Funda Orhan

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;117:313-319

Lower complement C1q levels in first-episode psychosis and in schizophrenia.

Koskuvi M; Malwade S; Gracias Lekander J; Hörbeck E; Bruno S; Holmen Larsson J; Pelanis A; Isgren A; Goulding A; Fatouros-Bergman H; Samudyata; Schalling M; Piehl F; Erhardt S; Landen M; Cervenka S; Orhan F; Sellgren CM
Article: BRAIN BEHAVIOR AND IMMUNITY. 2023;111:376-385

Immunological protein profiling of first-episode psychosis patients identifies CSF and blood biomarkers correlating with disease severity.

Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Article: SCHIZOPHRENIA RESEARCH. 2023;257:34-40

CSF dopamine is elevated in first-episode psychosis and associates to symptom severity and cognitive performance.

Orhan F; Goiny M; Becklén M; Mathé L; Piehl F; Schwieler L; Fatouros-Bergman H; Farde L; Cervenka S; Sellgren CM; Engberg G; Erhardt S
Article: NATURE COMMUNICATIONS. 2022;13(1):6427

Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia.

Gracias J; Orhan F; Hörbeck E; Holmén-Larsson J; Khanlarkani N; Malwade S; Goparaju SK; Schwieler L; Demirel İŞ; Fu T; Fatourus-Bergman H; Pelanis A; Goold CP; Goulding A; Annerbrink K; Isgren A; Sparding T; Schalling M; Yañez VAC; Göpfert JC; Nilsson J; Brinkmalm A; Blennow K; Zetterberg H; Engberg G; Piehl F; Sheridan SD; Perlis RH; Cervenka S; Erhardt S; Landen M; Sellgren CM
Article: MOLECULAR PSYCHIATRY. 2022;27(10):3939-3950

SARS-CoV-2 promotes microglial synapse elimination in human brain organoids.

Samudyata; Oliveira AO; Malwade S; Rufino de Sousa N; Goparaju SK; Gracias J; Orhan F; Steponaviciute L; Schalling M; Sheridan SD; Perlis RH; Rothfuchs AG; Sellgren CM
Article: TRANSLATIONAL PSYCHIATRY. 2022;12(1):229

Identification of cerebrospinal fluid and serum metabolomic biomarkers in first episode psychosis patients.

Shang P; Ho AM-C; Tufvesson-Alm M; Lindberg DR; Grant CW; Orhan F; Eren F; Bhat M; Engberg G; Schwieler L; Fatouros-Bergman H; Imbeault S; Iverson RM; Dasari S; Piehl F; Cervenka S; Sellgren CM; Erhardt S; Choi D-S
Article: BRAIN AND BEHAVIOR. 2022;12(1):e2472

Serum concentration of zinc is elevated in clinically stable bipolar disorder patients.

Jonsson BH; Orhan F; Bruno S; Oliveira AO; Sparding T; Landen M; Sellgren CM
Article: MOLECULAR PSYCHIATRY. 2021;26(11):6820-6832

GRK3 deficiency elicits brain immune activation and psychosis.

Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hökfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landén M; Engberg G; Erhardt S
Article: SCIENTIFIC REPORTS. 2021;11(1):7527

Plasma bilirubin levels are reduced in first-episode psychosis patients and associates to working memory and duration of untreated psychosis.

Becklén M; Orhan F; Piehl F; Cervenka S; Sellgren CM; Flyckt L; Erhardt S; Fatouros-Bergman H
Article: NATURE COMMUNICATIONS. 2020;11(1):4016

The genetic architecture of human brainstem structures and their involvement in common brain disorders.

Elvsåshagen T; Bahrami S; van der Meer D; Agartz I; Alnæs D; Barch DM; Baur-Streubel R; Bertolino A; Beyer MK; Blasi G; Borgwardt S; Boye B; Buitelaar J; Bøen E; Celius EG; Cervenka S; Conzelmann A; Coynel D; Di Carlo P; Djurovic S; Eisenacher S; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Gelao B; Harbo HF; Hartman CA; Håberg A; Heslenfeld D; Hoekstra PJ; Høgestøl EA; Jonassen R; Jönsson EG; Karolinska Schizophrenia Project (KaSP) consortium; Kirsch P; Kłoszewska I; Lagerberg TV; Landrø NI; Le Hellard S; Lesch K-P; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Nordvik JE; Nyberg L; Connell KSO; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; de Quervain D; Reif A; Rokicki J; van Rooij D; Shadrin AA; Schmidt A; Schwarz E; Selbæk G; Soininen H; Sowa P; Steen VM; Tsolaki M; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT; Kaufmann T
Article: NATURE NEUROSCIENCE. 2019;22(10):1617-1623

Common brain disorders are associated with heritable patterns of apparent aging of the brain.

Kaufmann T; van der Meer D; Doan NT; Schwarz E; Lund MJ; Agartz I; Alnæs D; Barch DM; Baur-Streubel R; Bertolino A; Bettella F; Beyer MK; Bøen E; Borgwardt S; Brandt CL; Buitelaar J; Celius EG; Cervenka S; Conzelmann A; Córdova-Palomera A; Dale AM; de Quervain DJF; Di Carlo P; Djurovic S; Dørum ES; Eisenacher S; Elvsåshagen T; Espeseth T; Fatouros-Bergman H; Flyckt L; Franke B; Frei O; Haatveit B; Håberg AK; Harbo HF; Hartman CA; Heslenfeld D; Hoekstra PJ; Høgestøl EA; Jernigan TL; Jonassen R; Jönsson EG; Karolinska Schizophrenia Project (KaSP); Kirsch P; Kłoszewska I; Kolskår KK; Landrø NI; Le Hellard S; Lesch K-P; Lovestone S; Lundervold A; Lundervold AJ; Maglanoc LA; Malt UF; Mecocci P; Melle I; Meyer-Lindenberg A; Moberget T; Norbom LB; Nordvik JE; Nyberg L; Oosterlaan J; Papalino M; Papassotiropoulos A; Pauli P; Pergola G; Persson K; Richard G; Rokicki J; Sanders A-M; Selbæk G; Shadrin AA; Smeland OB; Soininen H; Sowa P; Steen VM; Tsolaki M; Ulrichsen KM; Vellas B; Wang L; Westman E; Ziegler GC; Zink M; Andreassen OA; Westlye LT
Article: SCHIZOPHRENIA RESEARCH. 2019;210:221-227

Increased peripheral levels of TARC/CCL17 in first episode psychosis patients.

Malmqvist A; Schwieler L; Orhan F; Fatouros-Bergman H; Bauer M; Flyckt L; Cervenka S; Engberg G; Piehl F; Karolinska Schizophrenia Project (KaSP) consortium; Erhardt S
Article: JAMA PSYCHIATRY. 2019;76(7):739-748

Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.

Alnæs D; Kaufmann T; van der Meer D; Córdova-Palomera A; Rokicki J; Moberget T; Bettella F; Agartz I; Barch DM; Bertolino A; Brandt CL; Cervenka S; Djurovic S; Doan NT; Eisenacher S; Fatouros-Bergman H; Flyckt L; Di Giorgio A; Haatveit B; Jönsson EG; Kirsch P; Lund MJ; Meyer-Lindenberg A; Pergola G; Schwarz E; Smeland OB; Quarto T; Zink M; Andreassen OA; Westlye LT; Karolinska Schizophrenia Project Consortium
Article: TRANSLATIONAL PSYCHIATRY. 2019;9(1):12

Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder.

Schwarz E; Doan NT; Pergola G; Westlye LT; Kaufmann T; Wolfers T; Brecheisen R; Quarto T; Ing AJ; Di Carlo P; Gurholt TP; Harms RL; Noirhomme Q; Moberget T; Agartz I; Andreassen OA; Bellani M; Bertolino A; Blasi G; Brambilla P; Buitelaar JK; Cervenka S; Flyckt L; Frangou S; Franke B; Hall J; Heslenfeld DJ; Kirsch P; McIntosh AM; Nöthen MM; Papassotiropoulos A; de Quervain DJ-F; Rietschel M; Schumann G; Tost H; Witt SH; Zink M; Meyer-Lindenberg A; IMAGEMEND Consortium, Karolinska Schizophrenia Pro
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2018;138(5):432-440

Increased number of monocytes and plasma levels of MCP-1 and YKL-40 in first-episode psychosis.

Orhan F; Schwieler L; Fatouros-Bergman H; Malmqvist A; Cervenka S; Collste K; Flyckt L; Farde L; Sellgren CM; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Engberg G; Erhardt S
Article: BIOLOGICAL PSYCHIATRY. 2018;84(9):644-654

Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.

van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Bustillo JR; Clark VP; Agartz I; Mueller BA; Cahn W; de Zwarte SMC; Hulshoff Pol HE; Kahn RS; Ophoff RA; van Haren NEM; Andreassen OA; Dale AM; Doan NT; Gurholt TP; Hartberg CB; Haukvik UK; Jørgensen KN; Lagerberg TV; Melle I; Westlye LT; Gruber O; Kraemer B; Richter A; Zilles D; Calhoun VD; Crespo-Facorro B; Roiz-Santiañez R; Tordesillas-Gutiérrez D; Loughland C; Carr VJ; Catts S; Cropley VL; Fullerton JM; Green MJ; Henskens FA; Jablensky A; Lenroot RK; Mowry BJ; Michie PT; Pantelis C; Quidé Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Shannon Weickert C; Weickert TW; Morris DW; Hong E; Kochunov P; Beard LM; Gur RE; Gur RC; Satterthwaite TD; Wolf DH; Belger A; Brown GG; Ford JM; Macciardi F; Mathalon DH; O'Leary DS; Potkin SG; Preda A; Voyvodic J; Lim KO; McEwen S; Yang F; Tan Y; Tan S; Wang Z; Fan F; Chen J; Xiang H; Tang S; Guo H; Wan P; Wei D; Bockholt HJ; Ehrlich S; Wolthusen RPF; King MD; Shoemaker JM; Sponheim SR; De Haan L; Koenders L; Machielsen MW; van Amelsvoort T; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; McKenna PJ; Pomarol-Clotet E; Salvador R; Corvin A; Donohoe G; Kelly S; Whelan CD; Dickie EW; Rotenberg D; Voineskos AN; Ciufolini S; Radua J; Dazzan P; Murray R; Reis Marques T; Simmons A; Borgwardt S; Egloff L; Harrisberger F; Riecher-Rössler A; Smieskova R; Alpert KI; Wang L; Jönsson EG; Koops S; Sommer IEC; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Stephen JM; Kwon JS; Yun J-Y; Cannon DM; McDonald C; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Karolinska Schizophrenia Project; Busatto GF; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; Hagenaars SP; McIntosh AM; Whalley HC; Lawrie SM; Knöchel C; Oertel-Knöchel V; Stäblein M; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; McMahon A; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA
Article: MOLECULAR PSYCHIATRY. 2018;23(5):1244-1250

CSF GABA is reduced in first-episode psychosis and associates to symptom severity.

Orhan F; Fatouros-Bergman H; Goiny M; Malmqvist A; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Cervenka S; Collste K; Victorsson P; Sellgren CM; Flyckt L; Erhardt S; Engberg G
Article: PSYCHOLOGICAL MEDICINE. 2018;48(1):82-94

Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium.

Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santiañez R; Crespo-Facorro B; Suarez-Pinilla P; van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jørgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Morch-Johnsen L; Færden A; Flyckt L; Fatouros-Bergman H; Karolinska Schizophrenia Project Consortium (KaSP); Jönsson EG; Hashimoto R; Yamamori H; Fukunaga M; Jahanshad N; De Rossi P; Piras F; Banaj N; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Krämer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: MOLECULAR PSYCHIATRY. 2017;22(6):850-856

Lower levels of the glial cell marker TSPO in drug-naive first-episode psychosis patients as measured using PET and [11C]PBR28.

Collste K; Plavén-Sigray P; Fatouros-Bergman H; Victorsson P; Schain M; Forsberg A; Amini N; Aeinehband S; Karolinska Schizophrenia Project (KaSP) consortium; Erhardt S; Halldin C; Flyckt L; Farde L; Cervenka S
Article: ACTA PSYCHIATRICA SCANDINAVICA. 2017;135(5):439-447

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.

Walton E; Hibar DP; van Erp TGM; Potkin SG; Roiz-Santiañez R; Crespo-Facorro B; Suarez-Pinilla P; Van Haren NEM; de Zwarte SMC; Kahn RS; Cahn W; Doan NT; Jørgensen KN; Gurholt TP; Agartz I; Andreassen OA; Westlye LT; Melle I; Berg AO; Mørch-Johnsen L; Faerden A; Flyckt L; Fatouros-Bergman H; Karolinska Schizophrenia Project Consortium (KaSP); Jönsson EG; Hashimoto R; Yamamori H; Fukunaga M; Preda A; De Rossi P; Piras F; Banaj N; Ciullo V; Spalletta G; Gur RE; Gur RC; Wolf DH; Satterthwaite TD; Beard LM; Sommer IE; Koops S; Gruber O; Richter A; Krämer B; Kelly S; Donohoe G; McDonald C; Cannon DM; Corvin A; Gill M; Di Giorgio A; Bertolino A; Lawrie S; Nickson T; Whalley HC; Neilson E; Calhoun VD; Thompson PM; Turner JA; Ehrlich S
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;84(5):262-271

Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.

Orhan F; Bhat M; Sandberg K; Ståhl S; Piehl F; Karolinska Schizophrenia Project (KaSP) consortium; Svensson C; Erhardt S; Schwieler L
Article: NEUROCHEMICAL RESEARCH. 2016;41(9):2243-2255

Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.

Larsson MK; Faka A; Bhat M; Imbeault S; Goiny M; Orhan F; Oliveros A; Ståhl S; Liu XC; Choi DS; Sandberg K; Engberg G; Schwieler L; Erhardt S
Article: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2015;40(2):126-133

Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway.

Schwieler L; Larsson MK; Skogh E; Kegel ME; Orhan F; Abdelmoaty S; Finn A; Bhat M; Samuelsson M; Lundberg K; Dahl M-L; Sellgren C; Schuppe-Koistinen I; Svensson C; Erhardt S; Engberg G
Article: CELL. 2014;159(1):33-45

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Agudelo LZ; Femenía T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: BRAIN BEHAVIOR AND IMMUNITY. 2014;36:80-89

Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid.

Liu X-C; Holtze M; Powell SB; Terrando N; Larsson MK; Persson A; Olsson SK; Orhan F; Kegel M; Asp L; Goiny M; Schwieler L; Engberg G; Karlsson H; Erhardt S
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2014;7:1-7

Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies.

Wennström M; Nielsen HM; Orhan F; Londos E; Minthon L; Erhardt S
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Letter: BRAIN BEHAVIOR AND IMMUNITY. 2023;114:163-164

Preanalytic handling of clinical blood samples in assessing immunological proteins - Role of storage duration.

Eren F; Schwieler L; Orhan F; Malmqvist A; Piehl F; Cervenka S; Sellgren CM; Fatouros-Bergman H; Engberg G; Erhardt S
Corrigendum: MOLECULAR PSYCHIATRY. 2022;27(3):1855

Correction: GRK3 deficiency elicits brain immune activation and psychosis.

Sellgren CM; Imbeault S; Larsson MK; Oliveros A; Nilsson IAK; Codeluppi S; Orhan F; Bhat M; Tufvesson-Alm M; Gracias J; Kegel ME; Zheng Y; Faka A; Svedberg M; Powell SB; Caldwell S; Kamenski ME; Vawter MP; Schulmann A; Goiny M; Svensson CI; Hökfelt T; Schalling M; Schwieler L; Cervenka S; Choi D-S; Landén M; Engberg G; Erhardt S
Letter: SCHIZOPHRENIA RESEARCH. 2019;208:490-492

Neurogranin as a potential synaptic marker in the cerebrospinal fluid of patients with a first episode psychosis.

Santillo AF; Lundgren S; Xu C; Orhan F; Fatouros-Bergman H; Blennow K; Zetterberg H; Portelius E; Karolinska Schizophrenia Project (KaSP) Consortium; Cervenka S; Jönsson EG; Erhardt S; Engberg G
Letter: BIOLOGICAL PSYCHIATRY. 2019;85(7):e35-e39

Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

van Erp TGM; Walton E; Hibar DP; Schmaal L; Jiang W; Glahn DC; Pearlson GD; Yao N; Fukunaga M; Hashimoto R; Okada N; Yamamori H; Clark VP; Mueller BA; de Zwarte SMC; Ophoff RA; van Haren NEM; Andreassen OA; Gurholt TP; Gruber O; Kraemer B; Richter A; Calhoun VD; Crespo-Facorro B; Roiz-Santiañez R; Tordesillas-Gutiérrez D; Loughland C; Catts S; Fullerton JM; Green MJ; Henskens F; Jablensky A; Mowry BJ; Pantelis C; Quidé Y; Schall U; Scott RJ; Cairns MJ; Seal M; Tooney PA; Rasser PE; Cooper G; Shannon Weickert C; Weickert TW; Hong E; Kochunov P; Gur RE; Gur RC; Ford JM; Macciardi F; Mathalon DH; Potkin SG; Preda A; Fan F; Ehrlich S; King MD; De Haan L; Veltman DJ; Assogna F; Banaj N; de Rossi P; Iorio M; Piras F; Spalletta G; Pomarol-Clotet E; Kelly S; Ciufolini S; Radua J; Murray R; Marques TR; Simmons A; Borgwardt S; Schönborn-Harrisberger F; Riecher-Rössler A; Smieskova R; Alpert KI; Bertolino A; Bonvino A; Di Giorgio A; Neilson E; Mayer AR; Yun J-Y; Cannon DM; Lebedeva I; Tomyshev AS; Akhadov T; Kaleda V; Fatouros-Bergman H; Flyckt L; Karolinska Schizophrenia Project; Rosa PGP; Serpa MH; Zanetti MV; Hoschl C; Skoch A; Spaniel F; Tomecek D; McIntosh AM; Whalley HC; Knöchel C; Oertel-Knöchel V; Howells FM; Stein DJ; Temmingh HS; Uhlmann A; Lopez-Jaramillo C; Dima D; Faskowitz JI; Gutman BA; Jahanshad N; Thompson PM; Turner JA
Letter: SCHIZOPHRENIA RESEARCH. 2018;199:438-441

Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients.

Checa A; Malmqvist A; Flyckt L; Schwieler L; Samuelsson M; Skogh E; Cervenka S; Dahl M-L; Piehl F; Karolinska Schizophrenia Project (KaSP) Consortium; Erhardt S; Wheelock CE
Letter: SCHIZOPHRENIA RESEARCH. 2018;195:406-408

First-episode psychosis patients display increased plasma IL-18 that correlates with cognitive dysfunction.

Orhan F; Fatouros-Bergman H; Schwieler L; Cervenka S; Flyckt L; Sellgren CM; Karolinska Schizophrenia Project (KaSP) consortium; Engberg G; Erhardt S
KI thesis / dissertation: 2018

Deciphering the interplay between peripheral and central cytokine- and kynurenine pathways : importance for the pathophysiology of schizophrenia

Orhan, Funda

Anställningar

Biträdande Lektor, Fysiologi och farmakologi, Karolinska Institutet, 2023-2029

Examina och utbildning

Medicine Doktorsexamen, Institutionen för fysiologi och farmakologi, Karolinska Institutet, 2018

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