Hanna Eriksson

Om mig

Docent i Onkologi vid Institutionen för Onkologi-Patologi, Karolinska Institutet, och Onkolog vid Enheten för Huvud-hals-, Lung-, Hudcancer, Tema Cancer vid Karolinska Universitetssjukhuset,

 

Forskningsbeskrivning

Min forskargrupp arbetar med klinisk och translationell melanomforskning med målsättningen att förbättra överlevnaden och behandlingsmöjligheterna vid melanom.

Länk till forskargruppen Hanna Eriksson's Group | Karolinska Institutet (ki.se)

 

Publikationer (urval)

Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma

Yang M, Johnsson P, Bräutigam L, Yang Xr, Thrane K, Gao J, Tobin Np, Zhou Y, Yu R, Nagy N, Engström Pg, Tuominen R, Eriksson H, Lundeberg J, Tucker Ma, Goldstein Am, Egyhazi-brage S, Zhao J, Cao Y, Höiom V.

Genetics in Medicine : official journal of the American College of Medical Genetics 2022 Jan;24(1):157-169. doi: 10.1016/j.gim.2021.09.003.

 

Clinical Categorization Algorithm (CLICAL) and Machine Learning Approach (SRF-CLICAL) to Predict Clinical Benefit to Immunotherapy in Metastatic Melanoma Patients: Real-World Evidence from the Istituto Nazionale Tumori IRCCS Fondazione Pascale, Napoli, Italy

Madonna G, Masucci Gv, Capone M, Mallardo D, Grimaldi Am, Simeone E, Vanella V, Festino L, Palla M, Scarpato L, Tuffanelli M, D'angelo G, Villabona L, Krakowski I, Eriksson H, Simao F, Lewensohn R, Ascierto Pa.

Cancers 2021; Aug 19;13(16):4164. doi: 10.3390/cancers1316416

 

Impact of modern systemic therapies and clinical markers on treatment outcome for metastatic melanoma in a real-world setting

Krakowski I, Bottai M, Habel H, Masucci G, Girnita A, Smedby Ke, Eriksson H.

J Eur Acad Dermatol Venereol. 2021 Jan;35(1):105-115. doi: 10.1111/jdv.16678.

 

Pathological response and tumour bed histopathological features correlate with survival following neoadjuvant immunotherapy in stage III melanoma

Rawson Rv, Adhikari C, Bierman C, Lo Sn, Shklovskaya E, Rozeman Ea, Menzies Am, Van Akkooi Acj, Shannon Kf, Gonzalez M, Guminski Ad, Tetzlaff Mt, Stretch Jr, Eriksson H, Van Thienen Jv, Wouters Mw, Haanen Jbag, Klop Wmc, Zuur Cl, Van Houdt Wj, Nieweg Oe, Ch'ng S, Rizos H, Saw Rpm, Spillane Aj, Wilmott Js, Blank Cu, Long Gv, Van De Wiel Ba, Scolyer Ra.

Annals of Oncology: official journal of the European Society for Medical Oncology 2021 Jun;32(6):766-777.doi: 10.1016./j.annonc.2021.03.006.

 

Plasma proteome alterations by MAPK inhibitors in BRAFV600-mutated metastatic cutaneous melanoma

Babačić H, Eriksson H**, Pernemalm M**. (shared last author)

Neoplasia (New York, N.Y.) 2021 Aug;23(8):783-791. doi: 10.1016/j.neo.2021.06.002. 

 

Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma

Rozeman Ea, Hoefsmit Ep, Reijers Ilm, Saw Rpm, Versluis Jm, Krijgsman O, Dimitriadis P, Sikorska K, Van De Wiel Ba, Eriksson H, Gonzalez M, Torres Acosta A, Grijpink-ongering Lg, Shannon K, Haanen Jbag, Stretch J, Ch'ng S, Nieweg Oe, Mallo Ha, Adriaansz S, Kerkhoven Rm, Cornelissen S, Broeks A, Klop Wmc, Zuur Cl, Van Houdt Wj, Peeper Ds, Spillane Aj, Van Akkooi Acj, Scolyer Ra, Schumacher Tnm, Menzies Am, Long Gv, Blank Cu.

Nature Medicine  2021 Feb;27(2):256-263. doi: 10.1038/s41591-020-01211-7.

 

The Proportion Cured of Patients with Resected Stage II-III Cutaneous Melanoma in Sweden

Eriksson H, Utjes D, Bagge Ro, Gillgren P, Isaksson K, Lapins J, Schultz Il, Lyth J, Andersson Tml.

Cancers 2021 May 18;13(10):2456. doi: 10.3390/cancers13102456.

 

Trend Shifts in Age-Specific Incidence for In Situ and Invasive Cutaneous Melanoma in Sweden

Eriksson H, Nielsen K, Vassilaki I, Lapins J, Mikiver R, Lyth J, Isaksson K.

Cancers 2021 Jun 7;13(11):2838. doi: 10.3390/cancers13112838.

 

Bullous Pemphigoid-like Eruption Triggered by Targeted Therapy for Metastatic Melanoma

Eriksson H, Hansson J, Krynitz B, Masucci G, Girnita A, Lapins J, Huen Ao, Tawbi Ha, Davies Ma, Tetzlaff Mt, Curry Jl. (case report)

Acta Dermato-Venereologica 2020 Nov 26;100(18):adv00334. doi: 10.2340/00015555-3648.

 

Factors Affecting Sentinel Node Metastasis in Thin (T1) Cutaneous Melanomas: Development and External Validation of a Predictive Nomogram

Maurichi A, Miceli R, Eriksson H, Newton-bishop J, Nsengimana J, Chan M, Hayes Aj, Heelan K, Adams D, Patuzzo R, Barretta F, Gallino G, Harwood C, Bergamaschi D, Bennett D, Lasithiotakis K, Ghiorzo P, Dalmasso B, Manganoni A, Consoli F, Mattavelli I, Barbieri C, Leva A, Cortinovis U, Espeli V, Mangas C, Quaglino P, Ribero S, Broganelli P, Pellacani G, Longo C, Del Forno C, Borgognoni L, Sestini S, Pimpinelli N, Fortunato S, Chiarugi A, Nardini P, Morittu E, Florita A, Cossa M, Valeri B, Milione M, Pruneri G, Zoras O, Anichini A, Mortarini R, Santinami M.

Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology 2020 May 10;38(14):1591-1601. doi: 10.1200/JCO.19.01902.

 

Immune checkpoint inhibitors in cancer treatment and potential effect modification by age

Eriksson H, Smedby Ke.

Acta Oncologica 2020 Mar;59(3):247-248. doi: 10.1080/0284186X.2020.1724329.

 

Immunometabolic Network Interactions of the Kynurenine Pathway in Cutaneous Malignant Melanoma

Rad Pour S, Morikawa H, Kiani Na, Gomez-cabrero D, Hayes A, Zheng X, Pernemalm M, Lehtiö J, Mole Dj, Hansson J, Eriksson H, Tegnér J.

Frontiers in Oncology 2020 Feb 3;10:51. doi: 10.3389/fonc.2020.00051. 

 

In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma

Babacic H, Lehtio J, De Coana Yp, Pernemalm M, Eriksson H.

Journal for Immunotherapy of Cancer 2020 May;8(1):e000204. doi: 10.1136/jitc-2019-000204.

 

2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial

Utjés D, Malmstedt J, Teras J, Drzewiecki K, Gullestad Hp, Ingvar C, Eriksson H**, Gillgren P**. (shared last author)

Lancet 2019 Aug 10;394(10197):471-477. doi: 10.1016/S0140-6736(19)31132-8

 

Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial

Rozeman Ea, Menzies Am, Van Akkooi Acj, Adhikari C, Bierman C, Van De Wiel Ba, Scolyer Ra, Krijgsman O, Sikorska K, Eriksson H, Broeks A, Van Thienen Jv, Guminski Ad, Acosta At, Ter Meulen S, Koenen Am, Bosch Ljw, Shannon K, Pronk Lm, Gonzalez M, Ch'ng S, Grijpink-ongering Lg, Stretch J, Heijmink S, Van Tinteren H, Haanen Jbag, Nieweg Oe, Klop Wmc, Zuur Cl, Saw Rpm, Van Houdt Wj, Peeper Ds, Spillane Aj, Hansson J, Schumacher Tn, Long Gv, Blank Cu.

Lancet Oncology 2019 Jul;20(7):948-960. doi: 10.1016/S1470-2045(19)30151-2.

 

Extracellular microvesicle microRNAs as predictive biomarkers for targeted therapy in metastastic cutaneous malignant melanoma

Svedman Fc, Lohcharoenkal W, Bottai M, Brage Se, Sonkoly E, Hansson J, Pivarcsi A, Eriksson H.

PloS One 2018 Nov 6;13(11):e0206942. doi: 10.1371/journal.pone.0206942.

 

Spatially Resolved Transcriptomics Enables Dissection of Genetic Heterogeneity in Stage III Cutaneous Malignant Melanoma

Thrane K*, Eriksson H*, Maaskola J, Hansson J, Lundeberg J. (Shared first author)

Cancer Research 2018 Oct 15;78(20):5970-5979. doi: 10.1158/0008-5472.CAN-18-0747.

 

Reduced disease-specific survival following a diagnosis of multiple primary cutaneous malignant melanomas - a nationwide, population-based study

Utjés D, Lyth J, Lapins J, Eriksson H.

International Journal of Cancer 2017 Dec 1;141(11):2243-2252. doi: 10.1002/ijc.30925

 

Prognostic factors and disease-specific survival among immigrants diagnosed with cutaneous malignant melanoma in Sweden

Simberg-Danell C, Lyth J, Månsson-Brahme E, Frohm-Nilsson M, Carstensen J, Hansson J, Eriksson H.

International Journal of Cancer 2016 Aug 1;139(3):543-53. doi: 10.1002/ijc.30103. 

 

The proportion cured of patients diagnosed with Stage III-IV cutaneous malignant melanoma in Sweden 1990-2007: A population-based study

Eriksson H, Lyth J, Andersson Tm.

International Journal of Cancer 2016 Jun 15;138(12):2829-36.doi: 10.1002/ijc.30023.

 

BRAFV600E protein expression in primary cutaneous malignant melanomas and paired metastases

Eriksson H, Zebary A, Vassilaki I, Omholt K, Ghaderi M, Hansson J.

JAMA Dermatology  2015 Apr;151(4):410-6. doi: 10.1001/jamadermatol.2014.3689.

 

Prognostic factors in localized invasive primary cutaneous malignant melanoma: results of a large population-based study

Eriksson H, Frohm-Nilsson M, Järås J, Kanter-Lewensohn L, Kjellman P, Månsson-Brahme E, Vassilaki I, Hansson J.

The British Journal of Dermatology  2015 Jan;172(1):175-86. doi: 10.1111/bjd.13171.

 

Later stage at diagnosis and worse survival in cutaneous malignant melanoma among men living alone: a nationwide population-based study from Sweden

Eriksson H, Lyth J, Månsson-Brahme E, Frohm-Nilsson M, Ingvar C, Lindholm C, Naredi P, Stierner U, Carstensen J, Hansson J.

Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology 2014 May 1;32(13):1356-64. doi: 10.1200/JCO.2013.52.7564. 

 

Interobserver variability of histopathological prognostic parameters in cutaneous malignant melanoma: impact on patient management

Eriksson H, Frohm-Nilsson M, Hedblad Ma, Hellborg H, Kanter-Lewensohn L, Krawiec K, Lundh Rozell B, Månsson-Brahme E, Hansson J.

Acta Dermato-Venereologica 2013 Jul 6;93(4):411-6. doi: 10.2340/00015555-1517.

 

Low level of education is associated with later stage at diagnosis and reduced survival in cutaneous malignant melanoma: a nationwide population-based study in Sweden

Eriksson H, Lyth J, Månsson-brahme E, Frohm-nilsson M, Ingvar C, Lindholm C, Naredi P, Stierner U, Wagenius G, Carstensen J, Hansson J.

European Journal of Cancer 2013 Aug;49(12):2705-16.doi: 10.1016/j.ejca.2013.03.013. 

 

 

Pedagogiska meriter

Pågående huvudhandledare för doktorander och postdocs.

Regelbunden föreläsare vid Karolinska Institutet på grund- och avancerad nivå.

Organiserar doktorandkurserna:

Clinical Oncology for Pre-Clinical Doctoral Students (#5505), Karolinska Institutet.

Basic Course in Tumor Biology and Oncology (#3112), Karolinska Institutet.

Akademiska priser och utmärkelser

Etableringsbidrag, Vetenskapsrådet, 2023-2026.

Anställning som forskare i klinisk miljö, Vetenskapsrådet, 2022-2024.

Klinisk forskartjänst, Radiumhemmets forskningsfonder, 2020-2025.

Junior Clinical Investigator Award, Cancerfonden, 2021-2026.

Klinisk postdok, Region Stockholm, 2016-2019.

Postdok, Svenska Sällskapet för Medicinsk Forskning, 2017-2019.

Clincal Research Visit Grant to MD Anderson Cancer Center, StratCan, Karolinska Institutet, 2017-2018.