Herwig Schüler
Affiliated to Research
| Docent
E-mail: herwig.schuler@ki.se
Visiting address: Blickagången 16, 14151 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 Bionut Avdelningsgemensamt, 171 77 Stockholm
Part of:
About me
- Undergraduate studies in Frankfurt, Uppsala and Stockholm. Doctorate in cell
biology from Stockholm University. Postdoctoral studies in biochemistry at
New York University Medical Center. Group leader at KI since 2008 (2008 Team
leader, Structural Genomics Consortium, MBB - 2011, independent group leader,
MBB - 2018 BioNut). Associate Professor (docent) in structural biology 2013.
Chairman for Vetenskapsrådet review panel NT-9, 2017, 2018.
Research
- Posttranslational modifications (PTMs) orchestrate many vital events in
cells, including the remodeling of chromatin in gene activation and
inactivation, the transcription of active genes, the repair of damaged DNA,
and the interaction of proteins in cellular signaling networks. Many enzymes
are involved in putting these PTM marks in the right place at the right time,
and in removing them in the proper context. Specific binder domains are
involved in their recognition. Because of the consequences of their actions
and because they can often be inhibited by small compounds, these proteins
are often targets for drug development. With small compounds that act on
these proteins we can, for instance, kill cancer cells, or influence
signaling processes to reach a therapeutic outcome. This requires that we
understand the actions of both the target proteins and the inhibitor
substances to great detail in order for the therapeutic agents to be
effective and safe.
We are interested to understand to atomic detail how the PTM
ADP-ribosylation functions. For that, we study the 3-dimensional structures
of PARP and related enzymes with ADP-ribosyltransferase activity, and
determine their enzymatic properties. We also collaborate with chemists to
develop more portent and more selective PARP inhibitors. We study the binder
domains that recognize ADP-ribosylation marks in the cell. Finally, we study
bacterial toxins that catalyze the same reaction, with the aim to devise
novel anti-infectives.
Articles
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Article: CELLS. 2021;10(3):654
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Article: NATURE COMMUNICATIONS. 2021;12(1):1296
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Article: NATURE COMMUNICATIONS. 2020;11(1):5199
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Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2019;141(13):5169-5181
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Article: CELL CHEMICAL BIOLOGY. 2018;25(12):1547-1553.e12
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Article: NATURE COMMUNICATIONS. 2018;9(1):3785
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Article: CHEMMEDCHEM. 2018;13(13):1303-1307
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Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2018;28(11):2050-2054
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Article: SLAS DISCOVERY. 2018;23(4):353-362
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Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2018;143:568-576
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Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2017;27(13):2907-2911
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2017;60(4):1262-1271
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Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2017;56(1):248-253
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Article: JOURNAL OF BIOMOLECULAR SCREENING. 2016;21(6):590-595
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Article: STRUCTURE. 2016;24(5):789-796
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Article: CHEMICAL BIOLOGY & DRUG DESIGN. 2016;87(3):478-482
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2015;58(12):5143-5149
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Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2015;95:546-551
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Article: MOLECULAR MICROBIOLOGY. 2015;96(1):84-94
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Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2015;54(13):3927-3931
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(12):7336-7344
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2014;57(6):2807-2812
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2013;56(23):9556-9568
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Article: ACS CHEMICAL BIOLOGY. 2013;8(8):1698-1703
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Article: STRUCTURE. 2013;21(3):462-475
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2012;55(17):7706-7718
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Article: PHYTOPATHOLOGY. 2012;102(9):878-891
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(29):24077-24081
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(20):7705-7710
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Article: NATURE BIOTECHNOLOGY. 2012;30(3):283-288
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Article: PLOS ONE. 2012;7(1):e30581
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Article: CELLULAR MICROBIOLOGY. 2011;13(11):1714-1730
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Article: NATURE CHEMICAL BIOLOGY. 2011;7(12):950-958
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(32):28256-28264
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Article: PLOS ONE. 2011;6(6):e19521
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Article: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 2010;173(2):88-96
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Article: PLOS ONE. 2010;5(9):e12791
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Article: JOURNAL OF MOLECULAR BIOLOGY. 2010;400(4):768-782
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2010;53(14):5352-5355
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(15):11572-11583
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(11):8054-8060
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Article: BIOCHEMISTRY. 2010;49(6):1056-1058
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Article: PLOS ONE. 2010;5(1):e8625
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Article: MOLECULAR MICROBIOLOGY. 2009;74(6):1356-1367
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Article: PLOS ONE. 2009;4(10):e6975
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Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(9):3108-3111
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(16):10296-10300
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Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2008;73(4):1047-1052
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Article: STRUCTURE. 2008;16(11):1638-1648
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Article: FEBS JOURNAL. 2008;275(18):4627-4640
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Article: FEBS JOURNAL. 2008;275(1):59-68
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(5):3182-3187
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Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2006;62(Pt 11):1294-1299
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Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 7):613-617
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Article: TRENDS IN PARASITOLOGY. 2006;22(4):146-147
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Article: MOLECULAR BIOLOGY OF THE CELL. 2005;16(9):4013-4023
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Article: FEBS LETTERS. 2005;579(3):655-660
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Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;317(4):577-589
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Article: BIOCHEMICAL JOURNAL. 2001;355(Pt 3):771-778
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Article: FEBS LETTERS. 2000;476(3):155-159
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Article: FEBS JOURNAL. 2000;267(13):4054-4062
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Article: FEBS JOURNAL. 2000;267(2):476-486
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Article: FEBS JOURNAL. 1999;265(1):210-220
- Show more
All other publications
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Editorial comment: COMMUNICATIONS BIOLOGY. 2021;4(1):919
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Editorial comment: EMBO JOURNAL. 2016;35(7):703-705
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Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2015;384:153-166
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Review: MOLECULAR ASPECTS OF MEDICINE. 2013;34(6):1088-1108
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Editorial comment: FEBS JOURNAL. 2013;280(15):3542
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Review: FEBS JOURNAL. 2013;280(15):3563-3575
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Review: EUROPEAN JOURNAL OF CELL BIOLOGY. 2011;90(11):966-971
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Review: TRENDS IN BIOCHEMICAL SCIENCES. 2010;35(4):208-219
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Review: TRAFFIC. 2006;7(11):1433-1439
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Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1549(2):137-147
Employments
- Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024
Degrees and Education
- Docent, Karolinska Institutet, 2013