Harri Alenius

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Harri Alenius är professor i molekylär toxikologi och chef för enheten för systemtoxikologi vid Institutet för miljömedicin, Karolinska Institutet.

Forskningsbeskrivning

Alenius utgår i sin forskning bland annat från mänskliga kohorter med belysande kontraster.

Utvalda publikationer

Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2022;52(8):929-941

Bet v 1 triggers antiviral-type immune signalling in birch-pollen-allergic individuals.

Wisgrill L; Fyhrquist N; Ndika J; Paalanen L; Berger A; Laatikainen T; Karisola P; Haahtela T; Alenius H
Review: EXPERIMENTAL DERMATOLOGY. 2021;30(10):1517-1531

The power and potential of BIOMAP to elucidate host-microbiome interplay in skin inflammatory diseases.

Alenius H; Sinkko H; Moitinho-Silva L; Rodriguez E; Broderick C; Alexander H; Reiger M; Hjelmsø MH; Fyhrquist N; Olah P; Bryce P; Smith C; Koning F; Eyerich K; Greco D; van den Bogaard EH; Neumann AU; Traidl-Hoffmann C; Homey B; Flohr C; Bønnelykke K; Stokholm J; Weidinger S
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:704633

Integrative Transcriptomics Reveals Activation of Innate Immune Responses and Inhibition of Inflammation During Oral Immunotherapy for Egg Allergy in Children.

Karisola P; Palosuo K; Hinkkanen V; Wisgrill L; Savinko T; Fyhrquist N; Alenius H; Mäkelä MJ
Article: ACS NANO. 2019;13(6):6932-6946

Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model.

Kooter I; Ilves M; Gröllers-Mulderij M; Duistermaat E; Tromp PC; Kuper F; Kinaret P; Savolainen K; Greco D; Karisola P; Ndika J; Alenius H
Letter: ALLERGY. 2019;74(3):617-621

Tape-stripping alters the microbe-host correlations in mouse skin.

Karisola P; Suomalainen A; Fortino V; Ottman N; Vendelin J; Wolff HJ; Ruokolainen L; Greco D; Fyhrquist N; Alenius H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;143(3):1198-1206.e12

Soil exposure modifies the gut microbiota and supports immune tolerance in a mouse model.

Ottman N; Ruokolainen L; Suomalainen A; Sinkko H; Karisola P; Lehtimäki J; Lehto M; Hanski I; Alenius H; Fyhrquist N

Artiklar

Journal article: JOURNAL OF TRANSLATIONAL MEDICINE. 2024;22(1):64

Integrative network analysis suggests prioritised drugs for atopic dermatitis.

Federico A; Möbus L; Al-Abdulraheem Z; Pavel A; Fortino V; Del Giudice G; Alenius H; Fyhrquist N; Greco D
Journal article: CURRENT OPINION IN TOXICOLOGY. 2023;36:100442

Editorial: Role of the microbiome in toxicology

Alenius H; Fadeel B
Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(21):15629

Effects of Superficial Scratching and Engineered Nanomaterials on Skin Gene Profiles and Microbiota in SKH-1 Mice.

Mäenpää K; Ilves M; Zhao L; Alenius H; Sinkko H; Karisola P
Journal article: CURRENT OPINION IN TOXICOLOGY. 2023;35:100420

Host-microbiome interactions in atopic and allergic diseases

Fyhrquist N; Werner P; Alenius H
Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2023;143(5):s178

1038 Host transcriptomes that define microbiota during cutaneous homeostasis and inflammation

Olah P; Radai Z; Smits JP; Gomez-Casado C; Consortium EM; Sinkko H; Fyhrquist N; Andersson B; Alenius H; Homey B
Journal article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(6):5183

Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs.

Zhao L; Wang S; Ilves M; Lehtonen S; Saikko L; El-Nezami H; Alenius H; Karisola P
Journal article: ALLERGY. 2023;78(2):592-595

Systemic gene signature of inhaled corticosteroid treatment in allergic asthma to flour.

Ndika J; Suojalehto H; Lindström I; Airaksinen L; Wisgrill L; Alenius H; Karisola P
Article: NATURE NANOTECHNOLOGY. 2023;18(1):42-48

Graphene oxide elicits microbiome-dependent type 2 immune responses via the aryl hydrocarbon receptor.

Peng G; Sinkko HM; Alenius H; Lozano N; Kostarelos K; Bräutigam L; Fadeel B
Journal article: FRONTIERS IN ALLERGY. 2023;4:1152927

A short history from Karelia study to biodiversity and public health interventions.

Haahtela T; Alenius H; Auvinen P; Fyhrquist N; von Hertzen L; Jousilahti P; Karisola P; Laatikainen T; Lehtimäki J; Paalanen L; Ruokolainen L; Saarinen K; Valovirta E; Vasankari T; Vlasoff T; Erhola M; Bousquet J; Vartiainen E; Mäkelä MJ
Journal article: FOOD AND CHEMICAL TOXICOLOGY. 2022;169:113368

Oral exposure to Ag or TiO2 nanoparticles perturbed gut transcriptome and microbiota in a mouse model of ulcerative colitis.

Wang S; Kang X; Alenius H; Wong SH; Karisola P; El-Nezami H
Article: NATURE COMMUNICATIONS. 2022;13(1):3798

Biomarkers of nanomaterials hazard from multi-layer data.

Fortino V; Kinaret PAS; Fratello M; Serra A; Saarimäki LA; Gallud A; Gupta G; Vales G; Correia M; Rasool O; Ytterberg J; Monopoli M; Skoog T; Ritchie P; Moya S; Vázquez-Campos S; Handy R; Grafström R; Tran L; Zubarev R; Lahesmaa R; Dawson K; Loeschner K; Larsen EH; Krombach F; Norppa H; Kere J; Savolainen K; Alenius H; Fadeel B; Greco D
Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 2022;106(3):132-140

Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation.

Oláh P; Szlávicz E; Kuchner M; Nemmer J; Zeeuwen P; Lefèvre-Utile A; Fyhrquist N; Prast-Nielsen S; Skoog T; Serra A; Rodríguez E; Raap U; Meller S; Gyulai R; Hupé P; Kere J; Levi-Schaffer F; Tsoka S; Alexander H; Nestle FO; Schröder JM; Weidinger S; van den Bogaard E; Soumelis V; Greco D; Barker J; Lauerma A; Ranki A; Andersson B; Alenius H; Homey B
Article: ALLERGY. 2022;77(5):1486-1498

Transcriptome-based identification of novel endotypes in adult atopic dermatitis.

Lefèvre-Utile A; Saichi M; Oláh P; Delord M; Homey B; Soumelis V; MAARS consortium
Journal article: PLOS ONE. 2022;17(10):e0276071

Skin microbiota of oxazolone-induced contact hypersensitivity mouse model.

Mäenpää K; Wang S; Ilves M; El-Nezami H; Alenius H; Sinkko H; Karisola P
Journal article: FRONTIERS IN ALLERGY. 2022;3:878862

Epigenetic Differences in Long Non-coding RNA Expression in Finnish and Russian Karelia Teenagers With Contrasting Risk of Allergy and Asthma.

Ndika J; Karisola P; Lahti V; Fyhrquist N; Laatikainen T; Haahtela T; Alenius H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(4):1072-1080

Endotyping asthma related to 3 different work exposures.

Suojalehto H; Ndika J; Lindström I; Airaksinen L; Karisola P; Alenius H
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(19):10679

Transcriptomic Profiling of Adult-Onset Asthma Related to Damp and Moldy Buildings and Idiopathic Environmental Intolerance.

Suojalehto H; Ndika J; Lindström I; Airaksinen L; Karvala K; Kauppi P; Lauerma A; Toppila-Salmi S; Karisola P; Alenius H
Article: CELLS. 2021;10(5):1085

Profiling Non-Coding RNA Changes Associated with 16 Different Engineered Nanomaterials in a Mouse Airway Exposure Model.

Ndika J; Karisola P; Kinaret P; Ilves M; Alenius H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE. 2021;9(5):1892-1901.e1

A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children.

Palosuo K; Karisola P; Savinko T; Fyhrquist N; Alenius H; Mäkelä MJ
Article: ADVANCED SCIENCE. 2021;8(10):2004588

Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways.

Kinaret PAS; Ndika J; Ilves M; Wolff H; Vales G; Norppa H; Savolainen K; Skoog T; Kere J; Moya S; Handy RD; Karisola P; Fadeel B; Greco D; Alenius H
Article: EUROPEAN SPINE JOURNAL. 2021;30(4):1018-1027

Serum biomarkers for Modic changes in patients with chronic low back pain.

Karppinen J; Koivisto K; Ketola J; Haapea M; Paananen M; Herzig K-H; Alini M; Lotz J; Dudli S; Samartzis D; Risteli J; Majuri M-L; Alenius H; Kyllönen E; Järvinen J; Niinimäki J; Grad S
Article: ALLERGY. 2021;76(4):1173-1187

Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites.

Ottman N; Barrientos-Somarribas M; Fyhrquist N; Alexander H; Wisgrill L; Olah P; Tsoka S; Greco D; Levi-Schaffer F; Soumelis V; Schröder JM; Kere J; Nestle FO; Barker J; Ranki A; Lauerma A; Homey B; Andersson B; Alenius H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(3):1031-1040

Shared DNA methylation signatures in childhood allergy: The MeDALL study.

Xu C-J; Gruzieva O; Qi C; Esplugues A; Gehring U; Bergström A; Mason D; Chatzi L; Porta D; Lodrup Carlsen KC; Baïz N; Madore A-M; Alenius H; van Rijkom B; Jankipersadsing SA; van der Vlies P; Kull I; van Hage M; Bustamante M; Lertxundi A; Torrent M; Santorelli G; Fantini MP; Hovland V; Pesce G; BIOS Consortium; Fyhrquist N; Laatikainen T; Nawijn MC; Li Y; Wijmenga C; Netea MG; Bousquet J; Anto JM; Laprise C; Haahtela T; Annesi-Maesano I; Carlsen K-H; Gori D; Kogevinas M; Wright J; Söderhäll C; Vonk JM; Sunyer J; Melén E; Koppelman GH
Article: ALLERGY. 2021;76(3):804-815

Integrative transcriptome analysis deciphers mechanisms of nickel contact dermatitis.

Wisgrill L; Werner P; Jalonen E; Berger A; Lauerma A; Alenius H; Fyhrquist N
Article: MOLECULAR PHARMACEUTICS. 2021;18(2):699-713

Diffusion and Protein Corona Formation of Lipid-Based Nanoparticles in the Vitreous Humor: Profiling and Pharmacokinetic Considerations.

Tavakoli S; Kari OK; Turunen T; Lajunen T; Schmitt M; Lehtinen J; Tasaka F; Parkkila P; Ndika J; Viitala T; Alenius H; Urtti A; Subrizi A
Article: NANOTOXICOLOGY. 2021;15(1):96-113

Pulmonary toxicity of synthetic amorphous silica - effects of porosity and copper oxide doping.

Hadrup N; Aimonen K; Ilves M; Lindberg H; Atluri R; Sahlgren NM; Jacobsen NR; Barfod KK; Berthing T; Lawlor A; Norppa H; Wolff H; Jensen KA; Hougaard KS; Alenius H; Catalan J; Vogel U
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(52):33474-33485

Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.

Fortino V; Wisgrill L; Werner P; Suomela S; Linder N; Jalonen E; Suomalainen A; Marwah V; Kero M; Pesonen M; Lundin J; Lauerma A; Aalto-Korte K; Greco D; Alenius H; Fyhrquist N
Article: ADVANCED SCIENCE. 2020;7(22):2002221

Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect.

Gallud A; Delaval M; Kinaret P; Marwah VS; Fortino V; Ytterberg J; Zubarev R; Skoog T; Kere J; Correia M; Loeschner K; Al-Ahmady Z; Kostarelos K; Ruiz J; Astruc D; Monopoli M; Handy R; Moya S; Savolainen K; Alenius H; Greco D; Fadeel B
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2020;50(10):1148-1158

Immune-microbiota interaction in Finnish and Russian Karelia young people with high and low allergy prevalence.

Ruokolainen L; Fyhrquist N; Laatikainen T; Auvinen P; Fortino V; Scala G; Jousilahti P; Karisola P; Vendelin J; Karkman A; Markelova O; Mäkelä MJ; Lehtimäki S; Ndika J; Ottman N; Paalanen L; Paulin L; Vartiainen E; von Hertzen L; Greco D; Haahtela T; Alenius H
Article: SMALL. 2020;16(36):e2000527

Mechanistic Similarities between 3D Human Bronchial Epithelium and Mice Lung, Exposed to Copper Oxide Nanoparticles, Support Non-Animal Methods for Hazard Assessment.

Ndika J; Ilves M; Kooter IM; Gröllers-Mulderij M; Duistermaat E; Tromp PC; Kuper F; Kinaret P; Greco D; Karisola P; Alenius H
Article: ADVANCED HEALTHCARE MATERIALS. 2020;9(17):e2000529

Influence of Cell Membrane Wrapping on the Cell-Porous Silicon Nanoparticle Interactions.

Fontana F; Lindstedt H; Correia A; Chiaro J; Kari OK; Ndika J; Alenius H; Buck J; Sieber S; Mäkilä E; Salonen J; Urtti A; Cerullo V; Hirvonen JT; Santos HA
Journal article: ADVANCED HEALTHCARE MATERIALS. 2020;9(17)

Cell Membrane Wrapping: Influence of Cell Membrane Wrapping on the Cell−Porous Silicon Nanoparticle Interactions (Adv. Healthcare Mater. 17/2020)

Fontana F; Lindstedt H; Correia A; Chiaro J; Kari OK; Ndika J; Alenius H; Buck J; Sieber S; Mäkilä E; Salonen J; Urtti A; Cerullo V; Hirvonen JT; Santos HA
Article: PHARMACEUTICS. 2020;12(8):E763-763

Light-Activated Liposomes Coated with Hyaluronic Acid as a Potential Drug Delivery System.

Kari OK; Tavakoli S; Parkkila P; Baan S; Savolainen R; Ruoslahti T; Johansson NG; Ndika J; Alenius H; Viitala T; Urtti A; Lajunen T
Article: NANOTOXICOLOGY. 2020;14(4):453-467

Nanosized silver, but not titanium dioxide or zinc oxide, enhances oxidative stress and inflammatory response by inducing 5-HETE activation in THP-1 cells.

Poon W-L; Lee JC-Y; Leung KS; Alenius H; El-Nezami H; Karisola P
Journal article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2020;49(2):497-510

Reducing socio-economic inequalities in all-cause mortality: a counterfactual mediation approach.

Laine JE; Baltar VT; Stringhini S; Gandini M; Chadeau-Hyam M; Kivimaki M; Severi G; Perduca V; Hodge AM; Dugué P-A; Giles GG; Milne RL; Barros H; Sacerdote C; Krogh V; Panico S; Tumino R; Goldberg M; Zins M; Delpierre C; LIFEPATH Consortium; Vineis P
Journal article: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2020;190:110072

Silver nanoparticles regulate Arabidopsis root growth by concentration-dependent modification of reactive oxygen species accumulation and cell division.

Wang L; Sun J; Lin L; Fu Y; Alenius H; Lindsey K; Chen C
Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(3):495-503

Epigenetic Clocks and Allostatic Load Reveal Potential Sex-Specific Drivers of Biological Aging.

McCrory C; Fiorito G; McLoughlin S; Polidoro S; Cheallaigh CN; Bourke N; Karisola P; Alenius H; Vineis P; Layte R; Kenny RA
Article: NANOSCALE. 2020;12(3):1728-1741

In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow.

Kari OK; Ndika J; Parkkila P; Louna A; Lajunen T; Puustinen A; Viitala T; Alenius H; Urtti A
Article: SCIENTIFIC REPORTS. 2019;9(1):20069

An optimized, robust and reproducible protocol to generate well-differentiated primary nasal epithelial models from extremely premature infants.

Martens A; Amann G; Schmidt K; Gaupmann R; Böhm B; Dehlink E; Szépfalusi Z; Förster-Waldl E; Berger A; Fyhrquist N; Alenius H; Wisgrill L
Article: NATURE COMMUNICATIONS. 2019;10(1):5747

Artificially cloaked viral nanovaccine for cancer immunotherapy.

Fusciello M; Fontana F; Tähtinen S; Capasso C; Feola S; Martins B; Chiaro J; Peltonen K; Ylösmäki L; Ylösmäki E; Hamdan F; Kari OK; Ndika J; Alenius H; Urtti A; Hirvonen JT; Santos HA; Cerullo V
Article: DIAGNOSTICS. 2019;9(4):E212-212

The Effect of Zoledronic Acid on Serum Biomarkers among Patients with Chronic Low Back Pain and Modic Changes in Lumbar Magnetic Resonance Imaging.

Koivisto K; Karppinen J; Haapea M; Järvinen J; Kyllönen E; Tervonen O; Niinimäki J; Alini M; Lotz J; Dudli S; Samartzis D; Risteli J; Majuri M-L; Alenius H; Grad S
Article: NANOTOXICOLOGY. 2019;13(10):1380-1395

Silver, titanium dioxide, and zinc oxide nanoparticles trigger miRNA/isomiR expression changes in THP-1 cells that are proportional to their health hazard potential.

Ndika J; Seemab U; Poon W-L; Fortino V; El-Nezami H; Karisola P; Alenius H
Article: NATURE COMMUNICATIONS. 2019;10(1):4703

Microbe-host interplay in atopic dermatitis and psoriasis.

Fyhrquist N; Muirhead G; Prast-Nielsen S; Jeanmougin M; Olah P; Skoog T; Jules-Clement G; Feld M; Barrientos-Somarribas M; Sinkko H; van den Bogaard EH; Zeeuwen PLJM; Rikken G; Schalkwijk J; Niehues H; Däubener W; Eller SK; Alexander H; Pennino D; Suomela S; Tessas I; Lybeck E; Baran AM; Darban H; Gangwar RS; Gerstel U; Jahn K; Karisola P; Yan L; Hansmann B; Katayama S; Meller S; Bylesjö M; Hupé P; Levi-Schaffer F; Greco D; Ranki A; Schröder JM; Barker J; Kere J; Tsoka S; Lauerma A; Soumelis V; Nestle FO; Homey B; Andersson B; Alenius H
Article: PARTICLE AND FIBRE TOXICOLOGY. 2019;16(1):28

Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation.

Ilves M; Kinaret PAS; Ndika J; Karisola P; Marwah V; Fortino V; Fedutik Y; Correia M; Ehrlich N; Loeschner K; Besinis A; Vassallo J; Handy RD; Wolff H; Savolainen K; Greco D; Alenius H
Journal article: ALLERGY. 2019;74(7):1377-1380

CD300a expression is modulated in atopic dermatitis and could influence the inflammatory response.

Karra L; Gangwar RS; Puzzovio PG; Fyhrquist N; Minai-Fleminger Y; Landolina N; Simon H-U; Alenius H; Leibovici V; Simon D; Levi-Schaffer F
Article: PSYCHONEUROENDOCRINOLOGY. 2019;104:64-73

How does socio-economic position (SEP) get biologically embedded? A comparison of allostatic load and the epigenetic clock(s).

McCrory C; Fiorito G; Ni Cheallaigh C; Polidoro S; Karisola P; Alenius H; Layte R; Seeman T; Vineis P; Kenny RA
Article: PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE. 2019;35(3):157-163

Ultraviolet B radiation modifies circadian time in epidermal skin and in subcutaneous adipose tissue.

Nikkola V; Miettinen ME; Karisola P; Grönroos M; Ylianttila L; Alenius H; Snellman E; Partonen T
Journal article: PAEDIATRIC AND PERINATAL EPIDEMIOLOGY. 2019;33(3):226-237

Maternal educational inequalities in measured body mass index trajectories in three European countries.

McCrory C; Leahy S; Ribeiro AI; Fraga S; Barros H; Avendano M; Vineis P; Layte R; LIFEPATH consortium
Journal article: AGING-US. 2019;11(7):2045-2070

Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Fiorito G; McCrory C; Robinson O; Carmeli C; Ochoa-Rosales C; Zhang Y; Colicino E; Dugué P-A; Artaud F; McKay GJ; Jeong A; Mishra PP; Nøst TH; Krogh V; Panico S; Sacerdote C; Tumino R; Palli D; Matullo G; Guarrera S; Gandini M; Bochud M; Dermitzakis E; Muka T; Schwartz J; Vokonas PS; Just A; Hodge AM; Giles GG; Southey MC; Hurme MA; Young I; McKnight AJ; Kunze S; Waldenberger M; Peters A; Schwettmann L; Lund E; Baccarelli A; Milne RL; Kenny RA; Elbaz A; Brenner H; Kee F; Voortman T; Probst-Hensch N; Lehtimäki T; Elliot P; Stringhini S; Vineis P; Polidoro S; BIOS Consortium; Lifepath consortium
Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2019;66:116-125

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses.

Hadrup N; Knudsen KB; Berthing T; Wolff H; Bengtson S; Kofoed C; Espersen R; Højgaard C; Winther JR; Willemoës M; Wedin I; Nuopponen M; Alenius H; Norppa H; Wallin H; Vogel U
Article: SOURCE CODE FOR BIOLOGY AND MEDICINE. 2019;14:1

eUTOPIA: solUTion for Omics data PreprocessIng and Analysis.

Marwah VS; Scala G; Kinaret PAS; Serra A; Alenius H; Fortino V; Greco D
Article: NANOTOXICOLOGY. 2018;12(7):729-746

Nanofibrillated cellulose causes acute pulmonary inflammation that subsides within a month.

Ilves M; Vilske S; Aimonen K; Lindberg HK; Pesonen S; Wedin I; Nuopponen M; Vanhala E; Højgaard C; Winther JR; Willemoës M; Vogel U; Wolff H; Norppa H; Savolainen K; Alenius H
Article: ALLERGY. 2018;73(8):1700-1706

A novel glycocluster molecule prevents timothy-induced allergic airway inflammation in mice.

Lehto M; Wolff H; Leino R; Alenius H; Savolainen J
Article: NANOTOXICOLOGY. 2018;12(6):554-570

Elucidating differential nano-bio interactions of multi-walled andsingle-walled carbon nanotubes using subcellular proteomics.

Ndika JDT; Sund J; Alenius H; Puustinen A
Article: NATURE NANOTECHNOLOGY. 2018;13(7):537-543

Advanced tools for the safety assessment of nanomaterials.

Fadeel B; Farcal L; Hardy B; Vázquez-Campos S; Hristozov D; Marcomini A; Lynch I; Valsami-Jones E; Alenius H; Savolainen K
Article: INDOOR AIR. 2018;:721-731

Nasal mucosa and blood cell transcriptome profiles do not reflect respiratory symptoms associated with moisture damage.

Ndika J; Suojalehto H; Täubel M; Lehto M; Karvala K; Pallasaho P; Sund J; Auvinen P; Järvi K; Pekkanen J; Kinaret P; Greco D; Hyvärinen A; Alenius H
Journal article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2018;33(5):441-458

Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort.

Castagné R; Garès V; Karimi M; Chadeau-Hyam M; Vineis P; Delpierre C; Kelly-Irving M; Lifepath Consortium
Article: LANCET RESPIRATORY MEDICINE. 2018;6(5):379-388

DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Xu C-J; Söderhäll C; Bustamante M; Baïz N; Gruzieva O; Gehring U; Mason D; Chatzi L; Basterrechea M; Llop S; Torrent M; Forastiere F; Fantini MP; Carlsen KCL; Haahtela T; Morin A; Kerkhof M; Merid SK; van Rijkom B; Jankipersadsing SA; Bonder MJ; Ballereau S; Vermeulen CJ; Aguirre-Gamboa R; de Jongste JC; Smit HA; Kumar A; Pershagen G; Guerra S; Garcia-Aymerich J; Greco D; Reinius L; McEachan RRC; Azad R; Hovland V; Mowinckel P; Alenius H; Fyhrquist N; Lemonnier N; Pellet J; Auffray C; BIOS Consortium; van der Vlies P; van Diemen CC; Li Y; Wijmenga C; Netea MG; Moffatt MF; Cookson WOCM; Anto JM; Bousquet J; Laatikainen T; Laprise C; Carlsen K-H; Gori D; Porta D; Iñiguez C; Bilbao JR; Kogevinas M; Wright J; Brunekreef B; Kere J; Nawijn MC; Annesi-Maesano I; Sunyer J; Melén E; Koppelman GH
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(5):1288-1298

Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis.

Ndika J; Airaksinen L; Suojalehto H; Karisola P; Fyhrquist N; Puustinen A; Alenius H
Journal article: LONGITUDINAL AND LIFE COURSE STUDIES. 2017;8(4):417-449

The biology of inequalities in health: the LIFEPATH project

Vineis P; Avendano-Pabon M; Barros H; Chadeau-Hyam M; Costa G; Dijmarescu M; Delpierre C; D'Errico A; Fraga S; Giles G; Goldberg M; Zins M; Kelly-Irving M; Kivimaki M; Lang T; Layte R; Mackenbach JP; Marmot M; McCrory C; Carmeli C; Milne RL; Muennig P; Nusselder W; Polidoro S; Ricceri F; Robinson O; Stringhini S
Journal article: JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. 2017;71(10):981-989

Socioeconomic differences in children's growth trajectories from infancy to early adulthood: evidence from four European countries.

McCrory C; O'Leary N; Fraga S; Ribeiro AI; Barros H; Kartiosuo N; Raitakari O; Kivimäki M; Vineis P; Layte R; Lifepath Consortium
Article: NANOTOXICOLOGY. 2017;11(7):936-951

Nano-sized zinc oxide and silver, but not titanium dioxide, induce innate and adaptive immunity and antiviral response in differentiated THP-1 cells.

Poon W-L; Alenius H; Ndika J; Fortino V; Kolhinen V; Meščeriakovas A; Wang M; Greco D; Lähde A; Jokiniemi J; Lee JC-Y; El-Nezami H; Karisola P
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(5):665-674

Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia.

Ruokolainen L; Paalanen L; Karkman A; Laatikainen T; von Hertzen L; Vlasoff T; Markelova O; Masyuk V; Auvinen P; Paulin L; Alenius H; Fyhrquist N; Hanski I; Mäkelä MJ; Zilber E; Jousilahti P; Vartiainen E; Haahtela T
Article: ACS NANO. 2017;11(4):3786-3796

Network Analysis Reveals Similar Transcriptomic Responses to Intrinsic Properties of Carbon Nanomaterials in Vitro and in Vivo.

Kinaret P; Marwah V; Fortino V; Ilves M; Wolff H; Ruokolainen L; Auvinen P; Savolainen K; Alenius H; Greco D
Article: LANCET. 2017;389(10075):1229-1237

Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women.

Stringhini S; Carmeli C; Jokela M; Avendaño M; Muennig P; Guida F; Ricceri F; d'Errico A; Barros H; Bochud M; Chadeau-Hyam M; Clavel-Chapelon F; Costa G; Delpierre C; Fraga S; Goldberg M; Giles GG; Krogh V; Kelly-Irving M; Layte R; Lasserre AM; Marmot MG; Preisig M; Shipley MJ; Vollenweider P; Zins M; Kawachi I; Steptoe A; Mackenbach JP; Vineis P; Kivimäki M; LIFEPATH consortium
Article: ACS NANO. 2017;11(1):291-303

Inhalation and Oropharyngeal Aspiration Exposure to Rod-Like Carbon Nanotubes Induce Similar Airway Inflammation and Biological Responses in Mouse Lungs.

Kinaret P; Ilves M; Fortino V; Rydman E; Karisola P; Lähde A; Koivisto J; Jokiniemi J; Wolff H; Savolainen K; Greco D; Alenius H
Article: MUTAGENESIS. 2017;32(1):23-31

Genotoxic and inflammatory effects of nanofibrillated cellulose in murine lungs.

Catalán J; Rydman E; Aimonen K; Hannukainen K-S; Suhonen S; Vanhala E; Moreno C; Meyer V; Perez DDS; Sneck A; Forsström U; Højgaard C; Willemoes M; Winther JR; Vogel U; Wolff H; Alenius H; Savolainen KM; Norppa H
Article: EXPERIMENTAL DERMATOLOGY. 2016;25(6):477-478

Isotretinoin treatment reduces acne lesions but not directly lesional acne inflammation.

Kelhälä H-L; Fyhrquist N; Palatsi R; Lehtimäki S; Väyrynen JP; Kubin ME; Kallioinen M; Alenius H; Tasanen K; Lauerma A
Article: SCIENTIFIC REPORTS. 2016;6:24828

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.

Aho V; Ollila HM; Kronholm E; Bondia-Pons I; Soininen P; Kangas AJ; Hilvo M; Seppälä I; Kettunen J; Oikonen M; Raitoharju E; Hyötyläinen T; Kähönen M; Viikari JSA; Härmä M; Sallinen M; Olkkonen VM; Alenius H; Jauhiainen M; Paunio T; Lehtimäki T; Salomaa V; Orešič M; Raitakari OT; Ala-Korpela M; Porkka-Heiskanen T
Article: EUROPEAN SPINE JOURNAL. 2016;25(1):207-216

Osteoclast activators are elevated in intervertebral disks with Modic changes among patients operated for herniated nucleus pulposus.

Torkki M; Majuri M-L; Wolff H; Koskelainen T; Haapea M; Niinimäki J; Alenius H; Lotz J; Karppinen J
Article: ALLERGOLOGIA ET IMMUNOPATHOLOGIA. 2016;44(1):9-17

A novel mannoside-glycocluster adjuvant: Compared in vitro to CpG ODN and MPL and tested in vivo in mouse asthma model.

Mäkinen K; Mukherjee C; Leino M; Panchadhayee R; Lehto M; Wolff H; Alenius H; Leino R; Savolainen J
Article: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. 2016;11:2457-2465

Characterization of sputum biomarkers for asthma-COPD overlap syndrome.

Gao J; Iwamoto H; Koskela J; Alenius H; Hattori N; Kohno N; Laitinen T; Mazur W; Pulkkinen V
Article: NANOTOXICOLOGY. 2015;9(8):1059-1066

Size-dependent ROS production by palladium and nickel nanoparticles in cellular and acellular environments - An indication for the catalytic nature of their interactions.

Neubauer N; Palomaeki J; Karisola P; Alenius H; Kasper G
Article: BRAIN BEHAVIOR AND IMMUNITY. 2015;49:206-215

Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder.

Haapakoski R; Mathieu J; Ebmeier KP; Alenius H; Kivimäki M
Article: TOXICOLOGICAL SCIENCES. 2015;147(1):140-155

A Single Aspiration of Rod-like Carbon Nanotubes Induces Asbestos-like Pulmonary Inflammation Mediated in Part by the IL-1 Receptor.

Rydman EM; Ilves M; Vanhala E; Vippola M; Lehto M; Kinaret PAS; Pylkkänen L; Happo M; Hirvonen M-R; Greco D; Savolainen K; Wolff H; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135(9):2249-2257

Functional Beta2-Integrins Restrict Skin Inflammation In Vivo.

Savinko TS; Morrison VL; Uotila LM; Wolff CHJ; Alenius HT; Fagerholm SC
Article: NANOTOXICOLOGY. 2015;9(6):719-728

A secretomics analysis reveals major differences in the macrophage responses towards different types of carbon nanotubes.

Palomäki J; Sund J; Vippola M; Kinaret P; Greco D; Savolainen K; Puustinen A; Alenius H
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2015;28(8):1627-1635

Visualization of Nanofibrillar Cellulose in Biological Tissues Using a Biotinylated Carbohydrate Binding Module of β-1,4-Glycanase.

Knudsen KB; Kofoed C; Espersen R; Højgaard C; Winther JR; Willemoës M; Wedin I; Nuopponen M; Vilske S; Aimonen K; Weydahl IEK; Alenius H; Norppa H; Wolff H; Wallin H; Vogel U
Article: INHALATION TOXICOLOGY. 2015;27(8):378-386

Negligible respiratory irritation and inflammation potency of pigmentary TiO2 in mice.

Leppänen M; Korpi A; Yli-Pirilä P; Lehto M; Wolff H; Kosma V-M; Alenius H; Pasanen P
Article: PSYCHOLOGICAL MEDICINE. 2015;45(10):2137-2144

Interleukin-6 as a predictor of symptom resolution in psychological distress: a cohort study.

Virtanen M; Shipley MJ; Batty GD; Hamer M; Allan CL; Lowe GD; Ebmeier KP; Akbaraly TN; Alenius H; Haapakoski R; Singh-Manoux A; Kivimäki M
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2015;45(5):891-901

Hunt for the origin of allergy - comparing the Finnish and Russian Karelia.

Haahtela T; Laatikainen T; Alenius H; Auvinen P; Fyhrquist N; Hanski I; von Hertzen L; Jousilahti P; Kosunen TU; Markelova O; Mäkelä MJ; Pantelejev V; Uhanov M; Zilber E; Vartiainen E
Article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 2015;56(2):171-182

Genotoxic and immunotoxic effects of cellulose nanocrystals in vitro.

Catalán J; Ilves M; Järventaus H; Hannukainen K-S; Kontturi E; Vanhala E; Alenius H; Savolainen KM; Norppa H
Article: NANOTOXICOLOGY. 2015;9(2):210-218

Inhaled silica-coated TiO2 nanoparticles induced airway irritation, airflow limitation and inflammation in mice.

Leppänen M; Korpi A; Mikkonen S; Yli-Pirilä P; Lehto M; Pylkkänen L; Wolff H; Kosma V-M; Alenius H; Joutsensaari J; Pasanen P
Article: BMC BIOINFORMATICS. 2015;16(1):37

BACA: bubble chArt to compare annotations.

Fortino V; Alenius H; Greco D
Article: PLOS ONE. 2015;10(6):e0129446

Invariant Natural Killer T Cells Play a Role in Chemotaxis, Complement Activation and Mucus Production in a Mouse Model of Airway Hyperreactivity and Inflammation.

Karisola P; Lehto M; Kinaret P; Ahonen N; Haapakoski R; Anthoni M; Taniguchi M; Wolff H; Puustinen A; Alenius H
Article: PLOS ONE. 2015;10(5):e0127003

Level of Fatty Acid Binding Protein 5 (FABP5) Is Increased in Sputum of Allergic Asthmatics and Links to Airway Remodeling and Inflammation.

Suojalehto H; Kinaret P; Kilpeläinen M; Toskala E; Ahonen N; Wolff H; Alenius H; Puustinen A
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(6):1301-1309.e11

Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation.

Fyhrquist N; Ruokolainen L; Suomalainen A; Lehtimäki S; Veckman V; Vendelin J; Karisola P; Lehto M; Savinko T; Jarva H; Kosunen TU; Corander J; Auvinen P; Paulin L; von Hertzen L; Laatikainen T; Mäkelä M; Haahtela T; Greco D; Hanski I; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(12):2928-2937

Complex 2B4 regulation of mast cells and eosinophils in murine allergic inflammation.

Elishmereni M; Fyhrquist N; Singh Gangwar R; Lehtimäki S; Alenius H; Levi-Schaffer F
Article: PARTICLE AND FIBRE TOXICOLOGY. 2014;11:48

Inhalation of rod-like carbon nanotubes causes unconventional allergic airway inflammation.

Rydman EM; Ilves M; Koivisto AJ; Kinaret PAS; Fortino V; Savinko TS; Lehto MT; Pulkkinen V; Vippola M; Hämeri KJ; Matikainen S; Wolff H; Savolainen KM; Greco D; Alenius H
Article: JOURNAL OF PROTEOMICS. 2014;108:469-483

Phagocytosis of nano-sized titanium dioxide triggers changes in protein acetylation.

Sund J; Palomäki J; Ahonen N; Savolainen K; Alenius H; Puustinen A
Article: PARTICLE AND FIBRE TOXICOLOGY. 2014;11:38

Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model.

Ilves M; Palomäki J; Vippola M; Lehto M; Savolainen K; Savinko T; Alenius H
Article: LARYNGOSCOPE. 2014;124(6):E213-E218

Nasal nitric oxide is dependent on sinus obstruction in allergic rhinitis.

Suojalehto H; Vehmas T; Lindström I; Kennedy DW; Kilpeläinen M; Plosila T; Savukoski S; Sipilä J; Varpula M; Wolff H; Alenius H; Toskala E
Article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2014;11(5):5382-5402

Range-finding risk assessment of inhalation exposure to nanodiamonds in a laboratory environment.

Koivisto AJ; Palomäki JE; Viitanen A-K; Siivola KM; Koponen IK; Yu M; Kanerva TS; Norppa H; Alenius HT; Hussein T; Savolainen KM; Hämeri KJ
Article: HUMAN IMMUNOLOGY. 2014;75(2):134-140

Trichothecene mycotoxins activate NLRP3 inflammasome through a P2X7 receptor and Src tyrosine kinase dependent pathway.

Kankkunen P; Välimäki E; Rintahaka J; Palomäki J; Nyman T; Alenius H; Wolff H; Matikainen S
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;133(2):448-460

A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.

Cevikbas F; Wang X; Akiyama T; Kempkes C; Savinko T; Antal A; Kukova G; Buhl T; Ikoma A; Buddenkotte J; Soumelis V; Feld M; Alenius H; Dillon SR; Carstens E; Homey B; Basbaum A; Steinhoff M
Article: CLINICAL AND TRANSLATIONAL ALLERGY. 2014;4:35

Bronchoalveolar lavage in infants with recurrent lower respiratory symptoms.

Malmström K; Lehto M; Majuri M-L; Paavonen T; Sarna S; Pelkonen AS; Malmberg LP; Lindahl H; Kajosaari M; Saglani S; Alenius H; Mäkelä MJ
Article: PLOS ONE. 2014;9(8):e105238

IL-17/Th17 pathway is activated in acne lesions.

Kelhälä H-L; Palatsi R; Fyhrquist N; Lehtimäki S; Väyrynen JP; Kallioinen M; Kubin ME; Greco D; Tasanen K; Alenius H; Bertino B; Carlavan I; Mehul B; Déret S; Reiniche P; Martel P; Marty C; Blume-Peytavi U; Voegel JJ; Lauerma A
Article: PLOS ONE. 2014;9(9):e107801

A robust and accurate method for feature selection and prioritization from multi-class OMICs data.

Fortino V; Kinaret P; Fyhrquist N; Alenius H; Greco D
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2014;163(3):168-178

Altered microRNA expression of nasal mucosa in long-term asthma and allergic rhinitis.

Suojalehto H; Lindström I; Majuri M-L; Mitts C; Karjalainen J; Wolff H; Alenius H
Article: PLOS ONE. 2014;9(12):e114490

Co-exposure with fullerene may strengthen health effects of organic industrial chemicals.

Lehto M; Karilainen T; Róg T; Cramariuc O; Vanhala E; Tornaeus J; Taberman H; Jänis J; Alenius H; Vattulainen I; Laine O
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2013;133(11):2522-2529

ST2 regulates allergic airway inflammation and T-cell polarization in epicutaneously sensitized mice.

Savinko T; Karisola P; Lehtimäki S; Lappeteläinen A-M; Haapakoski R; Wolff H; Lauerma A; Alenius H
Article: INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY. 2013;3(8):612-620

MicroRNA profiles in nasal mucosa of patients with allergic and nonallergic rhinitis and asthma.

Suojalehto H; Toskala E; Kilpeläinen M; Majuri M-L; Mitts C; Lindström I; Puustinen A; Plosila T; Sipilä J; Wolff H; Alenius H
Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 2013;71(1):12-21

The chemokine receptor CCR3 participates in tissue remodeling during atopic skin inflammation.

Gaspar K; Kukova G; Bunemann E; Buhren BA; Sonkoly E; Szollosi AG; Muller A; Savinko T; Lauerma AI; Alenius H; Kemeny L; Dieu-Nosjean M-C; Stander S; Fischer JW; Ruzicka T; Zlotnik A; Szegedi A; Homey B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2013;133(4):964-972

Toll-like receptor activation during cutaneous allergen sensitization blocks development of asthma through IFN-gamma-dependent mechanisms.

Haapakoski R; Karisola P; Fyhrquist N; Savinko T; Lehtimäki S; Wolff H; Lauerma A; Alenius H
Article: PLOS ONE. 2013;8(4):e60111

Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma.

Acevedo N; Sääf A; Söderhäll C; Melén E; Mandelin J; Pietras CO; Ezer S; Karisola P; Vendelin J; Gennäs GBA; Yli-Kauhaluoma J; Alenius H; von Mutius E; Doekes G; Braun-Fahrländer C; Riedler J; van Hage M; D'Amato M; Scheynius A; Pershagen G; Kere J; Pulkkinen V
Article: PLOS ONE. 2013;8(10):e77184

Partial sleep restriction activates immune response-related gene expression pathways: experimental and epidemiological studies in humans.

Aho V; Ollila HM; Rantanen V; Kronholm E; Surakka I; van Leeuwen WMA; Lehto M; Matikainen S; Ripatti S; Härmä M; Sallinen M; Salomaa V; Jauhiainen M; Alenius H; Paunio T; Porkka-Heiskanen T
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(12):2744-2751

The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model.

Lehtimäki S; Savinko T; Lahl K; Sparwasser T; Wolff H; Lauerma A; Alenius H; Fyhrquist N
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2012;745(1-2):58-64

Genotoxicity of inhaled nanosized TiO(2) in mice.

Lindberg HK; Falck GC-M; Catalán J; Koivisto AJ; Suhonen S; Järventaus H; Rossi EM; Nykäsenoja H; Peltonen Y; Moreno C; Alenius H; Tuomi T; Savolainen KM; Norppa H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(6):1672-1680

Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis.

Fyhrquist N; Lehtimäki S; Lahl K; Savinko T; Lappeteläinen A-M; Sparwasser T; Wolff H; Lauerma A; Alenius H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(21):8334-8339

Environmental biodiversity, human microbiota, and allergy are interrelated.

Hanski I; von Hertzen L; Fyhrquist N; Koskinen K; Torppa K; Laatikainen T; Karisola P; Auvinen P; Paulin L; Mäkelä MJ; Vartiainen E; Kosunen TU; Alenius H; Haahtela T
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(5):1392-1400

IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors.

Savinko T; Matikainen S; Saarialho-Kere U; Lehto M; Wang G; Lehtimäki S; Karisola P; Reunala T; Wolff H; Lauerma A; Alenius H
Article: PLOS ONE. 2012;7(8):e41038

CD8+ T cell migration to the skin requires CD4+ help in a murine model of contact hypersensitivity.

Fyhrquist N; Wolff H; Lauerma A; Alenius H
Article: ACS NANO. 2011;5(9):6861-6870

Long, needle-like carbon nanotubes and asbestos activate the NLRP3 inflammasome through a similar mechanism.

Palomäki J; Välimäki E; Sund J; Vippola M; Clausen PA; Jensen KA; Savolainen K; Matikainen S; Alenius H
Article: ARCHIVES OF TOXICOLOGY. 2011;85(7):827-839

Nanosized TiO₂ caused minor airflow limitation in the murine airways.

Leppänen M; Korpi A; Miettinen M; Leskinen J; Torvela T; Rossi EM; Vanhala E; Wolff H; Alenius H; Kosma V-M; Joutsensaari J; Jokiniemi J; Pasanen P
Article: JOURNAL OF NANOPARTICLE RESEARCH. 2011;13(7):2949-2961

Aerosol characterization and lung deposition of synthesized TiO₂ nanoparticles for murine inhalation studies

Koivisto AJ; Makinen M; Rossi EM; Lindberg HK; Miettinen M; Falck GC-M; Norppa H; Alenius H; Korpi A; Riikonen J; Vanhala E; Vippola M; Pasanen P; Lehto V-P; Savolainen K; Jokiniemi J; Hameri K
Article: ACS NANO. 2011;5(6):4300-4309

Proteomic characterization of engineered nanomaterial-protein interactions in relation to surface reactivity.

Sund J; Alenius H; Vippola M; Savolainen K; Puustinen A
Article: BMC PULMONARY MEDICINE. 2011;11:39

The asthma candidate gene NPSR1 mediates isoform specific downstream signalling.

Pietras CO; Vendelin J; Anedda F; Bruce S; Adner M; Sundman L; Pulkkinen V; Alenius H; D'Amato M; Söderhäll C; Kere J
Article: CELLULOSE. 2011;18(3):775-786

Health and environmental safety aspects of friction grinding and spray drying of microfibrillated cellulose

Vartiainen J; Pohler T; Sirola K; Pylkkanen L; Alenius H; Hokkinen J; Tapper U; Lahtinen P; Kapanen A; Putkisto K; Hiekkataipale P; Eronen P; Ruokolainen J; Laukkanen A
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2011;44(5):639-647

Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-γ-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.

Haapakoski R; Karisola P; Fyhrquist N; Savinko T; Wolff H; Turjanmaa K; Palosuo T; Reunala T; Lauerma A; Alenius H
Article: CYTOKINE. 2011;54(2):149-153

Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders.

Rechardt M; Shiri R; Matikainen S; Viikari-Juntura E; Karppinen J; Alenius H
Article: ALLERGY. 2011;66(3):376-385

Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro.

Elishmereni M; Alenius HT; Bradding P; Mizrahi S; Shikotra A; Minai-Fleminger Y; Mankuta D; Eliashar R; Zabucchi G; Levi-Schaffer F
Article: RESPIRATORY RESEARCH. 2011;12(1):2

Attenuated expression of tenascin-C in ovalbumin-challenged STAT4-/- mice.

Meuronen A; Karisola P; Leino M; Savinko T; Sirola K; Majuri M-L; Piirilä P; Virtanen I; Mäkelä M; Laitinen A; Laitinen LA; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130(12):2743-2751

Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model.

Lehtimäki S; Tillander S; Puustinen A; Matikainen S; Nyman T; Fyhrquist N; Savinko T; Majuri M-L; Wolff H; Alenius H; Lauerma A
Article: PARTICLE AND FIBRE TOXICOLOGY. 2010;7:35

Inhalation exposure to nanosized and fine TiO2 particles inhibits features of allergic asthma in a murine model.

Rossi EM; Pylkkänen L; Koivisto AJ; Nykäsenoja H; Wolff H; Savolainen K; Alenius H
Article: BIOLOGICAL PSYCHIATRY. 2010;68(5):474-483

Assessment of the neuropeptide S system in anxiety disorders.

Donner J; Haapakoski R; Ezer S; Melén E; Pirkola S; Gratacòs M; Zucchelli M; Anedda F; Johansson LE; Söderhäll C; Orsmark-Pietras C; Suvisaari J; Martín-Santos R; Torrens M; Silander K; Terwilliger JD; Wickman M; Pershagen G; Lönnqvist J; Peltonen L; Estivill X; D'Amato M; Kere J; Alenius H; Hovatta I
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;126(3):581-9.e1-20-U306

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4.

Sonkoly E; Janson P; Majuri M-L; Savinko T; Fyhrquist N; Eidsmo L; Xu N; Meisgen F; Wei T; Bradley M; Stenvang J; Kauppinen S; Alenius H; Lauerma A; Homey B; Winqvist O; Ståhle M; Pivarcsi A
Article: BRITISH JOURNAL OF DERMATOLOGY. 2010;163(2):321-328

Narrowband ultraviolet B treatment improves vitamin D balance and alters antimicrobial peptide expression in skin lesions of psoriasis and atopic dermatitis.

Vähävihu K; Ala-Houhala M; Peric M; Karisola P; Kautiainen H; Hasan T; Snellman E; Alenius H; Schauber J; Reunala T
Article: JOURNAL OF IMMUNOLOGY. 2010;184(11):6335-6342

(1,3)-beta-glucans activate both dectin-1 and NLRP3 inflammasome in human macrophages.

Kankkunen P; Teirilä L; Rintahaka J; Alenius H; Wolff H; Matikainen S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(19):8736-8741

Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells.

Stutte S; Quast T; Gerbitzki N; Savinko T; Novak N; Reifenberger J; Homey B; Kolanus W; Alenius H; Förster I
Article: INTERNATIONAL IMMUNOPHARMACOLOGY. 2010;10(4):377-384

A murine model of epicutaneous protein sensitization is useful to study efficacies of topical drugs in atopic dermatitis.

Lehto M; Savinko T; Wolff H; Kvist PH; Kemp K; Lauerma A; Alenius H
Article: FASEB JOURNAL. 2010;24(4):1167-1177

ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses.

Pulkkinen V; Bruce S; Rintahaka J; Hodgson U; Laitinen T; Alenius H; Kinnula VL; Myllärniemi M; Matikainen S; Kere J
Article: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2010;104(2):139-146

Thaumatin-like protein and baker's respiratory allergy.

Lehto M; Airaksinen L; Puustinen A; Tillander S; Hannula S; Nyman T; Toskala E; Alenius H; Lauerma A
Article: TOXICOLOGICAL SCIENCES. 2010;113(2):422-433

Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice.

Rossi EM; Pylkkänen L; Koivisto AJ; Vippola M; Jensen KA; Miettinen M; Sirola K; Nykäsenoja H; Karisola P; Stjernvall T; Vanhala E; Kiilunen M; Pasanen P; Mäkinen M; Hämeri K; Joutsensaari J; Tuomi T; Jokiniemi J; Wolff H; Savolainen K; Matikainen S; Alenius H
Article: TOXICOLOGY. 2010;267(1-3):125-131

Engineered nanomaterials cause cytotoxicity and activation on mouse antigen presenting cells.

Palomäki J; Karisola P; Pylkkänen L; Savolainen K; Alenius H
Article: ALLERGY. 2010;65(1):61-68

Matrix metalloproteinases-7, -8, -9 and TIMP-1 in the follow-up of diisocyanate-induced asthma.

Piirilä P; Lauhio A; Majuri M-L; Meuronen A; Myllärniemi M; Tervahartiala T; Vuorinen K; Laitinen A; Alenius H; Kinnula VL; Sorsa T
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2010;151(2):155-167

Smad3 regulates dermal cytokine and chemokine expression and specific antibody production in murine responses to a respiratory chemical sensitizer.

Anthoni M; Fyhrquist N; Lehtimäki S; Alenius H; Wolff H; Lauerma A
Article: NEUROGASTROENTEROLOGY AND MOTILITY. 2010;22(1):79-e30

Neuropeptide S receptor 1 expression in the intestine and skin--putative role in peptide hormone secretion.

Sundman L; Saarialho-Kere U; Vendelin J; Lindfors K; Assadi G; Kaukinen K; Westerholm-Ormio M; Savilahti E; Mäki M; Alenius H; D'Amato M; Pulkkinen V; Kere J; Saavalainen P
Article: TOXICOLOGY. 2009;262(3):265-270

Wood dusts induce the production of reactive oxygen species and caspase-3 activity in human bronchial epithelial cells.

Pylkkänen L; Stockmann-Juvala H; Alenius H; Husgafvel-Pursiainen K; Savolainen K
Article: JOURNAL OF IMMUNOLOGY. 2009;182(10):6418-6425

Trichothecene mycotoxins activate inflammatory response in human macrophages.

Kankkunen P; Rintahaka J; Aalto A; Leino M; Majuri M-L; Alenius H; Wolff H; Matikainen S
Article: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2009;102(3):210-215

Low tumor necrosis factor alpha levels and neutrophil counts in nasal lavage after mold exposure.

Hellgren U-M; Leino M; Aarnisalo AA; Mussalo-Rauhamaa H; Alenius H; Reijula K
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2009;149(1):81-90

Contrasting immunological effects of two disparate dusts - preliminary observations.

Alenius H; Pakarinen J; Saris O; Andersson MA; Leino M; Sirola K; Majuri M-L; Niemela J; Matikainen S; Wolff H; von Hertzen L; Makela M; Haahtela T; Salkinoja-Salonen M
Article: PLOS ONE. 2009;4(2):e4589

Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP.

van Leeuwen WMA; Lehto M; Karisola P; Lindholm H; Luukkonen R; Sallinen M; Härmä M; Porkka-Heiskanen T; Alenius H
Article: BRITISH JOURNAL OF DERMATOLOGY. 2008;159(3):546-554

Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity.

Anthoni M; Fyhrquist-Vanni N; Wolff H; Alenius H; Lauerma A
Journal article: DRUG DISCOVERY TODAY: DISEASE MECHANISMS. 2008;5(2):e211-e220

Skin, drug and chemical reactions

Alenius H; Roberts DW; Tokura Y; Lauerma A; Patlewicz G; Roberts MS
Article: FOOD AND CHEMICAL TOXICOLOGY. 2008;46(5):1444-1451

Effects of fumonisin B(1) on the expression of cytokines and chemokines in human dendritic cells.

Stockmann-Juvala H; Alenius H; Savolainen K
Article: ALLERGY. 2008;63(5):583-591

Inflammation and functional outcome in diisocyanate-induced asthma after cessation of exposure.

Piirilä PL; Meuronen A; Majuri M-L; Luukkonen R; Mäntylä T; Wolff HJ; Nordman H; Alenius H; Laitinen A
Article: JOURNAL OF IMMUNOLOGY. 2008;180(3):1749-1757

Cytosolic antiviral RNA recognition pathway activates caspases 1 and 3.

Rintahaka J; Wiik D; Kovanen PE; Alenius H; Matikainen S
Article: RESPIRATION. 2008;75(4):450-458

Decreased cytokine and chemokine mRNA expression in bronchoalveolar lavage in asymptomatic smoking subjects.

Meuronen A; Majuri M-L; Alenius H; Mäntylä T; Wolff H; Piirilä P; Laitinen A
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2008;147(1):41-51

Immunostimulatory sequence CpG elicits Th1-type immune responses in inflammatory skin lesions in an atopic dermatitis murine model.

Wang G; Fyhrquist-Vanni N; Wolff H; Dieu-Nosjean M-C; Kemeny L; Homey B; Lauerma AI; Alenius H
Article: INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES. 2007;3(7):477-485

Smad3 -signalling and Th2 cytokines in normal mouse airways and in a mouse model of asthma.

Anthoni M; Wang G; Leino MS; Lauerma AI; Alenius HT; Wolff HJ
Article: DERMATOLOGIC CLINICS. 2007;25(4):613-x

Contact dermatitis.

Fyhrquist-Vanni N; Alenius H; Lauerma A
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(10):1502-1511

Latex allergy: low prevalence of immunoglobulin E to highly purified proteins Hev b 2 and Hev b 13.

Palosuo T; Lehto M; Kotovuori A; Kalkkinen N; Blanco C; Poza P; Carrillo T; Hamilton RG; Alenius H; Reunala T; Turjanmaa K
Article: TOXICOLOGICAL SCIENCES. 2007;99(1):260-266

Immunomodulatory effects of oak dust exposure in a murine model of allergic asthma.

Määttä J; Haapakoski R; Lehto M; Leino M; Tillander S; Husgafvel-Pursiainen K; Wolff H; Savolainen K; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2007;127(8):1923-1929

Smad3 signal transducer regulates skin inflammation and specific IgE response in murine model of atopic dermatitis.

Anthoni M; Wang G; Deng C; Wolff HJ; Lauerma AI; Alenius HT
Article: PLOS ONE. 2007;2(7):e610

MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?

Sonkoly E; Wei T; Janson PCJ; Sääf A; Lundeberg L; Tengvall-Linder M; Norstedt G; Alenius H; Homey B; Scheynius A; Ståhle M; Pivarcsi A
Article: ALLERGY. 2007;62(7):781-786

Latex allergy: the sum quantity of four major allergens shows the allergenic potential of medical gloves.

Palosuo T; Reinikka-Railo H; Kautiainen H; Alenius H; Kalkkinen N; Kulomaa M; Reunala T; Turjanmaa K
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(6):1470-1480

Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference.

Meller S; Lauerma AI; Kopp FM; Winterberg F; Anthoni M; Müller A; Gombert M; Haahtela A; Alenius H; Rieker J; Dieu-Nosjean M-C; Kubitza RC; Gleichmann E; Ruzicka T; Zlotnik A; Homey B
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(1):151-161

Repeated epicutaneous exposures to ovalbumin progressively induce atopic dermatitis-like skin lesions in mice.

Wang G; Savinko T; Wolff H; Dieu-Nosjean MC; Kemeny L; Homey B; Lauerma AI; Alenius H
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2007;37(1):133-140

Hev b 6.01 and Hev b 5 induce pro-inflammatory cytokines and chemokines from peripheral blood mononuclear cells in latex allergy.

Lehto M; Kotovuori A; Palosuo K; Varjonen E; Lehtimäki S; Kalkkinen N; Palosuo T; Reunala T; Alenius H
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2006;41(12):1405-1413

Murine model of food allergy after epicutaneous sensitization: role of mucosal mast cell protease-1.

Vaali K; Puumalainen TJ; Lehto M; Wolff H; Rita H; Alenius H; Palosuo T
Article: TOXICOLOGICAL SCIENCES. 2006;93(1):96-104

Mechanisms of particle-induced pulmonary inflammation in a mouse model: exposure to wood dust.

Määttä J; Lehto M; Leino M; Tillander S; Haapakoski R; Majuri M-L; Wolff H; Rautio S; Welling I; Husgafvel-Pursiainen K; Savolainen K; Alenius H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(6):1455-1461

The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen.

Yalcindag A; He R; Laouini D; Alenius H; Carroll M; Oettgen HC; Geha RS
Article: HUMAN MOLECULAR GENETICS. 2006;15(10):1667-1679

Neuropeptide S and G protein-coupled receptor 154 modulate macrophage immune responses.

Pulkkinen V; Majuri M-L; Wang G; Holopainen P; Obase Y; Vendelin J; Wolff H; Rytilä P; Laitinen LA; Haahtela T; Laitinen T; Alenius H; Kere J; Rehn M
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2006;173(5):512-518

Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice.

Leino MS; Alenius HT; Fyhrquist-Vanni N; Wolff HJ; Reijula KE; Hintikka E-L; Salkinoja-Salonen MS; Haahtela T; Mäkelä MJ
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(2):411-417

IL-31: a new link between T cells and pruritus in atopic skin inflammation.

Sonkoly E; Muller A; Lauerma AI; Pivarcsi A; Soto H; Kemeny L; Alenius H; Dieu-Nosjean M-C; Meller S; Rieker J; Steinhoff M; Hoffmann TK; Ruzicka T; Zlotnik A; Homey B
Article: TOXICOLOGY. 2006;218(1):13-21

Comparison of hardwood and softwood dust-induced expression of cytokines and chemokines in mouse macrophage RAW 264.7 cells.

Määttä J; Luukkonen R; Husgafvel-Pursiainen K; Alenius H; Savolainen K
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2006;140(1):30-35

Cladosporium herbarum and Pityrosporum ovale allergen extracts share cross-reacting glycoproteins.

Leino M; Reijula K; Mäkinen-Kiljunen S; Haahtela T; Mäkelä MJ; Alenius H
Article: JOURNAL OF IMMUNOLOGY. 2005;175(12):8320-8326

Topical superantigen exposure induces epidermal accumulation of CD8+ T cells, a mixed Th1/Th2-type dermatitis and vigorous production of IgE antibodies in the murine model of atopic dermatitis.

Savinko T; Lauerma A; Lehtimäki S; Gombert M; Majuri M-L; Fyhrquist-Vanni N; Dieu-Nosjean M-C; Kemeny L; Wolff H; Homey B; Alenius H
Article: TOXICOLOGY. 2005;215(1-2):25-36

Characterization of oak and birch dust-induced expression of cytokines and chemokines in mouse macrophage RAW 264.7 cells.

Määttä J; Majuri M-L; Luukkonen R; Lauerma A; Husgafvel-Pursiainen K; Alenius H; Savolainen K
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;125(5):962-968

Cutaneous, but not airway, latex exposure induces allergic lung inflammation and airway hyperreactivity in mice.

Lehto M; Haapakoski R; Wolff H; Majuri M-L; Mäkelä MJ; Leino M; Reunala T; Turjanmaa K; Palosuo T; Alenius H
Article: ALLERGY. 2005;60(10):1275-1279

In vivo relationship between collagenase-2 and interleukin-8 but not tumour necrosis factor-alpha in chronic rhinosinusitis with nasal polyposis.

Kostamo K; Sorsa T; Leino M; Tervahartiala T; Alenius H; Richardson M; Toskala E
Article: JOURNAL OF IMMUNOLOGY. 2005;174(8):5082-5091

CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation.

Gombert M; Dieu-Nosjean M-C; Winterberg F; Bünemann E; Kubitza RC; Da Cunha L; Haahtela A; Lehtimäki S; Müller A; Rieker J; Meller S; Pivarcsi A; Koreck A; Fridman W-H; Zentgraf H-W; Pavenstädt H; Amara A; Caux C; Kemeny L; Alenius H; Lauerma A; Ruzicka T; Zlotnik A; Homey B
Article: ALLERGY. 2005;60(4):506-509

IgE antibodies to omega-5 gliadin in children with wheat-induced anaphylaxis.

Daengsuwan T; Palosuo K; Phankingthongkum S; Visitsunthorn N; Jirapongsananuruk O; Alenius H; Vichyanond P; Reunala T
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(3):598-605

Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome.

Karisola P; Kotovuori A; Poikonen S; Niskanen E; Kalkkinen N; Turjanmaa K; Palosuo T; Reunala T; Alenius H; Kulomaa MS
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(2):s240

Mucosal mast cell protease-1 (MMCP-1) as a marker of intestinal immunopathology in food allergy model

Vaali K; Puumalainen T; Wolff H; Alenius H; Palosuo T
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(2):s110

Prevalence of IgE antibodies to extensively purified Hev b2, Hev b5, Hev b6.01, and Hev b13 in latex allergic patients in three geographic areas

Palosuo T; Lehto M; Kotovuori A; Kalkkinen N; Blanco C; Hamilton RG; Alenius H; Reunala T; Turjanmaa K
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(2):s110

N-terminal hevein-like domains (4.3 kDa) but not 31 kDa endochitinases are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome

Karisola P; Kotovuori A; Poikonen S; Niskanen E; Kalkkinen N; Turjanmaa K; Palosuo T; Reunala T; Alenius H; Kulomaa M
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(2):s110

Allergen specific induction of proinflammatory cytokines and chemokines in peripheral blood mononuclear cells of latex allergic patients

Lehto M; Palosuo K; Kotovuori A; Varjonen E; Lehtimäki S; Majuri M; Reunala T; Kalkkinen N; Palosuo T; Alenius H
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(2):s112

CpG treatment during the sensitization and elicitation critically regulates Th1/Th2 balance in a murine model of latex induced airway inflammation

Haapakoski R; Fyhrquist-Vanni N; Wolff H; Lauerma A; Turjanmaa K; Reunala T; Palosuo T; Alenius H
Article: ACTA DERMATO-VENEREOLOGICA. 2005;85(4):296-298

Decreased in vitro cellular response to tetanus toxoid and tuberculin in patients using topical corticosteroids.

Wang G; Molander G; Koivuluhta M; Alenius H; Lauerma A
Article: JOURNAL OF IMMUNOLOGY. 2004;173(9):5810-5817

CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.

Pivarcsi A; Gombert M; Dieu-Nosjean M-C; Lauerma A; Kubitza R; Meller S; Rieker J; Muller A; Da Cunha L; Haahtela A; Sonkoly E; Fridman W-H; Alenius H; Kemeny L; Ruzicka T; Zlotnik A; Homey B
Article: TOXICOLOGY. 2004;200(2-3):255-263

Exposure to Aspergillus fumigatus spores induces chemokine expression in mouse macrophages.

Pylkkänen L; Gullstén H; Majuri M-L; Andersson U; Vanhala E; Määttä J; Meklin T; Hirvonen M-R; Alenius H; Savolainen K
Article: ANNALS OF THE RHEUMATIC DISEASES. 2004;63(6):656-664

Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.

Joronen K; Ala-aho R; Majuri M-L; Alenius H; Kähäri V-M; Vuorio E
Article: SCIENCE. 2004;304(5668):300-304

Characterization of a common susceptibility locus for asthma-related traits.

Laitinen T; Polvi A; Rydman P; Vendelin J; Pulkkinen V; Salmikangas P; Mäkelä S; Rehn M; Pirskanen A; Rautanen A; Zucchelli M; Gullstén H; Leino M; Alenius H; Petäys T; Haahtela T; Laitinen A; Laprise C; Hudson TJ; Laitinen LA; Kere J
Article: JOURNAL OF IMMUNOLOGY. 2004;172(4):2621-2628

Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes.

Karisola P; Mikkola J; Kalkkinen N; Airenne KJ; Laitinen OH; Repo S; Pentikäinen OT; Reunala T; Turjanmaa K; Johnson MS; Palosuo T; Kulomaa MS; Alenius H
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(2):s87

CpG-oligonucleotides induce the production of Th1 type cytokines from mouse bone marrow derived mast cells

Lehtimäki S; Lauerma A; Wolff H; Alenius H
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(2):s61

Cutaneous route latex sensitization followed by latex challenge induces airway hyperresponsiveness (AHR) and Th2 dominated lung inflammation in mice

Lehto M; Haapakoski R; Wolff H; Majuri M; Turjanmaa K; Palosuo T; Reunala T; Alenius H
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(2):s77

Prevalence of IgE antibodies to extensively purified Hev b13 and Hev b2 in natural rubber latex (NRL) allergic patients

Palosuo T; Lehto M; Kotovuori A; Kalkkinen N; Alenius H; Reunala T; Turjanmaa K
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(2):s97

Repeated topical exposure to staphylococcal enterotoxin B (SEB) elicits vigorous IgE antibody production and exacerbates allergen induced skin inflammation

Träskbäck T; Lauerma A; Majuri M; Wolff H; Alenius H
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(2):s60

A significant decrease in the incidence of latex-allergic health care workers parallels with a decreasing percentage of highly allergenic latex gloves in the market in Finland

Reunala T; Turjanmaa K; Alenius H; Reinikka-Railo H; Palosuo T
Article: INTERNATIONAL IMMUNOLOGY. 2003;15(12):1431-1440

Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.

Pivniouk VI; Snapper SB; Kettner A; Alenius H; Laouini D; Falet H; Hartwig J; Alt FW; Geha RS
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2003;33(11):1603-1610

Intranasal exposure to a damp building mould, Stachybotrys chartarum, induces lung inflammation in mice by satratoxin-independent mechanisms.

Leino M; Mäkelä M; Reijula K; Haahtela T; Mussalo-Rauhamaa H; Tuomi T; Hintikka E-L; Alenius H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2003;112(7):1058-1066

IL-10 is critical for Th2 responses in a murine model of allergic dermatitis.

Laouini D; Alenius H; Bryce P; Oettgen H; Tsitsikov E; Geha RS
Article: ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY. 2003;91(3):280-287

IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum.

Reijula K; Leino M; Mussalo-Rauhamaa H; Nikulin M; Alenius H; Mikkola J; Elg P; Kari O; Mäkinen-Kiljunen S; Haahtela T
Journal article: TOXICOLOGY LETTERS. 2003;144:s163

609 The effect of wood dust on apoptosis in murine macrophages

Pylkkänen L; Stockman-Juvala H; Määttä J; Alenius H; Savolainen K
Journal article: TOXICOLOGY LETTERS. 2003;144:s36-s37

125 Cyto- and chemokine expression in the mouse macrophage raw 264.7 cell line cells exposed to hard- and softwood dusts

Määttä J; Majuri M-L; Andersson U; Alenius H; Savolainen K
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2003;111(6):1386-1392

Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis.

Palosuo K; Varjonen E; Nurkkala J; Kalkkinen N; Harvima R; Reunala T; Alenius H
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2003;120(4):633-640

Epicutaneous natural rubber latex sensitization induces T helper 2-type dermatitis and strong prohevein-specific IgE response.

Lehto M; Koivuluhta M; Wang G; Amghaiab I; Majuri M-L; Savolainen K; Turjanmaa K; Wolff H; Reunala T; Lauerma A; Palosuo T; Alenius H
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2003;111(2):s327

Hevein-like domain IV in wheat germ agglutinin (WGA) is responsible for the majority of IgE cross-reactivity between WGA and hevein (Hev b 6.02)

Karisola P; Alenius H; Turjanmaa K; Reunala T; Kalkkinen N; Palosuo T; Kulomaa M
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2003;111(2):s174

Recombinant allergen-based ELISA for the simultaneous detection of IgE to clinically relevant latex allergens

Palosuo T; Karkkainen T; Frisk K; Turjanmaa K; Alenius H; Kulomaa M; Kalkkinen N; Reunala T
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2003;33(1):90-95

Humoral and cellular responses to gliadin in wheat-dependent, exercise-induced anaphylaxis.

Lehto M; Palosuo K; Varjonen E; Majuri M-L; Andersson U; Reunala T; Alenius H
Article: ALLERGY. 2002;57(10):894-899

Phthalic anhydride allergy: development and characterization of optimized hapten-carrier conjugates for improved diagnosis.

Pakarinen M; Koivuluhta M; Kalkkinen N; Keskinen H; Nordman H; Estlander T; Tupasela O; Jolanki R; Lauerma AI; Pfäffli P; Alenius H
Article: JOURNAL OF THE AMERICAN DENTAL ASSOCIATION. 2002;133(10):1357-1367

Cross-reactivity between gutta-percha and natural rubber latex: assumptions vs. reality.

Hamann C; Rodgers PA; Alenius H; Halsey JF; Sullivan K
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2002;32(7):1077-1081

Extractable latex allergens in airborne glove powder and in cut glove pieces.

Kujala V; Alenius H; Palosuo T; Karvonen J; Pfäffli P; Reijula K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(25):22656-22661

The major conformational IgE-binding epitopes of hevein (Hev b6.02) are identified by a novel chimera-based allergen epitope mapping strategy.

Karisola P; Alenius H; Mikkola J; Kalkkinen N; Helin J; Pentikäinen OT; Repo S; Reunala T; Turjanmaa K; Johnson MS; Palosuo T; Kulomaa MS
Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2002;59(6):419-424

Natural rubber latex allergy.

Alenius H; Turjanmaa K; Palosuo T
Article: METHODS. 2002;27(1):52-58

Quantitation of latex allergens.

Palosuo T; Alenius H; Turjanmaa K
Article: ALLERGY AND ASTHMA PROCEEDINGS. 2002;23(2):141-147

Allergen cross-reactivity between proteins of the latex from Hevea brasiliensis, seeds and pollen of Ricinus communis, and pollen of Mercurialis annua, members of the Euphorbiaceae family.

Palosuo T; Panzani RC; Singh AB; Ariano R; Alenius H; Turjanmaa K
Article: JOURNAL OF CLINICAL INVESTIGATION. 2002;109(5):621-628

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation.

Ma W; Bryce PJ; Humbles AA; Laouini D; Yalcindag A; Alenius H; Friend DS; Oettgen HC; Gerard C; Geha RS
Article: NATURE MEDICINE. 2002;8(2):157-165

CCL27-CCR10 interactions regulate T cell-mediated skin inflammation.

Homey B; Alenius H; Müller A; Soto H; Bowman EP; Yuan W; McEvoy L; Lauerma AI; Assmann T; Bünemann E; Lehto M; Wolff H; Yen D; Marxhausen H; To W; Sedgwick J; Ruzicka T; Lehmann P; Zlotnik A
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):106-113

Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation.

Alenius H; Laouini D; Woodward A; Mizoguchi E; Bhan AK; Castigli E; Oettgen HC; Geha RS
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2001;108(4):634-638

Wheat omega-5 gliadin is a major allergen in children with immediate allergy to ingested wheat.

Palosuo K; Varjonen E; Kekki OM; Klemola T; Kalkkinen N; Alenius H; Reunala T
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2001;31(3):466-473

Rye gamma-70 and gamma-35 secalins and barley gamma-3 hordein cross-react with omega-5 gliadin, a major allergen in wheat-dependent, exercise-induced anaphylaxis.

Palosuo K; Alenius H; Varjonen E; Kalkkinen N; Reunala T
Article: CONTACT DERMATITIS. 2001;44(2):129

Recalcitrant allergic contact dermatitis from azathioprine tablets.

Lauerma AI; Koivuluhta M; Alenius H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2001;107(2):359-366

An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis.

Woodward AL; Spergel JM; Alenius H; Mizoguchi E; Bhan AK; Castigli E; Brodeur SR; Oettgen HC; Geha RS
Journal article: CONTACT DERMATITIS. 2001;44(2):119-121

Recalcitrant allergic contact dermatitis from azathioprine tablets

Lauerma AI; Koivuluhta M; Alenius H
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2000;30(11):1611-1617

Natural rubber latex allergy in children: a follow-up study.

Ylitalo L; Alenius H; Turjanmaa K; Palosuo T; Reunala T
Article: PROTEIN EXPRESSION AND PURIFICATION. 1999;17(1):139-145

Avidin is a promising tag for fusion proteins produced in baculovirus-infected insect cells.

Airenne KJ; Laitinen OH; Alenius H; Mikkola J; Kalkkinen N; Arif SA; Yeang HY; Palosuo T; Kulomaa MS
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1999;103(5 Pt 1):912-917

A novel wheat gliadin as a cause of exercise-induced anaphylaxis.

Palosuo K; Alenius H; Varjonen E; Koivuluhta M; Mikkola J; Keskinen H; Kalkkinen N; Reunala T
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1999;103(1 Pt 1):165-171

Identification of patatin as a novel allergen for children with positive skin prick test responses to raw potato.

Seppälä U; Alenius H; Turjanmaa K; Reunala T; Palosuo T; Kalkkinen N
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1998;102(6 Pt 1):1005-1012

Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana.

Mikkola JH; Alenius H; Kalkkinen N; Turjanmaa K; Palosuo T; Reunala T
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1998;102(4 Pt 1):659-664

IgE antibodies to prohevein, hevein, and rubber elongation factor in children with latex allergy.

Ylitalo L; Alenius H; Turjanmaa K; Palosuo T; Reunala T
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1998;115(4):294-302

Purification of filaggrin from human epidermis and measurement of antifilaggrin autoantibodies in sera from patients with rheumatoid arthritis by an enzyme-linked immunosorbent assay.

Palosuo T; Lukka M; Alenius H; Kalkkinen N; Aho K; Kurki P; Heikkilä R; Nykänen M; von Essen R
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1998;16:s34

A novel wheat gliadin causes exercise-induced anaphylaxis

Palosuo K; Koivuluhta M; Varjonen E; Mikkola J; Kalkkinen N; Alenius H; Reunala T
Article: ALLERGY. 1998;53(1):59-67

Measurement of natural rubber latex allergen levels in medical gloves by allergen-specific IgE-ELISA inhibition, RAST inhibition, and skin prick test.

Palosuo T; Mäkinen-Kiljunen S; Alenius H; Reunala T; Yip E; Turjanmaa K
Article: ALLERGY. 1997;52(1):41-50

Latex allergy diagnosis: in vivo and in vitro standardization of a natural rubber latex extract.

Turjanmaa K; Palosuo T; Alenius H; Leynadier F; Autegarden JE; André C; Sicard H; Hrabina M; Tran TX
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1996;109(4):362-368

Significance of rubber elongation factor as a latex allergen.

Alenius H; Kalkkinen N; Yip E; Hasmin H; Turjanmaa K; Mäkinen-Kiljunen S; Reunala T; Palosuo T
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1996;26(3):341-348

Crossreactivity between allergens in natural rubber latex and banana studied by immunoblot inhibition.

Alenius H; Mäkinen-Kiljunen S; Ahlroth M; Turjanmaa K; Reunala T; Palosuo T
Journal article: CLINICAL AND EXPERIMENTAL ALLERGY. 1996;26(3):341-348

Crossreactivity between allergens in natural rubber latex and banana studied by immunoblot inhibition

Alenius H; Makinen-Kiljunen S; Ahlroth M; Turjanmaa K; Reunala T; Palosuo T
Article: JOURNAL OF IMMUNOLOGY. 1996;156(4):1618-1625

The main IgE-binding epitope of a major latex allergen, prohevein, is present in its N-terminal 43-amino acid fragment, hevein.

Alenius H; Kalkkinen N; Reunala T; Turjanmaa K; Palosuo T
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1996;109(1):58-67

A two-dimensional electrophoretic analysis of latex peptides reacting with IgE and IgG antibodies from patients with latex allergy.

Kurup VP; Alenius H; Kelly KJ; Castillo L; Fink JN
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;97(1):324

565 IgE antibodies to 3 purified latex proteins measured by ELISA

Palosuo T; Alenius H; Kalkkinen N; Turjanmaa K; Mäkinen-Kiljunen S
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;97(1):321

554 Cross-reactivity between wheat germ agglutinin (WGA) and prohevein, a major latex allergen

Alenius H; Kalkkinen N; Turjanmaa K; Lauerma A; Reunala T; Palosuo T
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;97(1):325

570 In vivo and in vitro evaluation of allergenicity of natural rubber latex (NRL) gloves used in health care: A nation-wide study

Turjanmaa K; Mäkinen-Kiljunen S; Alenius H; Reunala T; Palosuo T
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1996;97(1):323

562 Latex allergy diagnosis: Standardization of a natural rubber latex (NRL) extract

Sicard H; Turjanmaa K; Palosuo T; Alenius H; Leynadier F; Autegarden JE; Andre C; Hrabina M; Tran TX
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1995;96(2):167-173

Cross-reacting allergens in natural rubber latex and avocado.

Ahlroth M; Alenius H; Turjanmaa K; Mäkinen-Kiljunen S; Reunala T; Palosuo T
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1995;25(7):659-665

Prohevein from the rubber tree (Hevea brasiliensis) is a major latex allergen.

Alenius H; Kalkkinen N; Lukka M; Reunala T; Turjanmaa K; Mäkinen-Kiljunen S; Yip E; Palosuo T
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1995;106(3):258-262

Purification and partial amino acid sequencing of a 27-kD natural rubber allergen recognized by latex-allergic children with spina bifida.

Alenius H; Kalkkinen N; Lukka M; Turjanmaa K; Reunala T; Mäkinen-Kiljunen S; Palosuo T
Article: IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA. 1995;15(1):71-88

NATURAL-RUBBER LATEX ALLERGY - THE EUROPEAN EXPERIENCE

TURJANMAA K; MAKINENKILJUNEN S; REUNALA T; ALENIUS H; PALOSUO T
Journal article: ANNALS OF ALLERGY. 1994;73(4):315-320

Allergen and protein content of latex gloves.

Alenius H; Mäkinen-Kiljunen S; Turjanmaa K; Palosuo T; Reunala T
Journal article: TRANSLATIONAL RESEARCH. 1994;123(5):712-720

Latex allergy: frequent occurrence of IgE antibodies to a cluster of 11 latex proteins in patients with spina bifida and histories of anaphylaxis.

Alenius H; Kurup V; Kelly K; Palosuo T; Turjanmaa K; Fink J
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1994;93(5):859-863

IgE immune response to rubber proteins in adult patients with latex allergy.

Alenius H; Turjanmaa K; Mäkinen-Kiljunen S; Reunala T; Palosuo T
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1993;6(1):99

Rubber proteins and milk casein as antigens in Surgeon's gloves

Reunala T; Mäkinen-Kiljumen S; Alenius H; Palosuo T; Cacioli P; Turjanmaa K
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1993;91(6):1128-1134

Immunoglobulin E reactivity to latex antigens in the sera of patients from Finland and the United States.

Kurup VP; Kelly KJ; Turjanmaa K; Alenius H; Reunala T; Palosuo T; Fink JN
Journal article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 1993;102(1):61-66

IgE reactivity to 14-kD and 27-kD natural rubber proteins in latex-allergic children with spina bifida and other congenital anomalies.

Alenius H; Palosuo T; Kelly K; Kurup V; Reunala T; Mäkinen-Kiljunen S; Turjanmaa K; Fink J
Journal article: ALLERGY PROCEEDINGS. 1992;13(2):75-78

Detection of IgG4 and IgE antibodies to rubber proteins by immunoblotting in latex allergy.

Alenius H; Reunala T; Turjanmaa K; Palosuo T
Journal article: INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY. 1991;96(4):376-380

Surgical latex glove allergy: characterization of rubber protein allergens by immunoblotting.

Alenius H; Turjanmaa K; Palosuo T; Mäkinen-Kiljunen S; Reunala T
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1991;87(1):270

524 Characterization of latex allergens with immunoelectrophoresis and immunoblotting

Mäkinen-Kiljunen S; Turjanmaa K; Alenius H; Palosuo T; Reunala T
Journal article: LANCET. 1990;336(8730):1588

Allergens in latex surgical gloves and glove powder.

Turjanmaa K; Reunala T; Alenius H; Brummer-Korvenkontio H; Palosuo T
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Preprint: BIORXIV. 2024

A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes

del Giudice G; Serra A; Pavel A; Maia MT; Saarimäki LA; Fratello M; Federico A; Alenius H; Fadeel B; Greco D
Review: NANOMATERIALS. 2022;12(8):1247

A New Look at the Effects of Engineered ZnO and TiO2 Nanoparticles: Evidence from Transcriptomics Studies.

Wang S; Alenius H; El-Nezami H; Karisola P
Review: ALLERGY. 2021;76(12):3613-3626

Immunological resilience and biodiversity for prevention of allergic diseases and asthma.

Haahtela T; Alenius H; Lehtimäki J; Sinkkonen A; Fyhrquist N; Hyöty H; Ruokolainen L; Mäkelä MJ
Letter: ALLERGY. 2021;76(4):1280-1284

Interplay between skin microbiota and immunity in atopic individuals.

Riskumäki M; Tessas I; Ottman N; Suomalainen A; Werner P; Karisola P; Lauerma A; Ruokolainen L; Karkman A; Wisgrill L; Sinkko H; Lehtimäki J; Alenius H; Fyhrquist N
Letter: ALLERGY. 2021;76(4):1257-1261

Identification of novel miRNA-mRNA regulatory networks in contact dermatitis by integrated microarray analysis.

Werner P; Wisgrill L; Riskumäki M; Jalonen E; Vendelin J; Suomela S; Lauerma A; Alenius H; Fyhrquist N
Book chapter: INTERACTION OF NANOMATERIALS WITH THE IMMUNE SYSTEM: MOLECULAR AND INTEGRATIVE TOXICOLOGY. 2020;p. 149-165

Allergy and Immunity Induced by Nanomaterials

Alenius H; Savolainen K
Corrigendum: INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. 2017;12:1191-1192

Erratum: Characterization of sputum biomarkers for asthma-COPD overlap syndrome [Erratum].
Book chapter: ADVERSE EFFECTS OF ENGINEERED NANOMATERIALS. 2017;p. 243-253

Chapter 10 Respiratory System, Part Two: Allergy and Asthma

Alenius H; Shurin MR; Shurin GV; Beezhold D; Shvedova AA
Meeting abstract: TOXICOLOGY LETTERS. 2016;259:S70-S71

Systems Biology as ToxicOmics

Alenius H
Meeting abstract: TOXICOLOGY LETTERS. 2016;259:S188

Toxicity of TiO₂, ZnO and Ag nanoparticles on macrophage-like THP-1 cells

Poon WL; Karisola P; Alenius H; Lee JCY; El-Nezami HS
Meeting abstract: TOXICOLOGY LETTERS. 2016;258:S22

Immunotoxic and pulmonary effects of engineered nanomaterials

Alenius H
Book chapter: BIOMEDICAL APPLICATIONS AND TOXICOLOGY OF CARBON NANOMATERIALS. 2016;p. 397-428

Modulation of Immune System by Carbon Nanotubes

Ilves M; Alenius H
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2016;66:63-72

Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances.

Haapakoski R; Ebmeier KP; Alenius H; Kivimäki M
Book chapter: HANDBOOK OF NANOSAFETY. 2014;p. 59-133

Chapter 3 Nanomaterials and Human Health

Alenius H; Catalán J; Lindberg H; Norppa H; Palomäki J; Savolainen K
Editorial comment: TOXICOLOGY. 2013;313(1):1-2

Nanotoxicology.

Fadeel B; Alenius H; Savolainen K
Meeting abstract: CYTOKINE. 2013;63(3):290

Beta-glucan inducible microRNAs negatively regulate inflammatory response

Poltajainen A; Matikainen S; Nyman T; Alenius H; Veckman V
Letter: NATURE NANOTECHNOLOGY. 2013;8(2):72

Disseminating widely.

Savolainen K; Alenius H
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S40-S41

Long needle-like CNT cause severe pulmonary inflammation after pharyngeal aspiration

Rydman (Nee Rossi) E; Ilves M; Vanhala E; Pylkkanen L; Wolff H; Savolainen K; Alenius H
Review: DUODECIM; LAAKETIETEELLINEN AIKAKAUSKIRJA. 2011;127(12):1289-1295

[Mechanisms and new innovations in hyposensitization].

Savolainen J; Alenius H; Renkonen R
Published conference paper: SAFETY SCIENCE. 2010;48(8):957-963

Nanotechnologies, engineered nanomaterials and occupational health and safety - A review

Savolainen K; Pylkkanen L; Norppa H; Falck G; Lindberg H; Tuomi T; Vippola M; Alenius H; Hameri K; Koivisto J; Brouwer D; Mark D; Bard D; Berges M; Jankowska E; Posniak M; Farmer P; Singh R; Krombach F; Bihari P; Kasper G; Seipenbusch M
Published conference paper: TOXICOLOGY. 2010;269(2-3):92-104

Risk assessment of engineered nanomaterials and nanotechnologies--a review.

Savolainen K; Alenius H; Norppa H; Pylkkänen L; Tuomi T; Kasper G
Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S21

Vision on safe nanoparticles and nanotechnologies: Global and EU perspective. Nanosafety and REACH

Savolainen K; Pylkkaenen L; Norppa H; Falck G; Lindberg H; Tuomi T; Vippola M; Alenius H; Brouwer D; Mark D; Bard D; Berges M; Jankowska E; Posniak M; Farmer P; Singh R; Krombach F
Book chapter: TEXTBOOK OF ATOPIC DERMATITIS. 2008;p. 249-258

Possible clinical associations of atopic dermatitis with bronchial asthma

Reitamo S; Lehto M; Virtanen H; Haapakoski R; Alenius H; Remitz A; Lauerma A
Book chapter: TEXTBOOK OF ATOPIC DERMATITIS. 2008;p. 237-246

Possible clinical associationsof atopic dermatitis with bronchial asthma

Reitamo S; Lehto M; Virtanen H; Haapakoski R; Alenius H; Remitz A; Lauerma A
Letter: CLINICAL AND EXPERIMENTAL ALLERGY. 2008;38(4):696-698

Assessing the prevalence of sensitization to specific latex allergens - Response

Palosuo T; Kalkkinen N; Alenius H; Hamilton RG; Blanco C
Review: CHEMICAL IMMUNOLOGY AND ALLERGY. 2007;93:181-194

Modulation of chemokines by staphylococcal superantigen in atopic dermatitis.

Homey B; Meller S; Savinko T; Alenius H; Lauerma A
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(1):s3

Cutaneous CpG administration reduces Th2-type airway inflammation but induces airway hyperreactivity

Haapakoski R; Fyhrquist-Vanni N; Savinko T; Wolff H; Turjanmaa K; Palosuo T; Reunala T; Lauerma A; Alenius H
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(1):s265

Settled barn and home dust induces distinct airway inflammation in mice not explained by endotoxin

Leino MS; Alenius H; Haahtela T; von Hertzen L; Wolff H; Salkinoja-Salonen M; Andersson MA; Saris O; Pylkkaenen L; Reijula K; Maekelae M
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(1):s138

Targeted disruption of smad3 affects the IL-13 expression of lung in a mouse model of asthma

Anthoni M; Wang G; Leino M; Lauerma A; Alenius H; Wolff H
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(1):s33

Latex Allergy: Low prevalence of IgE to highly purified Hev b 2 and Hev b 13

Palosuo T; Lehto M; Kotovuori A; Kalkkinen N; Blanco C; Poza P; Carillo T; Hamilton RG; Alenius H; Reunala T; Turjanmaa K
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2007;119(1):S284

The role of STAT6 in the murine model of atopic dermatitis

Alenius H; Savinko T; Lehtimaki S; Fyhrquist-Vanni N; Wolff H; Lauerma A
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;117(2):s245

The role of T cells in a murine model of contact hypersensitivity

Fyhrquist-Vanni N; Lauerma A; Alenius H
Corrigendum: JOURNAL OF IMMUNOLOGY. 2005;174(12):8219

CCL1-CCR8 interactions:: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to cites of atopic skin inflammation (vol 174, pg 5082, 2005)

Gombert M; Dieu-Nosjean MC; Winterberg F; Bünemann E; Kubitza RC; Da Cunha L; Haahtela A; Lehtimäki S; Müller A; Rieker J; Meller S; Pivarcsi A; Koreck A; Fridman WH; Zentgraf HW; Pavenstädt H; Amara A; Caux C; Kemeny L; Alenius H; Lauerma A; Ruzicka T; Zlotnik A; Homey B
Review: ERNST SCHERING RESEARCH FOUNDATION WORKSHOP. 2005;(50):167-174

Epicutaneous sensitization with allergens as an atopic dermatitis model.

Alenius H
Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2004;4(5):397-401

Latex allergy and skin.

Reunala T; Alenius H; Turjanmaa K; Palosuo T
Book chapter: LATEX INTOLERANCE. 2004;p. 15-26

Allergenic Proteins

Alenius H; Palosuo T
Review: CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY. 2002;2(5):407-412

Recent developments in latex allergy.

Turjanmaa K; Alenius H; Reunala T; Palosuo T
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):S348

Epicutaneous natural rubber latex sensitization induces localized Th2-dominated dermatitis and strong IgE response

Alenius HT; Lehto H; Amghaiab I; Majuri ML; Wang GY; Wolff H; Turjanmaa K; Lauerma A; Reunala T; Palosuo T
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):S337

Humoral and cellular immune responses to gliadin in inhalant wheat allergy and in wheat-dependent, exercise-induced anaphylaxis

Lehto M; Palosuo K; Varjonen E; Majuri ML; Andersson U; Reunala T; Alenius HT
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):s333

Identification of IgE-binding amino acids on the conformational epitopes of hevein (Hev b 602)

Karisola P; Mikkola J; Reunala T; Turjanmaa K; Kalkkinen N; Palosuo T; Kulomaa N; Alenius HT
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):s332

Concentrations of natural rubber latex (NRL) allergens Hev b1, 3, 5 and 602 in NRL gloves capable of causing positive skin prick test (SPT) reactions in NRL-allergic subjects

Palosuo T; Turjanmaa K; Ovod V; Kärkkäinen T; Frisk K; Alenius HT; Reunala T; Kulomaa M; Kalkkinen N; Reinikka-Railo H
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):s256

The CC chemokine receptor 3 is essential for skin eosinophilia and for airway hyper-responsiveness to inhaled antigen in a murine model of allergic skin inflammation

Ma WL; Bryce PJ; Humbles A; Laouini D; Yalcindag A; Alenius HT; Friend D; Oettgen HC; Gerard C; Geha RS
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):s182

Tissue transglutaminase increases binding of IgE to (ω)over-bar-5 gliadin in wheat-dependent, exercise-induced anaphylaxis

Palosuo K; Nurkkala J; Varjonen E; Kalkkinen N; Reunala T; Alenius HT
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2000;105(1):s245

Long-term outcome of children allergic to natural rubber latex

Ylitalo L; Turjanmaa K; Alenius H; Palosuo T; Reunala T
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2000;105(1):s242

Modification of allergenic properties of a major natural rubber latex allergen Hev b 6.02 by site directed mutagenesis

Karisola P; Mikkola J; Airenne K; Laitinen O; Alenius H; Kalkkinen N; Helin J; Reunala T; Turjanmaa K; Palosuo T; Kulomaa MS
Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2000;105(1):s183

Rye γ-secalin and parley γ-hordein are cross-reactive allergens in wheat-dependent, exercise-induced anaphylaxis

Palosuo K; Alenius H; Varjonen E; Kalkkinen N; Reunala T
Book chapter: HANDBOOK OF OCCUPATIONAL DERMATOLOGY. 2000;p. 719-729

Natural-Rubber-Latex Allergy

Turjanmaa K; Alenius H; Mäkinen-Kiljunen S; Reunala T; Palosuo T
Review: ALLERGY. 1996;51(9):593-602

Natural rubber latex allergy.

Turjanmaa K; Alenius H; Mäkinen-Kiljunen S; Reunala T; Palosuo T
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