Johan Hartman

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Professor i tumörpatologi vid Karolinska Institutet och överläkare i klinisk patologi vid Karolinska Universitetssjukhuset. Specialistområde är bröstsjukdomar med ämnesområdesansvar för bröstpatologi. Sedan 2020 är Johan vetenskaplig sekreterare för svensk förening för patologi. Han är medgrundare till Stratipath, ett spinn-off baserat på AI-forskning vid Karolinska Institutet med målsättning att förbättra diagnostiken av cancerpatienter.
Mellan 2017-2022 medlem och sammankallande i bröst-KVAST och representant för patologi i Nationella vårdprogramgruppen för bröstcancer.
Nuvarande vetenskaplig rådgivare till Socialstyrelsen.

Forskningsbeskrivning

Johans forskargrupp arbetar med bröstcancerdiagnostik, huvudsakligen fokuserad på individanpassad behandlingsprediktion. Målsättningen är att kunna ge rätt behandling till rätt patient. I forskargruppen ingår läkare, bioinformatiker och experiementalla forskare. Forskargruppen arbetar mycket nära forskare inom andra discipliner. Forskningen inkluderar digital bildanalys av biomarkörer, organotypiska patientderiverade ex vivo modeller mm.
Johan har publicerat >
100 vetenskapliga artiklar varav >
40 i high-impact tidskrifter (Cell, Science, PNAS etc), totalt >
10, 000 citeringar.

Undervisning

Tidigare huvudhandledare för fem doktorander (Ran Ma, Gustaf Rosin, Karthik Gowindasamy, Gustav Stålhammar, Stephanie Robertson), pågående huvudhandledare för tre doktorander. Regelbunden föreläsare inom patologi och tumörbiologi vid Karolinska Institutet på grund- och avancerad nivå.

Artiklar

Article: JOURNAL OF NUCLEAR MEDICINE. 2024;:jnumed.123.266847

Human Epidermal Growth Factor Receptor 2 (HER2) PET Imaging of HER2-Low Breast Cancer with [68Ga]Ga-ABY-025: Results from a Pilot Study.

Altena R; Burén SA; Blomgren A; Karlsson E; Tzortzakakis A; Brun N; Moein MM; Jussing E; Frejd FY; Bergh J; Tran TA; Hartman J; Axelsson R
Article: BREAST CANCER RESEARCH. 2024;26(1):24

Prognostic impact of HER2 biomarker levels in trastuzumab-treated early HER2-positive breast cancer.

Rönnlund C; Sifakis EG; Schagerholm C; Yang Q; Karlsson E; Chen X; Foukakis T; Weidler J; Bates M; Fredriksson I; Robertson S; Hartman J
Article: BRITISH JOURNAL OF SURGERY. 2024;111(2):znae037

Immune cell infiltrate in ductal carcinoma in situ and the risk of dying from breast cancer: case-control study.

Rask G; Wadsten C; Acs B; Hartman J; Fredriksson I; Garmo H; Wärnberg F; Sund M
Article: BREAST CANCER RESEARCH. 2024;26(1):17

Development and prognostic validation of a three-level NHG-like deep learning-based model for histological grading of breast cancer.

Sharma A; Weitz P; Wang Y; Liu B; Vallon-Christersson J; Hartman J; Rantalainen M
Article: CELL REPORTS. 2023;42(12):113507

VEGF-C-expressing TAMs rewire the metastatic fate of breast cancer cells.

Banerjee K; Kerzel T; Bekkhus T; de Souza Ferreira S; Wallmann T; Wallerius M; Landwehr L-S; Agardy DA; Schauer N; Malmerfeldt A; Bergh J; Bartish M; Hartman J; Östman A; Squadrito ML; Rolny C
Article: SCIENCE. 2023;382(6675):eadf8486

Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics.

Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpää S; Jangard M; Saez-Rodriguez J; Michaëlsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisén J
Article: BREAST CANCER RESEARCH. 2023;25(1):123

Comparison of SP142 and 22C3 PD-L1 assays in a population-based cohort of triple-negative breast cancer patients in the context of their clinically established scoring algorithms.

Sigurjonsdottir G; De Marchi T; Ehinger A; Hartman J; Bosch A; Staaf J; Killander F; Niméus E
Journal article: ANNALS OF ONCOLOGY. 2023;34:S279

Patient characteristics and real-world outcomes in HER2 negative/ ER zero and ER low patients treated as triple-negative breast cancer in Sweden 2008-2020

Fredriksson I; Acs B; Hartman J; Sonmez D; Lindman H
Article: EUROPEAN JOURNAL OF CANCER. 2023;191:112953

Transcriptional intra-tumour heterogeneity predicted by deep learning in routine breast histopathology slides provides independent prognostic information.

Wang Y; Ali MA; Vallon-Christersson J; Humphreys K; Hartman J; Rantalainen M
Article: BIOENGINEERING & TRANSLATIONAL MEDICINE. 2023;8(5):e10537

Development and characterization of a recombinant silk network for 3D culture of immortalized and fresh tumor-derived breast cancer cells.

Collodet C; Blust K; Gkouma S; Ståhl E; Chen X; Hartman J; Hedhammar M
Article: JOURNAL OF NUCLEAR MEDICINE. 2023;64(9):1364-1370

Human Epidermal Growth Factor Receptor 2-Targeting [68Ga]Ga-ABY-025 PET/CT Predicts Early Metabolic Response in Metastatic Breast Cancer.

Alhuseinalkhudhur A; Lindman H; Liss P; Sundin T; Frejd FY; Hartman J; Iyer V; Feldwisch J; Lubberink M; Rönnlund C; Tolmachev V; Velikyan I; Sörensen J
Article: SCIENTIFIC DATA. 2023;10(1):562

A Multi-Stain Breast Cancer Histological Whole-Slide-Image Data Set from Routine Diagnostics.

Weitz P; Valkonen M; Solorzano L; Carr C; Kartasalo K; Boissin C; Koivukoski S; Kuusela A; Rasic D; Feng Y; Sinius Pouplier S; Sharma A; Ledesma Eriksson K; Latonen L; Laenkholm A-V; Hartman J; Ruusuvuori P; Rantalainen M
Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088

Solid-phase capture and profiling of open chromatin by spatial ATAC.

Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisén J; Ståhl PL
Article: ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY. ANNUAL INTERNATIONAL CONFERENCE. 2023;2023:1-4

Multiresolution Self-Supervised Feature Integration via Attention Multiple Instance Learning for Histopathology Analysis.

Tsiknakis N; Tzoras E; Zerdes I; Manikis GC; Acs B; Hartman J; Hatschek T; Foukakis T; Marias K
Journal article: CANCER RESEARCH. 2023;83(7):5432

Validation of spatial gene expression patterns predicted by deep convolutional neural networks from breast cancer histopathology images

Ton K; Wang Y; Pan L; Kartasalo K; Acs B; Weitz P; Zhang L; Liang Y; Hartman J; Volkonen M; Larsson C; Ruusuvuori P; Beechem J; Rantalainen M
Article: NATURE COMMUNICATIONS. 2023;14(1):982

Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics.

Jun S-H; Toosi H; Mold J; Engblom C; Chen X; O'Flanagan C; Hagemann-Jensen M; Sandberg R; Aparicio S; Hartman J; Roth A; Lagergren J
Article: CLINICAL CANCER RESEARCH. 2023;29(3):532-540

Survival Outcomes, Digital TILs, and On-treatment PET/CT During Neoadjuvant Therapy for HER2-positive Breast Cancer: Results from the Randomized PREDIX HER2 Trial.

Matikas A; Johansson H; Grybäck P; Bjöhle J; Acs B; Boyaci C; Lekberg T; Fredholm H; Elinder E; Margolin S; Isaksson-Friman E; Bosch A; Lindman H; Adra J; Andersson A; Agartz S; Hellström M; Zerdes I; Hartman J; Bergh J; Hatschek T; Foukakis T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120

Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction.

Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Hui Min AT; Lövrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Article: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(35):4071-4082

Twenty-Year Benefit From Adjuvant Goserelin and Tamoxifen in Premenopausal Patients With Breast Cancer in a Controlled Randomized Clinical Trial.

Johansson A; Dar H; van 't Veer LJ; Tobin NP; Perez-Tenorio G; Nordenskjöld A; Johansson U; Hartman J; Skoog L; Yau C; Benz CC; Esserman LJ; Stål O; Nordenskjöld B; Fornander T; Lindström LS
Article: MODERN PATHOLOGY. 2022;35(10):1362-1369

Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study.

Acs B; Leung SCY; Kidwell KM; Arun I; Augulis R; Badve SS; Bai Y; Bane AL; Bartlett JMS; Bayani J; Bigras G; Blank A; Buikema H; Chang MC; Dietz RL; Dodson A; Fineberg S; Focke CM; Gao D; Gown AM; Gutierrez C; Hartman J; Kos Z; Lænkholm A-V; Laurinavicius A; Levenson RM; Mahboubi-Ardakani R; Mastropasqua MG; Nofech-Mozes S; Osborne CK; Penault-Llorca FM; Piper T; Quintayo MA; Rau TT; Reinhard S; Robertson S; Salgado R; Sugie T; van der Vegt B; Viale G; Zabaglo LA; Hayes DF; Dowsett M; Nielsen TO; Rimm DL; International Ki67 in Breast Cancer Working Group
Article: ISCIENCE. 2022;25(7):104663

Using deep learning to detect patients at risk for prostate cancer despite benign biopsies.

Liu B; Wang Y; Weitz P; Lindberg J; Hartman J; Wang W; Egevad L; Grönberg H; Eklund M; Rantalainen M
Article: NPJ BREAST CANCER. 2022;8(1):76

High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing.

Kostecka A; Nowikiewicz T; Olszewski P; Koczkowska M; Horbacz M; Heinzl M; Andreou M; Salazar R; Mair T; Madanecki P; Gucwa M; Davies H; Skokowski J; Buckley PG; Pęksa R; Śrutek E; Szylberg Ł; Hartman J; Jankowski M; Zegarski W; Tiemann-Boege I; Dumanski JP; Piotrowski A
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16_suppl):593

Combined assessment of metabolic response and tumor infiltrating lymphocytes as a predictor of outcomes following neoadjuvant therapy for HER2-positive breast cancer: Results from the randomized PREDIX HER2 trial.

Matikas A; Johansson H; Grybäck P; Bjöhle J; Lekberg T; Fredholm H; Acs B; Elinder E; Isaksson-Friman E; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh JCS; Hatschek T; Foukakis T
Article: CANCERS. 2022;14(11):2615

Real World Evaluation of the Prosigna/PAM50 Test in a Node-Negative Postmenopausal Swedish Population: A Multicenter Study.

Kjällquist U; Acs B; Margolin S; Karlsson E; Kessler LE; Garcia Hernandez S; Ekholm M; Lundgren C; Olsson E; Lindman H; Foukakis T; Matikas A; Hartman J
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592

A2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models.

Tay AHM; Prieto-Díaz R; Neo S; Tong L; Chen X; Carannante V; Önfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
Article: NATURE CANCER. 2022;3(2):251-261

The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Tamborero D; Dienstmann R; Rachid MH; Boekel J; Lopez-Fernandez A; Jonsson M; Razzak A; Braña I; De Petris L; Yachnin J; Baird RD; Loriot Y; Massard C; Martin-Romano P; Opdam F; Schlenk RF; Vernieri C; Masucci M; Villalobos X; Chavarria E; Cancer Core Europe consortium; Balmaña J; Apolone G; Caldas C; Bergh J; Ernberg I; Fröhling S; Garralda E; Karlsson C; Tabernero J; Voest E; Rodon J; Lehtiö J
Article: ANNALS OF ONCOLOGY. 2022;33(1):89-98

Improved breast cancer histological grading using deep learning.

Wang Y; Acs B; Robertson S; Liu B; Solorzano L; Wählby C; Hartman J; Rantalainen M
Article: NPJ BREAST CANCER. 2021;7(1):144

Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study.

Zerdes I; Simonetti M; Matikas A; Harbers L; Acs B; Boyaci C; Zhang N; Salgkamis D; Agartz S; Moreno-Ruiz P; Bai Y; Rimm DL; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Article: BIOMOLECULES. 2021;11(11):1612

Independent Clinical Validation of the Automated Ki67 Scoring Guideline from the International Ki67 in Breast Cancer Working Group.

Boyaci C; Sun W; Robertson S; Acs B; Hartman J
Article: CLINICAL CANCER RESEARCH. 2021;27(20):5557-5565

An Open-Source, Automated Tumor-Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer.

Bai Y; Cole K; Martinez-Morilla S; Ahmed FS; Zugazagoitia J; Staaf J; Bosch A; Ehinger A; Nimeus E; Hartman J; Acs B; Rimm DL
Article: CANCER RESEARCH. 2021;81(19):5115-5126

Predicting Molecular Phenotypes from Histopathology Images: A Transcriptome-Wide Expression-Morphology Analysis in Breast Cancer.

Wang Y; Kartasalo K; Weitz P; Ács B; Valkonen M; Larsson C; Ruusuvuori P; Hartman J; Rantalainen M
Article: CANCERS. 2021;13(19):4910

Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group.

Van Bockstal MR; Cooks M; Nederlof I; Brinkhuis M; Dutman A; Koopmans M; Kooreman L; van der Vegt B; Verhoog L; Vreuls C; Westenend P; Kok M; van Diest PJ; Nauwelaers I; Laudus N; Denkert C; Rimm D; Siziopikou KP; Ely S; Zardavas D; Roberts M; Floris G; Hartman J; Acs B; Peeters D; Bartlett JMS; Dequeker E; Salgado R; Giudici F; Michiels S; Horlings H; van Deurzen CHM
Article: JAMA ONCOLOGY. 2021;7(9):1360-1367

Neoadjuvant Trastuzumab, Pertuzumab, and Docetaxel vs Trastuzumab Emtansine in Patients With ERBB2-Positive Breast Cancer: A Phase 2 Randomized Clinical Trial.

Hatschek T; Foukakis T; Bjöhle J; Lekberg T; Fredholm H; Elinder E; Bosch A; Pekar G; Lindman H; Schiza A; Einbeigi Z; Adra J; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Agartz S; Azavedo E; Grybäck P; Hellström M; Johansson H; Maes C; Zerdes I; Hartman J; Brandberg Y; Bergh J
Article: ESMO OPEN. 2021;6(2):100076

Prognostic role of serum thymidine kinase 1 kinetics during neoadjuvant chemotherapy for early breast cancer.

Matikas A; Wang K; Lagoudaki E; Acs B; Zerdes I; Hartman J; Azavedo E; Bjöhle J; Carlsson L; Einbeigi Z; Hedenfalk I; Hellström M; Lekberg T; Loman N; Saracco A; von Wachenfeldt A; Rotstein S; Bergqvist M; Bergh J; Hatschek T; Foukakis T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(10):e2017089118

TAp73 represses NF-κB-mediated recruitment of tumor-associated macrophages in breast cancer.

Wolfsberger J; Sakil HAM; Zhou L; van Bree N; Baldisseri E; de Souza Ferreira S; Zubillaga V; Stantic M; Fritz N; Hartman J; Rolny C; Wilhelm MT
Article: CANCERS. 2021;13(5):1166

Variability in Breast Cancer Biomarker Assessment and the Effect on Oncological Treatment Decisions: A Nationwide 5-Year Population-Based Study.

Acs B; Fredriksson I; Rönnlund C; Hagerling C; Ehinger A; Kovács A; Røge R; Bergh J; Hartman J
Article: BREAST CANCER RESEARCH. 2021;23(1):20

Molecular analyses of triple-negative breast cancer in the young and elderly.

Aine M; Boyaci C; Hartman J; Häkkinen J; Mitra S; Campos AB; Nimeus E; Ehinger A; Vallon-Christersson J; Borg Å; Staaf J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(3):1354

The Importance of Sex in the Discovery of Colorectal Cancer Prognostic Biomarkers.

Hases L; Ibrahim A; Chen X; Liu Y; Hartman J; Williams C
Article: CANCER LETTERS. 2020;492:54-62

Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes.

Hases L; Indukuri R; Birgersson M; Nguyen-Vu T; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-Å; Katajisto P; Archer A; Williams C
Article: NATURE BIOMEDICAL ENGINEERING. 2020;4(9):875-888

Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies.

Tanaka N; Kanatani S; Kaczynska D; Fukumoto K; Louhivuori L; Mizutani T; Kopper O; Kronqvist P; Robertson S; Lindh C; Kis L; Pronk R; Niwa N; Matsumoto K; Oya M; Miyakawa A; Falk A; Hartman J; Sahlgren C; Clevers H; Uhlén P
Article: BREAST CANCER RESEARCH AND TREATMENT. 2020;183(1):161-175

Prognostic potential of automated Ki67 evaluation in breast cancer: different hot spot definitions versus true global score.

Robertson S; Acs B; Lippert M; Hartman J
Article: BREAST CANCER RESEARCH. 2020;22(1):80

Identification and targeting of selective vulnerability rendered by tamoxifen resistance.

Singh M; Zhou X; Chen X; Santos GS; Peuget S; Cheng Q; Rihani A; Arnér ESJ; Hartman J; Selivanova G
Article: NATURE COMMUNICATIONS. 2020;11(1):3747

Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers.

Glodzik D; Bosch A; Hartman J; Aine M; Vallon-Christersson J; Reuterswärd C; Karlsson A; Mitra S; Niméus E; Holm K; Häkkinen J; Hegardt C; Saal LH; Larsson C; Malmberg M; Rydén L; Ehinger A; Loman N; Kvist A; Ehrencrona H; Nik-Zainal S; Borg Å; Staaf J
Article: MOLECULAR ONCOLOGY. 2020;14(5):951-963

Programmed death-ligand 1 gene expression is a prognostic marker in early breast cancer and provides additional prognostic value to 21-gene and 70-gene signatures in estrogen receptor-positive disease.

Zerdes I; Sifakis EG; Matikas A; Chrétien S; Tobin NP; Hartman J; Rassidakis GZ; Bergh J; Foukakis T
Article: CANCER RESEARCH. 2020;80(7):1538-1550

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds.

Peuget S; Zhu J; Sanz G; Singh M; Gaetani M; Chen X; Shi Y; Saei AA; Visnes T; Lindström MS; Rihani A; Moyano-Galceran L; Carlson JW; Hjerpe E; Joneborg U; Lehti K; Hartman J; Helleday T; Zubarev R; Selivanova G
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(3):1185-1198

CD73 immune checkpoint defines regulatory NK cells within the tumor microenvironment.

Neo SY; Yang Y; Record J; Ma R; Chen X; Chen Z; Tobin NP; Blake E; Seitz C; Thomas R; Wagner AK; Andersson J; de Boniface J; Bergh J; Murray S; Alici E; Childs R; Johansson M; Westerberg LS; Haglund F; Hartman J; Lundqvist A
Article: SCIENTIFIC REPORTS. 2019;9(1):19384

CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance.

Langebäck A; Bacanu S; Laursen H; Mout L; Seki T; Erkens-Schulze S; Ramos AD; Berggren A; Cao Y; Hartman J; van Weerden W; Bergh J; Nordlund P; Lööf S
Article: NATURE COMMUNICATIONS. 2019;10(1):4732

CUTseq is a versatile method for preparing multiplexed DNA sequencing libraries from low-input samples.

Zhang X; Garnerone S; Simonetti M; Harbers L; Nicoś M; Mirzazadeh R; Venesio T; Sapino A; Hartman J; Marchiò C; Bienko M; Crosetto N
Article: NATURE COMMUNICATIONS. 2019;10(1):3589

PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.

Costa TDF; Zhuang T; Lorent J; Turco E; Olofsson H; Masia-Balague M; Zhao M; Rabieifar P; Robertson N; Kuiper R; Sjölund J; Spiess M; Hernández-Varas P; Rabenhorst U; Roswall P; Ma R; Gong X; Hartman J; Pietras K; Adams PD; Defilippi P; Strömblad S
Article: NATURE COMMUNICATIONS. 2019;10(1):2110

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.

Prakash V; Carson BB; Feenstra JM; Dass RA; Sekyrova P; Hoshino A; Petersen J; Guo Y; Parks MM; Kurylo CM; Batchelder JE; Haller K; Hashimoto A; Rundqivst H; Condeelis JS; Allis CD; Drygin D; Nieto MA; Andäng M; Percipalle P; Bergh J; Adameyko I; Farrants A-KÖ; Hartman J; Lyden D; Pietras K; Blanchard SC; Vincent CT
Article: BREAST CANCER RESEARCH AND TREATMENT. 2019;174(3):795-805

Re-testing of predictive biomarkers on surgical breast cancer specimens is clinically relevant.

Robertson S; Rönnlund C; de Boniface J; Hartman J
Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;172(3):703-712

Prognosis in patients diagnosed with loco-regional failure of breast cancer: 34 years longitudinal data from the Stockholm-Gotland cancer registry.

Falato C; Taylor SK; Szulkin R; Nordblom A; Eriksson L; Sofiadis A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Article: ONCOGENE. 2018;37(46):6083-6095

Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types.

Mutvei AP; Landor SK-J; Fox R; Braune E-B; Tsoi YL; Phoon YP; Sahlgren C; Hartman J; Bergh J; Jin S; Lendahl U
Article: JOURNAL OF TRAUMA AND ACUTE CARE SURGERY. 2018;85(4):717-724

Abdominal Aortic and Junctional Tourniquet release after 240 minutes is survivable and associated with small intestine and liver ischemia after porcine class II hemorrhage.

Brännström A; Rocksén D; Hartman J; Nyman N; Gustavsson J; Arborelius UP; Günther M
Article: JOURNAL OF CLINICAL PATHOLOGY. 2018;71(9):787-794

Prognostic value of Ki67 analysed by cytology or histology in primary breast cancer.

Robertson S; Stålhammar G; Darai-Ramqvist E; Rantalainen M; Tobin NP; Bergh J; Hartman J
Article: CELL. 2018;173(4):879-893.e13

Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing.

Kim C; Gao R; Sei E; Brandt R; Hartman J; Hatschek T; Crosetto N; Foukakis T; Navin NE
Article: HISTOPATHOLOGY. 2018;72(6):974-989

Digital image analysis of Ki67 in hot spots is superior to both manual Ki67 and mitotic counts in breast cancer.

Stålhammar G; Robertson S; Wedlund L; Lippert M; Rantalainen M; Bergh J; Hartman J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(4):1355-1370

Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes.

Ullah I; Karthik G-M; Alkodsi A; Kjällquist U; Stålhammar G; Lövrot J; Martinez N-F; Lagergren J; Hautaniemi S; Hartman J; Bergh J
Article: BMC CANCER. 2018;18(1):174

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).

Kjällquist U; Erlandsson R; Tobin NP; Alkodsi A; Ullah I; Stålhammar G; Karlsson E; Hatschek T; Hartman J; Linnarsson S; Bergh J
Article: BMC CANCER. 2017;17(1):802

Intra-tumor heterogeneity in breast cancer has limited impact on transcriptomic-based molecular profiling.

Karthik G-M; Rantalainen M; Stålhammar G; Lövrot J; Ullah I; Alkodsi A; Ma R; Wedlund L; Lindberg J; Frisell J; Bergh J; Hartman J
Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity.

Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Fernández Moro C; Dahlstrand H; Östman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlén P
Journal article: ANNALS OF ONCOLOGY. 2017;28:v95

288P Prognosis after loco-regional recurrence of breast cancer: 35 years longitudinal data from the Stockholm cancer register

Falato C; Eriksson L; Sofiadis A; Taylor SK; Nordblom A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Article: CLINICAL CANCER RESEARCH. 2017;23(16):4769-4779

A Zebrafish Model Discovers a Novel Mechanism of Stromal Fibroblast-Mediated Cancer Metastasis.

Liu C; Zhang Y; Lim S; Hosaka K; Yang Y; Pavlova T; Alkasalias T; Hartman J; Jensen L; Xing X; Wang X; Lu Y; Nie G; Cao Y
Article: CLINICAL CANCER RESEARCH. 2017;23(10):2584-2592

Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes.

Li J; Ivansson E; Klevebring D; Tobin NP; Lindström LS; Holm J; Prochazka G; Cristando C; Palmgren J; Törnberg S; Humphreys K; Hartman J; Frisell J; Rantalainen M; Lindberg J; Hall P; Bergh J; Grönberg H; Czene K
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2017;109(3):1-14

Estrogen Receptor β as a Therapeutic Target in Breast Cancer Stem Cells.

Ma R; Karthik G-M; Lövrot J; Haglund F; Rosin G; Katchy A; Zhang X; Viberg L; Frisell J; Williams C; Linder S; Fredriksson I; Hartman J
Article: MATURITAS. 2017;96:39-44

Differential expression of sex hormone receptors in abdominal aortic aneurysms.

Villard C; Eriksson P; Kronqvist M; Lengquist M; Jorns C; Hartman J; Roy J; Hultgren R
Article: SCIENTIFIC REPORTS. 2016;6:38037

Sequencing-based breast cancer diagnostics as an alternative to routine biomarkers.

Rantalainen M; Klevebring D; Lindberg J; Ivansson E; Rosin G; Kis L; Celebioglu F; Fredriksson I; Czene K; Frisell J; Hartman J; Bergh J; Grönberg H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(38):E5618-E5627

Pericyte-fibroblast transition promotes tumor growth and metastasis.

Hosaka K; Yang Y; Seki T; Fischer C; Dubey O; Fredlund E; Hartman J; Religa P; Morikawa H; Ishii Y; Sasahara M; Larsson O; Cossu G; Cao R; Lim S; Cao Y
Article: ONCOTARGET. 2016;7(24):35703-35723

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells.

Pellegrini P; Dyczynski M; Sbrana FV; Karlgren M; Buoncervello M; Hägg-Olofsson M; Ma R; Hartman J; Bajalica-Lagercrantz S; Grander D; Kharaziha P; De Milito A
Article: CANCER RESEARCH. 2016;76(11):3166-3178

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.

Wallerius M; Wallmann T; Bartish M; Östling J; Mezheyeuski A; Tobin NP; Nygren E; Pangigadde P; Pellegrini P; Squadrito ML; Pontén F; Hartman J; Bergh J; De Milito A; De Palma M; Östman A; Andersson J; Rolny C
Article: MODERN PATHOLOGY. 2016;29(4):318-329

Digital image analysis outperforms manual biomarker assessment in breast cancer.

Stålhammar G; Fuentes Martinez N; Lippert M; Tobin NP; Mølholm I; Kis L; Rosin G; Rantalainen M; Pedersen L; Bergh J; Grunkin M; Hartman J
Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3)

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells (vol 107, djv209, 2015)

Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: CANCER LETTERS. 2015;367(1):76-87

mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells.

Karthik G-M; Ma R; Lövrot J; Kis LL; Lindh C; Blomquist L; Fredriksson I; Bergh J; Hartman J
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells.

Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; García-Ibáñez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Östman A; Bergh J; Poljakovic M; Genové G
Article: ANNALS OF DIAGNOSTIC PATHOLOGY. 2015;19(4):203-210

Gene protein detection platform--a comparison of a new human epidermal growth factor receptor 2 assay with conventional immunohistochemistry and fluorescence in situ hybridization platforms.

Stålhammar G; Farrajota P; Olsson A; Silva C; Hartman J; Elmberger G
Article: ENDOCRINE CONNECTIONS. 2015;4(1):76-85

Tumour nuclear oestrogen receptor beta 1 correlates inversely with parathyroid tumour weight.

Haglund F; Rosin G; Nilsson I-L; Juhlin CC; Pernow Y; Norenstedt S; Dinets A; Larsson C; Hartman J; Höög A
Article: CANCER RESEARCH. 2015;75(2):306-315

Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.

Wang J; Cao Z; Zhang X-M; Nakamura M; Sun M; Hartman J; Harris RA; Sun Y; Cao Y
Article: MOLECULAR ONCOLOGY. 2014;8(8):1690-1702

miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer.

Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Article: BRITISH JOURNAL OF CANCER. 2014;111(5):918-926

Oestrogen receptors β1 and βcx have divergent roles in breast cancer survival and lymph node metastasis.

Rosin G; de Boniface J; Karthik GM; Frisell J; Bergh J; Hartman J
Article: NATURE COMMUNICATIONS. 2014;5:4557

AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.

Mojallal M; Zheng Y; Hultin S; Audebert S; van Harn T; Johnsson P; Lenander C; Fritz N; Mieth C; Corcoran M; Lembo F; Hallström M; Hartman J; Mazure NM; Weide T; Grandér D; Borg J-P; Uhlén P; Holmgren L
Article: BREAST CANCER RESEARCH. 2014;16(4):R72

Sequencing of breast cancer stem cell populations indicates a dynamic conversion between differentiation states in vivo.

Klevebring D; Rosin G; Ma R; Lindberg J; Czene K; Kere J; Fredriksson I; Bergh J; Hartman J
Article: LABORATORY INVESTIGATION. 2014;94(7):796-805

Superficial scrapings from breast tumors is a source for biobanking and research purposes.

Ma R; Fredriksson I; Karthik G-M; Winn G; Darai-Ramqvist E; Bergh J; Hartman J
Article: HISTOPATHOLOGY. 2014;64(7):971-980

Low concordance of biomarkers in histopathological and cytological material from breast cancer.

Stålhammar G; Rosin G; Fredriksson I; Bergh J; Hartman J
Article: VIRCHOWS ARCHIV. 2013;463(5):637-642

Lymphoid aggregates in Crohn's colitis and mucosal immunity.

Rubio CA; Ásmundsson J; Silva P; Illies C; Hartman J; Kis L
Article: PLOS ONE. 2013;8(2):e56795

High prevalence of human cytomegalovirus proteins and nucleic acids in primary breast cancer and metastatic sentinel lymph nodes.

Taher C; de Boniface J; Mohammad A-A; Religa P; Hartman J; Yaiw K-C; Frisell J; Rahbar A; Söderberg-Naucler C
Article: MOLECULAR ENDOCRINOLOGY. 2012;26(12):1991-2003

Estrogen receptors β1 and β2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3.

Dey P; Jonsson P; Hartman J; Williams C; Ström A; Gustafsson J-Å
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2012;97(12):4631-4639

Evidence of a functional estrogen receptor in parathyroid adenomas.

Haglund F; Ma R; Huss M; Sulaiman L; Lu M; Nilsson I-L; Höög A; Juhlin CC; Hartman J; Larsson C
Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(21):2601-2608

Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression.

Lindström LS; Karlsson E; Wilking UM; Johansson U; Hartman J; Lidbrink EK; Hatschek T; Skoog L; Bergh J
Article: BMC CANCER. 2012;12:79

The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer.

Rosin G; Hannelius U; Lindström L; Hall P; Bergh J; Hartman J; Kere J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2011;179(3):1148-1156

ERβ1 represses FOXM1 expression through targeting ERα to control cell proliferation in breast cancer.

Horimoto Y; Hartman J; Millour J; Pollock S; Olmos Y; Ho K-K; Coombes RC; Poutanen M; Mäkelä SI; El-Bahrawy M; Speirs V; Lam EW-F
Article: ONCOGENE. 2010;29(20):2983-2995

FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance.

Millour J; Constantinidou D; Stavropoulou AV; Wilson MSC; Myatt SS; Kwok JM-M; Sivanandan K; Coombes RC; Medema RH; Hartman J; Lykkesfeldt AE; Lam EW-F
Article: CANCER RESEARCH. 2009;69(15):6100-6106

Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells.

Hartman J; Edvardsson K; Lindberg K; Zhao C; Williams C; Ström A; Gustafsson J-A
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2009;35(1):57-68

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.

Francis RE; Myatt SS; Krol J; Hartman J; Peck B; McGovern UB; Wang J; Guest SK; Filipovic A; Gojis O; Palmieri C; Peston D; Shousha S; Yu Q; Sicinski P; Coombes RC; Lam EW-F
Article: BREAST CANCER RESEARCH. 2009;11(6):R79

Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.

Hartman J; Lam EW-F; Gustafsson J-A; Ström A
Article: CANCER RESEARCH. 2006;66(23):11207-11213

Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts.

Hartman J; Lindberg K; Morani A; Inzunza J; Ström A; Gustafsson J-A
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2006;24(18_suppl):10101

Estrogen receptor β represses breast tumor growth and angiogenesis in vivo

Hartman J; Lindberg K; Inzunza J; Wan J; Ström A; Gustafsson J
Article: BRITISH JOURNAL OF NUTRITION. 2005;94(5):623-632

The case for strategic international alliances to harness nutritional genomics for public and personal health.

Kaput J; Ordovas JM; Ferguson L; van Ommen B; Rodriguez RL; Allen L; Ames BN; Dawson K; German B; Krauss R; Malyj W; Archer MC; Barnes S; Bartholomew A; Birk R; van Bladeren P; Bradford KJ; Brown KH; Caetano R; Castle D; Chadwick R; Clarke S; Clément K; Cooney CA; Corella D; Manica da Cruz IB; Daniel H; Duster T; Ebbesson SOE; Elliott R; Fairweather-Tait S; Felton J; Fenech M; Finley JW; Fogg-Johnson N; Gill-Garrison R; Gibney MJ; Gillies PJ; Gustafsson J-A; Hartman JL; He L; Hwang J-K; Jais J-P; Jang Y; Joost H; Junien C; Kanter M; Kibbe WA; Koletzko B; Korf BR; Kornman K; Krempin DW; Langin D; Lauren DR; Ho Lee J; Leveille GA; Lin S-J; Mathers J; Mayne M; McNabb W; Milner JA; Morgan P; Muller M; Nikolsky Y; van der Ouderaa F; Park T; Pensel N; Perez-Jimenez F; Poutanen K; Roberts M; Saris WHM; Schuster G; Shelling AN; Simopoulos AP; Southon S; Tai ES; Towne B; Trayhurn P; Uauy R; Visek WJ; Warden C; Weiss R; Wiencke J; Winkler J; Wolff GL; Zhao-Wilson X; Zucker J-D
Article: ONCOGENE. 2004;23(54):8826-8833

HES-1 inhibits 17beta-estradiol and heregulin-beta1-mediated upregulation of E2F-1.

Hartman J; Müller P; Foster JS; Wimalasena J; Gustafsson J-A; Ström A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(6):1566-1571

Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D.

Ström A; Hartman J; Foster JS; Kietz S; Wimalasena J; Gustafsson J-A
Article: JOURNAL OF ENDOCRINOLOGY. 2001;171(3):R11-R15

Lithium chloride inhibits the expression and secretion of insulin-like growth factor-binding protein-1.

Lewitt MS; Brismar K; Ohlson J; Hartman J
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Alla övriga publikationer

Review: JOURNAL OF PATHOLOGY. 2024;262(3):271-288

Image-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast Cancer.

Jahangir CA; Page DB; Broeckx G; Gonzalez CA; Burke C; Murphy C; Reis-Filho JS; Ly A; Harms PW; Gupta RR; Vieth M; Hida AI; Kahila M; Kos Z; van Diest PJ; Verbandt S; Thagaard J; Khiroya R; Abduljabbar K; Acosta Haab G; Acs B; Adams S; Almeida JS; Alvarado-Cabrero I; Azmoudeh-Ardalan F; Badve S; Baharun NB; Bellolio ER; Bheemaraju V; Blenman KR; Botinelly Mendonça Fujimoto L; Burgues O; Chardas A; Cheang MCU; Ciompi F; Cooper LA; Coosemans A; Corredor G; Dantas Portela FL; Deman F; Demaria S; Dudgeon SN; Elghazawy M; Fernandez-Martín C; Fineberg S; Fox SB; Giltnane JM; Gnjatic S; Gonzalez-Ericsson PI; Grigoriadis A; Halama N; Hanna MG; Harbhajanka A; Hart SN; Hartman J; Hewitt S; Horlings HM; Husain Z; Irshad S; Janssen EA; Kataoka TR; Kawaguchi K; Khramtsov AI; Kiraz U; Kirtani P; Kodach LL; Korski K; Akturk G; Scott E; Kovács A; Laenkholm A-V; Lang-Schwarz C; Larsimont D; Lennerz JK; Lerousseau M; Li X; Madabhushi A; Maley SK; Manur Narasimhamurthy V; Marks DK; McDonald ES; Mehrotra R; Michiels S; Kharidehal D; Minhas FUAA; Mittal S; Moore DA; Mushtaq S; Nighat H; Papathomas T; Penault-Llorca F; Perera RD; Pinard CJ; Pinto-Cardenas JC; Pruneri G; Pusztai L; Rajpoot NM; Rapoport BL; Rau TT; Ribeiro JM; Rimm D; Vincent-Salomon A; Saltz J; Sayed S; Hytopoulos E; Mahon S; Siziopikou KP; Sotiriou C; Stenzinger A; Sughayer MA; Sur D; Symmans F; Tanaka S; Taxter T; Tejpar S; Teuwen J; Thompson EA; Tramm T; Tran WT; van der Laak J; Verghese GE; Viale G; Wahab N; Walter T; Waumans Y; Wen HY; Yang W; Yuan Y; Bartlett J; Loibl S; Denkert C; Savas P; Loi S; Specht Stovgaard E; Salgado R; Gallagher WM; Rahman A
Preprint: BIORXIV. 2024

Prelude to Malignancy: A Gene Expression Signature in Normal Mammary Gland from Breast Cancer Patients Suggests Pre-tumorous Alterations and Is Associated with Adverse Outcomes

Andreou M; Jąkalski M; Duzowska K; Filipowicz N; Kostecka A; Davies H; Horbacz M; Ławrynowicz U; Chojnowska K; Bruhn-Olszewska B; Jankau J; Śrutek E; Las-Jankowska M; Bała D; Hoffman J; Hartman J; Pęksa R; Skokowski J; Jankowski M; Szylberg Ł; Zegarski W; Nowikiewicz M; Nowikiewicz T; Dumanski JP; Mieczkowski J; Piotrowski A
Preprint: RESEARCH SQUARE. 2023

Clinical evaluation of deep learning-based risk profiling in breast cancer histopathology and comparison to an established multigene assay

Robertson S; Wang Y; Sun W; Karlsson E; Lövgren SK; Acs B; Rantalainen M; Hartman J
Preprint: MEDRXIV. 2023

Validation of an AI-based solution for breast cancer risk stratification using routine digital histopathology images

Sharma A; Lövgren SK; Eriksson KL; Wang Y; Robertson S; Hartman J; Rantalainen M
Preprint: MEDRXIV. 2023

Clinical evaluation of deep learning-based risk profiling in breast cancer histopathology and comparison to an established multigene assay

Wang Y; Sun W; Karlsson E; Lövgren SK; Ács B; Rantalainen M; Rantalainen M; Robertson S; Hartman J
Preprint: MEDRXIV. 2023

Deep learning-based risk stratification of preoperative breast biopsies using digital whole slide images

Boissin C; Wang Y; Sharma A; Weitz P; Karlsson E; Robertson S; Hartman J; Rantalainen M
Review: JOURNAL OF PATHOLOGY. 2023;260(5):498-513

Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.

Thagaard J; Broeckx G; Page DB; Jahangir CA; Verbandt S; Kos Z; Gupta R; Khiroya R; Abduljabbar K; Acosta Haab G; Acs B; Akturk G; Almeida JS; Alvarado-Cabrero I; Amgad M; Azmoudeh-Ardalan F; Badve S; Baharun NB; Balslev E; Bellolio ER; Bheemaraju V; Blenman KR; Botinelly Mendonça Fujimoto L; Bouchmaa N; Burgues O; Chardas A; Chon U Cheang M; Ciompi F; Cooper LA; Coosemans A; Corredor G; Dahl AB; Dantas Portela FL; Deman F; Demaria S; Doré Hansen J; Dudgeon SN; Ebstrup T; Elghazawy M; Fernandez-Martín C; Fox SB; Gallagher WM; Giltnane JM; Gnjatic S; Gonzalez-Ericsson PI; Grigoriadis A; Halama N; Hanna MG; Harbhajanka A; Hart SN; Hartman J; Hauberg S; Hewitt S; Hida AI; Horlings HM; Husain Z; Hytopoulos E; Irshad S; Janssen EA; Kahila M; Kataoka TR; Kawaguchi K; Kharidehal D; Khramtsov AI; Kiraz U; Kirtani P; Kodach LL; Korski K; Kovács A; Laenkholm A-V; Lang-Schwarz C; Larsimont D; Lennerz JK; Lerousseau M; Li X; Ly A; Madabhushi A; Maley SK; Manur Narasimhamurthy V; Marks DK; McDonald ES; Mehrotra R; Michiels S; Minhas FUAA; Mittal S; Moore DA; Mushtaq S; Nighat H; Papathomas T; Penault-Llorca F; Perera RD; Pinard CJ; Pinto-Cardenas JC; Pruneri G; Pusztai L; Rahman A; Rajpoot NM; Rapoport BL; Rau TT; Reis-Filho JS; Ribeiro JM; Rimm D; Roslind A; Vincent-Salomon A; Salto-Tellez M; Saltz J; Sayed S; Scott E; Siziopikou KP; Sotiriou C; Stenzinger A; Sughayer MA; Sur D; Fineberg S; Symmans F; Tanaka S; Taxter T; Tejpar S; Teuwen J; Thompson EA; Tramm T; Tran WT; van der Laak J; van Diest PJ; Verghese GE; Viale G; Vieth M; Wahab N; Walter T; Waumans Y; Wen HY; Yang W; Yuan Y; Zin RM; Adams S; Bartlett J; Loibl S; Denkert C; Savas P; Loi S; Salgado R; Specht Stovgaard E
Review: JOURNAL OF PATHOLOGY. 2023;260(5):514-532

Spatial analyses of immune cell infiltration in cancer: current methods and future directions: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.

Page DB; Broeckx G; Jahangir CA; Verbandt S; Gupta RR; Thagaard J; Khiroya R; Kos Z; Abduljabbar K; Acosta Haab G; Acs B; Akturk G; Almeida JS; Alvarado-Cabrero I; Azmoudeh-Ardalan F; Badve S; Baharun NB; Bellolio ER; Bheemaraju V; Blenman KR; Botinelly Mendonça Fujimoto L; Bouchmaa N; Burgues O; Cheang MCU; Ciompi F; Cooper LA; Coosemans A; Corredor G; Dantas Portela FL; Deman F; Demaria S; Dudgeon SN; Elghazawy M; Ely S; Fernandez-Martín C; Fineberg S; Fox SB; Gallagher WM; Giltnane JM; Gnjatic S; Gonzalez-Ericsson PI; Grigoriadis A; Halama N; Hanna MG; Harbhajanka A; Hardas A; Hart SN; Hartman J; Hewitt S; Hida AI; Horlings HM; Husain Z; Hytopoulos E; Irshad S; Janssen EA; Kahila M; Kataoka TR; Kawaguchi K; Kharidehal D; Khramtsov AI; Kiraz U; Kirtani P; Kodach LL; Korski K; Kovács A; Laenkholm A-V; Lang-Schwarz C; Larsimont D; Lennerz JK; Lerousseau M; Li X; Ly A; Madabhushi A; Maley SK; Manur Narasimhamurthy V; Marks DK; McDonald ES; Mehrotra R; Michiels S; Minhas FUAA; Mittal S; Moore DA; Mushtaq S; Nighat H; Papathomas T; Penault-Llorca F; Perera RD; Pinard CJ; Pinto-Cardenas JC; Pruneri G; Pusztai L; Rahman A; Rajpoot NM; Rapoport BL; Rau TT; Reis-Filho JS; Ribeiro JM; Rimm D; Vincent-Salomon A; Salto-Tellez M; Saltz J; Sayed S; Siziopikou KP; Sotiriou C; Stenzinger A; Sughayer MA; Sur D; Symmans F; Tanaka S; Taxter T; Tejpar S; Teuwen J; Thompson EA; Tramm T; Tran WT; van der Laak J; van Diest PJ; Verghese GE; Viale G; Vieth M; Wahab N; Walter T; Waumans Y; Wen HY; Yang W; Yuan Y; Adams S; Bartlett JMS; Loibl S; Denkert C; Savas P; Loi S; Salgado R; Specht Stovgaard E
Preprint: ARXIV. 2023

Increasing the usefulness of already existing annotations through WSI registration

Weitz P; Sartor V; Acs B; Robertson S; Budelmann D; Hartman J; Rantalainen M
Conference publication: CANCER RESEARCH. 2023;83(5):p5-02-20-p5-02-20

Correlative and longitudinal transcriptomic profiling predicts patient outcomes and the efficacy of neoadjuvant HER2-targeted treatments in the randomized PREDIX HER2 trial

Wang K; Zhu Y; Zerdes I; Matikas A; Sifakis E; Salgkamis D; Bjohle J; Elinder E; Margolin S; Campos AB; Pekar G; Lindman H; Schiza A; Einbeigi Z; Adra J; Andersson A; Carlsson L; Dreifaldt AC; Isaksson-Friman E; Agartz S; Johansson H; Hellstrom M; Azavedo E; Hartman J; Bergh J; Hatschek T; Foukakis T
Conference publication: CANCER RESEARCH. 2023;83(5):p2-21-02-p2-21-02

Longitudinal tumor-immune microenvironment changes in patients with clinical luminal A early breast cancer treated with neoadjuvant palbociclib and endocrine therapy: results from the Swedish randomized PREDIX Luminal A trial

Zerdes I; Salgkamis D; Matikas A; Selander L; Wang K; Tzoras E; Sifakis E; Agartz S; Chen X; Hellstrom M; Hartman J; Bergh J; Foukakis T; Hatschek T
Preprint: MEDRXIV. 2023

Development and prognostic validation of a three-level NHG-like deep learning-based model for histological grading of breast cancer

Sharma A; Weitz P; Wang Y; Liu B; Hartman J; Rantalainen M
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S640

Gene expression profiles in endocrine-resistant breast cancer

Schagerholm C; Robertson S; Sifakis EG; Hases L; Williams C; Hartman J
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):s614

The prognostic importance of high HER2 copy numbers and high HER2/CEP17 ratio in trastuzumab-treated early breast cancer

Ronnlund C; Robertson S; Sifakis EG; Fredriksson I; Foukakis T; Hartman J
Editorial comment: CANCERS. 2022;14(15):3762

External Quality Assessment 2.0: The Importance of a Standardized Implementation of TILs for Daily and Trial Practices.

Nauwelaers I; Laudus N; Peeters D; Acs B; Denkert C; Michiels S; Horlings H; Siziopikou KP; Ely S; Zardavas D; Mustimbo R; Bartlett J; Floris G; Hartman J; van Deurzen CHM; Ceusters D; Dequeker E; Salgado R
Meeting abstract: CANCER RESEARCH. 2022;82(4):p1-02-03-p1-02-03

Tumor-infiltrating lymphocytes but not HER2 copy number or ratio show prognostic value in trastuzumab-treated HER2-positive breast cancer

Robertson S; Ronnlund C; Fredriksson I; Foukakis T; Hartman J
Conference publication: CANCER RESEARCH. 2022;82(4):p3-02-06-p3-02-06

A phase II study of ⁶⁸Ga-ABY-025 PET for non-invasive quantification of HER2 expression in breast cancer

Alhuseinalkhudhur A; Lindman H; Liss P; Sundin T; Frejd FY; Hartman J; Iyer V; Lubberink M; Velikyan I; Sorensen J
Meeting abstract: CANCER RESEARCH. 2022;82(4):p1-07-07-p1-07-07

Endoresist: Prognostic and predictive gene profiles in endocrine-resistant breast cancers

Schagerholm C; Robertson S; Holm B; Lindberg K; Sifakis E; Hases L; Williams C; Hartman J
Conference publication: VIRCHOWS ARCHIV. 2022;481(SUPPL 1):S42-S43

PIK3CA mutations in endocrine-resistant breast cancer

Schagerholm C; Robertson S; Holm B; Awier H; Toosi H; Sifakis E; Hartman J
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16)

Combined assessment of metabolic response and tumor infiltrating lymphocytes as a predictor of outcomes following neoadjuvant therapy for HER2-positive breast cancer: Results from the randomized PREDIX HER2 trial.

Matikas A; Johansson H; Gryback P; Bjohle J; Lekberg T; Fredholm H; Acs B; Elinder E; Isaksson-Friman E; Agartz S; Hellstrom M; Zerdes I; Hartman J; Bergh JCS; Hatschek T; Foukakis T
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(46):e2117333118

Correction for Wolfsberger et al., TAp73 represses NF-κB-mediated recruitment of tumor-associated macrophages in breast cancer.
Editorial comment: EBIOMEDICINE. 2021;70:103520

What do we still need to learn on digitally assessed biomarkers?

Acs B; Salgado R; Hartman J
Corrigendum: BREAST CANCER RESEARCH. 2021;23(1):28

Correction to: Molecular analyses of triple-negative breast cancer in the young and elderly.

Aine M; Boyaci C; Hartman J; Häkkinen J; Mitra S; Campos AB; Nimeus E; Ehinger A; Vallon-Christersson J; Borg Å; Staaf J
Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2021;48(SUPPL 1):S300

⁶⁸Ga-ABY-025 PET Predicts the Metabolic Response in Breast Cancer Patients: Preliminary Results From a Phase II Study

Alhuseinalkhudhur A; Lindman H; Lubberink M; Iyer V; Liss P; Sundin T; Frejd FY; Hartman J; Velikyan I; Sorensen J
Conference publication: CANCER RESEARCH. 2021;81(4)

Integrated immuno-genomic analyses in early breast cancer: Results from the Scandinavian breast group 2004-1 (SBG-2004-1) randomized phase II trial

Zerdes I; Simonetti M; Matikas A; Harbers L; Zhang N; Salgkamis D; Agartz S; Zacharouli M; Moreno-Ruiz P; Hartman J; Mezheyeuski A; Bergh J; Crosetto N; Foukakis T
Conference publication: CANCER RESEARCH. 2020;80(16):2081

Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes

Hases L; Indukuri R; Birgersson M; Trang N-V; Lozano R; Saxena A; Hartman J; Frasor J; Gustafsson J-A; Katajisto P; Archer A; Williams C
Letter: NATURE MEDICINE. 2020;26(7):992-994

Support systems to guide clinical decision-making in precision oncology: The Cancer Core Europe Molecular Tumor Board Portal.

Tamborero D; Dienstmann R; Rachid MH; Boekel J; Baird R; Braña I; De Petris L; Yachnin J; Massard C; Opdam FL; Schlenk R; Vernieri C; Garralda E; Masucci M; Villalobos X; Chavarria E; Cancer Core Europe consortium; Calvo F; Fröhling S; Eggermont A; Apolone G; Voest EE; Caldas C; Tabernero J; Ernberg I; Rodon J; Lehtiö J
Review: JOURNAL OF INTERNAL MEDICINE. 2020;288(1):62-81

Artificial intelligence as the next step towards precision pathology.

Acs B; Rantalainen M; Hartman J
Conference publication: ANNALS OF ONCOLOGY. 2020;31:S49

PREDIX HER2 trial: Event-free survival and pathologic complete response in clinical subgroups and stromal TILs levels

Hatschek T; Andersson A; Bjohle J; Bosch A; Carlsson L; Dreifaldt AC; Einbeigi Z; Elinder E; Fredholm H; Isaksson-Friman E; Hellstrom M; Johansson H; Lekberg T; Lindman H; Zerdes I; Foukakis T; Hartman J; Brandberg Y; Bergh J
Meeting abstract: CANCER RESEARCH. 2020;80(4):p5-02-07-p5-02-07

Distribution of biomarker evaluation scores among the pathology departments of Sweden: Comparison study of 35,066 breast cancer cases

Acs B; Fredriksson I; Wilking U; Robertson S; Hartman J
Conference publication: CANCER RESEARCH. 2020;80(4):p5-02-01-p5-02-01

Analytical validation and prognostic potential of an automated digital scoring protocol for Ki67: An International Ki67 Working Group study

Acs B; Leung SCY; Kidwell KM; Arun I; Augulis R; Badve SS; Bai Y; Bane AL; Bartlett JMS; Bayani J; Bigras G; Blank A; Borgquist S; Buikema H; Chang MC; Dietz RL; Dodson A; Ehinger A; Fineberg S; Focke CM; Gao D; Gown AM; Gutierrez C; Hartman J; Hugh JC; Kos Z; Laenkholm A-V; Laurinavicius A; Levenson RM; Mahboubi-Ardakani R; Mastropasqua MG; Moriya T; Nofech-Mozes S; Osborne CK; Pantanowitz L; Penault-Llorca FM; Piper T; Quintayo MA; Rau TT; Reinhard S; Robertson S; Sakatani T; Salgado R; Spears M; Tarczynski JS; Sugie T; van der Vegt B; Viale G; Virk S; Zabaglo LA; Hayes DF; Dowsett M; Nielsen TO; Rimm DL
Conference publication: CANCER RESEARCH. 2020;80(4):p3-08-19-p3-08-19

Biomarkers associated with dcis related breast cancer death

Wadsten C; Hartman J; Fredriksson I; Garmo H; Warnberg F; Sund M
Conference publication: CANCER RESEARCH. 2020;80(4):p5-02-06-p5-02-06

Improved histologic grading of breast cancer by a novel deep learning-based model

Rantalainen M; Wang Y; Acz B; Robertson S; Hartman J
Review: NPJ BREAST CANCER. 2020;6:16

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.

Amgad M; Stovgaard ES; Balslev E; Thagaard J; Chen W; Dudgeon S; Sharma A; Kerner JK; Denkert C; Yuan Y; AbdulJabbar K; Wienert S; Savas P; Voorwerk L; Beck AH; Madabhushi A; Hartman J; Sebastian MM; Horlings HM; Hudeček J; Ciompi F; Moore DA; Singh R; Roblin E; Balancin ML; Mathieu M-C; Lennerz JK; Kirtani P; Chen I-C; Braybrooke JP; Pruneri G; Demaria S; Adams S; Schnitt SJ; Lakhani SR; Rojo F; Comerma L; Badve SS; Khojasteh M; Symmans WF; Sotiriou C; Gonzalez-Ericsson P; Pogue-Geile KL; Kim RS; Rimm DL; Viale G; Hewitt SM; Bartlett JMS; Penault-Llorca F; Goel S; Lien H-C; Loibl S; Kos Z; Loi S; Hanna MG; Michiels S; Kok M; Nielsen TO; Lazar AJ; Bago-Horvath Z; Kooreman LFS; van der Laak JAWM; Saltz J; Gallas BD; Kurkure U; Barnes M; Salgado R; Cooper LAD; International Immuno-Oncology Biomarker Working Gr
Editorial comment: JOURNAL OF PATHOLOGY. 2020;250(1):7-8

Next generation pathology: artificial intelligence enhances histopathology practice.

Acs B; Hartman J
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(15)

PREDIX II HER2: Improving pre-operative systemic therapy for human epidermal growth factor receptor 2 (HER2) amplified breast cancer (BC).

Kornalijnslijper-Altena R; Andersson A; Brandberg Y; Kessler LE; Elinder E; Hartman J; Hellstrom M; Johansson H; Killander F; Linderholm BK; Lindman H; Valachis A; Wennstig AK; Xie H; Hatschek T; Bergh JCS
Review: TRANSLATIONAL RESEARCH. 2018;194:19-35

Digital image analysis in breast pathology-from image processing techniques to artificial intelligence.

Robertson S; Azizpour H; Smith K; Hartman J
Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48

Publisher Correction: Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity.

Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Fernández Moro C; Dahlstrand H; Östman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlén P
Conference publication: CANCER RESEARCH. 2018;78(4)

Digital image analysis of Ki67 in hot spots is superior to alternative proliferation associated markers in breast cancer

Robertson S; Stalhammar G; Wedlund L; Gholizadeh S; Lippert M; Rantaleinen M; Bergh J; Hartman J
Conference publication: EUROPEAN JOURNAL OF CANCER. 2018;92:S67-S68

Biomarkers in DCIS associated with breast cancer death

Wadsten C; Warnberg F; Tolockiene E; Hartman J; Fredriksson I; Garmo H; Sund M
Meeting abstract: CANCER RESEARCH. 2017;77:p6-01-04-p6-01-04

Evolutionary analyses of matched primary and metastatic breast cancer reveal both linear and parallel progression with lack of axillary lymph node involvement

Ullah I; Muralidharan KG; Alkodsi A; Kjallquist U; Stalhammar G; Lovrot J; Martinez NF; Lagergren J; Hautaniemi S; Hartman J; Bergh J
Conference publication: CANCER RESEARCH. 2017;77:p2-03-03-p2-03-03

Molecular differences between screen-detected and interval breast cancers are largely explained by PAM50 subtypes

Czene K; Ivansson E; Klevebring D; Tobin NP; Lindstrom LS; Holm J; Prochazka G; Hilliges C; Palmgren J; Tornberg S; Humphreys K; Hartman J; Frisell J; Rantalainen M; Lindberg J; Hall P; Bergh J; Gronberg H; Li J
Conference publication: ANNALS OF ONCOLOGY. 2017;28

Prognosis after loco-regional recurrence of breast cancer: 35 years longitudinal data from the Stockholm cancer register

Falato C; Eriksson L; Sofiadis A; Taylor SK; Nordblom A; Fredriksson I; Hartman J; Bergh J; Foukakis T
Conference publication: CANCER RESEARCH. 2016;76:3933

CETSA as a diagnostic tool to guide personalized breast cancer therapy

Oeberg A; Laursen H; Packham S; Molina DM; Seki T; Cao Y; Hartman J; Bergh J; Nordlund P; Loeoef S
Conference publication: CANCER RESEARCH. 2016;76:p6-07-09-p6-07-09

Somatic mutations in A kinase anchoring proteins (AKAPs) in metastatic tumors - A potential characteristic of breast cancer metastasis

Kjallquist U; Erlandsson R; Alkodsi A; Tobin N; Karlsson E; Hatschek T; Hartman J; Linnarsson S; Bergh J
Conference publication: EUROPEAN JOURNAL OF CANCER. 2016;57:S130

Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A kinase anchoring protein family (AKAPs)

Kjallquist U; Erlandsson R; Hartman J; Alkodsi A; Tobin N; Hatschek T; Bergh J; Linnarsson S
Conference publication: CANCER RESEARCH. 2016;76

Digital image analysis outperforms manual scoring for breast cancer subclassification and prognostication

Stalhammar G; Rosin G; Kis L; Lippert M; Moelholm I; Grunkin M; Bergh J; Hartman J
Letter: HISTOPATHOLOGY. 2015;66(5):756-758

Response to correspondence on 'low concordance of biomarkers in histopathological and cytological material from breast cancer'.

Stålhammar G; Hartman J
Conference publication: MODERN PATHOLOGY. 2014;27:78A-79A

Exome Sequencing of Mammospheres and Primary Tumors Indicates Dynamic Transitions between Stem-Like and Differentiated States in Breast Cancer

Rosin G; Klevebring D; Ma R; Fredriksson I; Bergh J; Hartman J
Conference publication: LABORATORY INVESTIGATION. 2014;94:78A-79A

Exome Sequencing of Mammospheres and Primary Tumors Indicates Dynamic Transitions between Stem-Like and Differentiated States in Breast Cancer

Rosin G; Klevebring D; Ma R; Fredriksson I; Bergh J; Hartman J
Conference publication: CANCER RESEARCH. 2013;73:ot1-2-03-ot1-2-03

A prospective randomized phase II study to identify predictive biomarkers and mechanisms of resistance in patients with HER2-negative metastatic breast cancer treated with the combination of bevacizumab and paclitaxel

Foukakis T; Hartman J; Stone-Elander S; Jacobsson H; Bergh J
Conference publication: CANCER RESEARCH. 2013;73:p4-07-12-p4-07-12

miR-206 inhibits cell migration through direct targeting of the actin-binding protein coronin 1C in triple-negative breast cancer

Wang J; Tsouko E; Jonsson P; Bergh J; Hartman J; Aydogdu E; Williams C
Conference publication: CANCER RESEARCH. 2013;73(8):4915

Estrogen receptor β is expressed within breast cancer cells with stem cell like capacity and confers endocrine sensitivity

Ma R; Govindasamy KM; Rosin G; Gustafsson J; Katchy A; Lindstrom L; Hilliges C; Viberg L; Blomqvist L; Frisell J; Williams C; Fredriksson I; Bergh J; Hartman J
Review: STEROIDS. 2012;77(12):1262-1266

Current concepts and significance of estrogen receptor β in prostate cancer.

Hartman J; Ström A; Gustafsson J-Å
Editorial comment: CANCER PREVENTION RESEARCH. 2010;3(8):897-899

Estrogen receptors in colorectal cancer: goalkeepers, strikers, or bystanders?

Hartman J; Gustafsson J-A
Conference publication: ENDOCRINE JOURNAL. 2010;57:S321

Targeting of estrogen receptor beta as a future cancer treatment

Gustafsson J-A; Warner M; Strom A; Hartman J
Review: STEROIDS. 2009;74(8):635-641

Estrogen receptor beta in breast cancer--diagnostic and therapeutic implications.

Hartman J; Ström A; Gustafsson J-A
Conference publication: CANCER RESEARCH. 2009;69(24):642S

Function of HES6 an Inhibitor of HES1, in the Breast Cancer Cell Lines T47D and MCF-7 Is to Up-Regulate E2F-1 and Increased Proliferation

Strom AM; Hartman J; Lam EW-F; Lin C-Y; Gustafsson J-A
Review: PHYSIOLOGICAL REVIEWS. 2007;87(3):905-931

Estrogen receptors: how do they signal and what are their targets.

Heldring N; Pike A; Andersson S; Matthews J; Cheng G; Hartman J; Tujague M; Ström A; Treuter E; Warner M; Gustafsson J-A
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(21):8298

Estrogen receptor β inhibits 17β-estradiol-stimulated proliferation of the breast cancer cell line T47D (vol 101, pg 1566, 2004)

Ström A; Hartman J; Foster JS; Kietz S; Wimalasena J; Gustafsson JA
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2006;24(18):565S

Estrogen receptor β represses breast tumor growth and angiogenesis in vivo.

Hartman J; Lindberg K; Inzunza J; Wan J; Ström A; Gustafsson J
Visa fler

Anställningar

Professor/Överläkare, Onkologi-Patologi, Karolinska Institutet, 2023-

Examina och utbildning

Docent, Experimentell patologi, Karolinska Institutet, 2015
Läkarexamen, Karolinska Institutet, 2008
Medicine Doktorsexamen, Institutionen för biovetenskaper och näringslära, Karolinska Institutet, 2008

Priser och utmärkelser

Priset för innovation och nyttogörande, Karolinska Institutet, 2023
Athenapriset, Vetenskapsrådet/LIF/Dagens Medicin, https://www.dagensmedicin.se/alla-nyheter/utmarkelser/arets-vinnare-av-athenapriset-sorterar-brostcancer-med-ai/, 2022
Sophiastipendiet, Sophiahemmet Hospital, 2020
Clinical Investigator award, Swedish Cancer Society, 2016
Alvarengas pris, Swedish Society of Medicine, 2013
Asklepios pris, Swedish Society of Medicine, 2009
The McKinsey Award, 2007
Anders Wall pris, 2006

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