Hans-Erik Claesson

Publications
Public outreach and news

Articles

Journal article: HEMASPHERE. 2023;7(Suppl):e5045724

PB1920: TARGETING THE TUMOR MICROENVIRONMENT INTERACTIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING LEUKOTRIENE INHIBITORS

Sadeghi L; Merrien M; Bjorkholm M; Sander B; Claesson H; Wright A
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2021;156:106575

Intrinsic 5-lipoxygenase activity regulates migration and adherence of mantle cell lymphoma cells.

Xia C; Sadeghi L; Strååt K; Merrien M; Wright AP; Sander B; Xu D; Österborg A; Björkholm M; Claesson H-E
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2021;1866(5):158886

COX-1 dependent biosynthesis of 15-hydroxyeicosatetraenoic acid in human mast cells.

Johnsson A-K; Rönnberg E; Fuchs D; Kolmert J; Säfholm J; Claesson H-E; Hamberg M; Wheelock CE; Nilsson G; Dahlén S-E
Article: HAEMATOLOGICA. 2020;105(5):1339-1350

An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma.

Record J; Sendel A; Kritikou JS; Kuznetsov NV; Brauner H; He M; Nagy N; Oliveira MMS; Griseti E; Haase CB; Dahlström J; Boddul S; Wermeling F; Thrasher AJ; Liu C; Andersson J; Claesson H-E; Winqvist O; Burns SO; Björkholm M; Westerberg LS
Article: FRONTIERS IN ONCOLOGY. 2020;10:598872

Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures.

Xia C; Olsen TK; Zirakzadeh AA; Almamoun R; Sjöholm LK; Dahlström J; Sjöberg J; Claesson H-E; Johnsen JI; Winqvist O; Xu D; Ekström TJ; Björkholm M; Strååt K
Article: FASEB JOURNAL. 2019;33(5):6140-6153

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.

Werner M; Jordan PM; Romp E; Czapka A; Rao Z; Kretzer C; Koeberle A; Garscha U; Pace S; Claesson H-E; Serhan CN; Werz O; Gerstmeier J
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2017;57(6):692-701

Preferential Generation of 15-HETE-PE Induced by IL-13 Regulates Goblet Cell Differentiation in Human Airway Epithelial Cells.

Zhao J; Minami Y; Etling E; Coleman JM; Lauder SN; Tyrrell V; Aldrovandi M; O'Donnell V; Claesson H-E; Kagan V; Wenzel S
Article: FASEB JOURNAL. 2017;31(2):491-504

Human 15-lipoxygenase-1 is a regulator of dendritic-cell spreading and podosome formation.

Han H; Liang X; Ekberg M; Kritikou JS; Brunnström Å; Pelcman B; Matl M; Miao X; Andersson M; Yuan X; Schain F; Parvin S; Melin E; Sjöberg J; Xu D; Westerberg LS; Björkholm M; Claesson H-E
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt A):122-130

Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells.

Han H; Xue-Franzén Y; Miao X; Nagy E; Li N; Xu D; Sjöberg J; Björkholm M; Claesson H-E
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2015;100:33-40

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

Mahshid Y; Markoutsa S; Dincbas-Renqvist V; Sürün D; Christensson B; Sander B; Björkholm M; Sorg BL; Rådmark O; Claesson H-E
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2015;121(Pt A):83-90

On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.

Brunnström Å; Tryselius Y; Feltenmark S; Andersson E; Leksell H; James A; Mannervik B; Dahlén B; Claesson H-E
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2015;25(15):3024-3029

3-Substituted pyrazoles and 4-substituted triazoles as inhibitors of human 15-lipoxygenase-1.

Pelcman B; Sanin A; Nilsson P; No K; Schaal W; Öhrman S; Krog-Jensen C; Forsell P; Hallberg A; Larhed M; Boesen T; Kromann H; Vogensen SB; Groth T; Claesson H-E
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2015;25(15):3017-3023

N-Substituted pyrazole-3-carboxamides as inhibitors of human 15-lipoxygenase.

Pelcman B; Sanin A; Nilsson P; Schaal W; Olofsson K; Krog-Jensen C; Forsell P; Hallberg A; Larhed M; Boesen T; Kromann H; Claesson H-E
Article: PLOS ONE. 2014;9(2):e90018

Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial iNOS.

Roos AB; Mori M; Grönneberg R; Österlund C; Claesson H-E; Wahlström J; Grunewald J; Eklund A; Erjefält JS; Lundberg JO; Nord M
Article: PLOS ONE. 2014;9(1):e85085

Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells.

Han H; Xu D; Liu C; Claesson H-E; Björkholm M; Sjöberg J
Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2013;162(2):135-142

The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma.

James A; Daham K; Backman L; Brunnström A; Tingvall T; Kumlin M; Edenius C; Dahlén S-E; Dahlén B; Claesson H-E
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;385(1-2):60-70

Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells.

Rasul AE; Nagy N; Sohlberg E; Ádori M; Claesson H-E; Klein G; Klein E
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2012;87(4-5):159-163

Biosynthesis of eoxin C4 by porcine leukocytes.

Brunnström Å; Backman L; Tryselius Y; Claesson H-E
Article: LIPIDS. 2012;47(8):781-791

Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases.

Forsell PKA; Brunnström A; Johannesson M; Claesson H-E
Article: EXPERIMENTAL CELL RESEARCH. 2012;318(3):169-176

Epigenetic and transcriptional control of the 15-lipoxygenase-1 gene in a Hodgkin lymphoma cell line.

Liu C; Schain F; Han H; Xu D; Andersson-Sand H; Forsell P; Claesson H-E; Björkholm M; Sjöberg J
Article: PLOS ONE. 2012;7(12):e52703

Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation.

Liu C; Xu D; Han H; Fan Y; Schain F; Xu Z; Claesson H-E; Björkholm M; Sjöberg J
Article: LIPIDS. 2011;46(1):69-79

Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils.

Brunnström A; Hamberg M; Griffiths WJ; Mannervik B; Claesson H-E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(8):5369-5376

Applicability of the triad concept for the positional specificity of mammalian lipoxygenases.

Vogel R; Jansen C; Roffeis J; Reddanna P; Forsell P; Claesson H-E; Kuhn H; Walther M
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2010;82(2-3):121-129

Cloning, purification and characterization of non-human primate 12/15-lipoxygenases.

Johannesson M; Backman L; Claesson H-E; Forsell PKA
Article: EXPERIMENTAL HEMATOLOGY. 2010;38(2):116-123

Interleukin-13 stimulation of the mediastinal B-cell lymphoma cell line Karpas-1106P induces a phenotype resembling the Hodgkin lymphoma cell line L1236.

Andersson E; Schain F; Sjöberg J; Björkholm M; Claesson H-E
Journal article: CURRENT IMMUNOLOGY REVIEWS. 2010;6(1):23-28

The Central Role of Leukotriene B4 in Epstein Barr Virus Activated Innate Immunity In Vitro

Klein E; Claesson H-E
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2009;297(1):L196-L203

15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells.

Liu C; Xu D; Liu L; Schain F; Brunnström A; Björkholm M; Claesson H-E; Sjöberg J
Article: BMC IMMUNOLOGY. 2009;10:2

High expression of 5-lipoxygenase in normal and malignant mantle zone B lymphocytes.

Mahshid Y; Lisy M-R; Wang X; Spanbroek R; Flygare J; Christensson B; Björkholm M; Sander B; Habenicht AJR; Claesson H-E
Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(3):R83

Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids.

Gheorghe KR; Korotkova M; Catrina AI; Backman L; af Klint E; Claesson H-E; Rådmark O; Jakobsson P-J
Article: CLINICAL LYMPHOMA AND MYELOMA. 2008;8(6):340-347

Differential expression of cysteinyl leukotriene receptor 1 and 15-lipoxygenase-1 in non-Hodgkin lymphomas.

Schain F; Schain D; Mahshid Y; Liu C; Porwit A; Xu D; Claesson H-E; Sundström C; Björkholm M; Sjöberg J
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2008;39(6):648-656

Mice lacking 12/15-lipoxygenase have attenuated airway allergic inflammation and remodeling.

Andersson CK; Claesson H-E; Rydell-Törmänen K; Swedmark S; Hällgren A; Erjefält JS
Journal article: BLOOD. 2008;112(11):3774

Arachidonic Acid Metabolism-Related Molecules as Candidate Markers in Subclassification of Lymphoma

Sjoberg J; Schain F; Schain D; Mahshid Y; Porwit A; Xu D; Sundstrom C; Claesson H-E; Bjorkholm M
Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(10):2285-2293

Evidence for a pathophysiological role of cysteinyl leukotrienes in classical Hodgkin lymphoma.

Schain F; Tryselius Y; Sjöberg J; Porwit A; Backman L; Malec M; Xu D; Vockerodt M; Baumforth KRN; Wei W; Murray PG; Björkholm M; Claesson H-E
Article: FEBS JOURNAL. 2008;275(16):4222-4234

Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.

Claesson H-E; Griffiths WJ; Brunnström A; Schain F; Andersson E; Feltenmark S; Johnson HA; Porwit A; Sjöberg J; Björkholm M
Article: BLOOD. 2008;111(5):2693-2703

Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures.

Liu A; Claesson H-E; Mahshid Y; Klein G; Klein E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(2):680-685

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells.

Feltenmark S; Gautam N; Brunnström A; Griffiths W; Backman L; Edenius C; Lindbom L; Björkholm M; Claesson H-E
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;67(1):53-56

Expression of mast cell tryptases in Hodgkin and Reed-Sternberg (HRS) cells.

Carvalho RFS; Mahshid Y; Claesson H-E; Glimelius I; Fischer M; Nilsson G
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2007;79(6):468-476

The expression of cytosolic phospholipase A2 and biosynthesis of leukotriene B4 in acute myeloid leukemia cells.

Runarsson G; Feltenmark S; Forsell PKA; Sjöberg J; Björkholm M; Claesson H-E
Journal article: BLOOD. 2007;110(11):2269

Novel Findings Support a Patophysiological Role of the Arachidonic Cascade in Hodgkin Lymphoma.

Sjoberg J; Schain F; Tryselius Y; Backman L; Porwit A; Liu C; Xu D; Wei W; Baumforth K; Murray P; Bjorkholm M; Claesson H-E
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1771(9):1156-1165

Expression of 15-lipoxygenase type-1 in human mast cells.

Gulliksson M; Brunnström A; Johannesson M; Backman L; Nilsson G; Harvima I; Dahlén B; Kumlin M; Claesson H-E
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2006;1761(12):1498-1505

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity.

Andersson E; Schain F; Svedling M; Claesson H-E; Forsell PKA
Journal article: BLOOD. 2006;108(11):4593

Inhibition of Signal Transducer and Activator of Transcription 6 Activity in the Hodgkin Lymphoma Cell Line L1236 Induces Growth Inhibition and Apoptosis.

Liu C; Andersson M; Xu D; Claesson H-E; Bjorkholm M; Sjoberg J
Article: BLOOD. 2005;105(3):1274-1279

Leukotriene B4 plays a pivotal role in CD40-dependent activation of chronic B lymphocytic leukemia cells.

Runarsson G; Liu A; Mahshid Y; Feltenmark S; Pettersson A; Klein E; Björkholm M; Claesson H-E
Journal article: BLOOD. 2004;104(11):4808

Leukotriene B4 Plays a Pivotal Role in CD40 Dependent Activation of Chronic B Lymphocytic Leukemia Cells.

Claesson H-E; Runarsson G; Liu A; Mahshid Y; Feltenmark S; Klein E; Bjorkholm M
Article: EXPERIMENTAL CELL RESEARCH. 2004;297(1):61-67

Transcriptional regulation of 15-lipoxygenase expression by promoter methylation.

Liu C; Xu D; Sjöberg J; Forsell P; Björkholm M; Claesson H-E
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;116(2):326-331

Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism.

Huang YH; Schäfer-Elinder L; Wu R; Claesson HE; Frostegård J
Article: JOURNAL OF LIPID RESEARCH. 2000;41(8):1222-1230

Purification, characterization, and cDNA sequencing of cytosolic phospholipase A(2) from equine neutrophils.

Forsell PK; Lindberg A; Karlsson S; Lindgren JA; Claesson HE
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2000;20(2):146-152

Expression of cyclo-oxygenase-2 in human atherosclerotic carotid arteries.

Stemme V; Swedenborg J; Claesson H; Hansson GK
Article: FEBS JOURNAL. 1999;262(2):575-585

The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene.

Larsson Forsell PK; Kennedy BP; Claesson HE
Article: JOURNAL OF LIPID RESEARCH. 1999;40(3):439-446

Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1.

Sjölinder M; Tornhamre S; Claesson HE; Hydman J; Lindgren J
Article: FEBS LETTERS. 1998;434(3):295-299

On the expression of cytosolic calcium-independent phospholipase A2 (88kDa) in immature and mature myeloid cells and its role in leukotriene synthesis in human granulocytes.

Larsson Forsell PK; Runarsson G; Ibrahim M; Björkholm M; Claesson HE
Article: BIOCHEMICAL PHARMACOLOGY. 1998;55(6):863-871

Effects of 1-chloro-2,4,6-trinitrobenzene on 5-lipoxygenase activity and cellular leukotriene synthesis.

Larsson PK; Hammarberg T; Johnsson T; Lindgren JA; Rådmark O; Claesson HE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(1):207-214

Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity.

Larsson PK; Claesson HE; Kennedy BP
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1997;17(10):2257-2263

Expression of phospholipase A2 isoforms in human normal and atherosclerotic arterial wall.

Elinder LS; Dumitrescu A; Larsson P; Hedin U; Frostegård J; Claesson HE
Article: CELL DEATH AND DIFFERENTIATION. 1997;4(6):479-486

Inhibitors of arachidonic acid metabolism reduce DNA and nuclear fragmentation induced by TNF plus cycloheximide in U937 cells.

Vanags DM; Larsson P; Feltenmark S; Jakobsson PJ; Orrenius S; Claesson HE; Aguilar-Santelises M
Journal article: IMMUNOLOGY LETTERS. 1997;56:416

Effects on immune activation of lipid components in oxidized LDL

Huang YH; Schäfer-Elinder L; Claesson H-E; Frostegård J
Journal article: BIOCHEMICAL SOCIETY TRANSACTIONS. 1996;24(4):603s

TNFα + CYCLOHEXIMIDE INDUCE APOPTOSIS IN U937 THAT CORRELATES WITH CHANGES IN Bcl-2/Baxα RATIO AND IS INHIBITED BY 5-LIPOXYGENASE, FLAP AND cPLA2 INHIBITORS

Vanags D; Larsson P; Feltenmark S; Coppola S; Jakobsson PJ; Orrenius S; Claesson HE; Aguilar-Santelises M
Article: BIOCHEMISTRY. 1996;35(26):8511-8516

Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron.

Björnstedt M; Odlander B; Kuprin S; Claesson HE; Holmgren A
Article: FEBS JOURNAL. 1995;232(1):37-46

Studies on the regulation and localization of 5-lipoxygenase in human B-lymphocytes.

Jakobsson PJ; Shaskin P; Larsson P; Feltenmark S; Odlander B; Aguilar-Santelises M; Jondal M; Biberfeld P; Claesson HE
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1995;90(3):585-594

Diverse expression of cytosolic phospholipase A2, 5-lipoxygenase and prostaglandin H synthase 2 in acute pre-B-lymphocytic leukaemia cells.

Feltenmark S; Runarsson G; Larsson P; Jakobsson PJ; Björkholm M; Claesson HE
Journal article: JOURNAL OF LIPID MEDIATORS. 1993;6(1-3):15-22

Expression of 5-lipoxygenase and biosynthesis of leukotriene B4 in human monomorphonuclear leukocytes.

Claesson HE; Jakobsson PJ; Steinhilber D; Odlander B; Samuelsson B
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992;89(8):3521-3525

On the expression and regulation of 5-lipoxygenase in human lymphocytes.

Jakobsson PJ; Steinhilber D; Odlander B; Rådmark O; Claesson HE; Samuelsson B
Journal article: INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY. 1992;14(3):441-449

Leukotriene B4 in the immune system.

Claesson HE; Odlander B; Jakobsson PJ
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1991;178(1):302-308

Human B lymphocytes possess 5-lipoxygenase activity and convert arachidonic acid to leukotriene B4.

Jakobsson PJ; Odlander B; Steinhilber D; Rosén A; Claesson HE
Journal article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1991;287(1):167-174

Leukotriene A4 hydrolase in the human B-lymphocytic cell line Raji: indications of catalytically divergent forms of the enzyme.

Odlander B; Claesson HE; Bergman T; Rådmark O; Jörnvall H; Haeggström JZ
Journal article: FEBS JOURNAL. 1991;196(2):395-400

Effects of monocyte-lymphocyte interaction on the synthesis of leukotriene B4.

Jakobsson PJ; Odlander B; Claesson HE
Journal article: JOURNAL OF CELL SCIENCE. 1991;98 ( Pt 2):141-149

On the mechanism of induction of DNA synthesis in cultured arterial smooth muscle cells by leukotrienes. Possible role of prostaglandin endoperoxide synthase products and platelet-derived growth factor.

Palmberg L; Lindgren JA; Thyberg J; Claesson HE
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1991;21B:1005-1012

Biosynthesis and biological effects of leukotriene B4 in B lymphocytes.

Jakobsson PJ; Odlander B; Yamaoka KA; Rosén A; Claesson HE
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1991;21B:663-666

Studies of leukotriene A4-hydrolase and leukotriene C4-synthase in human endothelial cells: enzymes involved in the metabolism of monocyte released leukotriene A4.

Claesson HE; Johnson HA; Rådmark O; Jakobsson PJ
Journal article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1991;314:307-315

The role of leukotriene A4 hydrolase in cells and tissues lacking 5-lipoxygenase.

Claesson HE; Haeggström JZ; Odlander B; Medina JF; Wetterholm A; Jakobsson PJ; Rådmark O
Journal article: CELLULAR SIGNALLING. 1991;3(5):399-404

Intracellular mechanisms involved in leukotriene C4-stimulated adhesion of U-937 cells.

Skoglund G; Claesson HE
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1991;21A:133-136

Leukotriene A4 hydrolase in the B-lymphocytic cell line Raji.

Odlander B; Haeggström J; Bergman T; Rådmark O; Wetterholm A; Claesson HE
Journal article: AMERICAN JOURNAL OF PHYSIOLOGY. 1990;259(4 Pt 1):L255-L261

Cysteinyl leukotrienes enhance growth of human airway epithelial cells.

Leikauf GD; Claesson HE; Doupnik CA; Hybbinette S; Grafström RC
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1990;20:1-13

Leukotriene B4: biosynthesis and role in lymphocytes.

Samuelsson B; Claesson HE
Journal article: JOURNAL OF CELL SCIENCE. 1989;94 ( Pt 3):381-387

New insights into the evolutionary growth of tumors revealed by Southern gel analysis of tumors genetically tagged with plasmid or proviral DNA insertions.

Kerbel RS; Cornil I; Korczak B
Journal article: JOURNAL OF IMMUNOLOGY. 1989;143(6):1996-2000

Leukotriene B4 enhances activation, proliferation, and differentiation of human B lymphocytes.

Yamaoka KA; Claésson HE; Rosén A
Journal article: JOURNAL OF CELL SCIENCE. 1989;93 ( Pt 3):403-408

Effects of leukotrienes on phenotypic properties and growth of arterial smooth muscle cells in primary culture.

Palmberg L; Claesson HE; Thyberg J
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1989;161(2):740-745

B-lymphocytic cell line Raji expresses the leukotriene A4 hydrolase gene but not the 5-lipoxygenase gene.

Medina JF; Odlander B; Funk CD; Fu JY; Claesson HE; Rådmark O
Journal article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1989;559:112-120

Role of brain microvessels and choroid plexus in cerebral metabolism of leukotrienes.

Lindgren JA; Karnushina I; Claesson HE
Journal article: INTERNATIONAL JOURNAL OF TISSUE REACTIONS. 1989;11(6):277-289

Formation and effects of leukotriene B4 in human lymphocytes.

Odlander B; Jakobsson PJ; Medina JF; Rådmark O; Yamaoka KA; Rosén A; Claesson HE
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1988;153(1):203-208

Human B and T lymphocytes convert leukotriene A4 into leukotriene B4.

Odlander B; Jakobsson PJ; Rosén A; Claesson HE
Journal article: FEBS JOURNAL. 1988;173(1):93-100

Human endothelial cells stimulate leukotriene synthesis and convert granulocyte released leukotriene A4 into leukotrienes B4, C4, D4 and E4.

Claesson HE; Haeggström J
Journal article: ACTA ENDOCRINOLOGICA. 1988;117(4):463-469

Formation of leukotriene B4 and monohydroxy acids in slices of porcine thyroid gland.

Odlander B; Claesson HE
Journal article: TOXICON. 1988;26(12):1187-1191

Suppression of leukotriene synthesis in human leukocytes by a urea extract of Bordetella pertussis: evidence for mediation by adenylate cyclase toxin.

Green FA; Gustafsson B; Claesson HE
Journal article: PROSTAGLANDINS. 1987;34(4):603-610

Effects of immune complexes, zymosan preparations and ionophore A 23187 on leukotriene formation in human leukocytes.

Odlander B; Lindgren JA; Claesson HE
Journal article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1987;257(2):321-327

Lipoxygenase products from polymorphonuclear leukocytes and epithelial cells of human saliva.

Green FA; Claesson HE; Hamberg M
Journal article: JOURNAL OF CELL SCIENCE. 1987;88 ( Pt 2):151-159

Leukotrienes stimulate initiation of DNA synthesis in cultured arterial smooth muscle cells.

Palmberg L; Claesson HE; Thyberg J
Journal article: JOURNAL OF EXPERIMENTAL ZOOLOGY. 1987;243(2):211-215

Monohydroxyeicosatetraenoic acid and leukotriene production by the inflammatory cells of Xenopus laevis.

Green FA; Herman CA; Herman RP; Claesson HE; Hamberg M
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1987;142(2):309-314

Leukotrienes and related eicosanoids are produced by frog leukocytes.

Green FA; Herman CA; Herman RP; Claesson HE; Hamberg M
Journal article: BIOMEDICAL CHROMATOGRAPHY. 1987;2(4):145-147

A rapid and sensitive method for measurement of leukotrienes based on HPLC.

Odlander B; Claesson HE
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1987;17A:115-119

Metabolism of leukotriene A4 by human endothelial cells: evidence for leukotriene C4 and D4 formation by leukocyte-endothelial cell interaction.

Claesson HE; Haeggström J
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1986;140(3):782-788

Ethanol-enhanced transmembrane penetration of arachidonic acid and activation of the 5-lipoxygenase pathway in human leukocytes.

Green FA; Claesson HE
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1985;836(3):361-367

Opsonized bacteria stimulate leukotriene synthesis in human leukocytes.

Claesson HE; Lindgren JA; Gustafsson B
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1985;131(2):579-585

Stimulation of human myelopoiesis by leukotriene B4.

Claesson HE; Dahlberg N; Gahrton G
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1984;804(1):52-57

Relationship of cyclic-AMP levels in leukotriene B4-stimulated leukocytes to lysosomal enzyme release and the generation of superoxide anions.

Claesson HE; Feinmark SJ
Journal article: ACTA PHYSIOLOGICA. 1984;120(1):141-143

Inhibition of intradental nerve excitability by leukotriene B4 and C4.

Gazelius B; Panopoulos P; Odlander B; Claesson HE
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1983;12:7-12

Degranulation and cyclic AMP levels in leukotriene B4-stimulated human leukocytes.

Feinmark SJ; Malmsten C; Claesson HE
Journal article: FEBS LETTERS. 1982;139(2):305-308

Leukotrienes A4 and B4 stimulate the formation of cyclic AMP in human leukocytes.

Claesson HE
Journal article: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1982;9:53-60

Formation of novel biologically active leukotrienes by omega-oxidation in human leukocyte preparations.

Lindgren JA; Hansson G; Claesson HE; Samuelsson B
Journal article: FEBS LETTERS. 1981;136(1):141-144

Stimulation of human leukocyte degranulation by leukotriene B4 and its omega-oxidized metabolites.

Feinmark SJ; Lindgren JA; Claesson HE; Malmsten C; Samuelsson B
Journal article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1981;99(4):1230-1237

Serum-coated zymosan stimulates the synthesis of leukotriene B4 in human polymorphonuclear leukocytes. Inhibition by cyclic AMP.

Claesson HE; Lundberg U; Malmsten C
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1980;618(3):399-406

Prostaglandin I2 synthesis and elevation of cyclic AMP levels in 3T3 fibroblasts.

Claesson HE
Journal article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 1980;4(6):453-463

Inhibition of platelet aggregation and elevation of cyclic-AMP levels in platelets by 13,14-dehydro PGI2 methyl ester.

Malmsten C; Claesson HE; Fried J
Journal article: PROSTAGLANDINS. 1980;19(1):155-163

Endogenous synthesis of prostaglandins E1 and I2 in 3T3 fibroblasts transformed by polyoma virus. Effects on adenosine 3':5'-monophosphate production.

Goldyne ME; Lindgren JA; Claesson HE; Hammarström S
Journal article: ADVANCES IN PROSTAGLANDIN AND THROMBOXANE RESEARCH. 1980;6:541-545

Endogenous prostaglandin E2 production inhibits proliferation of polyoma virus-transformed 3T3 cells: correlation with cellular levels of cyclic AMP.

Claesson HE; Lindgren JA; Hammarström S
Journal article: ADVANCES IN PROSTAGLANDIN AND THROMBOXANE RESEARCH. 1980;6:275-281

Effects of platelet aggregation and adenosine 3':5'-monophosphate on the synthesis of thromboxane B2 in human platelets.

Lindgren JA; Claesson HE; Kindahl H; Hammarström S
Journal article: EXPERIMENTAL CELL RESEARCH. 1979;124(1):1-5

Endogenous prostaglandin E2 synthesis inhibits growth of polyoma virus-transformed 3T3 fibroblasts.

Lindgren JA; Claesson HE; Hammarström S
Journal article: FEBS LETTERS. 1979;98(2):247-250

Effects of adenosine 3':5'-monophosphate and platelet aggregation on thromboxane biosynthesis in human platelets.

Lindgren JA; Claesson HE; Kindahl H; Hammarström S
Journal article: ADVANCES IN PROSTAGLANDIN AND THROMBOXANE RESEARCH. 1978;3:167-174

Stimulation of arachidonic acid release and prostaglandin production in 3T3 fibroblasts by adenosine 3':5'-monophosphate.

Lindgren JA; Claesson HE; Hammarström S
Journal article: FEBS LETTERS. 1977;81(2):415-418

Elevation of adenosine 3',5'-monophosphate levels in 3T3 fibroblasts by arachidonic acid: evidence for mediation by prostaglandin I2.

Claesson HE; Lindgren JA; Hammarström S
Journal article: FEBS JOURNAL. 1977;76(1):277-284

On the interrelationship of prostaglandin endoperoxide G2 and cyclic nucleotides in platelet function.

Claesson HE; Malmsten C
Journal article: PROSTAGLANDINS. 1977;13(6):1093-1102

Inhibition of prostaglandin synthesis in mouse 3T3 fibroblasts and human platelets by substituted phenols.

Lindgren JA; Claesson HE; Hammarström S
Journal article: FEBS JOURNAL. 1977;74(1):13-18

Prostaglandin E2 production in 3T3 cells transformed by polyoma virus raises the intracellular adenosine 3':5'-monophosphate levels.

Claesson HE; Lindgren JA; Hammarström S
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Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2017;195

15-Lipoxygenase 1 Pathway Regulates Autophagy In Human Airway Epithelial Cells (haecs)

Miriam Y; Ethng E; Claesson H-E; Zhao J; Wenzel SE
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):341

An intronic deletion in MKL1 leads to hyperproliferation of B cells in triplets with Hodgkin lymphoma

Record J; Sendel A; Kritikos J; Kuznetsov NV; Brauner H; Nagy N; Griseti E; Andersson J; Claesson H-E; Winqvist O; Burns SO; Bjorkholm M; Westerberg LS
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193

The Effect Of The 15-Lipoxygenase 1 (15lo1) Inhibitor Blx2477 On Il-13-Induced Periostin Mrna Expression In Human Airway Epithelial Cells (haecs)

Minami Y; Etling EB; O'Donnell VB; Yecies EB; Trudeau JB; Claesson H; Zhao J; Wenzel SE
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2015;191

Lipoxygenase Metabolite Profile In Human Airway Epithelial Cells (haecs)

Etling EB; Tyrrell V; Yecies EB; Trudeau JB; Claesson H-E; O'Donnell VB; Zhao J; Wenzel SE
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2015;191

15-Lipoxygenase 1 Regulates Forkhead Box Protein A3 Expression And Goblet Cell Differentiation In Human Bronchial Epithelial Cells (baecs)

Yecies EB; Etling EB; Claesson H-E; Hu H; Trudeau JB; Zhao J; Wenzel SE
Corrigendum: PLOS ONE. 2014;9(2):e91499

Interleukin-4-Mediated 15-Lipoxygenase-1 Trans-Activation Requires UTX Recruitment and H3K27me3 Demethylation at the Promoter in A549 Cells (vol 9, e85085, 2014)

Han H; Xu D; Liu C; Claesson H-E; Bjoerkholm M
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2013;187

Epithelial Nitric Oxide Synthase Is Associated With Elevated Exhaled Nitric Oxide In Allergen-Provoked Asthma

Roos AB; Mori M; Gronneberg R; Osterlund C; Claesson H-E; Wahlstrom J; Erjefalt J; Grunewald J; Eklund A; Lundberg JO; Nord M
Review: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2009;89(3-4):120-125

On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma.

Claesson H-E
Corrigendum: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2009;1791(1):84

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity (vol 1761, pg 1498, 2006)

Andersson E; Schain F; Svedling M; Claesson H-E; Forsell PKA
Published conference paper: IMMUNOLOGY LETTERS. 2008;116(2):174-177

Activation of innate immunity by the leukotriene B 4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear cultures.

Klein E; Liu A; Claesson H-E
Conference publication: BLOOD. 2008;112(11):1292

Arachidonic Acid Metabolism-Related Molecules as Candidate Markers in Subclassification of Lymphoma.

Sjoberg J; Schain F; Schain D; Mahshid Y; Porwit A; Xu D; Sundstrom C; Claesson H-E; Bjorkholm M
Meeting abstract: CYTOKINE. 2007;39(1):24

Leukotriene b4 contributes to T cell mediated inhibition of B cell growth in the EBV infected cord blood mommuclear cell cultures

Liu A; Mahshid Y; Claesson H-E; Klein G; Klein E
Conference publication: MOLECULAR CANCER THERAPEUTICS. 2007;6(12):3609S

Inhibition of signal transducer and activator of transcription 6 activity in the Hodgkin lymphoma cell line L1236 induces growth inhibition and apoptosis

Liu C; Xu D; Claesson H-E; Bjoerkholm M; Sjoeberg J
Conference publication: BLOOD. 2007;110(11):673A

Novel findings support a patophysiological role of the arachidonic cascade in Hodgkin lymphoma

Sjoberg J; Schain F; Tryselius Y; Backman L; Porwit A; Liu C; Xu D; Wei W; Baumforth K; Murray P; Bjorkholm M; Claesson H-E
Conference publication: HAEMATOLOGICA. 2007;92:39-40

Transcriptional regulation of human 15-lipoxygenase-1 in Hodgkin/Reed-Sternberg cells

Liu C; Schain F; Xu D; Bjorkholm M; Claesson HE; Sjoberg J
Conference publication: HAEMATOLOGICA. 2007;92:39

Evidence for a pathophysiological role of 15-lipoxygenase and cysteinyl receptor 1 in classical Hodgkin lymphoma

Sjoeberg J; Chain F; Tryselius Y; Backman L; Malec M; Porwit A; Xu D; Murray PG; Bjorkholm M; Claesson HE
KI thesis / dissertation: 2006

Biosynthesis and biological role of leukotrienes in B lymphocytes

Mahshid, Yilmaz
Meeting abstract: BLOOD. 2006;108(11):640A

Leukotrienes stimulate the release of cytokines and proliferation of Hodgkin Reed-Sternberg cells.

Sjoberg J; Schain F; Tryselius Y; Backman L; Malec M; Porwit-MacDonald A; Bjorkholm M; Claesson H-E
Conference publication: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2006;79(1-2):177

Induction of 15-lipoxygenase in human cord blood derived mast cells

Kumlin M; Gulliksson M; Brunnström Å; Johanesson M; Nilsson G; Claesson HE
Conference publication: BLOOD. 2006;108(11):228B

Inhibition of signal transducer and activator of transcription 6 activity in the Hodgkin lymphoma cell line L1236 induces growth inhibition and apoptosis.

Liu C; Andersson M; Xu D; Claesson H-E; Bjorkholm M; Sjoberg J
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(2)

15-lipoxygenase is expressed in the skin of patients with atopic dermatitis and contact dermatitis

Linder MT; Melin E; Ekman GJ; Claesson HE
Conference publication: BLOOD. 2004;104(11):285B

Leukotriene B₄ plays a pivotal role in CD40 dependent activation of chronic B lymphocytic leukemia cells.

Claesson HE; Runarsson G; Liu AQ; Mahshid Y; Feltenmark S; Klein E; Bjorkholm M
Review: JOURNAL OF INTERNAL MEDICINE. 1999;245(3):205-227

Asthma and leukotrienes: antileukotrienes as novel anti-asthmatic drugs.

Claesson HE; Dahlén SE
Conference publication: BLOOD. 1996;88(10):2254

Expression of enzymes involved in the synthesis of prostaglandins and leukotrienes in peripheral blood stem cells and in blasts of patients with acute myeloid leukemia (AML)

Claesson HE; Runarsson G; Feltenmark S; Larsson P; Bjorkholm M
Conference publication: BRITISH JOURNAL OF HAEMATOLOGY. 1996;93:163

Expression of enzymes involved in the synthesis of prostaglandins and leukotrienes in peripheral blood stem cells and in blasts of patients with acute myeloid leukemia

Runarsson G; Feltenmark S; Larsson P; Bjorkholm M; Claesson HE
Review: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:293-298

The 5-lipoxygenase pathway in normal and malignant human B lymphocytes.

Jakobsson PJ; Larsson P; Feltenmark S; Odlander B; Runarsson G; Björkholm M; Claesson HE
Conference publication: BLOOD. 1994;84(10):A565

DIVERSE EXPRESSION OF CYTOSOLIC PHOSPHOLIPASE-A(2), 5-LIPOXYGENASE AND PROSTAGLANDIN-H SYNTHASE-2 IN ACUTE PRE B LYMPHOCYTIC-LEUKEMIA CELLS

CLAESSON HE; FELTENMARK S; LARSSON P; JAKOBSSON PJ; RUNARSSON G; BJORKHOLM M
Book chapter: EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION AND RADIATION INJURY. 1993;p. 31-34

Studies on Expression and Regulation of 5-Lipoxygenase in Human B Lymphocytes

Jakobsson P-J; Odlander B; Steinhilber D; Rosen A; Claesson H-E; Samuelsson B
Book chapter: EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER AND RADIATION INJURY. 1991;p. 313-317

Mitogenic Effects of Eicosanoids in Human Airway Epithelial Cells

Leikauf GD; Claesson H-E; Doupnik CA; Grafstrom RG
Conference publication: PROSTAGLANDINS. 1977;13(6):1009

BIOLOGICAL-ACTIVITIES OF 13,14-DEHYDROPROSTACYCLIN METHYL-ESTER

MALMSTEN C; CLAESSON HE; HAMMARSTROM S; FRIED J; BARTON J
Conference publication: FASEB JOURNAL. 1977;36(3):673

EFFECTS OF ENDOGENOUS PROSTAGLANDIN-E-2 PRODUCTION ON CELLULAR CAMP LEVELS IN TRANSFORMED 3T3 FIBROBLASTS

HAMMARSTROM S; LINDGREN JA; CLAESSON HE; GOLDYNE ME
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