B; Holst JJ; Treebak JT; Zierath JR; Barrès R
Article: NATURE METABOLISM. 2022;4(2):190-202

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation.

Maqdasy S; Lecoutre S; Renzi G; Frendo-Cumbo S; Rizo-Roca D; Moritz T; Juvany M; Hodek O; Gao H; Couchet M; Witting M; Kerr A; Bergo MO; Choudhury RP; Aouadi M; Zierath JR; Krook A; Mejhert N; Rydén M
Article: CELL METABOLISM. 2022;34(2):329-345.e8

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.

Sato S; Dyar KA; Treebak JT; Jepsen SL; Ehrlich AM; Ashcroft SP; Trost K; Kunzke T; Prade VM; Small L; Basse AL; Schönke M; Chen S; Samad M; Baldi P; Barrès R; Walch A; Moritz T; Holst JJ; Lutter D; Zierath JR; Sassone-Corsi P
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(2):353-368

Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine.

Kanaley JA; Colberg SR; Corcoran MH; Malin SK; Rodriguez NR; Crespo CJ; Kirwan JP; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2021;321(5):C770-C778

Discovery of thymosin β4 as a human exerkine and growth factor.

Gonzalez-Franquesa A; Stocks B; Borg ML; Kuefner M; Dalbram E; Nielsen TS; Agrawal A; Pankratova S; Chibalin AV; Karlsson HKR; Gheibi S; Björnholm M; Jørgensen NR; Clemmensen C; Hostrup M; Treebak JT; Krook A; Zierath JR; Deshmukh AS
Article: MOLECULAR METABOLISM. 2021;53:101290

Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health.

Williams K; Carrasquilla GD; Ingerslev LR; Hochreuter MY; Hansson S; Pillon NJ; Donkin I; Versteyhe S; Zierath JR; Kilpeläinen TO; Barrès R
Article: SCIENCE ADVANCES. 2021;7(43):eabi9654

Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle.

Gabriel BM; Altıntaş A; Smith JAB; Sardon-Puig L; Zhang X; Basse AL; Laker RC; Gao H; Liu Z; Dollet L; Treebak JT; Zorzano A; Huo Z; Rydén M; Lanner JT; Esser KA; Barrès R; Pillon NJ; Krook A; Zierath JR
Article: NATURE COMMUNICATIONS. 2021;12(1):5948

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.

Massart J; Sjögren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barrès R; O'Gorman DJ; Zierath JR; Krook A
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2021;12(5):1232-1248

Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance.

Borg ML; Massart J; De Castro Barbosa T; Archilla-Ortega A; Smith JAB; Lanner JT; Alsina-Fernandez J; Yaden B; Culver AE; Karlsson HKR; Brozinick JT; Zierath JR
Article: DIABETOLOGIA. 2021;64(9):2077-2091

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes.

Sjögren RJO; Rizo-Roca D; Chibalin AV; Chorell E; Furrer R; Katayama S; Harada J; Karlsson HKR; Handschin C; Moritz T; Krook A; Näslund E; Zierath JR
Article: PROTEOMES. 2021;9(3):37

Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome.

Gonzalez-Franquesa A; Peijs L; Cervone DT; Koçana C; Zierath JR; Deshmukh AS
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2021;321(2):E203-E216

Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity.

Smith JAB; Savikj M; Sethi P; Platt S; Gabriel BM; Hawley JA; Dunstan D; Krook A; Zierath JR; Näslund E
Article: CELL REPORTS. 2021;35(8):109180

Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity.

Gonzalez-Franquesa A; Stocks B; Chubanava S; Hattel HB; Moreno-Justicia R; Peijs L; Treebak JT; Zierath JR; Deshmukh AS
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2021;118:154726

Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study.

Karlsson HKR; Kasahara A; Ikeda M; Chibalin AV; Harada J; Rydén M; Krook A; Kato M; Kubota K; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:619447

The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle.

Maasar M-F; Turner DC; Gorski PP; Seaborne RA; Strauss JA; Shepherd SO; Cocks M; Pillon NJ; Zierath JR; Hulton AT; Drust B; Sharples AP
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(24):5739-5752

Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway.

Small L; Altıntaş A; Laker RC; Ehrlich A; Pattamaprapanont P; Villarroel J; Pillon NJ; Zierath JR; Barrès R
Article: CELL METABOLISM. 2020;32(5):844-859.e5

A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes.

Batista TM; Jayavelu AK; Wewer Albrechtsen NJ; Iovino S; Lebastchi J; Pan H; Dreyfuss JM; Krook A; Zierath JR; Mann M; Kahn CR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(38):23932-23941

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.

Brandão BB; Madsen S; Rabiee A; Oliverio M; Ruiz GP; Ferrucci DL; Branquinho JL; Razolli D; Pinto S; Nielsen TS; Festuccia WT; Martins AS; Guerra BA; Knittel TL; Søgaard D; Larsen S; Helge JW; Brandauer J; Velloso LA; Emanuelli B; Kornfeld J-W; Kahn CR; Vienberg SG; Zierath JR; Treebak JT; Mori MA
Article: NATURE COMMUNICATIONS. 2020;11(1):4643

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.

Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altıntaş A; Sato S; Sassone-Corsi P; Barrès R; Zierath JR; Hawley JA
Article: EPIGENOMICS. 2020;12(8):701-713

Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development.

Altıntaş A; Laker RC; Garde C; Barrès R; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2020;318(3):C615-C626

Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism.

Abdelmoez AM; Sardón Puig L; Smith JAB; Gabriel BM; Savikj M; Dollet L; Chibalin AV; Krook A; Zierath JR; Pillon NJ
Article: NATURE COMMUNICATIONS. 2020;11(1):470

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.

Pillon NJ; Gabriel BM; Dollet L; Smith JAB; Sardón Puig L; Botella J; Bishop DJ; Krook A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2020;318(1):E1-E10

Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression.

Sardon Puig L; Pillon NJ; Näslund E; Krook A; Zierath JR
Article: HEPATOLOGY RESEARCH. 2019;49(12):1451-1465

Identification of two microRNA nodes as potential cooperative modulators of liver metabolism.

Hochreuter MY; Altıntaş A; Garde C; Emanuelli B; Kahn CR; Zierath JR; Vienberg S; Barrès R
Article: FASEB JOURNAL. 2019;33(9):10551-10562

Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation.

Aoi W; Hirano N; Lassiter DG; Björnholm M; Chibalin AV; Sakuma K; Tanimura Y; Mizushima K; Takagi T; Naito Y; Zierath JR; Krook A
Article: CELL METABOLISM. 2019;30(1):92-110.e4

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis.

Sato S; Basse AL; Schönke M; Chen S; Samad M; Altıntaş A; Laker RC; Dalbram E; Barrès R; Baldi P; Treebak JT; Zierath JR; Sassone-Corsi P
Article: DIABETES. 2019;68(7):1403-1414

Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice.

Borg ML; Massart J; Schönke M; De Castro Barbosa T; Guo L; Wade M; Alsina-Fernandez J; Miles R; Ryan A; Bauer S; Coskun T; O'Farrell E; Niemeier EM; Chibalin AV; Krook A; Karlsson HK; Brozinick JT; Zierath JR
Article: FASEB JOURNAL. 2019;33(5):6269-6280

Paternal high-fat diet transgenerationally impacts hepatic immunometabolism.

de Castro Barbosa T; Alm PS; Krook A; Barrès R; Zierath JR
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2019;126(4):993-1005

Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action.

Dalbram E; Basse AL; Zierath JR; Treebak JT
Article: JOURNAL OF NUTRITION AND METABOLISM. 2019;2019:1840374-8

Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers.

Lundström P; Caidahl K; Eriksson MJ; Fritz T; Krook A; Zierath JR; Rickenlund A
Article: DIABETES. 2019;68(3):515-526

Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle.

Katayama M; Wiklander OPB; Fritz T; Caidahl K; El-Andaloussi S; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2019;316(2):E178-E185

Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults.

Nylén C; Lundell LS; Massart J; Zierath JR; Näslund E
Article: MOLECULAR METABOLISM. 2019;20:79-88

Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle.

Lundell LS; Massart J; Altıntaş A; Krook A; Zierath JR
Article: DIABETOLOGIA. 2019;62(2):233-237

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial.

Savikj M; Gabriel BM; Alm PS; Smith J; Caidahl K; Björnholm M; Fritz T; Krook A; Zierath JR; Wallberg-Henriksson H
Article: MOLECULAR METABOLISM. 2018;16:12-23

AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle.

Lassiter DG; Sjögren RJO; Gabriel BM; Krook A; Zierath JR
Article: JOURNAL OF OBESITY. 2018;2018:7461903-8

Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus.

Mashili FL; Ramaiya K; Lutale J; Njelekela M; Francis F; Zierath J; Krook A
Article: SCIENCE ADVANCES. 2018;4(8):eaar8590

Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans.

Cedernaes J; Schönke M; Westholm JO; Mi J; Chibalin A; Voisin S; Osler M; Vogel H; Hörnaeus K; Dickson SL; Lind SB; Bergquist J; Schiöth HB; Zierath JR; Benedict C
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1148-1163

Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells.

Pillon NJ; Frendo-Cumbo S; Jacobson MR; Liu Z; Milligan PL; Hoang Bui H; Zierath JR; Bilan PJ; Brozinick JT; Klip A
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1276-1282

Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism.

Schönke M; Massart J; Zierath JR
Article: ACTA PHYSIOLOGICA. 2018;223(3):e13051

Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury.

Lundell LS; Savikj M; Kostovski E; Iversen PO; Zierath JR; Krook A; Chibalin AV; Widegren U
Article: PHYSIOLOGICAL REPORTS. 2018;6(12):e13739

Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals.

Savikj M; Ruby MA; Kostovski E; Iversen PO; Zierath JR; Krook A; Widegren U
Article: PROTEOMICS. 2018;18(5-6):e1700375

Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition.

Schönke M; Björnholm M; Chibalin AV; Zierath JR; Deshmukh AS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(9):E2048-E2057

The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.

Younis S; Schönke M; Massart J; Hjortebjerg R; Sundström E; Gustafson U; Björnholm M; Krook A; Frystyk J; Zierath JR; Andersson L
Article: JOURNAL OF LIPID RESEARCH. 2018;59(2):273-282

Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet.

Nascimento EBM; Mannerås-Holm L; Chibalin AV; Björnholm M; Zierath JR
Article: DIABETOLOGIA. 2018;61(2):424-432

FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle.

Lassiter DG; Nylén C; Sjögren RJO; Chibalin AV; Wallberg-Henriksson H; Näslund E; Krook A; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1198

Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status.

Basse AL; Dalbram E; Larsson L; Gerhart-Hines Z; Zierath JR; Treebak JT
Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2324-2333

DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.

Benziane B; Borg ML; Tom RZ; Riedl I; Massart J; Björnholm M; Gilbert M; Chibalin AV; Zierath JR
Article: SCIENTIFIC REPORTS. 2017;7(1):15134

Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans.

Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barrès R
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2017;313(4):E483-E491

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle.

Ruby MA; Riedl I; Massart J; Åhlin M; Zierath JR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2017;595(14):4611-4630

Early vertebrate origin and diversification of small transmembrane regulators of cellular ion transport.

Pirkmajer S; Kirchner H; Lundell LS; Zelenin PV; Zierath JR; Makarova KS; Wolf YI; Chibalin AV
Article: DIABETES. 2017;66(7):1807-1818

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle.

Massart J; Sjögren RJO; Lundell LS; Mudry JM; Franck N; O'Gorman DJ; Egan B; Zierath JR; Krook A
Article: MOLECULAR METABOLISM. 2017;6(7):621-630

Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle.

Alm PS; de Castro Barbosa T; Barrès R; Krook A; Zierath JR
Article: JOURNAL OF LIPID RESEARCH. 2017;58(5):907-915

Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice.

Mannerås-Holm L; Schönke M; Brozinick JT; Vetterli L; Bui H-H; Sanders P; Nascimento EBM; Björnholm M; Chibalin AV; Zierath JR
Article: DIABETES. 2017;66(3):651-662

Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.

Mudry JM; Lassiter DG; Nylén C; García-Calzón S; Näslund E; Krook A; Zierath JR
Article: DIABETES. 2017;66(3):598-612

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Kjøbsted R; Munk-Hansen N; Birk JB; Foretz M; Viollet B; Björnholm M; Zierath JR; Treebak JT; Wojtaszewski JFP
Article: CELL REPORTS. 2017;18(3):636-646

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Ruby MA; Massart J; Hunerdosse DM; Schönke M; Correia JC; Louie SM; Ruas JL; Näslund E; Nomura DK; Zierath JR
Article: PLOS MEDICINE. 2016;13(11):e1002179

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA; Scott RA; Sharp SJ; Burgess S; Luan J; Tillin T; Schmidt AF; Imamura F; Stewart ID; Perry JRB; Marney L; Koulman A; Karoly ED; Forouhi NG; Sjögren RJO; Näslund E; Zierath JR; Krook A; Savage DB; Griffin JL; Chaturvedi N; Hingorani AD; Khaw K-T; Barroso I; McCarthy MI; O'Rahilly S; Wareham NJ; Langenberg C
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.

Mudry JM; Alm PS; Erhardt S; Goiny M; Fritz T; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2016;310(6):E461-E472

AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload.

Riedl I; Osler ME; Björnholm M; Egan B; Nader GA; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):171-183

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients.

Kirchner H; Sinha I; Gao H; Ruby MA; Schönke M; Lindvall JM; Barrès R; Krook A; Näslund E; Dahlman-Wright K; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):184-197

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.

de Castro Barbosa T; Ingerslev LR; Alm PS; Versteyhe S; Massart J; Rasmussen M; Donkin I; Sjögren R; Mudry JM; Vetterli L; Gupta S; Krook A; Zierath JR; Barrès R
Article: CELL METABOLISM. 2016;23(2):369-378

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans.

Donkin I; Versteyhe S; Ingerslev LR; Qian K; Mechta M; Nordkap L; Mortensen B; Appel EVR; Jørgensen N; Kristiansen VB; Hansen T; Workman CT; Zierath JR; Barrès R
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2016;310(1):E51-E60

Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics.

Jiang LQ; de Castro Barbosa T; Massart J; Deshmukh AS; Löfgren L; Duque-Guimaraes DE; Ozilgen A; Osler ME; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2015;4(12):891-902

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.

Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martínez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Björnholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: PHYSIOLOGICAL REPORTS. 2015;3(11):e12622

MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression.

Boon H; Sjögren RJO; Massart J; Egan B; Kostovski E; Iversen PO; Hjeltnes N; Chibalin AV; Widegren U; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2015;309(7):E679-E690

Skeletal muscle AMP-activated protein kinase γ1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity.

Schönke M; Myers MG; Zierath JR; Björnholm M
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(6):643-655

Effects of sleeping with reduced carbohydrate availability on acute training responses.

Lane SC; Camera DM; Lassiter DG; Areta JL; Bird SR; Yeo WK; Jeacocke NA; Krook A; Zierath JR; Burke LM; Hawley JA
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(9):E1255-E1261

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.

Cedernaes J; Osler ME; Voisin S; Broman J-E; Vogel H; Dickson SL; Zierath JR; Schiöth HB; Benedict C
Article: DIABETES & VASCULAR DISEASE RESEARCH. 2015;12(5):315-324

Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance.

Ring M; Eriksson MJ; Fritz T; Nyberg G; Östenson CG; Krook A; Zierath JR; Caidahl K
Article: DIABETES CARE. 2015;38(6):1154-1160

Changes in gene expression in responders and nonresponders to a low-intensity walking intervention.

Osler ME; Fritz T; Caidahl K; Krook A; Zierath JR; Wallberg-Henriksson H
Article: DIABETES. 2015;64(6):2042-2055

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

Kjøbsted R; Treebak JT; Fentz J; Lantier L; Viollet B; Birk JB; Schjerling P; Björnholm M; Zierath JR; Wojtaszewski JFP
Article: PHYSIOLOGICAL REPORTS. 2015;3(4):e12372

mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.

Mannerås-Holm L; Kirchner H; Björnholm M; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL REPORTS. 2015;3(3):e12314

Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle.

Riedl I; Osler ME; Benziane B; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2015;47(3):45-57

Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells.

Sjögren RJO; Egan B; Katayama M; Zierath JR; Krook A
Article: DIABETES. 2015;64(2):360-369

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation.

Pirkmajer S; Kulkarni SS; Tom RZ; Ross FA; Hawley SA; Hardie DG; Zierath JR; Chibalin AV
Article: CELL METABOLISM. 2015;21(1):138-149

Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.

Multhaup ML; Seldin MM; Jaffe AE; Lei X; Kirchner H; Mondal P; Li Y; Rodriguez V; Drong A; Hussain M; Lindgren C; McCarthy M; Näslund E; Zierath JR; Wong GW; Feinberg AP
Article: HYPERTENSION RESEARCH. 2014;37(11):999-1007

Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques.

Ring M; Eriksson MJ; Zierath JR; Caidahl K
Article: CELL. 2014;159(1):33-45

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Agudelo LZ; Femenía T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: NATURE. 2014;512(7513):190-193

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.

Moltke I; Grarup N; Jørgensen ME; Bjerregaard P; Treebak JT; Fumagalli M; Korneliussen TS; Andersen MA; Nielsen TS; Krarup NT; Gjesing AP; Zierath JR; Linneberg A; Wu X; Sun G; Jin X; Al-Aama J; Wang J; Borch-Johnsen K; Pedersen O; Nielsen R; Albrechtsen A; Hansen T
Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2014;10(4):671-678

Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass.

Kirchner H; Nylen C; Laber S; Barrès R; Yan J; Krook A; Zierath JR; Näslund E
Article: BMC RESEARCH NOTES. 2014;7:391

A simple and rapid method to characterize lipid fate in skeletal muscle.

Massart J; Zierath JR; Chibalin AV
Article: DIABETES. 2014;63(5):1560-1571

Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice.

Zachariah Tom R; Garcia-Roves PM; Sjögren RJO; Jiang LQ; Holmström MH; Deshmukh AS; Vieira E; Chibalin AV; Björnholm M; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1408-E1414

Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle.

Nascimento EB; Osler ME; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1359-E1366

Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7.

Jiang LQ; Franck N; Egan B; Sjögren RJO; Katayama M; Duque-Guimaraes D; Arner P; Zierath JR; Krook A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2013;591(20):5207-5220

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle.

Brandauer J; Vienberg SG; Andersen MA; Ringholm S; Risis S; Larsen PS; Kristensen JM; Frøsig C; Leick L; Fentz J; Jørgensen S; Kiens B; Wojtaszewski JFP; Richter EA; Zierath JR; Goodyear LJ; Pilegaard H; Treebak JT
Article: ENDOCRINOLOGY. 2013;154(10):3502-3514

Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.

Dokas J; Chadt A; Nolden T; Himmelbauer H; Zierath JR; Joost H-G; Al-Hasani H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2013;591(18):4637-4653

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training.

Russell AP; Lamon S; Boon H; Wada S; Güller I; Brown EL; Chibalin AV; Zierath JR; Snow RJ; Stepto N; Wadley GD; Akimoto T
Article: FASEB JOURNAL. 2013;27(9):3660-3671

Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet.

Cansby E; Amrutkar M; Mannerås Holm L; Nerstedt A; Reyahi A; Stenfeldt E; Borén J; Carlsson P; Smith U; Zierath JR; Mahlapuu M
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2013;62(9):1258-1267

Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice.

Holmström MH; Tom RZ; Björnholm M; Garcia-Roves PM; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2013;45(9):367-376

Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight.

Ka S; Markljung E; Ring H; Albert FW; Harun-Or-Rashid M; Wahlberg P; Garcia-Roves PM; Zierath JR; Denbow DM; Pääbo S; Siegel PB; Andersson L; Hallböök F
Article: CELL REPORTS. 2013;3(4):1020-1027

Weight loss after gastric bypass surgery in human obesity remodels promoter methylation.

Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Näslund E; Zierath JR
Article: DIABETES. 2013;62(2):355-361

Altered response of skeletal muscle to IL-6 in type 2 diabetic patients.

Jiang LQ; Duque-Guimaraes DE; Machado UF; Zierath JR; Krook A
Article: DIABETES. 2013;62(2):457-465

Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes.

Mashili F; Chibalin AV; Krook A; Zierath JR
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2013;62(1):79-89

L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway.

de Castro Barbosa T; Jiang LQ; Zierath JR; Nunes MT
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2013;29(1):25-32

Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance.

Fritz T; Caidahl K; Krook A; Lundström P; Mashili F; Osler M; Szekeres FLM; Östenson CG; Wändell P; Zierath JR
Article: PLOS ONE. 2013;8(9):e74098

Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle.

Egan B; O'Connor PL; Zierath JR; O'Gorman DJ
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;303(4):E524-E533

The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.

Szekeres F; Chadt A; Tom RZ; Deshmukh AS; Chibalin AV; Björnholm M; Al-Hasani H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(28):23451-23463

Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells.

Benziane B; Björnholm M; Pirkmajer S; Austin RL; Kotova O; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;302(6):E731-E739

Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.

Holmström MH; Iglesias-Gutierrez E; Zierath JR; Garcia-Roves PM
Article: CELL METABOLISM. 2012;15(3):405-411

Acute exercise remodels promoter methylation in human skeletal muscle.

Barrès R; Yan J; Egan B; Treebak JT; Rasmussen M; Fritz T; Caidahl K; Krook A; O'Gorman DJ; Zierath JR
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2012;61(2):175-185

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus.

Kulkarni SS; Salehzadeh F; Fritz T; Zierath JR; Krook A; Osler ME
Article: DIABETIC MEDICINE. 2011;28(11):1362-1372

Effects of Nordic walking on health-related quality of life in overweight individuals with type 2 diabetes mellitus, impaired or normal glucose tolerance.

Fritz T; Caidahl K; Osler M; Ostenson CG; Zierath JR; Wändell P
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(18):2555-2561

Evidence for non-CpG methylation in mammals.

Yan J; Zierath JR; Barrès R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(40):34567-34574

Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.

Kulkarni SS; Karlsson HKR; Szekeres F; Chibalin AV; Krook A; Zierath JR
Article: PROTEOMICS. 2011;11(8):1413-1428

2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training.

Egan B; Dowling P; O'Connor PL; Henry M; Meleady P; Zierath JR; O'Gorman DJ
Article: DIABETOLOGIA. 2011;54(4):795-802

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

Hribal ML; Presta I; Procopio T; Marini MA; Stančáková A; Kuusisto J; Andreozzi F; Hammarstedt A; Jansson P-A; Grarup N; Hansen T; Walker M; Stefan N; Fritsche A; Häring HU; Pedersen O; Smith U; Laakso M; Sesti G; EUGENE2 Consortium
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2011;27(3):286-297

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity.

Mashili FL; Austin RL; Deshmukh AS; Fritz T; Caidahl K; Bergdahl K; Zierath JR; Chibalin AV; Moller DE; Kharitonenkov A; Krook A
Article: THROMBOSIS AND HAEMOSTASIS. 2011;105(1):122-130

Strenuous physical exercise adversely affects monocyte chemotaxis.

Czepluch FS; Barrès R; Caidahl K; Olieslagers S; Krook A; Rickenlund A; Zierath JR; Waltenberger J
Article: DIABETOLOGIA. 2011;54(1):157-167

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

Vind BF; Pehmøller C; Treebak JT; Birk JB; Hey-Mogensen M; Beck-Nielsen H; Zierath JR; Wojtaszewski JFP; Højlund K
Article: JOURNAL OF BIOLOGICAL SYSTEMS. 2010;18(3):687-707

VALIDATION OF THE IN VITRO INCUBATION OF EXTENSOR DIGITORUM LONGUS MUSCLE FROM MICE WITH A MATHEMATICAL MODEL

Sogaard P; Harlen M; Long YC; Szekeres F; Barnes BR; Chibalin AV; Zierath JR
Article: MOLECULAR IMMUNOLOGY. 2010;47(14):2388-2396

The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells.

Feng X; Yan J; Wang Y; Zierath JR; Nordenskjöld M; Henter J-I; Fadeel B; Zheng C
Article: DIABETOLOGIA. 2010;53(6):1142-1150

Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle.

Deshmukh AS; Long YC; de Castro Barbosa T; Karlsson HKR; Glund S; Zavadoski WJ; Gibbs EM; Koistinen HA; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(Pt 10):1779-1790

Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle.

Egan B; Carson BP; Garcia-Roves PM; Chibalin AV; Sarsfield FM; Barron N; McCaffrey N; Moyna NM; Zierath JR; O'Gorman DJ
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2010;109(5):943-949

Spatial insulin signalling in isolated skeletal muscle preparations.

Sogaard P; Szekeres F; Garcia-Roves PM; Larsson D; Chibalin AV; Zierath JR
Article: CELL METABOLISM. 2010;11(3):213-219

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.

Cantó C; Jiang LQ; Deshmukh AS; Mataki C; Coste A; Lagouge M; Zierath JR; Auwerx J
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2010;298(1):E8-E16

Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

Jiang LQ; Garcia-Roves PM; de Castro Barbosa T; Zierath JR
Article: PLOS BIOLOGY. 2009;7(12):e1000256

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.

Markljung E; Jiang L; Jaffe JD; Mikkelsen TS; Wallerman O; Larhammar M; Zhang X; Wang L; Saenz-Vash V; Gnirke A; Lindroth AM; Barrés R; Yan J; Strömberg S; De S; Pontén F; Lander ES; Carr SA; Zierath JR; Kullander K; Wadelius C; Lindblad-Toh K; Andersson G; Hjälm G; Andersson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2009;297(6):C1554-C1566

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.

Benziane B; Björnholm M; Lantier L; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2009;297(6):E1388-E1394

Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle.

Deshmukh AS; Glund S; Tom RZ; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(44):30016-30023

Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation.

Peck GR; Chavez JA; Roach WG; Budnik BA; Lane WS; Karlsson HKR; Zierath JR; Lienhard GE
Article: DIABETOLOGIA. 2009;52(10):2182-2189

Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.

Rune A; Osler ME; Fritz T; Zierath JR
Article: CELL METABOLISM. 2009;10(3):189-198

Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

Barrès R; Osler ME; Yan J; Rune A; Fritz T; Caidahl K; Krook A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2009;296(5):E969-E972

Hunting for the SNARK in metabolic disease.

Egan B; Zierath JR
Article: DIABETOLOGIA. 2009;52(5):891-900

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Treebak JT; Frøsig C; Pehmøller C; Chen S; Maarbjerg SJ; Brandt N; MacKintosh C; Zierath JR; Hardie DG; Kiens B; Richter EA; Pilegaard H; Wojtaszewski JFP
Article: CIRCULATION RESEARCH. 2009;104(8):961-U97

T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice.

Sultan A; Strodthoff D; Robertson A-K; Paulsson-Berne G; Fauconnier J; Parini P; Rydén M; Thierry-Mieg N; Johansson ME; Chibalin AV; Zierath JR; Arner P; Hansson GK
Article: DIABETES. 2009;58(4):847-854

Kinetics of GLUT4 trafficking in rat and human skeletal muscle.

Karlsson HKR; Chibalin AV; Koistinen HA; Yang J; Koumanov F; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: ENDOCRINOLOGY. 2009;150(2):600-606

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

Glund S; Treebak JT; Long YC; Barres R; Viollet B; Wojtaszewski JF; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(51):35724-35734

Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle.

Garcia-Roves PM; Osler ME; Holmström MH; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2008;295(6):E1427-E1438

Divergent cell signaling after short-term intensified endurance training in human skeletal muscle.

Benziane B; Burton TJ; Scanlan B; Galuska D; Canny BJ; Chibalin AV; Zierath JR; Stepto NK
Article: NATURE GENETICS. 2008;40(11):1354-1359

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

Chadt A; Leicht K; Deshmukh A; Jiang LQ; Scherneck S; Bernhardt U; Dreja T; Vogel H; Schmolz K; Kluge R; Zierath JR; Hultschig C; Hoeben RC; Schürmann A; Joost H-G; Al-Hasani H
Article: JOURNAL OF ENDOCRINOLOGY. 2008;199(2):X1

The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms.

Lundholm L; Bryzgalova G; Gao H; Portwood N; Fält S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-Å; Efendic S; Dahlman-Wright K; Khan A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2008;295(5):E1032-E1037

Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

Vieira E; Nilsson EC; Nerstedt A; Ormestad M; Long YC; Garcia-Roves PM; Zierath JR; Mahlapuu M
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2008;24(7):554-562

Globular adiponectin stimulates glucose transport in type 2 diabetic muscle.

Kuoppamaa H; Skrobuk P; Sihvo M; Hiukka A; Chibalin AV; Zierath JR; Koistinen HA
Article: DIABETES. 2008;57(8):2066-2073

siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.

Austin RL; Rune A; Bouzakri K; Zierath JR; Krook A
Article: DIABETES. 2008;57(6):1508-1516

Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle.

Bouzakri K; Austin R; Rune A; Lassman ME; Garcia-Roves PM; Berger JP; Krook A; Chibalin AV; Zhang BB; Zierath JR
Article: CELL METABOLISM. 2008;7(6):545-554

Glutamate is a positive autocrine signal for glucagon release.

Cabrera O; Jacques-Silva MC; Speier S; Yang S-N; Köhler M; Fachado A; Vieira E; Zierath JR; Kibbey R; Berman DM; Kenyon NS; Ricordi C; Caicedo A; Berggren P-O
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2008;93(5):1924-1930

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

Stancáková A; Pihlajamäki J; Kuusisto J; Stefan N; Fritsche A; Häring H; Andreozzi F; Succurro E; Sesti G; Boesgaard TW; Hansen T; Pedersen O; Jansson PA; Hammarstedt A; Smith U; Laakso M; EUGENE2 Consortium
Article: MOLECULAR ENDOCRINOLOGY. 2008;22(5):1105-1112

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.

Deshmukh AS; Treebak JT; Long YC; Viollet B; Wojtaszewski JFP; Zierath JR
Article: DIABETOLOGIA. 2008;51(3):502-511

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.

Laakso M; Zilinskaite J; Hansen T; Boesgaard TW; Vänttinen M; Stancáková A; Jansson P-A; Pellmé F; Holst JJ; Kuulasmaa T; Hribal ML; Sesti G; Stefan N; Fritsche A; Häring H; Pedersen O; Smith U; EUGENE2 Consortium
Article: CELL. 2008;132(3):375-386

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

Chibalin AV; Leng Y; Vieira E; Krook A; Björnholm M; Long YC; Kotova O; Zhong Z; Sakane F; Steiler T; Nylén C; Wang J; Laakso M; Topham MK; Gilbert M; Wallberg-Henriksson H; Zierath JR
Article: EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM. 2007;2(4):477-485

Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes.

Krook A; Long YC; Zierath JR
Article: DIABETES. 2007;56(6):1630-1637

Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle.

Glund S; Deshmukh A; Long YC; Moller T; Koistinen HA; Caidahl K; Zierath JR; Krook A
Article: PLOS MEDICINE. 2007;4(5):e158-879

TXNIP regulates peripheral glucose metabolism in humans.

Parikh H; Carlsson E; Chutkow WA; Johansson LE; Storgaard H; Poulsen P; Saxena R; Ladd C; Schulze PC; Mazzini MJ; Jensen CB; Krook A; Björnholm M; Tornqvist H; Zierath JR; Ridderstråle M; Altshuler D; Lee RT; Vaag A; Groop LC; Mootha VK
Article: DIABETOLOGIA. 2007;50(5):1048-1057

Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor alpha/gamma agonist on glucose uptake.

Hu X; Feng Y; Liu X; Zhao X-F; Yu J-H; Yang Y-S; Sydow-Bäckman M; Hörling J; Zierath JR; Leng Y
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(11):7783-7789

MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance.

Bouzakri K; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(3):1607-1614

Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression.

Long YC; Glund S; Garcia-Roves PM; Zierath JR
Article: DIABETOLOGIA. 2006;49(12):2983-2992

Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes.

O'Gorman DJ; Karlsson HKR; McQuaid S; Yousif O; Rahman Y; Gasparro D; Glund S; Chibalin AV; Zierath JR; Nolan JJ
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2006;22(6):492-498

Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients.

Fritz T; Krämer DK; Karlsson HKR; Galuska D; Engfeldt P; Zierath JR; Krook A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2006;63(19-20):2405-2414

Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity.

Wang J; Shafqat J; Hall K; Ståhlberg M; Wivall-Helleryd I-L; Bouzakri K; Zierath JR; Brismar K; Jörnvall H; Lewitt MS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(31):21690-21697

Neuregulins mediate calcium-induced glucose transport during muscle contraction.

Cantó C; Chibalin AV; Barnes BR; Glund S; Suárez E; Ryder JW; Palacín M; Zierath JR; Zorzano A; Gumà A
Article: CELL METABOLISM. 2006;4(1):89-96

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.

Bouzakri K; Zachrisson A; Al-Khalili L; Zhang BB; Koistinen HA; Krook A; Zierath JR
Article: DIABETES. 2006;55(7):2051-2058

AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.

Treebak JT; Glund S; Deshmukh A; Klein DK; Long YC; Jensen TE; Jørgensen SB; Viollet B; Andersson L; Neumann D; Wallimann T; Richter EA; Chibalin AV; Zierath JR; Wojtaszewski JFP
Article: DIABETES. 2006;55(6):1776-1782

Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle.

Deshmukh A; Coffey VG; Zhong Z; Chibalin AV; Hawley JA; Zierath JR
Article: DIABETES. 2006;55(5):1283-1288

Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients.

Karlsson HKR; Ahlsén M; Zierath JR; Wallberg-Henriksson H; Koistinen HA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(11):7244-7252

Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice.

Nilsson EC; Long YC; Martinsson S; Glund S; Garcia-Roves P; Svensson LT; Andersson L; Zierath JR; Mahlapuu M
Article: DIABETES. 2006;55(3):785-791

IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.

Bouzakri K; Karlsson HKR; Vestergaard H; Madsbad S; Christiansen E; Zierath JR
Article: DIABETOLOGIA. 2006;49(3):588-597

Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver.

Bryzgalova G; Gao H; Ahren B; Zierath JR; Galuska D; Steiler TL; Dahlman-Wright K; Nilsson S; Gustafsson J-A; Efendic S; Khan A
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2006;17(1):45-52

Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise.

Kannisto K; Chibalin A; Glinghammar B; Zierath JR; Hamsten A; Ehrenborg E
Article: FASEB JOURNAL. 2006;20(1):190-192

Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans.

Coffey VG; Zhong Z; Shield A; Canny BJ; Chibalin AV; Zierath JR; Hawley JA
Article: DIABETES. 2005;54(12):3484-3489

Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice.

Barnes BR; Long YC; Steiler TL; Leng Y; Galuska D; Wojtaszewski JFP; Andersson L; Zierath JR
Article: DIABETOLOGIA. 2005;48(11):2354-2364

Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle.

Long YC; Barnes BR; Mahlapuu M; Steiler TL; Martinsson S; Leng Y; Wallberg-Henriksson H; Andersson L; Zierath JR
Article: DIABETES. 2005;54(10):2939-2945

Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation.

Plomgaard P; Bouzakri K; Krogh-Madsen R; Mittendorfer B; Zierath JR; Pedersen BK
Article: DIABETES. 2005;54(9):2685-2693

Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.

Bach D; Naon D; Pich S; Soriano FX; Vega N; Rieusset J; Laville M; Guillet C; Boirie Y; Wallberg-Henriksson H; Manco M; Calvani M; Castagneto M; Palacín M; Mingrone G; Zierath JR; Vidal H; Zorzano A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2005;567(Pt 2):379-386

Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle.

Ryder JW; Long YC; Nilsson E; Mahlapuu M; Zierath JR
Article: DIABETES. 2005;54(6):1692-1697

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects.

Karlsson HKR; Zierath JR; Kane S; Krook A; Lienhard GE; Wallberg-Henriksson H
Article: DIABETOLOGIA. 2005;48(6):1173-1179

Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.

Al-Khalili L; Forsgren M; Kannisto K; Zierath JR; Lönnqvist F; Krook A
Article: FASEB JOURNAL. 2005;19(7):773-779

5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics.

Barnes BR; Glund S; Long YC; Hjälm G; Andersson L; Zierath JR
Article: DIABETES. 2005;54(5):1459-1467

Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study.

Karlsson HKR; Hällsten K; Björnholm M; Tsuchida H; Chibalin AV; Virtanen KA; Heinonen OJ; Lönnqvist F; Nuutila P; Zierath JR
Article: DIABETES. 2005;54(4):1157-1163

Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.

Krämer DK; Al-Khalili L; Perrini S; Skogsberg J; Wretenberg P; Kannisto K; Wallberg-Henriksson H; Ehrenborg E; Zierath JR; Krook A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(37):38441-38447

The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle.

Barnes BR; Marklund S; Steiler TL; Walter M; Hjälm G; Amarger V; Mahlapuu M; Leng Y; Johansson C; Galuska D; Lindgren K; Abrink M; Stapleton D; Zierath JR; Andersson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;287(3):E553-E557

Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake.

Al-Khalili L; Krook A; Zierath JR; Cartee GD
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;287(1):E1-E7

Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise.

Karlsson HKR; Nilsson P-A; Nilsson J; Chibalin AV; Zierath JR; Blomstrand E
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2004;36(7):1212-1217

Sending the signal: molecular mechanisms regulating glucose uptake.

Krook A; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2004;53(6):1436-1444

Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice.

Leng Y; Steiler TL; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2004;286(6):C1410-C1416

MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways.

Al-Khalili L; Chibalin AV; Yu M; Sjödin B; Nylén C; Zierath JR; Krook A
Article: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. 2004;5(2):111-117

Insulin signaling defects in type 2 diabetes.

Leng Y; Karlsson HKR; Zierath JR
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2004;89(3):1301-1311

Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

Storgaard H; Jensen CB; Björnholm M; Song XM; Madsbad S; Zierath JR; Vaag AA
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;286(2):E194-E200

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle.

Mahlapuu M; Johansson C; Lindgren K; Hjälm G; Barnes BR; Krook A; Zierath JR; Andersson L; Marklund S
Article: OBESITY. 2004;12(1):25-31

Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects.

Koistinen HA; Forsgren M; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2004;53(1):21-24

Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle.

Perrini S; Henriksson J; Zierath JR; Widegren U
Article: ENDOCRINOLOGY. 2003;144(12):5259-5267

Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats.

Steiler TL; Galuska D; Leng Y; Chibalin AV; Gilbert M; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(45):44298-44304

Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways.

Ryder JW; Bassel-Duby R; Olson EN; Zierath JR
Article: DIABETOLOGIA. 2003;46(10):1324-1328

Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.

Koistinen HA; Chibalin AV; Zierath JR
Article: BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2003;17(3):385-398

The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle.

Zierath JR; Kawano Y
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2003;550(Pt 1):305-315

Insulin signalling and resistance in patients with chronic heart failure.

Kemppainen J; Tsuchida H; Stolen K; Karlsson H; Björnholm M; Heinonen OJ; Nuutila P; Krook A; Knuuti J; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(19):17190-17197

Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.

Bach D; Pich S; Soriano FX; Vega N; Baumgartner B; Oriola J; Daugaard JR; Lloberas J; Camps M; Zierath JR; Rabasa-Lhoret R; Wallberg-Henriksson H; Laville M; Palacín M; Vidal H; Rivera F; Brand M; Zorzano A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(5):991-998

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content.

Al-Khalili L; Chibalin AV; Kannisto K; Zhang BB; Permert J; Holman GD; Ehrenborg E; Ding VDH; Zierath JR; Krook A
Article: DIABETES. 2003;52(5):1066-1072

5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.

Koistinen HA; Galuska D; Chibalin AV; Yang J; Zierath JR; Holman GD; Wallberg-Henriksson H
Article: PANCREAS. 2003;26(2):173-177

Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients.

Isaksson B; Strömmer L; Friess H; Büchler MW; Herrington MK; Wang F; Zierath JR; Wallberg-Henriksson H; Larsson J; Permert J
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2003;546(Pt 2):327-335

Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise.

Yu M; Stepto NK; Chibalin AV; Fryer LGD; Carling D; Krook A; Hawley JA; Zierath JR
Article: DIABETOLOGIA. 2002;45(12):1697-1702

Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans.

Björnholm M; He AR; Attersand A; Lake S; Liu SCH; Lienhard GE; Taylor S; Arner P; Zierath JR
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;445(1):25-31

Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects.

Tsuchida H; Björnholm M; Fernström M; Galuska D; Johansson P; Wallberg-Henriksson H; Zierath JR; Lake S; Krook A
Article: DIABETES. 2002;51(9):2703-2708

Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction.

Barnes BR; Ryder JW; Steiler TL; Fryer LGD; Carling D; Zierath JR
Article: DIABETOLOGIA. 2002;45(8):1128-1135

Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet.

Björnholm M; Al-Khalili L; Dicker A; Näslund E; Rössner S; Zierath JR; Arner P
Article: DIABETOLOGIA. 2002;45(1):56-65

5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.

Song XM; Fiedler M; Galuska D; Ryder JW; Fernström M; Chibalin AV; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2001;50(12):2770-2778

Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

Storgaard H; Song XM; Jensen CB; Madsbad S; Björnholm M; Vaag A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2001;281(6):E1255-E1259

Evidence against high glucose as a mediator of ERK1/2 or p38 MAPK phosphorylation in rat skeletal muscle.

Kawano Y; Ryder JW; Rincon J; Zierath JR; Krook A; Wallberg-Henriksson H
Article: DIABETOLOGIA. 2001;44(12):2180-2186

5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice.

Fiedler M; Zierath JR; Selén G; Wallberg-Henriksson H; Liang Y; Sakariassen KS
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2001;536(Pt 1):273-282

Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle.

Yu M; Blomstrand E; Chibalin AV; Krook A; Zierath JR
Article: ENDOCRINOLOGY. 2001;142(8):3474-3482

Insulin- and glucose-induced phosphorylation of the Na(+),K(+)-adenosine triphosphatase alpha-subunits in rat skeletal muscle.

Chibalin AV; Kovalenko MV; Ryder JW; Féraille E; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2001;50(5):1149-1157

Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression.

Ryder JW; Portocarrero CP; Song XM; Cui L; Yu M; Combatsiaris T; Galuska D; Bauman DE; Barbano DM; Charron MJ; Zierath JR; Houseknecht KL
Article: FASEB JOURNAL. 2001;15(6):958-969

Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity.

Tsao TS; Li J; Chang KS; Stenbit AE; Galuska D; Anderson JE; Zierath JR; McCarter RJ; Charron MJ
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2001;90(1):29-34

Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport.

Yu M; Blomstrand E; Chibalin AV; Wallberg-Henriksson H; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;279(5):R1716-R1721

Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle.

Krook A; Widegren U; Jiang XJ; Henriksson J; Wallberg-Henriksson H; Alessi D; Zierath JR
Article: HUMAN MOLECULAR GENETICS. 2000;9(14):2149-2158

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.

Fakhrai-Rad H; Nikoshkov A; Kamel A; Fernström M; Zierath JR; Norgren S; Luthman H; Galli J
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2000;279(1):E206-E212

Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.

Del Aguila LF; Krishnan RK; Ulbrecht JS; Farrell PA; Correll PH; Lang CH; Zierath JR; Kirwan JP
Article: DIABETES. 2000;49(4):647-654

Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.

Ryder JW; Yang J; Galuska D; Rincón J; Björnholm M; Krook A; Lund S; Pedersen O; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: DIABETES. 2000;49(2):284-292

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.

Krook A; Björnholm M; Galuska D; Jiang XJ; Fahlman R; Myers MG; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1457-1462

Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.

Ryder JW; Fahlman R; Wallberg-Henriksson H; Alessi DR; Krook A; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(1):38-43

Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2.

Chibalin AV; Yu M; Ryder JW; Song XM; Galuska D; Krook A; Wallberg-Henriksson H; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;277(6):R1690-R1696

Muscle fiber type specificity in insulin signal transduction.

Song XM; Ryder JW; Kawano Y; Chibalin AV; Krook A; Zierath JR
Article: FASEB JOURNAL. 1999;13(15):2246-2256

Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice.

Ryder JW; Kawano Y; Galuska D; Fahlman R; Wallberg-Henriksson H; Charron MJ; Zierath JR
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1999;439(1-2):130-133

Effect of the nicotine metabolite 5'-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle.

Rincón J; Galuska D; Ryder JW; Kawano Y; Wallberg-Henriksson H; Gorrod JW; Zierath JR
Article: BIOCHEMICAL JOURNAL. 1999;342 ( Pt 2)(Pt 2):321-328

In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle.

Ryder JW; Kawano Y; Chibalin AV; Rincón J; Tsao TS; Stenbit AE; Combatsiaris T; Yang J; Holman GD; Charron MJ; Zierath JR
Article: DIABETOLOGIA. 1999;42(9):1071-1079

Changes in glucose transport and protein kinase Cbeta(2) in rat skeletal muscle induced by hyperglycaemia.

Kawano Y; Rincon J; Soler A; Ryder JW; Nolte LA; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1999;42(Suppl 1):a1-a330

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999.
Article: DIABETOLOGIA. 1999;42(7):826-830

Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects.

Hjeltnes N; Fernström M; Zierath JR; Krook A
Article: SCIENCE. 1999;284(5416):974-977

Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.

Zhang B; Salituro G; Szalkowski D; Li Z; Zhang Y; Royo I; Vilella D; Díez MT; Pelaez F; Ruby C; Kendall RL; Mao X; Griffin P; Calaycay J; Zierath JR; Heck JV; Smith RG; Moller DE
Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 1999;19(2):135-142

Altered skeletal muscle glucose transport and blood lipid levels in habitual cigarette smokers.

Rincón J; Krook A; Galuska D; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(3):664-670

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

Song XM; Kawano Y; Krook A; Ryder JW; Efendic S; Roth RA; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(2):310-320

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

Kim YB; Zhu JS; Zierath JR; Shen HQ; Baron AD; Kahn BB
Article: FASEB JOURNAL. 1998;12(15):1701-1712

Exercise-induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: molecular mechanism for improved glucose homeostasis.

Hjeltnes N; Galuska D; Björnholm M; Aksnes AK; Lannem A; Zierath JR; Wallberg-Henriksson H
Article: ENDOCRINOLOGY. 1998;139(12):5034-5041

Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action.

Zierath JR; Ryder JW; Doebber T; Woods J; Wu M; Ventre J; Li Z; McCrary C; Berger J; Zhang B; Moller DE
Article: DIABETOLOGIA. 1998;41(11):1343-1354

Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway.

Zierath JR; Livingston JN; Thörne A; Bolinder J; Reynisdottir S; Lönnqvist F; Arner P
Article: FASEB JOURNAL. 1998;12(13):1379-1389

Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle.

Widegren U; Jiang XJ; Krook A; Chibalin AV; Björnholm M; Tally M; Roth RA; Henriksson J; Wallberg-henriksson H; Zierath JR
Article: DIABETES. 1998;47(9):1528-1531

Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients.

Krook A; Digby J; O'Rahilly S; Zierath JR; Wallberg-Henriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(33):20910-20915

Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation.

Zierath JR; Tsao TS; Stenbit AE; Ryder JW; Galuska D; Charron MJ
Article: DIABETES. 1998;47(8):1281-1286

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects.

Krook A; Roth RA; Jiang XJ; Zierath JR; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1998;275(2):E351-E358

Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport.

Strömmer L; Permert J; Arnelo U; Koehler C; Isaksson B; Larsson J; Lundkvist I; Björnholm M; Kawano Y; Wallberg-Henriksson H; Zierath JR
Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1998;182(1-2):153-160

Insulin action in skeletal muscle from patients with NIDDM.

Zierath JR; Krook A; Wallberg-Henriksson H
Article: MOLECULAR BIOLOGY OF THE CELL. 1998;9(5):1209-1220

Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na+, K+-ATPase alpha subunit in response to dopamine.

Chibalin AV; Zierath JR; Katz AI; Berggren PO; Bertorello AM
Article: DIABETES. 1998;47(1):1-4

Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes.

Zierath JR; Frevert EU; Ryder JW; Berggren PO; Kahn BB
Article: DIABETES. 1997;46(12):2110-2114

Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats.

Krook A; Kawano Y; Song XM; Efendić S; Roth RA; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1997;46(12):1965-1969

Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique.

Lund S; Holman GD; Zierath JR; Rincon J; Nolte LA; Clark AE; Schmitz O; Pedersen O; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1997;40(10):1172-1177

Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism.

Shepherd PR; Nave BT; Rincon J; Haigh RJ; Foulstone E; Proud C; Zierath JR; Siddle K; Wallberg-Henriksson H
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;100(3):671-677

Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism.

Tsao TS; Stenbit AE; Li J; Houseknecht KL; Zierath JR; Katz EB; Charron MJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(30):19000-19007

Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.

Shepherd PR; Navé BT; Rincon J; Nolte LA; Bevan AP; Siddle K; Zierath JR; Wallberg-Henriksson H
Article: DIABETES. 1997;46(3):524-527

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation.

Björnholm M; Kawano Y; Lehtihet M; Zierath JR
Article: DIABETOLOGIA. 1996;39(10):1180-1189

Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM.

Zierath JR; He L; Gumà A; Odegoard Wahlström E; Klip A; Wallberg-Henriksson H
Article: JOURNAL OF INTERNAL MEDICINE. 1996;240(3):115-124

C-peptide revisited--new physiological effects and therapeutic implications.

Wahren J; Johansson BL; Wallberg-Henriksson H; Linde B; Fernqvist-Forbes E; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1996;271(3 Pt 1):E593-E600

Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients.

Aksnes AK; Hjeltnes N; Wahlström EO; Katz A; Zierath JR; Wallberg-Henriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(19):11347-11355

Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.

Houseknecht KL; Zhu AX; Gnudi L; Hamann A; Zierath JR; Tozzo E; Flier JS; Kahn BB
Article: DIABETES. 1996;45(5):615-621

Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment.

Rincon J; Holmäng A; Wahlström EO; Lönnroth P; Björntorp P; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1996;39(3):306-313

C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation.

Zierath JR; Handberg A; Tally M; Wallberg-Henriksson H
Article: BIOCHEMICAL JOURNAL. 1995;311 ( Pt 2)(Pt 2):517-521

Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.

Zierath JR; Nolte LA; Wahlström E; Galuska D; Shepherd PR; Kahn BB; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1995;268(4 Pt 1):E613-E622

Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle.

Gumà A; Zierath JR; Wallberg-Henriksson H; Klip A
Article: DIABETES. 1995;44(3):347-353

Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.

Echwald SM; Bjørbaek C; Hansen T; Clausen JO; Vestergaard H; Zierath JR; Printz RL; Granner DK; Pedersen O
Article: CLINICAL SCIENCE. 1995;88(3):301-306

Development of decreased insulin-induced glucose transport in skeletal muscle of glucose-intolerant hybrids of diabetic GK rats.

Nolte LA; Abdel-Halim SM; Martin IK; Guenifi A; Zierath JR; Ostenson CG; Wallberg-Henriksson H
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All other publications

Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2023;24(9):607-632

Exercise metabolism and adaptation in skeletal muscle.

Smith JAB; Murach KA; Dyar KA; Zierath JR
Letter: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(11):713

Reply to 'Lactate as a major myokine and exerkine'.

Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Gao Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder M
Review: ENDOCRINE REVIEWS. 2022;43(4):654-677

Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity.

Stocks B; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(5):273-289

Exerkines in health, resilience and disease.

Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Gao Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder MP
Review: JOURNAL OF PHYSIOLOGY-LONDON. 2022;600(5):1027-1036

Zeitgebers of skeletal muscle and implications for metabolic health.

Gabriel BM; Zierath JR
Editorial comment: METABOLISM-CLINICAL AND EXPERIMENTAL. 2021;119:154769

COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic.

Tessier CM; Kokkinos A; Mingrone G; Koliaki C; Zierath JR; Mantzoros CS
Review: CELL. 2021;184(6):1530-1544

Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.

Pillon NJ; Loos RJF; Marshall SM; Zierath JR
Review: CURRENT OPINION IN LIPIDOLOGY. 2021;32(1):16-23

The role of the molecular circadian clock in human energy homeostasis.

Dollet L; Pendergrast LA; Zierath JR
Review: DIABETOLOGIA. 2020;63(11):2253-2259

Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men.

Hawley JA; Sassone-Corsi P; Zierath JR
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):5142

Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.

Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altıntaş A; Sato S; Sassone-Corsi P; Barrès R; Zierath JR; Hawley JA
Review: DIABETOLOGIA. 2020;63(8):1491-1499

Train like an athlete: applying exercise interventions to manage type 2 diabetes.

Savikj M; Zierath JR
Editorial comment: CURRENT DIABETES REPORTS. 2019;19(11):118

Major Advances and Discoveries in Diabetes - 2019 in Review.

Zierath JR
Corrigendum: JOURNAL OF ENDOCRINOLOGY. 2019;243(2):X1

The estrogen receptor α-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice: potential molecular mechanisms.

Lundholm L; Bryzgalova G; Gao H; Portwood N; Fält S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-Å; Efendic S; Dahlman-Wright K; Khan A
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2019;30(9):603-617

Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.

Massart J; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2019;15(4):197-206

Circadian rhythms and exercise - re-setting the clock in metabolic disease.

Gabriel BM; Zierath JR
Review: JOURNAL OF PHYSIOLOGY-LONDON. 2019;597(6):1439-1450

Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue.

Dollet L; Zierath JR
Other: CELL METABOLISM. 2018;28(3):329

John O. Holloszy (1933-2018) Obituary

Zierath JR; Hagberg JM; Coyle EF
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):5008

Author Correction: Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans.

Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barrès R
Editorial comment: CELL METABOLISM. 2017;25(5):978-984

Exercise Metabolism.
Review: CELL METABOLISM. 2017;25(5):1000-1011

The Limits of Exercise Physiology: From Performance to Health.

Gabriel BM; Zierath JR
Editorial comment: CELL. 2016;167(5):1155-1158

Building Bridges through Scientific Conferences.

Zierath JR
Editorial comment: CELL METABOLISM. 2016;24(2):342-342.e1

SnapShot: Exercise Metabolism.

Egan B; Hawley JA; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2016;12(8):441-451

The role of diet and exercise in the transgenerational epigenetic landscape of T2DM.

Barrès R; Zierath JR
Review: CELL METABOLISM. 2016;23(6):1034-1047

Exercise Promotes Healthy Aging of Skeletal Muscle.

Cartee GD; Hepple RT; Bamman MM; Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(12):2685-2687

Turning the page.

Zierath JR
Corrigendum: DIABETOLOGIA. 2015;58(12):2899

Erratum to: Turning the page.

Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(8):1685-1687

Diabetologia at 50: celebrating half a century of progress in diabetes research and care.

Zierath JR
Review: CELL METABOLISM. 2015;22(1):25-30

Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?

Zierath JR; Wallberg-Henriksson H
Editorial comment: CELL METABOLISM. 2015;21(5):654-657

Women in metabolism: part I.
Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2015;11(4):198-200

Metabolism. Exercise remodels subcutaneous fat tissue and improves metabolism.

Wallberg-Henriksson H; Zierath JR
Other: CELL. 2015;161(1):173-174

How to Stop the Obesity Epidemic?

Chen Z; Zierath J; Kahn CR; Spiegelman B; O'Rahilly S; Bruning JC
Review: CELL. 2014;159(4):738-749

Integrative biology of exercise.

Hawley JA; Hargreaves M; Joyner MJ; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2014;307(9):C774-C787

Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes.

Al-Khalili L; de Castro Barbosa T; Ostling J; Massart J; Cuesta PG; Osler ME; Katayama M; Nyström A-C; Oscarsson J; Zierath JR
Review: DRUG DISCOVERY TODAY. 2014;19(7):1010-1014

Dynamic epigenetic responses to muscle contraction.

Rasmussen M; Zierath JR; Barrès R
Corrigendum: CELL REPORTS. 2013;3(5):1755

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation (vol 3, pg 1020, 2013)

Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Naslund E; Zierath JR
Review: TRENDS IN CELL BIOLOGY. 2013;23(5):203-209

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

Kirchner H; Osler ME; Krook A; Zierath JR
Review: CELL METABOLISM. 2013;17(2):162-184

Exercise metabolism and the molecular regulation of skeletal muscle adaptation.

Egan B; Zierath JR
Editorial comment: DIABETOLOGIA. 2012;55(1):1-2

Remembering our classics: then and now.

Zierath JR
Published conference paper: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2011;93(4):897S-8900

DNA methylation in metabolic disorders.

Barres R; Zierath JR
Editorial comment: DIABETOLOGIA. 2011;54(1):1-3

Keeping ahead of the fast pace of science

Zierath JR
Review: LAKARTIDNINGEN. 2010;107(45):2802-2805

[Molecular mechanisms underlying insulin resistance in skeletal muscle].

Zierath JR; Krook A
Review: DIABETOLOGIA. 2009;52(7):1231-1239

Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA.

Krook A; Zierath JR
Editorial comment: CELL. 2009;137(1):22-24

A new twist on brown fat metabolism.

Wallberg-Henriksson H; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2008;295(3):E545-E552

Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle.

Long YC; Zierath JR
Published conference paper: INTERNATIONAL JOURNAL OF OBESITY. 2008;32 Suppl 4:S18-S23

Exercise-induced phospho-proteins in skeletal muscle.

Deshmukh AS; Hawley JA; Zierath JR
Review: ENDOCRINOLOGY. 2008;149(3):935-941

Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle.

Osler ME; Zierath JR
Editorial comment: ACTA PHYSIOLOGICA. 2008;192(1):1

Xth International Symposium on insulin receptors and insulin action.

Zierath JR
Editorial comment: DIABETOLOGIA. 2007;50(7):1362-1364

Fighting the battle of the bulge: exercise training in early-onset type 2 diabetes.

Osler ME; Zierath JR
Editorial comment: CELL METABOLISM. 2007;5(3):161-163

The path to insulin resistance: paved with ceramides?

Zierath JR
Published conference paper: CELL BIOCHEMISTRY AND BIOPHYSICS. 2007;48(2-3):103-113

Insulin signaling and glucose transport in insulin resistant human skeletal muscle.

Karlsson HKR; Zierath JR
Review: ESSAYS IN BIOCHEMISTRY. 2006;42:1-12

Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation.

Hawley JA; Hargreaves M; Zierath JR
Review: JOURNAL OF CLINICAL INVESTIGATION. 2006;116(7):1776-1783

AMP-activated protein kinase signaling in metabolic regulation.

Long YC; Zierath JR
Editorial comment: DIABETOLOGIA. 2005;48(12):2451-2453

Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling.

Long YC; Zierath JR
Review: CURRENT DIABETES REVIEWS. 2005;1(2):167-174

Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes.

Bouzakri K; Koistinen HA; Zierath JR
Review: CURRENT MOLECULAR MEDICINE. 2005;5(3):341-348

Role of AMP--activated protein kinase in the control of glucose homeostasis.

Barnes BR; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2005;33(Pt 2):354-357

Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes.

Björnholm M; Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):121-123

Kinases in diabetes. Part II. 11-12 November 2004, Manchester, UK.

Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):118-120

Kinases in diabetes. Part I. 11-12 November 2004, Manchester, UK.

Zierath JR
Letter: ACTA PHYSIOLOGICA. 2005;183(1):125-126

Integration of mathematical and experimental approaches to resolve insulin signalling.

Sögård P; Harlén M; Svensson LT; Zierath JR; Nilsson P
Editorial comment: ACTA PHYSIOLOGICA. 2005;183(1):1-2

Theme: Skeletal muscle and adipose tissue metabolism - Regulation, exercise, diabetes and ageing - Foreword

Zierath JR; Handberg A; Jensen J
Editorial comment: PLOS BIOLOGY. 2004;2(10):e348

Skeletal muscle fiber type: influence on contractile and metabolic properties.

Zierath JR; Hawley JA
Published conference paper: PROCEEDINGS OF THE NUTRITION SOCIETY. 2004;63(2):227-232

Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle.

Long YC; Widegren U; Zierath JR
Review: EXERCISE AND SPORT SCIENCES REVIEWS. 2004;32(1):4-8

Integration of metabolic and mitogenic signal transduction in skeletal muscle.

Hawley JA; Zierath JR
Editorial comment: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2003;26(7):690-692

Skeletal muscle insulin resistance: is it important for the pathogenesis of type 2 diabetes after all?

Koistinen HA; Zierath JR
Review: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES. 2003;111(4):191-197

Analysis of insulin signaling pathways through comparative genomics. Mapping mechanisms for insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus.

Lake S; Krook A; Zierath JR
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):219

Effects of diet and exercise on the regulation of PPARα, δ and γ expression in rat skeletal muscle and visceral adipose tissue

Kannisto K; Chibalin A; Zierath JR; Hamsten A; Ehrenborg E
Review: FASEB JOURNAL. 2002;16(10):1163-1176

Analysis of paradoxical observations on the association between leptin and insulin resistance.

Ceddia RB; Koistinen HA; Zierath JR; Sweeney G
Review: JOURNAL OF APPLIED PHYSIOLOGY. 2002;93(2):773-781

Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle.

Zierath JR
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2002;967:120-134

From receptor to effector: insulin signal transduction in skeletal muscle from type II diabetic patients.

Zierath JR; Wallberg-Henriksson H
Review: ANNALS OF MEDICINE. 2002;34(6):410-418

Regulation of glucose transport in human skeletal muscle.

Koistinen HA; Zierath JR
Review: ACTA PHYSIOLOGICA. 2001;172(3):227-238

Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction.

Widegren U; Ryder JW; Zierath JR
Review: MOLECULAR MEMBRANE BIOLOGY. 2001;18(3):205-211

GLUT4: a key player regulating glucose homeostasis? Insights from transgenic and knockout mice (review).

Wallberg-Henriksson H; Zierath JR
Published conference paper: ACTA PHYSIOLOGICA. 2001;171(3):249-257

Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle.

Ryder JW; Chibalin AV; Zierath JR
Review: FRONTIERS IN BIOSCIENCE - LANDMARK. 2001;6:D154-D163

Skeletal muscle and insulin sensitivity: pathophysiological alterations.

Ryder JW; Gilbert M; Zierath JR
Review: DIABETOLOGIA. 2000;43(7):821-835

Insulin action and insulin resistance in human skeletal muscle.

Zierath JR; Krook A; Wallberg-Henriksson H
Review: SPORTS MEDICINE. 1998;25(1):25-35

Exercise in the management of non-insulin-dependent diabetes mellitus.

Wallberg-Henriksson H; Rincon J; Zierath JR
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1998;441:73-85

Insulin signaling and glucose transport in insulin resistant skeletal muscle. Special reference to GLUT4 transgenic and GLUT4 knockout mice.

Galuska D; Ryder J; Kawano Y; Charron MJ; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1997;25(3):963-968

Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscle.

Charron MJ; Katz EB; Zierath JR
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 1996;7(2):295-307

Glucose transporters and diabetes

Zierath JR; Houseknecht KL; Kahn BB
Other: DIABETES. 1995;44(11):1345-1348

Hyperglycemia activates glucose transport in rat skeletal muscle via a Ca(2+)-dependent mechanism.

Nolte LA; Rincón J; Wahlström EO; Craig BW; Zierath JR; Wallberg-Henriksson H
Review: ACTA PHYSIOLOGICA SCANDINAVICA, SUPPLEMENT. 1995;626:1-96

In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport.

Zierath JR
Review: ACTA PHYSIOLOGICA. 1995;155:11-96

IN-VITRO STUDIES OF HUMAN SKELETAL-MUSCLE - HORMONAL AND METABOLIC-REGULATION OF GLUCOSE-TRANSPORT - INTRODUCTION

ZIERATH JR
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Employments

Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2009-

Degrees and Education

Docent, Karolinska Institutet, 1998

About me

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Employments

Degrees and Education

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