Heela Sarlus
Forskningsspecialist
E-postadress: heela.sarlus@ki.se
Besöksadress: L8:04, CMM Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postadress: K8 Klinisk neurovetenskap, K8 Neuro Harris, 171 77 Stockholm
Om mig
- We study the role of microglia in the context of neurodegenerative diseases
such as Alzheimer's disease, amyotrophic lateral sclerosis and multipel
sclerosis and aim to devise myeloid cells as therapy for these neurological
diseases.
2015 - PhD degree in Medical Science, Karolinska Institutet, Stockholm,
Sweden.
2008 - MSc in Molecular Biology, Stockholm University, Stockholm, Sweden
Forskningsbeskrivning
- I am studying whether microglia replacement therapy will reduce progression
in neurodegenerative diseases using /in vivo/ and /in vitro/ models. We
remove dysfunctional microglia from CNS using genetic and pharmacological
approaches and repopulate the brain with microglia-like cells that we
develop/ in vitro/.
I am also studying the potential of amniotic epithelial cells, a type of stem
cell derived from human placenta, as cell therapy for MS (in collaboration
with assoc. prof Roberto Gramignoli at KI). Currently, there is no cure for
the progressive states of MS and our aim is to develop new strategies that
target progressive MS.
Undervisning
- 2020 - current
Teaching biochemistry in Scandinavian Chiropractor institute, Stockholm,
Sweden
2018 – 2020
Different teaching activities: Lectured the autonomic nervous system,
laboratory work involving the hearing and vestibular lab and seminars
including motor functions to medical students at Karolinska Institutet.
Artiklar
-
Article: ACTA BIOMATERIALIA. 2022;142:36-48
-
Article: HEARING RESEARCH. 2022;415:108395
-
Article: EMBO JOURNAL. 2021;40(24):e108662
-
Article: CELL REPORTS. 2021;36(13):109758
-
Article: NEUROSCIENCE. 2020;448:14-27
-
Article: FASEB JOURNAL. 2020;34(10):13978-13992
-
Article: JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA. 2019;146(5):3960-3966
-
Article: CURRENT BIOLOGY. 2019;29(15):2477-2487.e6
-
Article: JOURNAL OF ALZHEIMERS DISEASE. 2015;48(2):495-505
-
Article: JOURNAL OF NEUROINFLAMMATION. 2013;10:99
-
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(10):2401-2412
Alla övriga publikationer
-
Review: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2020;8(1):217
-
Review: HEARING RESEARCH. 2019;377:53-60
-
Review: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(9):3240-3249
Anställningar
- Forskningsspecialist, Klinisk neurovetenskap, Karolinska Institutet, 2022-
Examina och utbildning
- Medicine Doktorsexamen, Institutionen för neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2015