Om mig

Docent, gruppledare tillsammans med Prof. Jan-Åke Gustafsson

Forskningsbeskrivning

Min forskning fokuserar på det kvinnliga könshormonet östrogen och dess signalering i hjärnan under utveckling och i den vuxna individen. Specifikt undersöker jag östrogenets verkningar i olika neuorlogiska sjukdomar som Alzheimers sjukdom. Dessutom forskar jag på östrogenreceptorernas roll i bröst- och prostatacancer.

 

Länk till forskargrupp

 

Urval publikationer:

Motor Function Deficits in the Estrogen Receptor Beta Knockout Mouse: Role on Excitatory Neurotransmission and Myelination in the Motor Cortex

Varshney M, Yu YLN, Katayama S, Lin X, Lin T, Wu WF, Töhönen V, Krjutskov K, Kere J, Fan X, Inzunza J, Gustafsson JÅ, Nalvarte I.

Neuroendocrinology, 2020 Jan 28, DOI: 10.1159/000506162

 

Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERbeta gene

Warner M, Wu W-F, Montanholi L, Nalvarte I, Antonson P, Gustafsson JÅ.

Proc Natl Acad Sci U S A, 2020 Mar 3;117(9):4902-4909

 

Sex stratified treatment of neurological disorders: Challenges and perspectives

Nalvarte I.

Brain Sci, Feb14, 2020, 10(2)

 

Fluoxetine Affects Differentiation of Midbrain Dopaminergic Neurons In Vitro.

Lupu D, Varshney MK, Mucs D, Inzunza J, Norinder U, Loghin F, Nalvarte I, Rüegg J.

Mol Pharmacol. 2018 Oct;94(4):1220-1231. doi: 10.1124/mol.118.112342. Epub 2018 Aug 16.

 

Role of estrogen receptor beta in neural differentiation of mouse embryonic stem cells.

Varshney MK, Inzunza J, Lupu D, Ganapathy V, Antonson P, Rüegg J, Nalvarte I*, Gustafsson JÅ*.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10428-E10437. doi: 10.1073/pnas.1714094114. Epub 2017 Nov 13.

 

Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders.

Varshney M, Nalvarte I.

Brain Sci. 2017 Feb 23;7(3). pii: E24. doi: 10.3390/brainsci7030024. Review.

 

Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.

Frei A, MacDonald G, Lund I, Gustafsson JÅ, Hynes NE, Nalvarte I.

Oncotarget. 2016 Aug 30;7(35):56170-56182. doi: 10.18632/oncotarget.10856.

 

Memo is a copper-dependent redox protein with an essential role in migration and metastasis.

MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Dolemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D, Seebacher J, Keusch JJ, Gut H, Salaun D, Mazzarol G, Disalvatore D, Bentires-Alj M, Di Fiore PP, Badache A, Hynes NE.

Sci Signal. 2014 Jun 10;7(329):ra56. doi: 10.1126/scisignal.2004870.

 

Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells.

Gattelli A*, Nalvarte I*, Boulay A, Roloff TC, Schreiber M, Carragher N, Macleod KK, Schlederer M, Lienhard S, Kenner L, Torres-Arzayus MI, Hynes NE.

EMBO Mol Med. 2013 Sep;5(9):1335-50. doi: 10.1002/emmm.201302625. Epub 2013 Jul 19.

 

The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation.

Tammimies K, Tapia-Páez I, Rüegg J, Rosin G, Kere J, Gustafsson JÅ, Nalvarte I.

Mol Endocrinol. 2012 Apr;26(4):619-29. doi: 10.1210/me.2011-1376. Epub 2012 Mar 1.

Pedagogiska meriter

2019- : Course leader: Biomedicine Master program thesis work and examination, Karolinska Institutet

2018- : Target Organ Toxicology, Nuclear receptor signalling & EDCs, Karolinska Institutet

2016- : Tutor in “Sex hormones and ESC differentiation”, Post-graduate course in Human Embryonic Stem Cells, 2212, Karolinska Institutet

2015-: Responsible for the practicum in course Functional Genomics, Biomedicine Bachelor programme, Karolinska Institute, Stockholm, Sweden

2014-2017: Applied Science Communication (ACB2), Biomedicine Master programme, Karolinska Institute, Stockholm, Sweden

2013- : Applied Science Communication (ACB4), Biomedicine Master programme, Karolinska Institute, Stockholm, Sweden

2014- : Tutor in “Proteomic techniques and applications”, Biomedicine Bachelor programme, Karolinska Institute, Stockholm, Sweden

03/2012: Tutor in WiMo 2012 Wissenschaftsmonat für Medizinstudierende, theory, University of Basel, basel, Switzerland

09-10/2011: Tutor in Introduction to Biology, theory. University of Basel, Basel, Switzerland

2008-2009: Tutor in “Proteomic techniques and applications”, Molecular Nutrition undergraduate programme, Stockholm University, Stockholm, Sweden

2008-2009: Responsible for the Theoretical and practical teaching in proteomics for researchers. Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden

2007-2009: Molecular biology. Theory and practice. Co-responsible for the course. Biomedicine undergraduate programme, Karolinska Institute, Stockholm, Sweden

2002-2006: Teaching assistance at undergraduate courses in Molecular immunology, Molecular Biology, Cell Biology, and General Chemistry at Södertörns högskola and Karolinska Institute, Stockholm, Sweden.

Utbildning

Doktorandstudier 2002-2006 (Inst. Biovetenskaper och Näringslära, Karolinska Instiutet)

Post doc 2006-2010 (Östrogen signallering, Inst. Biovetenskaper och Näringslära, Karolinska Instiutet)

Post doc 2010-2013 (Bröstcancerforskning, Friedrich Miescher Instsitute, Basel, Switzerland)

Forskarassistent 2013 - (Östrogen signallering, Inst. Biovetenskaper och Näringslära, Karolinska Instiutet)

Formell gruppledare 2018 (informell, biträdande, sedan 2014)

Docent 2018 (Molekylär Endokrinologi / Forskning / Karolinska Institutet)

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