Gunnar Schulte

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Om mig

Gunnar Schulte leder forskargruppen inom receptorbiologi och signalering vid institutionen för fysiologi och farmakologi. I februari 2017 utnämndes han till professor i receptorfarmakologi vid Karolinska Institutet.

Artiklar

Journal article: TRENDS IN PHARMACOLOGICAL SCIENCES. 2024;:S0165-6147(24)00051-8

Frizzleds act as dynamic pharmacological entities.

Schulte G; Scharf MM; Bous J; Voss JH; Grätz L; Kozielewicz P
Article: CELL REPORTS. 2024;43(2):113727

Structural and functional insight into the interaction of Clostridioides difficile toxin B and FZD7.

Kinsolving J; Bous J; Kozielewicz P; Košenina S; Shekhani R; Grätz L; Masuyer G; Wang Y; Stenmark P; Dong M; Schulte G
Article: HEPATOLOGY. 2023

Wnt/β-catenin and NFκB signaling synergize to trigger growth factor-free regeneration of adult primary human hepatocytes.

Oliva-Vilarnau N; Beusch CM; Sabatier P; Sakaraki E; Tjaden A; Graetz L; Büttner FA; Dorotea D; Nguyen M; Bergqvist F; Sundström Y; Müller S; Zubarev RA; Schulte G; Tredup C; Gramignoli R; Tietge UJF; Lauschke VM
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180 Suppl 2:S23-S144

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Alexander SPH; Christopoulos A; Davenport AP; Kelly E; Mathie AA; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Davies JA; Abbracchio MP; Abraham G; Agoulnik A; Alexander W; Al-Hosaini K; Bäck M; Baker JG; Barnes NM; Bathgate R; Beaulieu J-M; Beck-Sickinger AG; Behrens M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Bräuner-Osborne H; Burnstock G; Caló G; Castaño JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Cox HM; Csaba Z; Dahlgren C; Dent G; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; Garelja ML; de Gasparo M; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Grätz L; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Herr D; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Larhammar D; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Lolait SJ; Lupp A; Macrae R; Maguire J; Malfacini D; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Müller CE; Murphy PM; Nahon J-L; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schöneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Singh KD; Smith CM; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PBMWM; Tirupula K; Toll L; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Williams TL; Woodruff TM; Yao C; Ye RD
Article: NATURE COMMUNICATIONS. 2023;14(1):4573

Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.

Grätz L; Kowalski-Jahn M; Scharf MM; Kozielewicz P; Jahn M; Bous J; Lambert NA; Gloriam DE; Schulte G
Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2023;2023(1)

Class Frizzled GPCRs in GtoPdb v.2023.1

Arthofer E; Dijksterhuis J; Grätz L; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023

NanoBiT- and NanoBiT/BRET-based assays allow the analysis of binding kinetics of Wnt-3a to endogenous Frizzled 7 in a colorectal cancer model.

Grätz L; Sajkowska-Kozielewicz JJ; Wesslowski J; Kinsolving J; Bridge LJ; Petzold K; Davidson G; Schulte G; Kozielewicz P
Article: SCIENCE SIGNALING. 2023;16(779):eabo4974

WNT stimulation induces dynamic conformational changes in the Frizzled-Dishevelled interaction.

Bowin C-F; Kozielewicz P; Grätz L; Kowalski-Jahn M; Schihada H; Schulte G
Article: METHODS IN MOLECULAR BIOLOGY. 2023;2676:201-213

Conformational GPCR BRET Sensors Based on Bioorthogonal Labeling of Noncanonical Amino Acids.

Kowalski-Jahn M; Schihada H; Schulte G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(9):102328

Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias.

Schihada H; Klompstra TM; Humphrys LJ; Cervenka I; Dadvar S; Kolb P; Ruas JL; Schulte G
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2374:195-204

NanoBRET and NanoBiT/BRET-Based Ligand Binding Assays Permit Quantitative Assessment of Small Molecule Ligand Binding to Smoothened.

Kozielewicz P; Schulte G
Article: SCIENCE ADVANCES. 2021;7(46):eabj7917

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain.

Kowalski-Jahn M; Schihada H; Turku A; Huber T; Sakmar TP; Schulte G
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178 Suppl 1:S27-S156

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.

Alexander SP; Christopoulos A; Davenport AP; Kelly E; Mathie A; Peters JA; Veale EL; Armstrong JF; Faccenda E; Harding SD; Pawson AJ; Southan C; Davies JA; Abbracchio MP; Alexander W; Al-Hosaini K; Bäck M; Barnes NM; Bathgate R; Beaulieu J-M; Bernstein KE; Bettler B; Birdsall NJM; Blaho V; Boulay F; Bousquet C; Bräuner-Osborne H; Burnstock G; Caló G; Castaño JP; Catt KJ; Ceruti S; Chazot P; Chiang N; Chini B; Chun J; Cianciulli A; Civelli O; Clapp LH; Couture R; Csaba Z; Dahlgren C; Dent G; Singh KD; Douglas SD; Dournaud P; Eguchi S; Escher E; Filardo EJ; Fong T; Fumagalli M; Gainetdinov RR; Gasparo MD; Gerard C; Gershengorn M; Gobeil F; Goodfriend TL; Goudet C; Gregory KJ; Gundlach AL; Hamann J; Hanson J; Hauger RL; Hay DL; Heinemann A; Hollenberg MD; Holliday ND; Horiuchi M; Hoyer D; Hunyady L; Husain A; IJzerman AP; Inagami T; Jacobson KA; Jensen RT; Jockers R; Jonnalagadda D; Karnik S; Kaupmann K; Kemp J; Kennedy C; Kihara Y; Kitazawa T; Kozielewicz P; Kreienkamp H-J; Kukkonen JP; Langenhan T; Leach K; Lecca D; Lee JD; Leeman SE; Leprince J; Li XX; Williams TL; Lolait SJ; Lupp A; Macrae R; Maguire J; Mazella J; McArdle CA; Melmed S; Michel MC; Miller LJ; Mitolo V; Mouillac B; Müller CE; Murphy P; Nahon J-L; Ngo T; Norel X; Nyimanu D; O'Carroll A-M; Offermanns S; Panaro MA; Parmentier M; Pertwee RG; Pin J-P; Prossnitz ER; Quinn M; Ramachandran R; Ray M; Reinscheid RK; Rondard P; Rovati GE; Ruzza C; Sanger GJ; Schöneberg T; Schulte G; Schulz S; Segaloff DL; Serhan CN; Stoddart LA; Sugimoto Y; Summers R; Tan VP; Thal D; Thomas WW; Timmermans PBMWM; Tirupula K; Tulipano G; Unal H; Unger T; Valant C; Vanderheyden P; Vaudry D; Vaudry H; Vilardaga J-P; Walker CS; Wang JM; Ward DT; Wester H-J; Willars GB; Woodruff TM; Yao C; Ye RD
Article: SCIENCE SIGNALING. 2021;14(699):eabf1653

Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors.

Schihada H; Shekhani R; Schulte G
Article: SCIENCE ADVANCES. 2021;7(36):eabi6856

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine.

Zhou Y; Arribas GH; Turku A; Jürgenson T; Mkrtchian S; Krebs K; Wang Y; Svobodova B; Milani L; Schulte G; Korabecny J; Gastaldello S; Lauschke VM
Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2021;2021(3)

Class Frizzled GPCRs in GtoPdb v.2021.3

Arthofer E; Dijksterhuis J; Hot B; Kozielewicz P; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
Article: NATURE COMMUNICATIONS. 2021;12(1):3919

Residue 6.43 defines receptor function in class F GPCRs.

Turku A; Schihada H; Kozielewicz P; Bowin C-F; Schulte G
Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2021;4(3):1235-1245

Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments.

Kozielewicz P; Shekhani R; Moser S; Bowin C-F; Wesslowski J; Davidson G; Schulte G
Article: BIOSENSORS & BIOELECTRONICS. 2021;177:112948

Deconvolution of WNT-induced Frizzled conformational dynamics with fluorescent biosensors.

Schihada H; Kowalski-Jahn M; Turku A; Schulte G
Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;269:101-115

Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation.

Kozielewicz P; Schihada H; Schulte G
Article: ACS SENSORS. 2020;5(6):1734-1742

Development of a Conformational Histamine H3 Receptor Biosensor for the Synchronous Screening of Agonists and Inverse Agonists.

Schihada H; Ma X; Zabel U; Vischer HF; Schulte G; Leurs R; Pockes S; Lohse MJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(26):8759-8774

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled.

Wesslowski J; Kozielewicz P; Wang X; Cui H; Schihada H; Kranz D; Karuna M P; Levkin P; Gross JC; Boutros M; Schulte G; Davidson G
Article: NATURE COMMUNICATIONS. 2020;11(1):414

Structural insight into small molecule action on Frizzleds.

Kozielewicz P; Turku A; Bowin C-F; Petersen J; Valnohova J; Cañizal MCA; Ono Y; Inoue A; Hoffmann C; Schulte G
Article: MOLECULAR PHARMACOLOGY. 2020;97(1):23-34

A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine.

Kozielewicz P; Bowin C-F; Turku A; Schulte G
Article: CELLS. 2019;8(11):1372

Wnt-3a Induces Cytokine Release in Human Mast Cells.

Tebroke J; Lieverse JE; Säfholm J; Schulte G; Nilsson G; Rönnberg E
Journal article: IUPHAR/BPS GUIDE TO PHARMACOLOGY CITE. 2019;2019(4)

Class Frizzled GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Arthofer E; Dijksterhuis J; Hot B; Kozielewicz PL; Lauth M; Olofsson J; Petersen J; Polonio T; Schulte G; Strakova K; Valnohova J; Wright S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(31):11677-11684

WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins.

Bowin C-F; Inoue A; Schulte G
Article: NATURE COMMUNICATIONS. 2019;10(1):667

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection.

Wright SC; Kozielewicz P; Kowalski-Jahn M; Petersen J; Bowin C-F; Slodkowicz G; Marti-Solano M; Rodríguez D; Hot B; Okashah N; Strakova K; Valnohova J; Babu MM; Lambert NA; Carlsson J; Schulte G
Article: SCIENCE SIGNALING. 2018;11(559):eaar5536

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs.

Wright SC; Cañizal MCA; Benkel T; Simon K; Le Gouill C; Matricon P; Namkung Y; Lukasheva V; König GM; Laporte SA; Carlsson J; Kostenis E; Bouvier M; Schulte G; Hoffmann C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(48):18477-18493

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.

Strakova K; Kowalski-Jahn M; Gybel T; Valnohova J; Dhople VM; Harnos J; Bernatik O; Ganji RS; Zdrahal Z; Mulder J; Lindskog C; Bryja V; Schulte G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2018;293(46):17875-17887

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment.

Valnohova J; Kowalski-Jahn M; Sunahara RK; Schulte G
Article: CELLULAR SIGNALLING. 2017;38:85-96

The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.

Strakova K; Matricon P; Yokota C; Arthofer E; Bernatik O; Rodriguez D; Arenas E; Carlsson J; Bryja V; Schulte G
Article: NATURE COMMUNICATIONS. 2017;8(1):226

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling.

Petersen J; Wright SC; Rodríguez D; Matricon P; Lahav N; Vromen A; Friedler A; Strömqvist J; Wennmalm S; Carlsson J; Schulte G
Article: CELLULAR SIGNALLING. 2017;32:93-103

FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.

Hot B; Valnohova J; Arthofer E; Simon K; Shin J; Uhlén M; Kostenis E; Mulder J; Schulte G
Article: MOLECULAR PHARMACOLOGY. 2016;90(4):447-459

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

Arthofer E; Hot B; Petersen J; Strakova K; Jäger S; Grundmann M; Kostenis E; Gutkind JS; Schulte G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(33):9304-9309

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins.

Cervenka I; Valnohova J; Bernatik O; Harnos J; Radsetoulal M; Sedova K; Hanakova K; Potesil D; Sedlackova M; Salasova A; Steinhart Z; Angers S; Schulte G; Hampl A; Zdrahal Z; Bryja V
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2016;310(3):R297-R304

CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.

Strömberg A; Olsson K; Dijksterhuis JP; Rullman E; Schulte G; Gustafsson T
Article: EXPERIMENTAL CELL RESEARCH. 2015;339(2):280-288

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.

Dijksterhuis JP; Arthofer E; Marinescu VD; Nelander S; Uhlén M; Pontén F; Mulder J; Schulte G
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2015;763(Pt B):191-195

Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics.

Schulte G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(11):6789-6798

Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.

Dijksterhuis JP; Baljinnyam B; Stanger K; Sercan HO; Ji Y; Andres O; Rubin JS; Hannoush RN; Schulte G
Article: CELL COMMUNICATION AND SIGNALING. 2015;13:2

Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.

Kaucká M; Petersen J; Janovská P; Radaszkiewicz T; Smyčková L; Daulat AM; Borg J-P; Schulte G; Bryja V
Article: CELLULAR SIGNALLING. 2014;26(9):1943-1949

Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity.

Kilander MBC; Dahlström J; Schulte G
Article: MOLECULAR PSYCHIATRY. 2014;19(6):733-741

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.

Persson A; Sim SC; Virding S; Onishchenko N; Schulte G; Ingelman-Sundberg M
Article: FASEB JOURNAL. 2014;28(5):2293-2305

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

Kilander MBC; Petersen J; Andressen KW; Ganji RS; Levy FO; Schuster J; Dahl N; Bryja V; Schulte G
Article: ACTA PHYSIOLOGICA. 2014;210(3):590-599

Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors.

Yang J; Zheng X; Haugen F; Darè E; Lövdahl C; Schulte G; Fredholm BB; Valen G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(2):1128-1141

β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

Kríz V; Pospíchalová V; Masek J; Kilander MBC; Slavík J; Tanneberger K; Schulte G; Machala M; Kozubík A; Behrens J; Bryja V
Article: JOURNAL OF NEUROCHEMISTRY. 2013;125(6):803-808

WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia.

Halleskog C; Schulte G
Article: CELLULAR SIGNALLING. 2013;25(4):822-828

Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.

Halleskog C; Schulte G
Journal article: EUROPEAN JOURNAL OF ANAESTHESIOLOGY, SUPPLEMENT. 2012;29:144

Effects of sevoflurane exposure on muscarinic acetylcholine receptor gene expression, protein amount and cellular localization

Wiklund A; Gustavsson D; Ebberyd A; Fagerlund MJ; Eriksson LI; Schulte G
Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:111

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation.

Halleskog C; Dijksterhuis JP; Kilander MBC; Becerril-Ortega J; Villaescusa JC; Lindgren E; Arenas E; Schulte G
Article: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2012;56(5):608-615

Prolonged attenuation of acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 following sevoflurane exposure.

Wiklund A; Gustavsson D; Ebberyd A; Sundman E; Schulte G; Jonsson Fagerlund M; Eriksson LI
Article: ACTA PHYSIOLOGICA. 2011;203(3):363-372

Recombinant WNTs differentially activate β-catenin-dependent and -independent signalling in mouse microglia-like cells.

Kilander MBC; Halleskog C; Schulte G
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2011;88(6):852-860

Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.

Fröjmark A-S; Schuster J; Sobol M; Entesarian M; Kilander MBC; Gabrikova D; Nawaz S; Baig SM; Schulte G; Klar J; Dahl N
Article: EMBO JOURNAL. 2011;30(8):1433-1443

Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.

Tanneberger K; Pfister AS; Brauburger K; Schneikert J; Hadjihannas MV; Kriz V; Schulte G; Bryja V; Behrens J
Article: BRAIN. 2011;134(Pt 4):1041-1060

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease.

Mulder J; Zilberter M; Pasquaré SJ; Alpár A; Schulte G; Ferreira SG; Köfalvi A; Martín-Moreno AM; Keimpema E; Tanila H; Watanabe M; Mackie K; Hortobágyi T; de Ceballos ML; Harkany T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(12):10396-10410

Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.

Bernatik O; Ganji RS; Dijksterhuis JP; Konik P; Cervenka I; Polonio T; Krejci P; Schulte G; Bryja V
Article: CELLULAR SIGNALLING. 2011;23(3):550-554

WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.

Kilander MB; Dijksterhuis JP; Ganji RS; Bryja V; Schulte G
Article: MOLECULAR AND CELLULAR BIOLOGY. 2011;31(1):179-189

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

Červenka I; Wolf J; Mašek J; Krejci P; Wilcox WR; Kozubík A; Schulte G; Gutkind JS; Bryja V
Article: GLIA. 2011;59(1):119-131

WNT signaling in activated microglia is proinflammatory.

Halleskog C; Mulder J; Dahlström J; Mackie K; Hortobágyi T; Tanila H; Kumar Puli L; Färber K; Harkany T; Schulte G
Article: ANESTHESIOLOGY. 2010;113(6):1270-1279

The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia.

Fagerlund MJ; Kåhlin J; Ebberyd A; Schulte G; Mkrtchian S; Eriksson LI
Article: NEUROSCIENCE. 2010;170(3):923-928

Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.

Li L; Hao JX; Fredholm BB; Schulte G; Wiesenfeld-Hallin Z; Xu XJ
Journal article: DEVELOPMENT. 2010;137(4):e406

Vang-like protein 2 and Rac1 interact to regulate adherens junctions

Lindqvist M; Horn Z; Bryja V; Schulte G; Papachristou P; Ajima R; Dyberg C; Arenas E; Yamaguchi TP; Lagercrantz H; Ringstedt T
Article: JOURNAL OF CELL SCIENCE. 2010;123(Pt 3):472-483

Vang-like protein 2 and Rac1 interact to regulate adherens junctions.

Lindqvist M; Horn Z; Bryja V; Schulte G; Papachristou P; Ajima R; Dyberg C; Arenas E; Yamaguchi TP; Lagercrantz H; Ringstedt T
Article: EMBO REPORTS. 2008;9(12):1244-1250

Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways.

Bryja V; Schambony A; Cajánek L; Dominguez I; Arenas E; Schulte G
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;590(1-3):36-42

Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.

Brand F; Klutz AM; Jacobson KA; Fredholm BB; Schulte G
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):15-20

Modulation of glial cell functions by adenosine receptors.

Daré E; Schulte G; Karovic O; Hammarberg C; Fredholm BB
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(16):6690-6695

Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.

Bryja V; Gradl D; Schambony A; Arenas E; Schulte G
Article: CELLULAR SIGNALLING. 2007;19(3):610-616

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin.

Bryja V; Schulte G; Arenas E
Article: JOURNAL OF CELL SCIENCE. 2007;120(Pt 4):586-595

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.

Bryja V; Schulte G; Rawal N; Grahn A; Arenas E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(52):19115-19120

Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.

Berghuis P; Dobszay MB; Wang X; Spano S; Ledda F; Sousa KM; Schulte G; Ernfors P; Mackie K; Paratcha G; Hurd YL; Harkany T
Article: EXPERIMENTAL CELL RESEARCH. 2005;305(1):200-213

PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage.

Hemström TH; Joseph B; Schulte G; Lewensohn R; Zhivotovsky B
Article: JOURNAL OF NEUROCHEMISTRY. 2005;92(6):1550-1553

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation.

Schulte G; Bryja V; Rawal N; Castelo-Branco G; Sousa KM; Arenas E
Article: ACTA PHYSIOLOGICA. 2004;182(2):133-143

Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia.

Schulte G; Sommerschild H; Yang J; Tokuno S; Goiny M; Lövdahl C; Johansson B; Fredholm BB; Valen G
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2004;20(5):1290-1306

Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons.

Berghuis P; Dobszay MB; Sousa KM; Schulte G; Mager PP; Härtig W; Görcs TJ; Zilberter Y; Ernfors P; Harkany T
Article: JOURNAL OF NEUROSCIENCE. 2004;24(21):4978-4988

Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3.

Harkany T; Holmgren C; Härtig W; Qureshi T; Chaudhry FA; Storm-Mathisen J; Dobszay MB; Berghuis P; Schulte G; Sousa KM; Fremeau RT; Edwards RH; Mackie K; Ernfors P; Zilberter Y
Article: BIOCHEMICAL PHARMACOLOGY. 2004;67(1):129-134

Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase.

Hammarberg C; Fredholm BB; Schulte G
Article: JOURNAL OF NEUROCHEMISTRY. 2003;86(4):1051-1054

Evidence for functional adenosine A3 receptors in microglia cells.

Hammarberg C; Schulte G; Fredholm BB
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;307(1):180-187

Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells.

Lynge J; Schulte G; Nordsborg N; Fredholm BB; Hellsten Y
Article: NEUROSCIENCE. 2003;121(4):907-916

Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations.

Schulte G; Robertson B; Fredholm BB; DeLander GE; Shortland P; Molander C
Article: BIOCHEMICAL PHARMACOLOGY. 2001;61(4):443-448

Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.

Fredholm BB; Irenius E; Kull B; Schulte G
Article: MOLECULAR PHARMACOLOGY. 2000;58(3):477-482

Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2.

Schulte G; Fredholm BB
Article: EUROPEAN JOURNAL OF PAIN. 1999;3(2):115-129

Effects of sciatic nerve injuries on delta -opioid receptor and substance P immunoreactivities in the superficial dorsal horn of the rat.

Robertson B; Schulte G; Elde R; Grant G
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Alla övriga publikationer

Preprint: RESEARCH SQUARE. 2024

SAG1.3-derived Frizzled-targeting negative allosteric modulators

Schulte G; Grätz L; Turku A; Kozielewicz P; Bowin C-F; Scharf M; Voss J; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; Körber M; Lauschke V; Löber S; Gmeiner P
Review: BRITISH JOURNAL OF PHARMACOLOGY. 2024

The dark sides of the GPCR tree - research progress on understudied GPCRs.

Scharf MM; Humphrys LJ; Berndt S; Di Pizio A; Lehmann J; Liebscher I; Nicoli A; Niv MY; Peri L; Schihada H; Schulte G
Conference publication: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(4):479-480

NanoBiT/BRET assessment of eGFP-WNT-3A binding to FZD₇ in SW480 cells under endogenous promotion

Kozielewicz P; Gratz L; Sajkowska-Kozielewicz J; Moser S; Davidson G; Schulte G
Preprint: BIORXIV. 2022

WNT stimulation induced conformational dynamics in the Frizzled-Dishevelled interaction

Bowin C-F; Kozielewicz P; Grätz L; Kowalski-Jahn M; Schihada H; Schulte G
Preprint: BIORXIV. 2022

Receptor levels determine binding affinity of WNT-3A to Frizzled 7 in a colorectal cancer model

Grätz L; Sajkowska-Kozielewicz J; Wesslowski J; Petzold K; Davidson G; Schulte G; Kozielewicz P
Letter: CELL RESEARCH. 2021;31(12):1311-1314

Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs.

Xu L; Chen B; Schihada H; Wright SC; Turku A; Wu Y; Han G-W; Kowalski-Jahn M; Kozielewicz P; Bowin C-F; Zhang X; Li C; Bouvier M; Schulte G; Xu F
Preprint: BIORXIV. 2021

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

Kowalski-Jahn M; Schihada H; Turku A; Huber T; Sakmar T; Schulte G
Preprint: BIORXIV. 2021

Quantitative assessment of constitutive G protein-coupled receptor activity with BRET-based G protein biosensors

Schihada H; Shekhani R; Schulte G
Review: BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY. 2020;126 Suppl 6:17-24

Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?

Schulte G; Kozielewicz P
Review: MOLECULAR PHARMACOLOGY. 2020;97(2):62-71

Molecular Pharmacology of Class F Receptor Activation.

Kozielewicz P; Turku A; Schulte G
Preprint: BIORXIV. 2019

A NanoBRET-based binding assay for Smoothened allows real time analysis of small-molecule ligand binding and distinction of two separate ligand binding sites for BODIPY-cyclopamine

Kozielewicz P; Bowin C-F; Schulte G
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2018;39(9):828-842

Frizzleds as GPCRs - More Conventional Than We Thought!

Schulte G; Wright SC
Editorial comment: BRITISH JOURNAL OF PHARMACOLOGY. 2017;174(24):4543-4546

WNT signalling: mechanisms and therapeutic opportunities.

Schulte G; Bryja V
Conference publication: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2017;390:S28

Frizzled as GPCRs: a FRET-based approach to investigate Frizzled 5 receptor activation

Canizal MCA; Valnohova J; Wright S; Proverbio D; Aastrup T; Schulte G; Hoffmann C
Meeting abstract: SPRINGERPLUS. 2015;4(Suppl 1):L50

WNT signaling in microglia and the glioma microenvironment.

Schulte G
Book chapter: WNT SIGNALING IN DEVELOPMENT AND DISEASE. 2014;p. 195-206

Frizzleds as G Protein‐Coupled Receptors

Schulte G
Review: BRITISH JOURNAL OF PHARMACOLOGY. 2014;171(5):1195-1209

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3.

Dijksterhuis JP; Petersen J; Schulte G
Conference publication: JOURNAL OF NEUROCHEMISTRY. 2013;125:232

The human CYP2C19 enzyme influences fetal brain development and adult phenotypes in transgenic mice

Persson A; Sim SC; Virding S; Onishchenko N; Schulte G; Ingelman-Sundberg M
Editorial comment: ACTA PHYSIOLOGICA. 2012;204(1):6-7

19th Acta Physiologica international symposium WNT Signaling in Physiology and Disease'- a long way from developmental biology to physiology

Schulte G; Bryja V; Schambony A
Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(50):19839-19840

β-Arrestin and dishevelled coordinate biased signaling.

Schulte G; Shenoy SK
Conference publication: GLIA. 2011;59:S50

WNTS AS NOVEL PROINFLAMMATORY MODULATORS OF MICROGLIA FUNCTION

Halleskog C; Dijksterhuis J; Eva L; Schulte G
Review: PHARMACOLOGICAL REVIEWS. 2010;62(4):632-667

International Union of Basic and Clinical Pharmacology. LXXX. The class Frizzled receptors.

Schulte G
Book chapter: GPCR MOLECULAR PHARMACOLOGY AND DRUG TARGETING. 2010;p. 113-137

Molecular Pharmacology of Frizzleds—with Implications for Possible Therapy

Schulte G
Review: BRITISH JOURNAL OF PHARMACOLOGY. 2010;159(5):1051-1058

beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

Schulte G; Schambony A; Bryja V
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2007;28(10):518-525

The Frizzled family of unconventional G-protein-coupled receptors.

Schulte G; Bryja V
Editorial comment: ACTA PHYSIOLOGICA. 2007;190(1):1

A Nordic meeting on G-protein-coupled receptors: from molecular aspects to novel therapy.

Schulte G; Fredholm B
Published conference paper: ACTA PHYSIOLOGICA. 2007;190(1):55-61

Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation.

Bryja V; Cajánek L; Grahn A; Schulte G
Published conference paper: ACTA PHYSIOLOGICA. 2007;190(1):33-38

Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity.

Schulte G; Levy FO
Book chapter: ADENOSINE RECEPTORS. 2006;p. 143-155

Adenosine, Adenosine Receptors, and the Regulation of Glial Cells in Neuronal Damage

Fredholm B; Schulte G; Färber K; Daré E
Conference publication: MECHANISMS OF DEVELOPMENT. 2005;122:S136

Regulation of midbrain dopaminergic neurogenesis by Wnts

Arenas E; Castelo-Branco G; Parish C; Sousa K; Hall A; Brija V; Schulte G; Rawal N; Kele J; Sousa S; Salto C
Published conference paper: EXPERIMENTAL CELL RESEARCH. 2003;290(1):168-176

The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.

Schulte G; Fredholm BB
Review: CELLULAR SIGNALLING. 2003;15(9):813-827

Signalling from adenosine receptors to mitogen-activated protein kinases.

Schulte G; Fredholm BB
Published conference paper: DRUG DEVELOPMENT RESEARCH. 2003;58(4):350-353

Consequences of eliminating adenosine A₁ receptors in mice

Fredholm BB; Halldner L; Johansson C; Schulte G; Lövdahl C; Thorén P; Dunwiddie TV; Masino SA; Poelchen W; Diao LH; Illes P; Zahniser NR; Valen G; Tokuno S; Sommerschild H; Giménez-Llort L; Fernández-Teruel A; Escorihuela RM; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Herlenius E; Pekny S; Gebré-Medhin S; Brown R; Ollerstam A; Persson AEG; Skott O; Johansson B
Published conference paper: MOLECULAR PHARMACOLOGY. 2002;62(5):1137-1146

Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.

Schulte G; Fredholm BB
Meeting abstract: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2002;34(6):A59

A1 receptors mediate delayed remote preconditioning, possible involvement of MAPK

Sommershild HT; Fredholm BB; Schulte G; Jägerbrink T; Lövdahl C; Tokuno S; Valen G
Published conference paper: CELLULAR SIGNALLING. 2002;14(2):109-113

Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists.

Schulte G; Fredholm BB
Conference publication: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 2002;29(8):A88

In a model of delayed remote preconditioning the adenosine A1 receptor mediates protection, without change in MAP kinase signalling

Sommerschild HT; Schulte G; Tokuno S; Lövdahl C; Fredholm BB; Valen BB
Published conference paper: DRUG DEVELOPMENT RESEARCH. 2001;52(1-2):274-282

Adenosine receptor signaling in vitro and in vivo

Fredholm BB; Arslan G; Halldner L; Kull B; Schulte G; Ådén U; Svenningsson P
Review: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2000;362(4-5):364-374

Structure and function of adenosine receptors and their genes.

Fredholm BB; Arslan G; Halldner L; Kull B; Schulte G; Wasserman W
Conference publication: NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 1998;358(1):R123

Activation of protein kinase C increases NECA induced cyclic AMP production in Chinese hamster ovary cells stably transfected with the human adenosine A_2A or A_2B receptor

Schulte G; Fredholm BB
Visa fler

Forskningsbidrag

Integration of two concepts in WNT signalling: Signalosome formation and Frizzled conformational dynamics

Deutsche Forschungsgemeinschaft

1 January 2023
Development of novel molecular tools for FZDs

Deutsche Forschungsgemeinschaft

1 January 2022
In silico prediction of small molecule ligands for class Frizzled GPCRs and investigation of the structural basis of FZD signalling

Deutsche Forschungsgemeinschaft

1 January 2021
Receptor pharmacology as a tool to develop new drugs

Swedish Research Council

1 January 2020 - 31 December 2024
Activation mechanisms of Class F GPCRs – from structural understanding to novel therapeutics

Deutsche Forschungsgemeinschaft

1 January 2019 - 31 December 2021
WNT / Frizzled signals - a new target for cancer treatment

Swedish Cancer Society

1 January 2018
WNT/Frizzled communication as a druggable endocrine signalling system

Novo Nordisk Foundation

1 October 2017 - 1 October 2020
WNT / Frizzled signals - a new target for cancer treatment

Swedish Cancer Society

1 January 2017
The role of receptor complex composition and dynamics for signal specification and initiation in the WNT/Frizzled pathway

Deutsche Forschungsgemeinschaft

1 January 2016 - 31 December 2020
Cell-cell communication in brain tumors is important for tumor induction, maintenance and spreading

Swedish Cancer Society

1 January 2016
Mechanisms of signal intitiation through Class Frizzled receptors

Swedish Research Council

1 January 2016 - 31 December 2019
Cell-cell communication in brain tumors is important for tumor induction, maintenance and spreading

Swedish Cancer Society

1 January 2015
Cell-cell communication in brain tumors is important for tumor induction, maintenance and spreading

Swedish Cancer Society

1 January 2014
Posttranslational modification of cell surface receptors as a means of defining signaling

Czech Science Foundation

2 January 2013 - 31 December 2015
Frizzleds - from receptor biology and pharmacology to a novel quaternary receptor model

Swedish Research Council

1 January 2012 - 31 December 2014
European WNT meeting 2010 "WNT Signaling in Physiology and Disease"

Swedish Research Council

1 July 2010 - 31 December 2010

Anställningar

Professor, Fysiologi och farmakologi, Karolinska Institutet, 2017-

Examina och utbildning

Docent, Farmakologi, Karolinska Institutet, 2008
MEDICINE DOKTORSEXAMEN, Institutionen för fysiologi och farmakologi, Karolinska Institutet, 2002

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