Hugo Zeberg
Assistant Professor
E-mail: hugo.zeberg@ki.se
Telephone: +46852482909
Visiting address: Solnavägen 9, Biomedicum C4, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa FK Genetisk och farmakologisk epidemiologi, 171 77 Stockholm
Research
- We study gene flow from Neandertals and Denisovans into modern humans. In addition, we are interested in genetic variability and the functional consequences thereof, particularly for membrane-bound proteins such as receptors and ion channels. Other topics of interest include the genetic predisposition to infectious diseases, such as COVID-19 (see https://swecovid.org/ [1]).The Zeberg laboratory is pleased to consider applications from prospective master- and PhD students, particularly keen experimentalists.Group members: Richard Ågren, Kristoffer Sahlholm, Hugh Robinson*Selection of recent publications*Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. [2] Hultström M, Frithiof R, Grip J, /.../, Lipcsey M, *Zeberg H* * & Eriksson O* /Nature Immunology 2022 May/The major genetic risk factor for severe COVID-19 is associated with protection against HIV. [3] *Zeberg H */PNAS 2022 Feb/Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. [4] Huffman JE, Butler-Laporte G, Khan A, /.../, Kiryluk K, Richards JB & *Zeberg H* /Nature Genetics 2022 Jan/A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans. [5] Coppo C, Mishra P, Siefert N , Holmgren A, Pääbo S & *Zeberg H* /Science Advances 2022 Jan/Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. [6]Nakanishi T, Pigazzini S, Degenhardt F, /.../, *Zeberg H*, Richards JB & Ganna A/ J Clin Invest 2021 Oct/Mapping the human genetic architecture of COVID-19. [7]COVID-19 Host Genetics Initiative (incl. SweCovid). /Nature 2021 Jul/A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity. [8]Zhou S, Butler-Laporte G, Nakanishi T, /.../, *Zeberg H*, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE & Richards JB /Nature Medicine 2021 Feb/A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. [9]*Zeberg H *& Pääbo S /PNAS 2021/Longitudinal variability in mortality predicts COVID-19 deaths. [10]Lundberg JO & *Zeberg H*/Eur J Epidemiol 2021 Jul/The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. [11]*Zeberg H *& Pääbo S/Nature 2020/A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans. [12]*Zeberg H*, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, /et al//Curr. Biol. 2020/The Neandertal Progesterone Receptor. [13]*Zeberg H*, Kelso J & Pääbo S/Mol. Biol. Evol. 2020/Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects. [14]*Zeberg H *& Sahlholm K/Nature Commun 2018/[1] https://swecovid.org/[2] https://doi.org/10.1038/s41590-022-01227-w[3] https://pubmed.ncbi.nlm.nih.gov/35193979/[4] https://www.nature.com/articles/s41588-021-00996-8[5] https://pubmed.ncbi.nlm.nih.gov/34985944[6] https://pubmed.ncbi.nlm.nih.gov/34597274[7] https://pubmed.ncbi.nlm.nih.gov/34237774[8] https://pubmed.ncbi.nlm.nih.gov/33633408[9] https://pubmed.ncbi.nlm.nih.gov/33593941[10] https://pubmed.ncbi.nlm.nih.gov/34218343[11] https://pubmed.ncbi.nlm.nih.gov/32998156[12] https://pubmed.ncbi.nlm.nih.gov/32707058[13] https://pubmed.ncbi.nlm.nih.gov/32437543[14] https://pubmed.ncbi.nlm.nih.gov/30177830
Articles
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Article: NATURE. 2024;626(7998):341-346
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Article: SCIENTIFIC REPORTS. 2024;14(1):3000
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Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(9):599-606
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Article: MOLECULAR BIOLOGY AND EVOLUTION. 2023;40(6):msad130
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Article: NATURE COMMUNICATIONS. 2023;14(1):3092
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Article: ANATOMICAL SCIENCES EDUCATION. 2023;16(3):452-464
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Article: SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY. 2023;58(4):537-545
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Article: SCIENTIFIC REPORTS. 2023;13(1):3747
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Article: NATURE METABOLISM. 2023;5(2):248-264
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Article: HUMAN MOLECULAR GENETICS. 2022;31(22):3789-3806
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Article: PLOS GENETICS. 2022;18(11):e1010367
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Article: INTERNATIONAL JOURNAL OF MEDICAL EDUCATION. 2022;13:221-229
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Article: NATURE COMMUNICATIONS. 2022;13(1):4484
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Article: BIOSENSORS-BASEL. 2022;12(8):601
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Article: NATURE. 2022;607(7917):97-103
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Article: PHARMACOGENOMICS JOURNAL. 2022;22(4):247-249
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Article: BMC MEDICAL EDUCATION. 2022;22(1):477
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(9):e2116435119
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Article: NATURE GENETICS. 2022;54(2):125-127
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Article: SCIENCE ADVANCES. 2022;8(1):eabm1148
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Article: HUMAN GENETICS. 2022;141(1):147-173
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Article: NATURE. 2021;600(7889):472-477
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(23):e152386
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Article: CELL REPORTS. 2021;37(7):110020
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Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2021;36(6):599-603
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Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(8):4078
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Article: NATURE MEDICINE. 2021;27(4):659-667
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(9):e2026309118
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Article: JOURNAL OF NEUROSCIENCE METHODS. 2021;348:108984
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Article: NATURE. 2020;587(7835):610-612
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Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(19):3130-3143
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Article: CURRENT BIOLOGY. 2020;30(17):3465-3469.e4
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Article: MOLECULAR BIOLOGY AND EVOLUTION. 2020;37(9):2655-2660
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Article: PLOS ONE. 2020;15(12):e0244824
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Article: JOURNAL OF NEUROSURGERY. 2019;:1-8
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Article: ACTA NEUROCHIRURGICA. 2019;161(5):955-965
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Article: CEREBRAL CORTEX. 2019;29(3):1328-1341
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Article: PLOS ONE. 2019;14(2):e0213265
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Article: JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL. 2018;147(2):298-303
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Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2018;12:33
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Article: CUREUS. 2017;9(2):e1020
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Article: BIOPHYSICAL JOURNAL. 2016;111(8):1679-1691
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Article: COGNITION. 2016;155:44-56
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Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(3):467-476
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Article: JOURNAL OF NEUROPHYSIOLOGY. 2015;113(2):537-549
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(2):690-695
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Article: AGE. 2012;34(6):1435-1452
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Article: PLOS COMPUTATIONAL BIOLOGY. 2010;6(9):e1000951
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Article: PLOS COMPUTATIONAL BIOLOGY. 2010;6(4):e1000753
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All other publications
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Review: CELL. 2024;187(5):1047-1058
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Letter: NATURE. 2023;621(7977):E7-E26
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Editorial comment: SCIENCE. 2023;379(6636):eadf2212
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Editorial comment: NATURE. 2022;608(7921):E1-E10
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Editorial comment: NATURE IMMUNOLOGY. 2022;23(6):861-864
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Preprint: MEDRXIV. 2021;MEDRXIV
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Preprint: MEDRXIV. 2021;MEDRXIV
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Letter: NATURE COMMUNICATIONS. 2018;9(1):3577
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KI thesis / dissertation: 2015
Employments
- Assistant Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2024
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2016
- University Medical Degree, Karolinska Institutet, 2013