Juleen Zierath

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Forskningsbeskrivning

Forskargruppsledare för gruppen Integrativ fysiologi vid institutionen för fysiologi och farmakologi och vid institutionen för molekylär medicin och kirurgi.

Artiklar

Journal article: CELL METABOLISM. 2024;36(2):278-300

Exercise induces tissue-specific adaptations to enhance cardiometabolic health.

Ashcroft SP; Stocks B; Egan B; Zierath JR
Article: CELL METABOLISM. 2023;35(10):1722-1735.e5

Seasonal light hours modulate peripheral clocks and energy metabolism in mice.

Small L; Lundell LS; Iversen J; Ehrlich AM; Dall M; Basse AL; Dalbram E; Hansen AN; Treebak JT; Barrès R; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(14):e2220102120

NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner.

Basse AL; Nielsen KN; Karavaeva I; Ingerslev LR; Ma T; Havelund JF; Nielsen TS; Frost M; Peics J; Dalbram E; Dall M; Zierath JR; Barrès R; Færgeman NJ; Treebak JT; Gerhart-Hines Z
Article: STAR PROTOCOLS. 2023;4(1):101985

Protocol to assess arteriovenous differences across the liver and hindlimb muscles in mice following treadmill exercise.

Ashcroft SP; Jepsen SL; Ehrlich AM; Treebak JT; Holst JJ; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(8):e2218510120

Time of day determines postexercise metabolism in mouse adipose tissue.

Pendergrast LA; Lundell LS; Ehrlich AM; Ashcroft SP; Schönke M; Basse AL; Krook A; Treebak JT; Dollet L; Zierath JR
Article: GEROSCIENCE. 2023;45(1):569-589

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary.

Erickson ML; Allen JM; Beavers DP; Collins LM; Davidson KW; Erickson KI; Esser KA; Hesselink MKC; Moreau KL; Laber EB; Peterson CA; Peterson CM; Reusch JE; Thyfault JP; Youngstedt SD; Zierath JR; Goodpaster BH; LeBrasseur NK; Buford TW; Sparks LM
Article: LIFE SCIENCE ALLIANCE. 2023;6(1):e202201598

Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers.

Pillon NJ; Sardón Puig L; Altıntaş A; Kamble PG; Casaní-Galdón S; Gabriel BM; Barrès R; Conesa A; Chibalin AV; Näslund E; Krook A; Zierath JR
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2022;135:155268

Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients - A randomized crossover trial.

Savikj M; Stocks B; Sato S; Caidahl K; Krook A; Deshmukh AS; Zierath JR; Wallberg-Henriksson H
Article: SCIENCE ADVANCES. 2022;8(36):eabo3192

Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes.

Pillon NJ; Smith JAB; Alm PS; Chibalin AV; Alhusen J; Arner E; Carninci P; Fritz T; Otten J; Olsson T; van Doorslaer de Ten Ryen S; Deldicque L; Caidahl K; Wallberg-Henriksson H; Krook A; Zierath JR
Article: NATURE GENETICS. 2022;54(9):1332-1344

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Wang Z; Emmerich A; Pillon NJ; Moore T; Hemerich D; Cornelis MC; Mazzaferro E; Broos S; Ahluwalia TS; Bartz TM; Bentley AR; Bielak LF; Chong M; Chu AY; Berry D; Dorajoo R; Dueker ND; Kasbohm E; Feenstra B; Feitosa MF; Gieger C; Graff M; Hall LM; Haller T; Hartwig FP; Hillis DA; Huikari V; Heard-Costa N; Holzapfel C; Jackson AU; Johansson Å; Jørgensen AM; Kaakinen MA; Karlsson R; Kerr KF; Kim B; Koolhaas CM; Kutalik Z; Lagou V; Lind PA; Lorentzon M; Lyytikäinen L-P; Mangino M; Metzendorf C; Monroe KR; Pacolet A; Pérusse L; Pool R; Richmond RC; Rivera NV; Robiou-du-Pont S; Schraut KE; Schulz C-A; Stringham HM; Tanaka T; Teumer A; Turman C; van der Most PJ; Vanmunster M; van Rooij FJA; van Vliet-Ostaptchouk JV; Zhang X; Zhao J-H; Zhao W; Balkhiyarova Z; Balslev-Harder MN; Baumeister SE; Beilby J; Blangero J; Boomsma DI; Brage S; Braund PS; Brody JA; Bruinenberg M; Ekelund U; Liu C-T; Cole JW; Collins FS; Cupples LA; Esko T; Enroth S; Faul JD; Fernandez-Rhodes L; Fohner AE; Franco OH; Galesloot TE; Gordon SD; Grarup N; Hartman CA; Heiss G; Hui J; Illig T; Jago R; James A; Joshi PK; Jung T; Kähönen M; Kilpeläinen TO; Koh W-P; Kolcic I; Kraft PP; Kuusisto J; Launer LJ; Li A; Linneberg A; Luan J; Vidal PM; Medland SE; Milaneschi Y; Moscati A; Musk B; Nelson CP; Nolte IM; Pedersen NL; Peters A; Peyser PA; Power C; Raitakari OT; Reedik M; Reiner AP; Ridker PM; Rudan I; Ryan K; Sarzynski MA; Scott LJ; Scott RA; Sidney S; Siggeirsdottir K; Smith AV; Smith JA; Sonestedt E; Strøm M; Tai ES; Teo KK; Thorand B; Tönjes A; Tremblay A; Uitterlinden AG; Vangipurapu J; van Schoor N; Völker U; Willemsen G; Williams K; Wong Q; Xu H; Young KL; Yuan JM; Zillikens MC; Zonderman AB; Ameur A; Bandinelli S; Bis JC; Boehnke M; Bouchard C; Chasman DI; Smith GD; de Geus EJC; Deldicque L; Dörr M; Evans MK; Ferrucci L; Fornage M; Fox C; Garland T; Gudnason V; Gyllensten U; Hansen T; Hayward C; Horta BL; Hyppönen E; Jarvelin M-R; Johnson WC; Kardia SLR; Kiemeney LA; Laakso M; Langenberg C; Lehtimäki T; Marchand LL; Lifelines Cohort Study; Magnusson PKE; Martin NG; Melbye M; Metspalu A; Meyre D; North KE; Ohlsson C; Oldehinkel AJ; Orho-Melander M; Pare G; Park T; Pedersen O; Penninx BWJH; Pers TH; Polasek O; Prokopenko I; Rotimi CN; Samani NJ; Sim X; Snieder H; Sørensen TIA; Spector TD; Timpson NJ; van Dam RM; van der Velde N; van Duijn CM; Vollenweider P; Völzke H; Voortman T; Waeber G; Wareham NJ; Weir DR; Wichmann H-E; Wilson JF; Hevener AL; Krook A; Zierath JR; Thomis MAI; Loos RJF; Hoed MD
Article: DIABETES. 2022;71(4):624-636

Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes.

Dollet L; Kuefner M; Caria E; Rizo-Roca D; Pendergrast L; Abdelmoez AM; Karlsson HKR; Björnholm M; Dalbram E; Treebak JT; Harada J; Näslund E; Rydén M; Zierath JR; Pillon NJ; Krook A
Article: MOLECULAR & CELLULAR PROTEOMICS. 2022;21(3):100207

Integrated Liver and Plasma Proteomics in Obese Mice Reveals Complex Metabolic Regulation.

Stocks B; Gonzalez-Franquesa A; Borg ML; Björnholm M; Niu L; Zierath JR; Deshmukh AS
Article: MOLECULAR METABOLISM. 2022;57:101440

Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice.

Small L; Ehrlich A; Iversen J; Ashcroft SP; Trošt K; Moritz T; Hartmann B; Holst JJ; Treebak JT; Zierath JR; Barrès R
Article: NATURE METABOLISM. 2022;4(2):190-202

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation.

Maqdasy S; Lecoutre S; Renzi G; Frendo-Cumbo S; Rizo-Roca D; Moritz T; Juvany M; Hodek O; Gao H; Couchet M; Witting M; Kerr A; Bergo MO; Choudhury RP; Aouadi M; Zierath JR; Krook A; Mejhert N; Rydén M
Article: CELL METABOLISM. 2022;34(2):329-345.e8

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.

Sato S; Dyar KA; Treebak JT; Jepsen SL; Ehrlich AM; Ashcroft SP; Trost K; Kunzke T; Prade VM; Small L; Basse AL; Schönke M; Chen S; Samad M; Baldi P; Barrès R; Walch A; Moritz T; Holst JJ; Lutter D; Zierath JR; Sassone-Corsi P
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(2):353-368

Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine.

Kanaley JA; Colberg SR; Corcoran MH; Malin SK; Rodriguez NR; Crespo CJ; Kirwan JP; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2021;321(5):C770-C778

Discovery of thymosin β4 as a human exerkine and growth factor.

Gonzalez-Franquesa A; Stocks B; Borg ML; Kuefner M; Dalbram E; Nielsen TS; Agrawal A; Pankratova S; Chibalin AV; Karlsson HKR; Gheibi S; Björnholm M; Jørgensen NR; Clemmensen C; Hostrup M; Treebak JT; Krook A; Zierath JR; Deshmukh AS
Article: MOLECULAR METABOLISM. 2021;53:101290

Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health.

Williams K; Carrasquilla GD; Ingerslev LR; Hochreuter MY; Hansson S; Pillon NJ; Donkin I; Versteyhe S; Zierath JR; Kilpeläinen TO; Barrès R
Article: SCIENCE ADVANCES. 2021;7(43):eabi9654

Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle.

Gabriel BM; Altıntaş A; Smith JAB; Sardon-Puig L; Zhang X; Basse AL; Laker RC; Gao H; Liu Z; Dollet L; Treebak JT; Zorzano A; Huo Z; Rydén M; Lanner JT; Esser KA; Barrès R; Pillon NJ; Krook A; Zierath JR
Article: NATURE COMMUNICATIONS. 2021;12(1):5948

Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.

Massart J; Sjögren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barrès R; O'Gorman DJ; Zierath JR; Krook A
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2021;12(5):1232-1248

Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance.

Borg ML; Massart J; De Castro Barbosa T; Archilla-Ortega A; Smith JAB; Lanner JT; Alsina-Fernandez J; Yaden B; Culver AE; Karlsson HKR; Brozinick JT; Zierath JR
Article: DIABETOLOGIA. 2021;64(9):2077-2091

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes.

Sjögren RJO; Rizo-Roca D; Chibalin AV; Chorell E; Furrer R; Katayama S; Harada J; Karlsson HKR; Handschin C; Moritz T; Krook A; Näslund E; Zierath JR
Article: PROTEOMES. 2021;9(3):37

Insulin and 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome.

Gonzalez-Franquesa A; Peijs L; Cervone DT; Koçana C; Zierath JR; Deshmukh AS
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2021;321(2):E203-E216

Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity.

Smith JAB; Savikj M; Sethi P; Platt S; Gabriel BM; Hawley JA; Dunstan D; Krook A; Zierath JR; Näslund E
Article: CELL REPORTS. 2021;35(8):109180

Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity.

Gonzalez-Franquesa A; Stocks B; Chubanava S; Hattel HB; Moreno-Justicia R; Peijs L; Treebak JT; Zierath JR; Deshmukh AS
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2021;118:154726

Quantitative phosphoproteomic analysis of IRS1 in skeletal muscle from men with normal glucose tolerance or type 2 diabetes: A case-control study.

Karlsson HKR; Kasahara A; Ikeda M; Chibalin AV; Harada J; Rydén M; Krook A; Kato M; Kubota K; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2021;12:619447

The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle.

Maasar M-F; Turner DC; Gorski PP; Seaborne RA; Strauss JA; Shepherd SO; Cocks M; Pillon NJ; Zierath JR; Hulton AT; Drust B; Sharples AP
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(24):5739-5752

Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway.

Small L; Altıntaş A; Laker RC; Ehrlich A; Pattamaprapanont P; Villarroel J; Pillon NJ; Zierath JR; Barrès R
Article: CELL METABOLISM. 2020;32(5):844-859.e5

A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes.

Batista TM; Jayavelu AK; Wewer Albrechtsen NJ; Iovino S; Lebastchi J; Pan H; Dreyfuss JM; Krook A; Zierath JR; Mann M; Kahn CR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(38):23932-23941

Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.

Brandão BB; Madsen S; Rabiee A; Oliverio M; Ruiz GP; Ferrucci DL; Branquinho JL; Razolli D; Pinto S; Nielsen TS; Festuccia WT; Martins AS; Guerra BA; Knittel TL; Søgaard D; Larsen S; Helge JW; Brandauer J; Velloso LA; Emanuelli B; Kornfeld J-W; Kahn CR; Vienberg SG; Zierath JR; Treebak JT; Mori MA
Article: NATURE COMMUNICATIONS. 2020;11(1):4643

Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.

Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altıntaş A; Sato S; Sassone-Corsi P; Barrès R; Zierath JR; Hawley JA
Article: EPIGENOMICS. 2020;12(8):701-713

Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development.

Altıntaş A; Laker RC; Garde C; Barrès R; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2020;318(3):C615-C626

Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism.

Abdelmoez AM; Sardón Puig L; Smith JAB; Gabriel BM; Savikj M; Dollet L; Chibalin AV; Krook A; Zierath JR; Pillon NJ
Article: NATURE COMMUNICATIONS. 2020;11(1):470

Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.

Pillon NJ; Gabriel BM; Dollet L; Smith JAB; Sardón Puig L; Botella J; Bishop DJ; Krook A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2020;318(1):E1-E10

Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression.

Sardon Puig L; Pillon NJ; Näslund E; Krook A; Zierath JR
Article: HEPATOLOGY RESEARCH. 2019;49(12):1451-1465

Identification of two microRNA nodes as potential cooperative modulators of liver metabolism.

Hochreuter MY; Altıntaş A; Garde C; Emanuelli B; Kahn CR; Zierath JR; Vienberg S; Barrès R
Article: FASEB JOURNAL. 2019;33(9):10551-10562

Secreted protein acidic and rich in cysteine (SPARC) improves glucose tolerance via AMP-activated protein kinase activation.

Aoi W; Hirano N; Lassiter DG; Björnholm M; Chibalin AV; Sakuma K; Tanimura Y; Mizushima K; Takagi T; Naito Y; Zierath JR; Krook A
Article: CELL METABOLISM. 2019;30(1):92-110.e4

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis.

Sato S; Basse AL; Schönke M; Chen S; Samad M; Altıntaş A; Laker RC; Dalbram E; Barrès R; Baldi P; Treebak JT; Zierath JR; Sassone-Corsi P
Article: DIABETES. 2019;68(7):1403-1414

Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice.

Borg ML; Massart J; Schönke M; De Castro Barbosa T; Guo L; Wade M; Alsina-Fernandez J; Miles R; Ryan A; Bauer S; Coskun T; O'Farrell E; Niemeier EM; Chibalin AV; Krook A; Karlsson HK; Brozinick JT; Zierath JR
Article: FASEB JOURNAL. 2019;33(5):6269-6280

Paternal high-fat diet transgenerationally impacts hepatic immunometabolism.

de Castro Barbosa T; Alm PS; Krook A; Barrès R; Zierath JR
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2019;126(4):993-1005

Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action.

Dalbram E; Basse AL; Zierath JR; Treebak JT
Article: JOURNAL OF NUTRITION AND METABOLISM. 2019;2019:1840374-8

Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers.

Lundström P; Caidahl K; Eriksson MJ; Fritz T; Krook A; Zierath JR; Rickenlund A
Article: DIABETES. 2019;68(3):515-526

Circulating Exosomal miR-20b-5p Is Elevated in Type 2 Diabetes and Could Impair Insulin Action in Human Skeletal Muscle.

Katayama M; Wiklander OPB; Fritz T; Caidahl K; El-Andaloussi S; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2019;316(2):E178-E185

Short-term low-calorie diet remodels skeletal muscle lipid profile and metabolic gene expression in obese adults.

Nylén C; Lundell LS; Massart J; Zierath JR; Näslund E
Article: MOLECULAR METABOLISM. 2019;20:79-88

Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle.

Lundell LS; Massart J; Altıntaş A; Krook A; Zierath JR
Article: DIABETOLOGIA. 2019;62(2):233-237

Afternoon exercise is more efficacious than morning exercise at improving blood glucose levels in individuals with type 2 diabetes: a randomised crossover trial.

Savikj M; Gabriel BM; Alm PS; Smith J; Caidahl K; Björnholm M; Fritz T; Krook A; Zierath JR; Wallberg-Henriksson H
Article: MOLECULAR METABOLISM. 2018;16:12-23

AMPK activation negatively regulates GDAP1, which influences metabolic processes and circadian gene expression in skeletal muscle.

Lassiter DG; Sjögren RJO; Gabriel BM; Krook A; Zierath JR
Article: JOURNAL OF OBESITY. 2018;2018:7461903-8

Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus.

Mashili FL; Ramaiya K; Lutale J; Njelekela M; Francis F; Zierath J; Krook A
Article: SCIENCE ADVANCES. 2018;4(8):eaar8590

Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans.

Cedernaes J; Schönke M; Westholm JO; Mi J; Chibalin A; Voisin S; Osler M; Vogel H; Hörnaeus K; Dickson SL; Lind SB; Bergquist J; Schiöth HB; Zierath JR; Benedict C
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1148-1163

Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells.

Pillon NJ; Frendo-Cumbo S; Jacobson MR; Liu Z; Milligan PL; Hoang Bui H; Zierath JR; Bilan PJ; Brozinick JT; Klip A
Article: JOURNAL OF LIPID RESEARCH. 2018;59(7):1276-1282

Effects of high-fat diet and AMP-activated protein kinase modulation on the regulation of whole-body lipid metabolism.

Schönke M; Massart J; Zierath JR
Article: ACTA PHYSIOLOGICA. 2018;223(3):e13051

Protein translation, proteolysis and autophagy in human skeletal muscle atrophy after spinal cord injury.

Lundell LS; Savikj M; Kostovski E; Iversen PO; Zierath JR; Krook A; Chibalin AV; Widegren U
Article: PHYSIOLOGICAL REPORTS. 2018;6(12):e13739

Retained differentiation capacity of human skeletal muscle satellite cells from spinal cord-injured individuals.

Savikj M; Ruby MA; Kostovski E; Iversen PO; Zierath JR; Krook A; Widegren U
Article: PROTEOMICS. 2018;18(5-6):e1700375

Proteomics Analysis of Skeletal Muscle from Leptin-Deficient ob/ob Mice Reveals Adaptive Remodeling of Metabolic Characteristics and Fiber Type Composition.

Schönke M; Björnholm M; Chibalin AV; Zierath JR; Deshmukh AS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(9):E2048-E2057

The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle and internal organs in placental mammals.

Younis S; Schönke M; Massart J; Hjortebjerg R; Sundström E; Gustafson U; Björnholm M; Krook A; Frystyk J; Zierath JR; Andersson L
Article: JOURNAL OF LIPID RESEARCH. 2018;59(2):273-282

Diacylglycerol kinase α deficiency alters inflammation markers in adipose tissue in response to a high-fat diet.

Nascimento EBM; Mannerås-Holm L; Chibalin AV; Björnholm M; Zierath JR
Article: DIABETOLOGIA. 2018;61(2):424-432

FAK tyrosine phosphorylation is regulated by AMPK and controls metabolism in human skeletal muscle.

Lassiter DG; Nylén C; Sjögren RJO; Chibalin AV; Wallberg-Henriksson H; Näslund E; Krook A; Zierath JR
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1198

Skeletal Muscle Insulin Sensitivity Show Circadian Rhythmicity Which Is Independent of Exercise Training Status.

Basse AL; Dalbram E; Larsson L; Gerhart-Hines Z; Zierath JR; Treebak JT
Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2324-2333

DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.

Benziane B; Borg ML; Tom RZ; Riedl I; Massart J; Björnholm M; Gilbert M; Chibalin AV; Zierath JR
Article: SCIENTIFIC REPORTS. 2017;7(1):15134

Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans.

Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barrès R
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2017;313(4):E483-E491

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle.

Ruby MA; Riedl I; Massart J; Åhlin M; Zierath JR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2017;595(14):4611-4630

Early vertebrate origin and diversification of small transmembrane regulators of cellular ion transport.

Pirkmajer S; Kirchner H; Lundell LS; Zelenin PV; Zierath JR; Makarova KS; Wolf YI; Chibalin AV
Article: DIABETES. 2017;66(7):1807-1818

Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle.

Massart J; Sjögren RJO; Lundell LS; Mudry JM; Franck N; O'Gorman DJ; Egan B; Zierath JR; Krook A
Article: MOLECULAR METABOLISM. 2017;6(7):621-630

Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle.

Alm PS; de Castro Barbosa T; Barrès R; Krook A; Zierath JR
Article: JOURNAL OF LIPID RESEARCH. 2017;58(5):907-915

Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice.

Mannerås-Holm L; Schönke M; Brozinick JT; Vetterli L; Bui H-H; Sanders P; Nascimento EBM; Björnholm M; Chibalin AV; Zierath JR
Article: DIABETES. 2017;66(3):651-662

Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.

Mudry JM; Lassiter DG; Nylén C; García-Calzón S; Näslund E; Krook A; Zierath JR
Article: DIABETES. 2017;66(3):598-612

Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.

Kjøbsted R; Munk-Hansen N; Birk JB; Foretz M; Viollet B; Björnholm M; Zierath JR; Treebak JT; Wojtaszewski JFP
Article: CELL REPORTS. 2017;18(3):636-646

Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.

Ruby MA; Massart J; Hunerdosse DM; Schönke M; Correia JC; Louie SM; Ruas JL; Näslund E; Nomura DK; Zierath JR
Article: PLOS MEDICINE. 2016;13(11):e1002179

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA; Scott RA; Sharp SJ; Burgess S; Luan J; Tillin T; Schmidt AF; Imamura F; Stewart ID; Perry JRB; Marney L; Koulman A; Karoly ED; Forouhi NG; Sjögren RJO; Näslund E; Zierath JR; Krook A; Savage DB; Griffin JL; Chaturvedi N; Hingorani AD; Khaw K-T; Barroso I; McCarthy MI; O'Rahilly S; Wareham NJ; Langenberg C
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2016;32(7):754-761

Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.

Mudry JM; Alm PS; Erhardt S; Goiny M; Fritz T; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2016;310(6):E461-E472

AMPKγ3 is dispensable for skeletal muscle hypertrophy induced by functional overload.

Riedl I; Osler ME; Björnholm M; Egan B; Nader GA; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):171-183

Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients.

Kirchner H; Sinha I; Gao H; Ruby MA; Schönke M; Lindvall JM; Barrès R; Krook A; Näslund E; Dahlman-Wright K; Zierath JR
Article: MOLECULAR METABOLISM. 2016;5(3):184-197

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.

de Castro Barbosa T; Ingerslev LR; Alm PS; Versteyhe S; Massart J; Rasmussen M; Donkin I; Sjögren R; Mudry JM; Vetterli L; Gupta S; Krook A; Zierath JR; Barrès R
Article: CELL METABOLISM. 2016;23(2):369-378

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans.

Donkin I; Versteyhe S; Ingerslev LR; Qian K; Mechta M; Nordkap L; Mortensen B; Appel EVR; Jørgensen N; Kristiansen VB; Hansen T; Workman CT; Zierath JR; Barrès R
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2016;310(1):E51-E60

Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energetics.

Jiang LQ; de Castro Barbosa T; Massart J; Deshmukh AS; Löfgren L; Duque-Guimaraes DE; Ozilgen A; Osler ME; Chibalin AV; Zierath JR
Article: MOLECULAR METABOLISM. 2015;4(12):891-902

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.

Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martínez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Björnholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: PHYSIOLOGICAL REPORTS. 2015;3(11):e12622

MicroRNA-208b progressively declines after spinal cord injury in humans and is inversely related to myostatin expression.

Boon H; Sjögren RJO; Massart J; Egan B; Kostovski E; Iversen PO; Hjeltnes N; Chibalin AV; Widegren U; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2015;309(7):E679-E690

Skeletal muscle AMP-activated protein kinase γ1(H151R) overexpression enhances whole body energy homeostasis and insulin sensitivity.

Schönke M; Myers MG; Zierath JR; Björnholm M
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(6):643-655

Effects of sleeping with reduced carbohydrate availability on acute training responses.

Lane SC; Camera DM; Lassiter DG; Areta JL; Bird SR; Yeo WK; Jeacocke NA; Krook A; Zierath JR; Burke LM; Hawley JA
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2015;100(9):E1255-E1261

Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.

Cedernaes J; Osler ME; Voisin S; Broman J-E; Vogel H; Dickson SL; Zierath JR; Schiöth HB; Benedict C
Article: DIABETES & VASCULAR DISEASE RESEARCH. 2015;12(5):315-324

Influence of physical activity and gender on arterial function in type 2 diabetes, normal and impaired glucose tolerance.

Ring M; Eriksson MJ; Fritz T; Nyberg G; Östenson CG; Krook A; Zierath JR; Caidahl K
Article: DIABETES. 2015;64(6):2042-2055

Prior AICAR stimulation increases insulin sensitivity in mouse skeletal muscle in an AMPK-dependent manner.

Kjøbsted R; Treebak JT; Fentz J; Lantier L; Viollet B; Birk JB; Schjerling P; Björnholm M; Zierath JR; Wojtaszewski JFP
Article: DIABETES CARE. 2015;38(6):1154-1160

Changes in gene expression in responders and nonresponders to a low-intensity walking intervention.

Osler ME; Fritz T; Caidahl K; Krook A; Zierath JR; Wallberg-Henriksson H
Article: PHYSIOLOGICAL REPORTS. 2015;3(4):e12372

mRNA expression of diacylglycerol kinase isoforms in insulin-sensitive tissues: effects of obesity and insulin resistance.

Mannerås-Holm L; Kirchner H; Björnholm M; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL REPORTS. 2015;3(3):e12314

Association of the ACTN3 R577X polymorphism with glucose tolerance and gene expression of sarcomeric proteins in human skeletal muscle.

Riedl I; Osler ME; Benziane B; Chibalin AV; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2015;47(3):45-57

Temporal analysis of reciprocal miRNA-mRNA expression patterns predicts regulatory networks during differentiation in human skeletal muscle cells.

Sjögren RJO; Egan B; Katayama M; Zierath JR; Krook A
Article: DIABETES. 2015;64(2):360-369

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation.

Pirkmajer S; Kulkarni SS; Tom RZ; Ross FA; Hawley SA; Hardie DG; Zierath JR; Chibalin AV
Article: CELL METABOLISM. 2015;21(1):138-149

Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes.

Multhaup ML; Seldin MM; Jaffe AE; Lei X; Kirchner H; Mondal P; Li Y; Rodriguez V; Drong A; Hussain M; Lindgren C; McCarthy M; Näslund E; Zierath JR; Wong GW; Feinberg AP
Article: HYPERTENSION RESEARCH. 2014;37(11):999-1007

Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques.

Ring M; Eriksson MJ; Zierath JR; Caidahl K
Article: CELL. 2014;159(1):33-45

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Agudelo LZ; Femenía T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: NATURE. 2014;512(7513):190-193

A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.

Moltke I; Grarup N; Jørgensen ME; Bjerregaard P; Treebak JT; Fumagalli M; Korneliussen TS; Andersen MA; Nielsen TS; Krarup NT; Gjesing AP; Zierath JR; Linneberg A; Wu X; Sun G; Jin X; Al-Aama J; Wang J; Borch-Johnsen K; Pedersen O; Nielsen R; Albrechtsen A; Hansen T
Article: SURGERY FOR OBESITY AND RELATED DISEASES. 2014;10(4):671-678

Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass.

Kirchner H; Nylen C; Laber S; Barrès R; Yan J; Krook A; Zierath JR; Näslund E
Article: BMC RESEARCH NOTES. 2014;7:391

A simple and rapid method to characterize lipid fate in skeletal muscle.

Massart J; Zierath JR; Chibalin AV
Article: DIABETES. 2014;63(5):1560-1571

Effects of AMPK activation on insulin sensitivity and metabolism in leptin-deficient ob/ob mice.

Zachariah Tom R; Garcia-Roves PM; Sjögren RJO; Jiang LQ; Holmström MH; Deshmukh AS; Vieira E; Chibalin AV; Björnholm M; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1408-E1414

Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle.

Nascimento EB; Osler ME; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2013;305(11):E1359-E1366

Autocrine role of interleukin-13 on skeletal muscle glucose metabolism in type 2 diabetic patients involves microRNA let-7.

Jiang LQ; Franck N; Egan B; Sjögren RJO; Katayama M; Duque-Guimaraes D; Arner P; Zierath JR; Krook A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2013;591(20):5207-5220

AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle.

Brandauer J; Vienberg SG; Andersen MA; Ringholm S; Risis S; Larsen PS; Kristensen JM; Frøsig C; Leick L; Fentz J; Jørgensen S; Kiens B; Wojtaszewski JFP; Richter EA; Zierath JR; Goodyear LJ; Pilegaard H; Treebak JT
Article: ENDOCRINOLOGY. 2013;154(10):3502-3514

Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.

Dokas J; Chadt A; Nolden T; Himmelbauer H; Zierath JR; Joost H-G; Al-Hasani H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2013;591(18):4637-4653

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training.

Russell AP; Lamon S; Boon H; Wada S; Güller I; Brown EL; Chibalin AV; Zierath JR; Snow RJ; Stepto N; Wadley GD; Akimoto T
Article: FASEB JOURNAL. 2013;27(9):3660-3671

Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet.

Cansby E; Amrutkar M; Mannerås Holm L; Nerstedt A; Reyahi A; Stenfeldt E; Borén J; Carlsson P; Smith U; Zierath JR; Mahlapuu M
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2013;62(9):1258-1267

Effect of leptin treatment on mitochondrial function in obese leptin-deficient ob/ob mice.

Holmström MH; Tom RZ; Björnholm M; Garcia-Roves PM; Zierath JR
Article: PHYSIOLOGICAL GENOMICS. 2013;45(9):367-376

Expression of carnitine palmitoyl-CoA transferase-1B is influenced by a cis-acting eQTL in two chicken lines selected for high and low body weight.

Ka S; Markljung E; Ring H; Albert FW; Harun-Or-Rashid M; Wahlberg P; Garcia-Roves PM; Zierath JR; Denbow DM; Pääbo S; Siegel PB; Andersson L; Hallböök F
Article: CELL REPORTS. 2013;3(4):1020-1027

Weight loss after gastric bypass surgery in human obesity remodels promoter methylation.

Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Näslund E; Zierath JR
Article: DIABETES. 2013;62(2):355-361

Altered response of skeletal muscle to IL-6 in type 2 diabetic patients.

Jiang LQ; Duque-Guimaraes DE; Machado UF; Zierath JR; Krook A
Article: DIABETES. 2013;62(2):457-465

Constitutive STAT3 phosphorylation contributes to skeletal muscle insulin resistance in type 2 diabetes.

Mashili F; Chibalin AV; Krook A; Zierath JR
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2013;62(1):79-89

L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway.

de Castro Barbosa T; Jiang LQ; Zierath JR; Nunes MT
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2013;29(1):25-32

Effects of Nordic walking on cardiovascular risk factors in overweight individuals with type 2 diabetes, impaired or normal glucose tolerance.

Fritz T; Caidahl K; Krook A; Lundström P; Mashili F; Osler M; Szekeres FLM; Östenson CG; Wändell P; Zierath JR
Article: PLOS ONE. 2013;8(9):e74098

Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle.

Egan B; O'Connor PL; Zierath JR; O'Gorman DJ
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;303(4):E524-E533

The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.

Szekeres F; Chadt A; Tom RZ; Deshmukh AS; Chibalin AV; Björnholm M; Al-Hasani H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(28):23451-23463

Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells.

Benziane B; Björnholm M; Pirkmajer S; Austin RL; Kotova O; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;302(6):E731-E739

Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.

Holmström MH; Iglesias-Gutierrez E; Zierath JR; Garcia-Roves PM
Article: CELL METABOLISM. 2012;15(3):405-411

Acute exercise remodels promoter methylation in human skeletal muscle.

Barrès R; Yan J; Egan B; Treebak JT; Rasmussen M; Fritz T; Caidahl K; Krook A; O'Gorman DJ; Zierath JR
Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2012;61(2):175-185

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus.

Kulkarni SS; Salehzadeh F; Fritz T; Zierath JR; Krook A; Osler ME
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(18):2555-2561

Evidence for non-CpG methylation in mammals.

Yan J; Zierath JR; Barrès R
Article: DIABETIC MEDICINE. 2011;28(11):1362-1372

Effects of Nordic walking on health-related quality of life in overweight individuals with type 2 diabetes mellitus, impaired or normal glucose tolerance.

Fritz T; Caidahl K; Osler M; Ostenson CG; Zierath JR; Wändell P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(40):34567-34574

Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle.

Kulkarni SS; Karlsson HKR; Szekeres F; Chibalin AV; Krook A; Zierath JR
Article: PROTEOMICS. 2011;11(8):1413-1428

2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training.

Egan B; Dowling P; O'Connor PL; Henry M; Meleady P; Zierath JR; O'Gorman DJ
Article: DIABETOLOGIA. 2011;54(4):795-802

Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

Hribal ML; Presta I; Procopio T; Marini MA; Stančáková A; Kuusisto J; Andreozzi F; Hammarstedt A; Jansson P-A; Grarup N; Hansen T; Walker M; Stefan N; Fritsche A; Häring HU; Pedersen O; Smith U; Laakso M; Sesti G; EUGENE2 Consortium
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2011;27(3):286-297

Direct effects of FGF21 on glucose uptake in human skeletal muscle: implications for type 2 diabetes and obesity.

Mashili FL; Austin RL; Deshmukh AS; Fritz T; Caidahl K; Bergdahl K; Zierath JR; Chibalin AV; Moller DE; Kharitonenkov A; Krook A
Article: THROMBOSIS AND HAEMOSTASIS. 2011;105(1):122-130

Strenuous physical exercise adversely affects monocyte chemotaxis.

Czepluch FS; Barrès R; Caidahl K; Olieslagers S; Krook A; Rickenlund A; Zierath JR; Waltenberger J
Article: DIABETOLOGIA. 2011;54(1):157-167

Impaired insulin-induced site-specific phosphorylation of TBC1 domain family, member 4 (TBC1D4) in skeletal muscle of type 2 diabetes patients is restored by endurance exercise-training.

Vind BF; Pehmøller C; Treebak JT; Birk JB; Hey-Mogensen M; Beck-Nielsen H; Zierath JR; Wojtaszewski JFP; Højlund K
Article: JOURNAL OF BIOLOGICAL SYSTEMS. 2010;18(3):687-707

VALIDATION OF THE IN VITRO INCUBATION OF EXTENSOR DIGITORUM LONGUS MUSCLE FROM MICE WITH A MATHEMATICAL MODEL

Sogaard P; Harlen M; Long YC; Szekeres F; Barnes BR; Chibalin AV; Zierath JR
Article: MOLECULAR IMMUNOLOGY. 2010;47(14):2388-2396

The proteasome inhibitor bortezomib disrupts tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression and natural killer (NK) cell killing of TRAIL receptor-positive multiple myeloma cells.

Feng X; Yan J; Wang Y; Zierath JR; Nordenskjöld M; Henter J-I; Fadeel B; Zheng C
Article: DIABETOLOGIA. 2010;53(6):1142-1150

Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)alpha1-specific activity and glucose transport in human skeletal muscle.

Deshmukh AS; Long YC; de Castro Barbosa T; Karlsson HKR; Glund S; Zavadoski WJ; Gibbs EM; Koistinen HA; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(Pt 10):1779-1790

Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle.

Egan B; Carson BP; Garcia-Roves PM; Chibalin AV; Sarsfield FM; Barron N; McCaffrey N; Moyna NM; Zierath JR; O'Gorman DJ
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2010;109(5):943-949

Spatial insulin signalling in isolated skeletal muscle preparations.

Sogaard P; Szekeres F; Garcia-Roves PM; Larsson D; Chibalin AV; Zierath JR
Article: CELL METABOLISM. 2010;11(3):213-219

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.

Cantó C; Jiang LQ; Deshmukh AS; Mataki C; Coste A; Lagouge M; Zierath JR; Auwerx J
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2010;298(1):E8-E16

Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.

Jiang LQ; Garcia-Roves PM; de Castro Barbosa T; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2009;297(6):C1554-C1566

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase.

Benziane B; Björnholm M; Lantier L; Viollet B; Zierath JR; Chibalin AV
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2009;297(6):E1388-E1394

Role of the AMPKgamma3 isoform in hypoxia-stimulated glucose transport in glycolytic skeletal muscle.

Deshmukh AS; Glund S; Tom RZ; Zierath JR
Article: PLOS BIOLOGY. 2009;7(12):e1000256

ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.

Markljung E; Jiang L; Jaffe JD; Mikkelsen TS; Wallerman O; Larhammar M; Zhang X; Wang L; Saenz-Vash V; Gnirke A; Lindroth AM; Barrés R; Yan J; Strömberg S; De S; Pontén F; Lander ES; Carr SA; Zierath JR; Kullander K; Wadelius C; Lindblad-Toh K; Andersson G; Hjälm G; Andersson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(44):30016-30023

Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation.

Peck GR; Chavez JA; Roach WG; Budnik BA; Lane WS; Karlsson HKR; Zierath JR; Lienhard GE
Article: DIABETOLOGIA. 2009;52(10):2182-2189

Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.

Rune A; Osler ME; Fritz T; Zierath JR
Article: CELL METABOLISM. 2009;10(3):189-198

Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.

Barrès R; Osler ME; Yan J; Rune A; Fritz T; Caidahl K; Krook A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2009;296(5):E969-E972

Hunting for the SNARK in metabolic disease.

Egan B; Zierath JR
Article: DIABETOLOGIA. 2009;52(5):891-900

Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle.

Treebak JT; Frøsig C; Pehmøller C; Chen S; Maarbjerg SJ; Brandt N; MacKintosh C; Zierath JR; Hardie DG; Kiens B; Richter EA; Pilegaard H; Wojtaszewski JFP
Article: CIRCULATION RESEARCH. 2009;104(8):961-U97

T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice.

Sultan A; Strodthoff D; Robertson A-K; Paulsson-Berne G; Fauconnier J; Parini P; Rydén M; Thierry-Mieg N; Johansson ME; Chibalin AV; Zierath JR; Arner P; Hansson GK
Article: DIABETES. 2009;58(4):847-854

Kinetics of GLUT4 trafficking in rat and human skeletal muscle.

Karlsson HKR; Chibalin AV; Koistinen HA; Yang J; Koumanov F; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: ENDOCRINOLOGY. 2009;150(2):600-606

Role of adenosine 5'-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.

Glund S; Treebak JT; Long YC; Barres R; Viollet B; Wojtaszewski JF; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(51):35724-35734

Gain-of-function R225Q mutation in AMP-activated protein kinase gamma3 subunit increases mitochondrial biogenesis in glycolytic skeletal muscle.

Garcia-Roves PM; Osler ME; Holmström MH; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2008;295(6):E1427-E1438

Divergent cell signaling after short-term intensified endurance training in human skeletal muscle.

Benziane B; Burton TJ; Scanlan B; Galuska D; Canny BJ; Chibalin AV; Zierath JR; Stepto NK
Article: JOURNAL OF ENDOCRINOLOGY. 2008;199(2):X1

The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms.

Lundholm L; Bryzgalova G; Gao H; Portwood N; Fält S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-Å; Efendic S; Dahlman-Wright K; Khan A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2008;295(5):E1032-E1037

Relationship between AMPK and the transcriptional balance of clock-related genes in skeletal muscle.

Vieira E; Nilsson EC; Nerstedt A; Ormestad M; Long YC; Garcia-Roves PM; Zierath JR; Mahlapuu M
Article: NATURE GENETICS. 2008;40(11):1354-1359

Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.

Chadt A; Leicht K; Deshmukh A; Jiang LQ; Scherneck S; Bernhardt U; Dreja T; Vogel H; Schmolz K; Kluge R; Zierath JR; Hultschig C; Hoeben RC; Schürmann A; Joost H-G; Al-Hasani H
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2008;24(7):554-562

Globular adiponectin stimulates glucose transport in type 2 diabetic muscle.

Kuoppamaa H; Skrobuk P; Sihvo M; Hiukka A; Chibalin AV; Zierath JR; Koistinen HA
Article: DIABETES. 2008;57(8):2066-2073

siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle.

Austin RL; Rune A; Bouzakri K; Zierath JR; Krook A
Article: DIABETES. 2008;57(6):1508-1516

Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle.

Bouzakri K; Austin R; Rune A; Lassman ME; Garcia-Roves PM; Berger JP; Krook A; Chibalin AV; Zhang BB; Zierath JR
Article: CELL METABOLISM. 2008;7(6):545-554

Glutamate is a positive autocrine signal for glucagon release.

Cabrera O; Jacques-Silva MC; Speier S; Yang S-N; Köhler M; Fachado A; Vieira E; Zierath JR; Kibbey R; Berman DM; Kenyon NS; Ricordi C; Caicedo A; Berggren P-O
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2008;93(5):1924-1930

Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance.

Stancáková A; Pihlajamäki J; Kuusisto J; Stefan N; Fritsche A; Häring H; Andreozzi F; Succurro E; Sesti G; Boesgaard TW; Hansen T; Pedersen O; Jansson PA; Hammarstedt A; Smith U; Laakso M; EUGENE2 Consortium
Article: MOLECULAR ENDOCRINOLOGY. 2008;22(5):1105-1112

Role of adenosine 5'-monophosphate-activated protein kinase subunits in skeletal muscle mammalian target of rapamycin signaling.

Deshmukh AS; Treebak JT; Long YC; Viollet B; Wojtaszewski JFP; Zierath JR
Article: DIABETOLOGIA. 2008;51(3):502-511

Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.

Laakso M; Zilinskaite J; Hansen T; Boesgaard TW; Vänttinen M; Stancáková A; Jansson P-A; Pellmé F; Holst JJ; Kuulasmaa T; Hribal ML; Sesti G; Stefan N; Fritsche A; Häring H; Pedersen O; Smith U; EUGENE2 Consortium
Article: CELL. 2008;132(3):375-386

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

Chibalin AV; Leng Y; Vieira E; Krook A; Björnholm M; Long YC; Kotova O; Zhong Z; Sakane F; Steiler T; Nylén C; Wang J; Laakso M; Topham MK; Gilbert M; Wallberg-Henriksson H; Zierath JR
Article: EXPERT REVIEW OF ENDOCRINOLOGY AND METABOLISM. 2007;2(4):477-485

Skeletal muscle AMP kinase as a target to prevent pathogenesis of Type 2 diabetes.

Krook A; Long YC; Zierath JR
Article: DIABETES. 2007;56(6):1630-1637

Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle.

Glund S; Deshmukh A; Long YC; Moller T; Koistinen HA; Caidahl K; Zierath JR; Krook A
Article: PLOS MEDICINE. 2007;4(5):e158-879

TXNIP regulates peripheral glucose metabolism in humans.

Parikh H; Carlsson E; Chutkow WA; Johansson LE; Storgaard H; Poulsen P; Saxena R; Ladd C; Schulze PC; Mazzini MJ; Jensen CB; Krook A; Björnholm M; Tornqvist H; Zierath JR; Ridderstråle M; Altshuler D; Lee RT; Vaag A; Groop LC; Mootha VK
Article: DIABETOLOGIA. 2007;50(5):1048-1057

Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor alpha/gamma agonist on glucose uptake.

Hu X; Feng Y; Liu X; Zhao X-F; Yu J-H; Yang Y-S; Sydow-Bäckman M; Hörling J; Zierath JR; Leng Y
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(11):7783-7789

MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance.

Bouzakri K; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(3):1607-1614

Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression.

Long YC; Glund S; Garcia-Roves PM; Zierath JR
Article: DIABETOLOGIA. 2006;49(12):2983-2992

Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes.

O'Gorman DJ; Karlsson HKR; McQuaid S; Yousif O; Rahman Y; Gasparro D; Glund S; Chibalin AV; Zierath JR; Nolan JJ
Article: DIABETES-METABOLISM RESEARCH AND REVIEWS. 2006;22(6):492-498

Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients.

Fritz T; Krämer DK; Karlsson HKR; Galuska D; Engfeldt P; Zierath JR; Krook A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2006;63(19-20):2405-2414

Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity.

Wang J; Shafqat J; Hall K; Ståhlberg M; Wivall-Helleryd I-L; Bouzakri K; Zierath JR; Brismar K; Jörnvall H; Lewitt MS
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(31):21690-21697

Neuregulins mediate calcium-induced glucose transport during muscle contraction.

Cantó C; Chibalin AV; Barnes BR; Glund S; Suárez E; Ryder JW; Palacín M; Zierath JR; Zorzano A; Gumà A
Article: CELL METABOLISM. 2006;4(1):89-96

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.

Bouzakri K; Zachrisson A; Al-Khalili L; Zhang BB; Koistinen HA; Krook A; Zierath JR
Article: DIABETES. 2006;55(7):2051-2058

AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits.

Treebak JT; Glund S; Deshmukh A; Klein DK; Long YC; Jensen TE; Jørgensen SB; Viollet B; Andersson L; Neumann D; Wallimann T; Richter EA; Chibalin AV; Zierath JR; Wojtaszewski JFP
Article: DIABETES. 2006;55(6):1776-1782

Exercise-induced phosphorylation of the novel Akt substrates AS160 and filamin A in human skeletal muscle.

Deshmukh A; Coffey VG; Zhong Z; Chibalin AV; Hawley JA; Zierath JR
Article: DIABETES. 2006;55(5):1283-1288

Insulin signaling and glucose transport in skeletal muscle from first-degree relatives of type 2 diabetic patients.

Karlsson HKR; Ahlsén M; Zierath JR; Wallberg-Henriksson H; Koistinen HA
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(11):7244-7252

Opposite transcriptional regulation in skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out mice.

Nilsson EC; Long YC; Martinsson S; Glund S; Garcia-Roves P; Svensson LT; Andersson L; Zierath JR; Mahlapuu M
Article: DIABETES. 2006;55(3):785-791

IRS-1 serine phosphorylation and insulin resistance in skeletal muscle from pancreas transplant recipients.

Bouzakri K; Karlsson HKR; Vestergaard H; Madsbad S; Christiansen E; Zierath JR
Article: DIABETOLOGIA. 2006;49(3):588-597

Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver.

Bryzgalova G; Gao H; Ahren B; Zierath JR; Galuska D; Steiler TL; Dahlman-Wright K; Nilsson S; Gustafsson J-A; Efendic S; Khan A
Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2006;17(1):45-52

Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise.

Kannisto K; Chibalin A; Glinghammar B; Zierath JR; Hamsten A; Ehrenborg E
Article: FASEB JOURNAL. 2006;20(1):190-192

Early signaling responses to divergent exercise stimuli in skeletal muscle from well-trained humans.

Coffey VG; Zhong Z; Shield A; Canny BJ; Chibalin AV; Zierath JR; Hawley JA
Article: DIABETES. 2005;54(12):3484-3489

Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice.

Barnes BR; Long YC; Steiler TL; Leng Y; Galuska D; Wojtaszewski JFP; Andersson L; Zierath JR
Article: DIABETOLOGIA. 2005;48(11):2354-2364

Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle.

Long YC; Barnes BR; Mahlapuu M; Steiler TL; Martinsson S; Leng Y; Wallberg-Henriksson H; Andersson L; Zierath JR
Article: DIABETES. 2005;54(10):2939-2945

Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation.

Plomgaard P; Bouzakri K; Krogh-Madsen R; Mittendorfer B; Zierath JR; Pedersen BK
Article: DIABETES. 2005;54(9):2685-2693

Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.

Bach D; Naon D; Pich S; Soriano FX; Vega N; Rieusset J; Laville M; Guillet C; Boirie Y; Wallberg-Henriksson H; Manco M; Calvani M; Castagneto M; Palacín M; Mingrone G; Zierath JR; Vidal H; Zorzano A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2005;567(Pt 2):379-386

Effects of calcineurin activation on insulin-, AICAR- and contraction-induced glucose transport in skeletal muscle.

Ryder JW; Long YC; Nilsson E; Mahlapuu M; Zierath JR
Article: DIABETES. 2005;54(6):1692-1697

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects.

Karlsson HKR; Zierath JR; Kane S; Krook A; Lienhard GE; Wallberg-Henriksson H
Article: DIABETOLOGIA. 2005;48(6):1173-1179

Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1.

Al-Khalili L; Forsgren M; Kannisto K; Zierath JR; Lönnqvist F; Krook A
Article: FASEB JOURNAL. 2005;19(7):773-779

5'-AMP-activated protein kinase regulates skeletal muscle glycogen content and ergogenics.

Barnes BR; Glund S; Long YC; Hjälm G; Andersson L; Zierath JR
Article: DIABETES. 2005;54(5):1459-1467

Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study.

Karlsson HKR; Hällsten K; Björnholm M; Tsuchida H; Chibalin AV; Virtanen KA; Heinonen OJ; Lönnqvist F; Nuutila P; Zierath JR
Article: DIABETES. 2005;54(4):1157-1163

Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta.

Krämer DK; Al-Khalili L; Perrini S; Skogsberg J; Wretenberg P; Kannisto K; Wallberg-Henriksson H; Ehrenborg E; Zierath JR; Krook A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(37):38441-38447

The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle.

Barnes BR; Marklund S; Steiler TL; Walter M; Hjälm G; Amarger V; Mahlapuu M; Leng Y; Johansson C; Galuska D; Lindgren K; Abrink M; Stapleton D; Zierath JR; Andersson L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;287(3):E553-E557

Prior serum- and AICAR-induced AMPK activation in primary human myocytes does not lead to subsequent increase in insulin-stimulated glucose uptake.

Al-Khalili L; Krook A; Zierath JR; Cartee GD
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;287(1):E1-E7

Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise.

Karlsson HKR; Nilsson P-A; Nilsson J; Chibalin AV; Zierath JR; Blomstrand E
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2004;36(7):1212-1217

Sending the signal: molecular mechanisms regulating glucose uptake.

Krook A; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2004;53(6):1436-1444

Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice.

Leng Y; Steiler TL; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2004;286(6):C1410-C1416

MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways.

Al-Khalili L; Chibalin AV; Yu M; Sjödin B; Nylén C; Zierath JR; Krook A
Article: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. 2004;5(2):111-117

Insulin signaling defects in type 2 diabetes.

Leng Y; Karlsson HKR; Zierath JR
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2004;89(3):1301-1311

Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes.

Storgaard H; Jensen CB; Björnholm M; Song XM; Madsbad S; Zierath JR; Vaag AA
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2004;286(2):E194-E200

Expression profiling of the gamma-subunit isoforms of AMP-activated protein kinase suggests a major role for gamma3 in white skeletal muscle.

Mahlapuu M; Johansson C; Lindgren K; Hjälm G; Barnes BR; Krook A; Zierath JR; Andersson L; Marklund S
Article: OBESITY. 2004;12(1):25-31

Insulin action on expression of novel adipose genes in healthy and type 2 diabetic subjects.

Koistinen HA; Forsgren M; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2004;53(1):21-24

Exercise-induced protein kinase C isoform-specific activation in human skeletal muscle.

Perrini S; Henriksson J; Zierath JR; Widegren U
Article: ENDOCRINOLOGY. 2003;144(12):5259-5267

Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats.

Steiler TL; Galuska D; Leng Y; Chibalin AV; Gilbert M; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(45):44298-44304

Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways.

Ryder JW; Bassel-Duby R; Olson EN; Zierath JR
Article: DIABETOLOGIA. 2003;46(10):1324-1328

Aberrant p38 mitogen-activated protein kinase signalling in skeletal muscle from Type 2 diabetic patients.

Koistinen HA; Chibalin AV; Zierath JR
Article: BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2003;17(3):385-398

The effect of hyperglycaemia on glucose disposal and insulin signal transduction in skeletal muscle.

Zierath JR; Kawano Y
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2003;550(Pt 1):305-315

Insulin signalling and resistance in patients with chronic heart failure.

Kemppainen J; Tsuchida H; Stolen K; Karlsson H; Björnholm M; Heinonen OJ; Nuutila P; Krook A; Knuuti J; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(19):17190-17197

Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.

Bach D; Pich S; Soriano FX; Vega N; Baumgartner B; Oriola J; Daugaard JR; Lloberas J; Camps M; Zierath JR; Rabasa-Lhoret R; Wallberg-Henriksson H; Laville M; Palacín M; Vidal H; Rivera F; Brand M; Zorzano A
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2003;60(5):991-998

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content.

Al-Khalili L; Chibalin AV; Kannisto K; Zhang BB; Permert J; Holman GD; Ehrenborg E; Ding VDH; Zierath JR; Krook A
Article: DIABETES. 2003;52(5):1066-1072

5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes.

Koistinen HA; Galuska D; Chibalin AV; Yang J; Zierath JR; Holman GD; Wallberg-Henriksson H
Article: PANCREAS. 2003;26(2):173-177

Impaired insulin action on phosphatidylinositol 3-kinase activity and glucose transport in skeletal muscle of pancreatic cancer patients.

Isaksson B; Strömmer L; Friess H; Büchler MW; Herrington MK; Wang F; Zierath JR; Wallberg-Henriksson H; Larsson J; Permert J
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2003;546(Pt 2):327-335

Metabolic and mitogenic signal transduction in human skeletal muscle after intense cycling exercise.

Yu M; Stepto NK; Chibalin AV; Fryer LGD; Carling D; Krook A; Hawley JA; Zierath JR
Article: DIABETOLOGIA. 2002;45(12):1697-1702

Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans.

Björnholm M; He AR; Attersand A; Lake S; Liu SCH; Lienhard GE; Taylor S; Arner P; Zierath JR
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;445(1):25-31

Gene expression of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in skeletal muscle from type 2 diabetic subjects.

Tsuchida H; Björnholm M; Fernström M; Galuska D; Johansson P; Wallberg-Henriksson H; Zierath JR; Lake S; Krook A
Article: DIABETES. 2002;51(9):2703-2708

Isoform-specific regulation of 5' AMP-activated protein kinase in skeletal muscle from obese Zucker (fa/fa) rats in response to contraction.

Barnes BR; Ryder JW; Steiler TL; Fryer LGD; Carling D; Zierath JR
Article: DIABETOLOGIA. 2002;45(8):1128-1135

Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet.

Björnholm M; Al-Khalili L; Dicker A; Näslund E; Rössner S; Zierath JR; Arner P
Article: DIABETOLOGIA. 2002;45(1):56-65

5-Aminoimidazole-4-carboxamide ribonucleoside treatment improves glucose homeostasis in insulin-resistant diabetic (ob/ob) mice.

Song XM; Fiedler M; Galuska D; Ryder JW; Fernström M; Chibalin AV; Wallberg-Henriksson H; Zierath JR
Article: DIABETOLOGIA. 2001;44(12):2180-2186

5-aminoimidazole-4-carboxy-amide-1-beta-D-ribofuranoside treatment ameliorates hyperglycaemia and hyperinsulinaemia but not dyslipidaemia in KKAy-CETP mice.

Fiedler M; Zierath JR; Selén G; Wallberg-Henriksson H; Liang Y; Sakariassen KS
Article: DIABETES. 2001;50(12):2770-2778

Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients [corrected].

Storgaard H; Song XM; Jensen CB; Madsbad S; Björnholm M; Vaag A; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2001;281(6):E1255-E1259

Evidence against high glucose as a mediator of ERK1/2 or p38 MAPK phosphorylation in rat skeletal muscle.

Kawano Y; Ryder JW; Rincon J; Zierath JR; Krook A; Wallberg-Henriksson H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2001;536(Pt 1):273-282

Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle.

Yu M; Blomstrand E; Chibalin AV; Krook A; Zierath JR
Article: ENDOCRINOLOGY. 2001;142(8):3474-3482

Insulin- and glucose-induced phosphorylation of the Na(+),K(+)-adenosine triphosphatase alpha-subunits in rat skeletal muscle.

Chibalin AV; Kovalenko MV; Ryder JW; Féraille E; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 2001;50(5):1149-1157

Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression.

Ryder JW; Portocarrero CP; Song XM; Cui L; Yu M; Combatsiaris T; Galuska D; Bauman DE; Barbano DM; Charron MJ; Zierath JR; Houseknecht KL
Article: FASEB JOURNAL. 2001;15(6):958-969

Metabolic adaptations in skeletal muscle overexpressing GLUT4: effects on muscle and physical activity.

Tsao TS; Li J; Chang KS; Stenbit AE; Galuska D; Anderson JE; Zierath JR; McCarter RJ; Charron MJ
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2001;90(1):29-34

Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport.

Yu M; Blomstrand E; Chibalin AV; Wallberg-Henriksson H; Zierath JR; Krook A
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2000;279(5):R1716-R1721

Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle.

Krook A; Widegren U; Jiang XJ; Henriksson J; Wallberg-Henriksson H; Alessi D; Zierath JR
Article: HUMAN MOLECULAR GENETICS. 2000;9(14):2149-2158

Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats.

Fakhrai-Rad H; Nikoshkov A; Kamel A; Fernström M; Zierath JR; Norgren S; Luthman H; Galli J
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2000;279(1):E206-E212

Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.

Del Aguila LF; Krishnan RK; Ulbrecht JS; Farrell PA; Correll PH; Lang CH; Zierath JR; Kirwan JP
Article: DIABETES. 2000;49(4):647-654

Use of a novel impermeable biotinylated photolabeling reagent to assess insulin- and hypoxia-stimulated cell surface GLUT4 content in skeletal muscle from type 2 diabetic patients.

Ryder JW; Yang J; Galuska D; Rincón J; Björnholm M; Krook A; Lund S; Pedersen O; Wallberg-Henriksson H; Zierath JR; Holman GD
Article: DIABETES. 2000;49(2):284-292

Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients.

Krook A; Björnholm M; Galuska D; Jiang XJ; Fahlman R; Myers MG; Wallberg-Henriksson H; Zierath JR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1457-1462

Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.

Ryder JW; Fahlman R; Wallberg-Henriksson H; Alessi DR; Krook A; Zierath JR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(1):38-43

Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor substrates 1 and 2.

Chibalin AV; Yu M; Ryder JW; Song XM; Galuska D; Krook A; Wallberg-Henriksson H; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1999;277(6):R1690-R1696

Muscle fiber type specificity in insulin signal transduction.

Song XM; Ryder JW; Kawano Y; Chibalin AV; Krook A; Zierath JR
Article: FASEB JOURNAL. 1999;13(15):2246-2256

Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4-deficient mice.

Ryder JW; Kawano Y; Galuska D; Fahlman R; Wallberg-Henriksson H; Charron MJ; Zierath JR
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1999;439(1-2):130-133

Effect of the nicotine metabolite 5'-hydroxycotinine on glucose transport and glycogen synthase activity in rat skeletal muscle.

Rincón J; Galuska D; Ryder JW; Kawano Y; Wallberg-Henriksson H; Gorrod JW; Zierath JR
Article: BIOCHEMICAL JOURNAL. 1999;342 ( Pt 2)(Pt 2):321-328

In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle.

Ryder JW; Kawano Y; Chibalin AV; Rincón J; Tsao TS; Stenbit AE; Combatsiaris T; Yang J; Holman GD; Charron MJ; Zierath JR
Article: DIABETOLOGIA. 1999;42(9):1071-1079

Changes in glucose transport and protein kinase Cbeta(2) in rat skeletal muscle induced by hyperglycaemia.

Kawano Y; Rincon J; Soler A; Ryder JW; Nolte LA; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1999;42(Suppl 1):a1-a330

35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999.
Article: DIABETOLOGIA. 1999;42(7):826-830

Regulation of UCP2 and UCP3 by muscle disuse and physical activity in tetraplegic subjects.

Hjeltnes N; Fernström M; Zierath JR; Krook A
Article: SCIENCE. 1999;284(5416):974-977

Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.

Zhang B; Salituro G; Szalkowski D; Li Z; Zhang Y; Royo I; Vilella D; Díez MT; Pelaez F; Ruby C; Kendall RL; Mao X; Griffin P; Calaycay J; Zierath JR; Heck JV; Smith RG; Moller DE
Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 1999;19(2):135-142

Altered skeletal muscle glucose transport and blood lipid levels in habitual cigarette smokers.

Rincón J; Krook A; Galuska D; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(3):664-670

Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats.

Song XM; Kawano Y; Krook A; Ryder JW; Efendic S; Roth RA; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1999;48(2):310-320

Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

Kim YB; Zhu JS; Zierath JR; Shen HQ; Baron AD; Kahn BB
Article: FASEB JOURNAL. 1998;12(15):1701-1712

Exercise-induced overexpression of key regulatory proteins involved in glucose uptake and metabolism in tetraplegic persons: molecular mechanism for improved glucose homeostasis.

Hjeltnes N; Galuska D; Björnholm M; Aksnes AK; Lannem A; Zierath JR; Wallberg-Henriksson H
Article: ENDOCRINOLOGY. 1998;139(12):5034-5041

Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action.

Zierath JR; Ryder JW; Doebber T; Woods J; Wu M; Ventre J; Li Z; McCrary C; Berger J; Zhang B; Moller DE
Article: DIABETOLOGIA. 1998;41(11):1343-1354

Regional difference in insulin inhibition of non-esterified fatty acid release from human adipocytes: relation to insulin receptor phosphorylation and intracellular signalling through the insulin receptor substrate-1 pathway.

Zierath JR; Livingston JN; Thörne A; Bolinder J; Reynisdottir S; Lönnqvist F; Arner P
Article: FASEB JOURNAL. 1998;12(13):1379-1389

Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle.

Widegren U; Jiang XJ; Krook A; Chibalin AV; Björnholm M; Tally M; Roth RA; Henriksson J; Wallberg-henriksson H; Zierath JR
Article: DIABETES. 1998;47(9):1528-1531

Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients.

Krook A; Digby J; O'Rahilly S; Zierath JR; Wallberg-Henriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(33):20910-20915

Restoration of hypoxia-stimulated glucose uptake in GLUT4-deficient muscles by muscle-specific GLUT4 transgenic complementation.

Zierath JR; Tsao TS; Stenbit AE; Ryder JW; Galuska D; Charron MJ
Article: DIABETES. 1998;47(8):1281-1286

Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects.

Krook A; Roth RA; Jiang XJ; Zierath JR; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1998;275(2):E351-E358

Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport.

Strömmer L; Permert J; Arnelo U; Koehler C; Isaksson B; Larsson J; Lundkvist I; Björnholm M; Kawano Y; Wallberg-Henriksson H; Zierath JR
Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1998;182(1-2):153-160

Insulin action in skeletal muscle from patients with NIDDM.

Zierath JR; Krook A; Wallberg-Henriksson H
Article: MOLECULAR BIOLOGY OF THE CELL. 1998;9(5):1209-1220

Phosphatidylinositol 3-kinase-mediated endocytosis of renal Na+, K+-ATPase alpha subunit in response to dopamine.

Chibalin AV; Zierath JR; Katz AI; Berggren PO; Bertorello AM
Article: DIABETES. 1998;47(1):1-4

Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes.

Zierath JR; Frevert EU; Ryder JW; Berggren PO; Kahn BB
Article: DIABETES. 1997;46(12):2110-2114

Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats.

Krook A; Kawano Y; Song XM; Efendić S; Roth RA; Wallberg-Henriksson H; Zierath JR
Article: DIABETES. 1997;46(12):1965-1969

Effect of insulin on GLUT4 cell surface content and turnover rate in human skeletal muscle as measured by the exofacial bis-mannose photolabeling technique.

Lund S; Holman GD; Zierath JR; Rincon J; Nolte LA; Clark AE; Schmitz O; Pedersen O; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1997;40(10):1172-1177

Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism.

Shepherd PR; Nave BT; Rincon J; Haigh RJ; Foulstone E; Proud C; Zierath JR; Siddle K; Wallberg-Henriksson H
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;100(3):671-677

Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism.

Tsao TS; Stenbit AE; Li J; Houseknecht KL; Zierath JR; Katz EB; Charron MJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(30):19000-19007

Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.

Shepherd PR; Navé BT; Rincon J; Nolte LA; Bevan AP; Siddle K; Zierath JR; Wallberg-Henriksson H
Article: DIABETES. 1997;46(3):524-527

Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation.

Björnholm M; Kawano Y; Lehtihet M; Zierath JR
Article: DIABETOLOGIA. 1996;39(10):1180-1189

Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM.

Zierath JR; He L; Gumà A; Odegoard Wahlström E; Klip A; Wallberg-Henriksson H
Article: JOURNAL OF INTERNAL MEDICINE. 1996;240(3):115-124

C-peptide revisited--new physiological effects and therapeutic implications.

Wahren J; Johansson BL; Wallberg-Henriksson H; Linde B; Fernqvist-Forbes E; Zierath JR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1996;271(3 Pt 1):E593-E600

Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients.

Aksnes AK; Hjeltnes N; Wahlström EO; Katz A; Zierath JR; Wallberg-Henriksson H
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(19):11347-11355

Overexpression of Ha-ras selectively in adipose tissue of transgenic mice. Evidence for enhanced sensitivity to insulin.

Houseknecht KL; Zhu AX; Gnudi L; Hamann A; Zierath JR; Tozzo E; Flier JS; Kahn BB
Article: DIABETES. 1996;45(5):615-621

Mechanisms behind insulin resistance in rat skeletal muscle after oophorectomy and additional testosterone treatment.

Rincon J; Holmäng A; Wahlström EO; Lönnroth P; Björntorp P; Zierath JR; Wallberg-Henriksson H
Article: DIABETOLOGIA. 1996;39(3):306-313

C-peptide stimulates glucose transport in isolated human skeletal muscle independent of insulin receptor and tyrosine kinase activation.

Zierath JR; Handberg A; Tally M; Wallberg-Henriksson H
Article: BIOCHEMICAL JOURNAL. 1995;311 ( Pt 2)(Pt 2):517-521

Carrier-mediated fructose uptake significantly contributes to carbohydrate metabolism in human skeletal muscle.

Zierath JR; Nolte LA; Wahlström E; Galuska D; Shepherd PR; Kahn BB; Wallberg-Henriksson H
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1995;268(4 Pt 1):E613-E622

Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle.

Gumà A; Zierath JR; Wallberg-Henriksson H; Klip A
Article: DIABETES. 1995;44(3):347-353

Identification of four amino acid substitutions in hexokinase II and studies of relationships to NIDDM, glucose effectiveness, and insulin sensitivity.

Echwald SM; Bjørbaek C; Hansen T; Clausen JO; Vestergaard H; Zierath JR; Printz RL; Granner DK; Pedersen O
Article: CLINICAL SCIENCE. 1995;88(3):301-306

Development of decreased insulin-induced glucose transport in skeletal muscle of glucose-intolerant hybrids of diabetic GK rats.

Nolte LA; Abdel-Halim SM; Martin IK; Guenifi A; Zierath JR; Ostenson CG; Wallberg-Henriksson H
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Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2023;24(9):607-632

Exercise metabolism and adaptation in skeletal muscle.

Smith JAB; Murach KA; Dyar KA; Zierath JR
Letter: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(11):713

Reply to 'Lactate as a major myokine and exerkine'.

Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Gao Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder M
Review: ENDOCRINE REVIEWS. 2022;43(4):654-677

Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity.

Stocks B; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2022;18(5):273-289

Exerkines in health, resilience and disease.

Chow LS; Gerszten RE; Taylor JM; Pedersen BK; van Praag H; Trappe S; Febbraio MA; Galis ZS; Gao Y; Haus JM; Lanza IR; Lavie CJ; Lee C-H; Lucia A; Moro C; Pandey A; Robbins JM; Stanford KI; Thackray AE; Villeda S; Watt MJ; Xia A; Zierath JR; Goodpaster BH; Snyder MP
Review: JOURNAL OF PHYSIOLOGY-LONDON. 2022;600(5):1027-1036

Zeitgebers of skeletal muscle and implications for metabolic health.

Gabriel BM; Zierath JR
Editorial comment: METABOLISM-CLINICAL AND EXPERIMENTAL. 2021;119:154769

COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pandemic.

Tessier CM; Kokkinos A; Mingrone G; Koliaki C; Zierath JR; Mantzoros CS
Review: CELL. 2021;184(6):1530-1544

Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.

Pillon NJ; Loos RJF; Marshall SM; Zierath JR
Review: CURRENT OPINION IN LIPIDOLOGY. 2021;32(1):16-23

The role of the molecular circadian clock in human energy homeostasis.

Dollet L; Pendergrast LA; Zierath JR
Review: DIABETOLOGIA. 2020;63(11):2253-2259

Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men.

Hawley JA; Sassone-Corsi P; Zierath JR
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):5142

Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.

Lundell LS; Parr EB; Devlin BL; Ingerslev LR; Altıntaş A; Sato S; Sassone-Corsi P; Barrès R; Zierath JR; Hawley JA
Review: DIABETOLOGIA. 2020;63(8):1491-1499

Train like an athlete: applying exercise interventions to manage type 2 diabetes.

Savikj M; Zierath JR
Editorial comment: CURRENT DIABETES REPORTS. 2019;19(11):118

Major Advances and Discoveries in Diabetes - 2019 in Review.

Zierath JR
Corrigendum: JOURNAL OF ENDOCRINOLOGY. 2019;243(2):X1

The estrogen receptor α-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice: potential molecular mechanisms.

Lundholm L; Bryzgalova G; Gao H; Portwood N; Fält S; Berndt KD; Dicker A; Galuska D; Zierath JR; Gustafsson J-Å; Efendic S; Dahlman-Wright K; Khan A
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2019;30(9):603-617

Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis.

Massart J; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2019;15(4):197-206

Circadian rhythms and exercise - re-setting the clock in metabolic disease.

Gabriel BM; Zierath JR
Review: JOURNAL OF PHYSIOLOGY-LONDON. 2019;597(6):1439-1450

Interplay between diet, exercise and the molecular circadian clock in orchestrating metabolic adaptations of adipose tissue.

Dollet L; Zierath JR
Other: CELL METABOLISM. 2018;28(3):329

John O. Holloszy (1933-2018) Obituary

Zierath JR; Hagberg JM; Coyle EF
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):5008

Author Correction: Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans.

Laker RC; Garde C; Camera DM; Smiles WJ; Zierath JR; Hawley JA; Barrès R
Editorial comment: CELL METABOLISM. 2017;25(5):978-984

Exercise Metabolism.
Review: CELL METABOLISM. 2017;25(5):1000-1011

The Limits of Exercise Physiology: From Performance to Health.

Gabriel BM; Zierath JR
Editorial comment: CELL. 2016;167(5):1155-1158

Building Bridges through Scientific Conferences.

Zierath JR
Editorial comment: CELL METABOLISM. 2016;24(2):342-342.e1

SnapShot: Exercise Metabolism.

Egan B; Hawley JA; Zierath JR
Review: NATURE REVIEWS ENDOCRINOLOGY. 2016;12(8):441-451

The role of diet and exercise in the transgenerational epigenetic landscape of T2DM.

Barrès R; Zierath JR
Review: CELL METABOLISM. 2016;23(6):1034-1047

Exercise Promotes Healthy Aging of Skeletal Muscle.

Cartee GD; Hepple RT; Bamman MM; Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(12):2685-2687

Turning the page.

Zierath JR
Corrigendum: DIABETOLOGIA. 2015;58(12):2899

Erratum to: Turning the page.

Zierath JR
Editorial comment: DIABETOLOGIA. 2015;58(8):1685-1687

Diabetologia at 50: celebrating half a century of progress in diabetes research and care.

Zierath JR
Review: CELL METABOLISM. 2015;22(1):25-30

Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?

Zierath JR; Wallberg-Henriksson H
Editorial comment: CELL METABOLISM. 2015;21(5):654-657

Women in metabolism: part I.
Editorial comment: NATURE REVIEWS ENDOCRINOLOGY. 2015;11(4):198-200

Metabolism. Exercise remodels subcutaneous fat tissue and improves metabolism.

Wallberg-Henriksson H; Zierath JR
Other: CELL. 2015;161(1):173-174

How to Stop the Obesity Epidemic?

Chen Z; Zierath J; Kahn CR; Spiegelman B; O'Rahilly S; Bruning JC
Review: CELL. 2014;159(4):738-749

Integrative biology of exercise.

Hawley JA; Hargreaves M; Joyner MJ; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2014;307(9):C774-C787

Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes.

Al-Khalili L; de Castro Barbosa T; Ostling J; Massart J; Cuesta PG; Osler ME; Katayama M; Nyström A-C; Oscarsson J; Zierath JR
Review: DRUG DISCOVERY TODAY. 2014;19(7):1010-1014

Dynamic epigenetic responses to muscle contraction.

Rasmussen M; Zierath JR; Barrès R
Corrigendum: CELL REPORTS. 2013;3(5):1755

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation (vol 3, pg 1020, 2013)

Barres R; Kirchner H; Rasmussen M; Yan J; Kantor FR; Krook A; Naslund E; Zierath JR
Review: TRENDS IN CELL BIOLOGY. 2013;23(5):203-209

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

Kirchner H; Osler ME; Krook A; Zierath JR
Review: CELL METABOLISM. 2013;17(2):162-184

Exercise metabolism and the molecular regulation of skeletal muscle adaptation.

Egan B; Zierath JR
Editorial comment: DIABETOLOGIA. 2012;55(1):1-2

Remembering our classics: then and now.

Zierath JR
Published conference paper: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2011;93(4):897S-8900

DNA methylation in metabolic disorders.

Barres R; Zierath JR
Editorial comment: DIABETOLOGIA. 2011;54(1):1-3

Keeping ahead of the fast pace of science

Zierath JR
Review: LAKARTIDNINGEN. 2010;107(45):2802-2805

[Molecular mechanisms underlying insulin resistance in skeletal muscle].

Zierath JR; Krook A
Review: DIABETOLOGIA. 2009;52(7):1231-1239

Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA.

Krook A; Zierath JR
Editorial comment: CELL. 2009;137(1):22-24

A new twist on brown fat metabolism.

Wallberg-Henriksson H; Zierath JR
Review: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2008;295(3):E545-E552

Influence of AMP-activated protein kinase and calcineurin on metabolic networks in skeletal muscle.

Long YC; Zierath JR
Published conference paper: INTERNATIONAL JOURNAL OF OBESITY. 2008;32 Suppl 4:S18-S23

Exercise-induced phospho-proteins in skeletal muscle.

Deshmukh AS; Hawley JA; Zierath JR
Review: ENDOCRINOLOGY. 2008;149(3):935-941

Adenosine 5'-monophosphate-activated protein kinase regulation of fatty acid oxidation in skeletal muscle.

Osler ME; Zierath JR
Editorial comment: ACTA PHYSIOLOGICA. 2008;192(1):1

Xth International Symposium on insulin receptors and insulin action.

Zierath JR
Editorial comment: DIABETOLOGIA. 2007;50(7):1362-1364

Fighting the battle of the bulge: exercise training in early-onset type 2 diabetes.

Osler ME; Zierath JR
Editorial comment: CELL METABOLISM. 2007;5(3):161-163

The path to insulin resistance: paved with ceramides?

Zierath JR
Published conference paper: CELL BIOCHEMISTRY AND BIOPHYSICS. 2007;48(2-3):103-113

Insulin signaling and glucose transport in insulin resistant human skeletal muscle.

Karlsson HKR; Zierath JR
Review: ESSAYS IN BIOCHEMISTRY. 2006;42:1-12

Signalling mechanisms in skeletal muscle: role in substrate selection and muscle adaptation.

Hawley JA; Hargreaves M; Zierath JR
Review: JOURNAL OF CLINICAL INVESTIGATION. 2006;116(7):1776-1783

AMP-activated protein kinase signaling in metabolic regulation.

Long YC; Zierath JR
Editorial comment: DIABETOLOGIA. 2005;48(12):2451-2453

Fine-tuning insulin and nitric oxide signalling by turning up the AMPs: new insights into AMP-activated protein kinase signalling.

Long YC; Zierath JR
Review: CURRENT DIABETES REVIEWS. 2005;1(2):167-174

Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes.

Bouzakri K; Koistinen HA; Zierath JR
Review: CURRENT MOLECULAR MEDICINE. 2005;5(3):341-348

Role of AMP--activated protein kinase in the control of glucose homeostasis.

Barnes BR; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2005;33(Pt 2):354-357

Insulin signal transduction in human skeletal muscle: identifying the defects in Type II diabetes.

Björnholm M; Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):121-123

Kinases in diabetes. Part II. 11-12 November 2004, Manchester, UK.

Zierath JR
Editorial comment: IDRUGS : THE INVESTIGATIONAL DRUGS JOURNAL. 2005;8(2):118-120

Kinases in diabetes. Part I. 11-12 November 2004, Manchester, UK.

Zierath JR
Letter: ACTA PHYSIOLOGICA. 2005;183(1):125-126

Integration of mathematical and experimental approaches to resolve insulin signalling.

Sögård P; Harlén M; Svensson LT; Zierath JR; Nilsson P
Editorial comment: ACTA PHYSIOLOGICA. 2005;183(1):1-2

Theme: Skeletal muscle and adipose tissue metabolism - Regulation, exercise, diabetes and ageing - Foreword

Zierath JR; Handberg A; Jensen J
Editorial comment: PLOS BIOLOGY. 2004;2(10):e348

Skeletal muscle fiber type: influence on contractile and metabolic properties.

Zierath JR; Hawley JA
Published conference paper: PROCEEDINGS OF THE NUTRITION SOCIETY. 2004;63(2):227-232

Exercise-induced mitogen-activated protein kinase signalling in skeletal muscle.

Long YC; Widegren U; Zierath JR
Review: EXERCISE AND SPORT SCIENCES REVIEWS. 2004;32(1):4-8

Integration of metabolic and mitogenic signal transduction in skeletal muscle.

Hawley JA; Zierath JR
Editorial comment: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2003;26(7):690-692

Skeletal muscle insulin resistance: is it important for the pathogenesis of type 2 diabetes after all?

Koistinen HA; Zierath JR
Review: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES. 2003;111(4):191-197

Analysis of insulin signaling pathways through comparative genomics. Mapping mechanisms for insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus.

Lake S; Krook A; Zierath JR
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):219

Effects of diet and exercise on the regulation of PPARα, δ and γ expression in rat skeletal muscle and visceral adipose tissue

Kannisto K; Chibalin A; Zierath JR; Hamsten A; Ehrenborg E
Review: FASEB JOURNAL. 2002;16(10):1163-1176

Analysis of paradoxical observations on the association between leptin and insulin resistance.

Ceddia RB; Koistinen HA; Zierath JR; Sweeney G
Review: JOURNAL OF APPLIED PHYSIOLOGY. 2002;93(2):773-781

Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle.

Zierath JR
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2002;967:120-134

From receptor to effector: insulin signal transduction in skeletal muscle from type II diabetic patients.

Zierath JR; Wallberg-Henriksson H
Review: ANNALS OF MEDICINE. 2002;34(6):410-418

Regulation of glucose transport in human skeletal muscle.

Koistinen HA; Zierath JR
Review: ACTA PHYSIOLOGICA. 2001;172(3):227-238

Mitogen-activated protein kinase signal transduction in skeletal muscle: effects of exercise and muscle contraction.

Widegren U; Ryder JW; Zierath JR
Review: MOLECULAR MEMBRANE BIOLOGY. 2001;18(3):205-211

GLUT4: a key player regulating glucose homeostasis? Insights from transgenic and knockout mice (review).

Wallberg-Henriksson H; Zierath JR
Published conference paper: ACTA PHYSIOLOGICA. 2001;171(3):249-257

Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle.

Ryder JW; Chibalin AV; Zierath JR
Review: FRONTIERS IN BIOSCIENCE - LANDMARK. 2001;6:D154-D163

Skeletal muscle and insulin sensitivity: pathophysiological alterations.

Ryder JW; Gilbert M; Zierath JR
Review: DIABETOLOGIA. 2000;43(7):821-835

Insulin action and insulin resistance in human skeletal muscle.

Zierath JR; Krook A; Wallberg-Henriksson H
Review: SPORTS MEDICINE. 1998;25(1):25-35

Exercise in the management of non-insulin-dependent diabetes mellitus.

Wallberg-Henriksson H; Rincon J; Zierath JR
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1998;441:73-85

Insulin signaling and glucose transport in insulin resistant skeletal muscle. Special reference to GLUT4 transgenic and GLUT4 knockout mice.

Galuska D; Ryder J; Kawano Y; Charron MJ; Zierath JR
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 1997;25(3):963-968

Metabolic and molecular consequences of modifying GLUT4 expression in skeletal muscle.

Charron MJ; Katz EB; Zierath JR
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 1996;7(2):295-307

Glucose transporters and diabetes

Zierath JR; Houseknecht KL; Kahn BB
Other: DIABETES. 1995;44(11):1345-1348

Hyperglycemia activates glucose transport in rat skeletal muscle via a Ca(2+)-dependent mechanism.

Nolte LA; Rincón J; Wahlström EO; Craig BW; Zierath JR; Wallberg-Henriksson H
Review: ACTA PHYSIOLOGICA SCANDINAVICA, SUPPLEMENT. 1995;626:1-96

In vitro studies of human skeletal muscle: hormonal and metabolic regulation of glucose transport.

Zierath JR
Review: ACTA PHYSIOLOGICA. 1995;155:11-96

IN-VITRO STUDIES OF HUMAN SKELETAL-MUSCLE - HORMONAL AND METABOLIC-REGULATION OF GLUCOSE-TRANSPORT - INTRODUCTION

ZIERATH JR
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Professor, Fysiologi och farmakologi, Karolinska Institutet, 2009-

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Docent, inriktning: fysiologi med inriktning metabolism, Karolinska Institutet, 1998

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