Felix Grassmann

Om mig
Publikationer
Populärvetenskap och samverkan

Om mig

Please see my personal page in English under
https://staff.ki.se/people/felgra

Artiklar

Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2023;115(11):1310-1317

Prediction of breast cancer risk for sisters of women attending screening.

Mao X; He W; Eriksson M; Lindström LS; Holowko N; Bajalica-Lagercrantz S; Hammarström M; Grassmann F; Humphreys K; Easton D; Hall P; Czene K
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2023;115(9):1020-1028

Risk of estrogen receptor-specific breast cancer by family history of estrogen receptor subtypes and other cancers.

Wang Q-L; Zhang Y; Zeng E; Grassmann F; He W; Czene K
Article: BREAST CANCER RESEARCH. 2023;25(1):93

A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.

Middha P; Wang X; Behrens S; Bolla MK; Wang Q; Dennis J; Michailidou K; Ahearn TU; Andrulis IL; Anton-Culver H; Arndt V; Aronson KJ; Auer PL; Augustinsson A; Baert T; Freeman LEB; Becher H; Beckmann MW; Benitez J; Bojesen SE; Brauch H; Brenner H; Brooks-Wilson A; Campa D; Canzian F; Carracedo A; Castelao JE; Chanock SJ; Chenevix-Trench G; CTS Consortium; Cordina-Duverger E; Couch FJ; Cox A; Cross SS; Czene K; Dossus L; Dugué P-A; Eliassen AH; Eriksson M; Evans DG; Fasching PA; Figueroa JD; Fletcher O; Flyger H; Gabrielson M; Gago-Dominguez M; Giles GG; González-Neira A; Grassmann F; Grundy A; Guénel P; Haiman CA; Håkansson N; Hall P; Hamann U; Hankinson SE; Harkness EF; Holleczek B; Hoppe R; Hopper JL; Houlston RS; Howell A; Hunter DJ; Ingvar C; ABCTB Investigators; kConFab Investigators; Isaksson K; Jernström H; John EM; Jones ME; Kaaks R; Keeman R; Kitahara CM; Ko Y-D; Koutros S; Kurian AW; Lacey JV; Lambrechts D; Larson NL; Larsson S; Le Marchand L; Lejbkowicz F; Li S; Linet M; Lissowska J; Martinez ME; Maurer T; Mulligan AM; Mulot C; Murphy RA; Newman WG; Nielsen SF; Nordestgaard BG; Norman A; O'Brien KM; Olson JE; Patel AV; Prentice R; Rees-Punia E; Rennert G; Rhenius V; Ruddy KJ; Sandler DP; Scott CG; Shah M; Shu X-O; Smeets A; Southey MC; Stone J; Tamimi RM; Taylor JA; Teras LR; Tomczyk K; Troester MA; Truong T; Vachon CM; Wang SS; Weinberg CR; Wildiers H; Willett W; Winham SJ; Wolk A; Yang XR; Zamora MP; Zheng W; Ziogas A; Dunning AM; Pharoah PDP; García-Closas M; Schmidt MK; Kraft P; Milne RL; Lindström S; Easton DF; Chang-Claude J
Article: CANCER MEDICINE. 2023;12(15):16142-16162

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.

Morra A; Schreurs MAC; Andrulis IL; Anton-Culver H; Augustinsson A; Beckmann MW; Behrens S; Bojesen SE; Bolla MK; Brauch H; Broeks A; Buys SS; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chung WK; NBCS Collaborators; Colonna SV; Couch FJ; Cox A; Cross SS; Czene K; Daly MB; Dennis J; Devilee P; Dörk T; Dunning AM; Dwek M; Easton DF; Eccles DM; Eriksson M; Evans DG; Fasching PA; Fehm TN; Figueroa JD; Flyger H; Gabrielson M; Gago-Dominguez M; García-Closas M; García-Sáenz JA; Genkinger J; Grassmann F; Gündert M; Hahnen E; Haiman CA; Hamann U; Harrington PA; Hartikainen JM; Hoppe R; Hopper JL; Houlston RS; Howell A; ABCTB Investigators; kConFab Investigators; Jakubowska A; Janni W; Jernström H; John EM; Johnson N; Jones ME; Kristensen VN; Kurian AW; Lambrechts D; Le Marchand L; Lindblom A; Lubiński J; Lux MP; Mannermaa A; Mavroudis D; Mulligan AM; Muranen TA; Nevanlinna H; Nevelsteen I; Neven P; Newman WG; Obi N; Offit K; Olshan AF; Park-Simon T-W; Patel AV; Peterlongo P; Phillips K-A; Plaseska-Karanfilska D; Polley EC; Presneau N; Pylkäs K; Rack B; Radice P; Rashid MU; Rhenius V; Robson M; Romero A; Saloustros E; Sawyer EJ; Schmutzler RK; Schuetze S; Scott C; Shah M; Smichkoska S; Southey MC; Tapper WJ; Teras LR; Tollenaar RAEM; Tomczyk K; Tomlinson I; Troester MA; Vachon CM; van Veen EM; Wang Q; Wendt C; Wildiers H; Winqvist R; Ziogas A; Hall P; Pharoah PDP; Adank MA; Hollestelle A; Schmidt MK; Hooning MJ
Article: CANCERS. 2023;15(13):3313

Spectrum and Frequency of Germline FANCM Protein-Truncating Variants in 44,803 European Female Breast Cancer Cases.

Figlioli G; Billaud A; Wang Q; Bolla MK; Dennis J; Lush M; Kvist A; Adank MA; Ahearn TU; Antonenkova NN; Auvinen P; Behrens S; Bermisheva M; Bogdanova NV; Bojesen SE; Bonanni B; Brüning T; Camp NJ; Campbell A; Castelao JE; Cessna MH; Nbcs Collaborators; Czene K; Devilee P; Dörk T; Eriksson M; Fasching PA; Flyger H; Gabrielson M; Gago-Dominguez M; García-Closas M; Glendon G; Gómez Garcia EB; González-Neira A; Grassmann F; Guénel P; Hahnen E; Hamann U; Hillemanns P; Hooning MJ; Hoppe R; Howell A; Humphreys K; kConFab Investigators; Jakubowska A; Khusnutdinova EK; Kristensen VN; Lindblom A; Loizidou MA; Lubiński J; Mannermaa A; Maurer T; Mavroudis D; Newman WG; Obi N; Panayiotidis MI; Radice P; Rashid MU; Rhenius V; Ruebner M; Saloustros E; Sawyer EJ; Schmidt MK; Schmutzler RK; Shah M; Southey MC; Tomlinson I; Truong T; van Veen EM; Wendt C; Yang XR; Michailidou K; Dunning AM; Pharoah PDP; Easton DF; Andrulis IL; Evans DG; Hollestelle A; Chang-Claude J; Milne RL; Peterlongo P
Article: CARDIOVASCULAR RESEARCH. 2023;119(4):998-1007

Low leukocyte mitochondrial DNA abundance drives atherosclerotic cardiovascular diseases: a cohort and Mendelian randomization study.

Luo J; Noordam R; Jukema JW; van Dijk KW; Hägg S; Grassmann F; le Cessie S; van Heemst D
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31(5):578-587

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women.

Figlioli G; Billaud A; Ahearn TU; Antonenkova NN; Becher H; Beckmann MW; Behrens S; Benitez J; Bermisheva M; Blok MJ; Bogdanova NV; Bonanni B; Burwinkel B; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chanock SJ; NBCS Collaborators; Czene K; Devilee P; Dörk T; Engel C; Eriksson M; Fasching PA; Figueroa JD; Gabrielson M; Gago-Dominguez M; García-Closas M; González-Neira A; Grassmann F; Guénel P; Gündert M; Hadjisavvas A; Hahnen E; Hall P; Hamann U; Harrington PA; He W; Hillemanns P; Hollestelle A; Hooning MJ; Hoppe R; Howell A; Humphreys K; KConFab Investigators; Jager A; Jakubowska A; Khusnutdinova EK; Ko Y-D; Kristensen VN; Lindblom A; Lissowska J; Lubiński J; Mannermaa A; Manoukian S; Margolin S; Mavroudis D; Newman WG; Obi N; Panayiotidis MI; Rashid MU; Rhenius V; Rookus MA; Saloustros E; Sawyer EJ; Schmutzler RK; Shah M; Sironen R; Southey MC; Suvanto M; Tollenaar RAEM; Tomlinson I; Truong T; van der Kolk LE; van Veen EM; Wappenschmidt B; Yang XR; Bolla MK; Dennis J; Dunning AM; Easton DF; Lush M; Michailidou K; Pharoah PDP; Wang Q; Adank MA; Schmidt MK; Andrulis IL; Chang-Claude J; Nevanlinna H; Chenevix-Trench G; Evans DG; Milne RL; Radice P; Peterlongo P
Article: GENOME MEDICINE. 2023;15(1):7

Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.

Mueller SH; Lai AG; Valkovskaya M; Michailidou K; Bolla MK; Wang Q; Dennis J; Lush M; Abu-Ful Z; Ahearn TU; Andrulis IL; Anton-Culver H; Antonenkova NN; Arndt V; Aronson KJ; Augustinsson A; Baert T; Freeman LEB; Beckmann MW; Behrens S; Benitez J; Bermisheva M; Blomqvist C; Bogdanova NV; Bojesen SE; Bonanni B; Brenner H; Brucker SY; Buys SS; Castelao JE; Chan TL; Chang-Claude J; Chanock SJ; Choi J-Y; Chung WK; NBCS Collaborators; Colonna SV; CTS Consortium; Cornelissen S; Couch FJ; Czene K; Daly MB; Devilee P; Dörk T; Dossus L; Dwek M; Eccles DM; Ekici AB; Eliassen AH; Engel C; Evans DG; Fasching PA; Fletcher O; Flyger H; Gago-Dominguez M; Gao Y-T; García-Closas M; García-Sáenz JA; Genkinger J; Gentry-Maharaj A; Grassmann F; Guénel P; Gündert M; Haeberle L; Hahnen E; Haiman CA; Håkansson N; Hall P; Harkness EF; Harrington PA; Hartikainen JM; Hartman M; Hein A; Ho W-K; Hooning MJ; Hoppe R; Hopper JL; Houlston RS; Howell A; Hunter DJ; Huo D; ABCTB Investigators; Ito H; Iwasaki M; Jakubowska A; Janni W; John EM; Jones ME; Jung A; Kaaks R; Kang D; Khusnutdinova EK; Kim S-W; Kitahara CM; Koutros S; Kraft P; Kristensen VN; Kubelka-Sabit K; Kurian AW; Kwong A; Lacey JV; Lambrechts D; Le Marchand L; Li J; Linet M; Lo W-Y; Long J; Lophatananon A; Mannermaa A; Manoochehri M; Margolin S; Matsuo K; Mavroudis D; Menon U; Muir K; Murphy RA; Nevanlinna H; Newman WG; Niederacher D; O'Brien KM; Obi N; Offit K; Olopade OI; Olshan AF; Olsson H; Park SK; Patel AV; Patel A; Perou CM; Peto J; Pharoah PDP; Plaseska-Karanfilska D; Presneau N; Rack B; Radice P; Ramachandran D; Rashid MU; Rennert G; Romero A; Ruddy KJ; Ruebner M; Saloustros E; Sandler DP; Sawyer EJ; Schmidt MK; Schmutzler RK; Schneider MO; Scott C; Shah M; Sharma P; Shen C-Y; Shu X-O; Simard J; Surowy H; Tamimi RM; Tapper WJ; Taylor JA; Teo SH; Teras LR; Toland AE; Tollenaar RAEM; Torres D; Torres-Mejía G; Troester MA; Truong T; Vachon CM; Vijai J; Weinberg CR; Wendt C; Winqvist R; Wolk A; Wu AH; Yamaji T; Yang XR; Yu J-C; Zheng W; Ziogas A; Ziv E; Dunning AM; Easton DF; Hemingway H; Hamann U; Kuchenbaecker KB
Journal article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31(5):578-587

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Figlioli G; Billaud A; Ahearn TU; Antonenkova NN; Becher H; Beckmann MW; Behrens S; Benitez J; Bermisheva M; Blok MJ; Bogdanova NV; Bonanni B; Burwinkel B; Camp NJ; Campbell A; Castelao JE; Cessna MH; Chanock SJ; Czene K; Devilee P; Doerk T; Engel C; Eriksson M; Fasching PA; Figueroa JD; Gabrielson M; Gago-Dominguez M; Garcia-Closas M; Gonzalez-Neira A; Grassmann F; Guenel P; Guendert M; Hadjisavvas A; Hahnen E; Hall P; Hamann U; Harrington PA; He W; Hillemanns P; Hollestelle A; Hooning MJ; Hoppe R; Howell A; Humphreys K; Jager A; Jakubowska A; Khusnutdinova EK; Ko Y-D; Kristensen VN; Lindblom A; Lissowska J; Lubinski J; Mannermaa A; Manoukian S; Margolin S; Mavroudis D; Newman WG; Obi N; Panayiotidis MI; Rashid MU; Rhenius V; Rookus MA; Saloustros E; Sawyer EJ; Schmutzler RK; Shah M; Sironen R; Southey MC; Suvanto M; Tollenaar RAEM; Tomlinson I; Truong T; van der Kolk LE; van Veen EM; Wappenschmidt B; Yang XR; Bolla MK; Dennis J; Dunning AM; Easton DF; Lush M; Michailidou K; Pharoah PDP; Wang Q; Adank MA; Schmidt MK; Andrulis IL; Chang-Claude J; Nevanlinna H; Chenevix-Trench G; Evans DG; Milne RL; Radice P; Peterlongo P
Journal article: EXPERIMENTAL EYE RESEARCH. 2022;225:109248

Systems genomics in age-related macular degeneration.

den Hollander AI; Mullins RF; Orozco LD; Voigt AP; Chen H-H; Strunz T; Grassmann F; Haines JL; Kuiper JJW; Tumminia SJ; Allikmets R; Hageman GS; Stambolian D; Klaver CCW; Boeke JD; Chen H; Honigberg L; Katti S; Frazer KA; Weber BHF; Gorin MB
Article: DIABETOLOGIA. 2022;65(10):1676-1686

Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus: a multivariable-adjusted regression and Mendelian randomisation study.

Wang W; Luo J; Willems van Dijk K; Hägg S; Grassmann F; T Hart LM; van Heemst D; Noordam R
Article: ATHEROSCLEROSIS. 2022;354:1-7

The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses.

Martens LG; Luo J; Wermer MJH; Willems van Dijk K; Hägg S; Grassmann F; Noordam R; van Heemst D
Journal article: EXPERIMENTAL EYE RESEARCH. 2022;220:109092

Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials.

Yaghy A; Lee AY; Keane PA; Keenan TDL; Mendonca LSM; Lee CS; Cairns AM; Carroll J; Chen H; Clark J; Cukras CA; de Sisternes L; Domalpally A; Durbin MK; Goetz KE; Grassmann F; Haines JL; Honda N; Hu ZJ; Mody C; Orozco LD; Owsley C; Poor S; Reisman C; Ribeiro R; Sadda SR; Sivaprasad S; Staurenghi G; Ting DS; Tumminia SJ; Zalunardo L; Waheed NK
Journal article: HUMAN MOLECULAR GENETICS. 2022;31(6):875-887

Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513.

Kiel C; Strunz T; Hasler D; Meister G; Grassmann F; Weber BHF
Article: ELIFE. 2022;11:e71562

Risk of heart disease following treatment for breast cancer - results from a population-based cohort study.

Yang H; Bhoo-Pathy N; Brand JS; Hedayati E; Grassmann F; Zeng E; Bergh J; Bian W; Ludvigsson JF; Hall P; Czene K
Article: EUROPEAN JOURNAL OF CANCER. 2022;162:194-205

Interval breast cancer is associated with interferon immune response.

Ugalde-Morales E; Grassmann F; Humphreys K; Li J; Eriksson M; Tobin NP; Lindström LS; Vallon-Christersson J; Borg Å; Hall P; Czene K
Journal article: JOURNAL OF TRANSLATIONAL GENETICS AND GENOMICS. 2022;6(1):46-62

In vitro modeling of the complex retinal condition age-related macular degeneration

Plössl K; Webster E; Kiel C; Grassmann F; Brandl C; Weber BHF
Article: ANNALS OF ONCOLOGY. 2021;32(10):1286-1293

CYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial.

He W; Eriksson M; Eliasson E; Grassmann F; Bäcklund M; Gabrielson M; Hammarström M; Margolin S; Thorén L; Wengström Y; Borgquist S; Hall P; Czene K
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;149(6):1348-1357

Lymph node metastases in breast cancer: Investigating associations with tumor characteristics, molecular subtypes and polygenic risk score using a continuous growth model.

Isheden G; Grassmann F; Czene K; Humphreys K
Article: EUROPEAN HEART JOURNAL. 2021;42(34):3361-3370

Mammographic features are associated with cardiometabolic disease risk and mortality.

Grassmann F; Yang H; Eriksson M; Azam S; Hall P; Czene K
Article: HUMAN GENETICS. 2021;140(6):849-861

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.

Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Article: INTERNATIONAL JOURNAL OF CANCER. 2021;148(4):884-894

Association between breast cancer risk and disease aggressiveness: Characterizing underlying gene expression patterns.

Ugalde-Morales E; Grassmann F; Humphreys K; Li J; Eriksson M; Tobin NP; Borg Å; Vallon-Christersson J; Hall P; Czene K
Article: SCIENTIFIC REPORTS. 2020;10(1):18392

A systems genomics approach to uncover the molecular properties of cancer genes.

Grassmann F; Pawitan Y; Czene K
Article: CELLS. 2020;9(10):E2257-2257

Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD).

Kiel C; Strunz T; International Amd Genomics Consortium Project Mana; Grassmann F; Weber BHF
Article: ACTA RADIOLOGICA. 2020;61(10):1326-1334

The association of single nucleotide polymorphisms (SNPs) with breast density and breast cancer survival: the Malmö Diet and Cancer Study.

Sartor H; Brandt J; Grassmann F; Eriksson M; Czene K; Melander O; Zackrisson S
Article: PLOS GENETICS. 2020;16(9):e1008934

A mega-analysis of expression quantitative trait loci in retinal tissue.

Strunz T; Kiel C; Grassmann F; Ratnapriya R; Kwicklis M; Karlstetter M; Fauser S; Arend N; Swaroop A; Langmann T; Wolf A; Weber BHF
Article: BMC MEDICAL GENOMICS. 2020;13(1):120

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.

Winkler TW; Grassmann F; Brandl C; Kiel C; Günther F; Strunz T; Weidner L; Zimmermann ME; Korb CA; Poplawski A; Schuster AK; Müller-Nurasyid M; Peters A; Rauscher FG; Elze T; Horn K; Scholz M; Cañadas-Garre M; McKnight AJ; Quinn N; Hogg RE; Küchenhoff H; Heid IM; Stark KJ; Weber BHF
Article: BMC MEDICINE. 2020;18(1):225

Hyperthyroidism is associated with breast cancer risk and mammographic and genetic risk predictors.

Yang H; Holowko N; Grassmann F; Eriksson M; Hall P; Czene K
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(8):2689

A Circulating MicroRNA Profile in a Laser-Induced Mouse Model of Choroidal Neovascularization.

Kiel C; Berber P; Karlstetter M; Aslanidis A; Strunz T; Langmann T; Grassmann F; Weber BHF
Article: HUMAN GENETICS. 2020;139(3):401-407

Insights into the loss of the Y chromosome with age in control individuals and in patients with age-related macular degeneration using genotyping microarray data.

Grassmann F; International AMD Genomics Consortium (IAMDGC); Weber BHF; Veitia RA
Article: JOURNAL OF CLINICAL ONCOLOGY. 2020;38(6):548-557

CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer.

He W; Grassmann F; Eriksson M; Eliasson E; Margolin S; Thorén L; Hall P; Czene K
Journal article: SCIENTIFIC REPORTS. 2020;10(1):1584

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration.

Strunz T; Lauwen S; Kiel C; International AMD Genomics Consortium (IAMDGC); Hollander AD; Weber BHF
Article: NATURE COMMUNICATIONS. 2019;10(1):4648

Interval breast cancer is associated with other types of tumors.

Grassmann F; He W; Eriksson M; Gabrielson M; Hall P; Czene K
Article: HUMAN MUTATION. 2019;40(10):1749-1759

Cost-effective molecular inversion probe-based ABCA4 sequencing reveals deep-intronic variants in Stargardt disease.

Khan M; Cornelis SS; Khan MI; Elmelik D; Manders E; Bakker S; Derks R; Neveling K; van de Vorst M; Gilissen C; Meunier I; Defoort S; Puech B; Devos A; Schulz HL; Stöhr H; Grassmann F; Weber BHF; Dhaenens C-M; Cremers FPM
Article: GENETICS IN MEDICINE. 2019;21(8):1751-1760

Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides.

Sangermano R; Garanto A; Khan M; Runhart EH; Bauwens M; Bax NM; van den Born LI; Khan MI; Cornelis SS; Verheij JBGM; Pott J-WR; Thiadens AAHJ; Klaver CCW; Puech B; Meunier I; Naessens S; Arno G; Fakin A; Carss KJ; Raymond FL; Webster AR; Dhaenens C-M; Stöhr H; Grassmann F; Weber BHF; Hoyng CB; De Baere E; Albert S; Collin RWJ; Cremers FPM
Article: JAMA OPHTHALMOLOGY. 2019;137(8):867-876

Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration.

Grassmann F; Harsch S; Brandl C; Kiel C; Nürnberg P; Toliat MR; Fleckenstein M; Pfau M; Schmitz-Valckenberg S; Holz FG; Chew EY; Swaroop A; Ratnapriya R; Klein ML; Mulyukov Z; Zamiri P; Weber BHF
Article: JOURNAL OF NEUROINFLAMMATION. 2019;16(1):43

The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia.

Mages K; Grassmann F; Jägle H; Rupprecht R; Weber BHF; Hauck SM; Grosche A
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1834:29-43

Conduct and Quality Control of Differential Gene Expression Analysis Using High-Throughput Transcriptome Sequencing (RNASeq).

Grassmann F
Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27(1):36-41

Y chromosome mosaicism is associated with age-related macular degeneration.

Grassmann F; Kiel C; den Hollander AI; Weeks DE; Lotery A; Cipriani V; Weber BHF; International Age-related Macular Degeneration Gen
Article: OPHTHALMOLOGICA. 2019;241(1):32-37

Spectral Domain Optical Coherence Tomography Allows the Unification of Clinical Decision Making for the Evaluation of Choroidal Neovascularization Activity.

Volz C; Grassmann F; Greslechner R; Märker DA; Peters P; Helbig H; Gamulescu M-A
Article: OPHTHALMOLOGY. 2018;125(9):1410-1420

A Deep Learning Algorithm for Prediction of Age-Related Eye Disease Study Severity Scale for Age-Related Macular Degeneration from Color Fundus Photography.

Grassmann F; Mengelkamp J; Brandl C; Harsch S; Zimmermann ME; Linkohr B; Peters A; Heid IM; Palm C; Weber BHF
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(19):E4433-E4442

Recurrent structural variation, clustered sites of selection, and disease risk for the complement factor H (CFH) gene family.

Cantsilieris S; Nelson BJ; Huddleston J; Baker C; Harshman L; Penewit K; Munson KM; Sorensen M; Welch AE; Dang V; Grassmann F; Richardson AJ; Guymer RH; Graves-Lindsay TA; Wilson RK; Weber BHF; Baird PN; Allikmets R; Eichler EE
Article: SCIENTIFIC REPORTS. 2018;8(1):5865

A mega-analysis of expression quantitative trait loci (eQTL) provides insight into the regulatory architecture of gene expression variation in liver.

Strunz T; Grassmann F; Gayán J; Nahkuri S; Souza-Costa D; Maugeais C; Fauser S; Nogoceke E; Weber BHF
Article: PLOS ONE. 2018;13(8):e0200739

Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration.

Pujol-Lereis LM; Liebisch G; Schick T; Lin Y; Grassmann F; Uchida K; Zipfel PF; Fauser S; Skerka C; Weber BHF
Article: PLOS ONE. 2018;13(3):e0194321

Investigating the modulation of genetic effects on late AMD by age and sex: Lessons learned and two additional loci.

Winkler TW; Brandl C; Grassmann F; Gorski M; Stark K; Loss J; Weber BHF; Heid IM; International Age-related Macular Degeneration Gen
Article: MEDIZINISCHE GENETIK. 2017;29(2):195-201

Genetic risks and therapy development in retinal degeneration

Grassmann F; Weber B
Article: GENOME MEDICINE. 2017;9(1):29

Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits.

Grassmann F; Kiel C; Zimmermann ME; Gorski M; Grassmann V; Stark K; International AMD Genomics Consortium (IAMDGC); Heid IM; Weber BHF
Article: GENETICS. 2017;205(2):919-924

Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration.

Grassmann F; Heid IM; Weber BHF; International AMD Genomics Consortium (IAMDGC)
Article: JOURNAL OF NEUROINFLAMMATION. 2017;14(1):4

Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator.

Micklisch S; Lin Y; Jacob S; Karlstetter M; Dannhausen K; Dasari P; von der Heide M; Dahse H-M; Schmölz L; Grassmann F; Alene M; Fauser S; Neumann H; Lorkowski S; Pauly D; Weber BH; Joussen AM; Langmann T; Zipfel PF; Skerka C
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017;58(1):394-403

Mutation Spectrum of the ABCA4 Gene in 335 Stargardt Disease Patients From a Multicenter German Cohort-Impact of Selected Deep Intronic Variants and Common SNPs.

Schulz HL; Grassmann F; Kellner U; Spital G; Rüther K; Jägle H; Hufendiek K; Rating P; Huchzermeyer C; Baier MJ; Weber BHF; Stöhr H
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016;57(6):2463-2471

Distinct Genetic Risk Profile of the Rapidly Progressing Diffuse-Trickling Subtype of Geographic Atrophy in Age-Related Macular Degeneration (AMD).

Fleckenstein M; Grassmann F; Lindner M; Pfau M; Czauderna J; Strunz T; von Strachwitz C; Schmitz-Valckenberg S; Holz FG; Weber BHF
Article: JOURNAL OF NEUROINFLAMMATION. 2016;13(1):81

Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD).

Grassmann F; Cantsilieris S; Schulz-Kuhnt A-S; White SJ; Richardson AJ; Hewitt AW; Vote BJ; Schmied D; Guymer RH; Weber BHF; Baird PN
Article: NATURE GENETICS. 2016;48(2):134-143

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.

Fritsche LG; Igl W; Bailey JNC; Grassmann F; Sengupta S; Bragg-Gresham JL; Burdon KP; Hebbring SJ; Wen C; Gorski M; Kim IK; Cho D; Zack D; Souied E; Scholl HPN; Bala E; Lee KE; Hunter DJ; Sardell RJ; Mitchell P; Merriam JE; Cipriani V; Hoffman JD; Schick T; Lechanteur YTE; Guymer RH; Johnson MP; Jiang Y; Stanton CM; Buitendijk GHS; Zhan X; Kwong AM; Boleda A; Brooks M; Gieser L; Ratnapriya R; Branham KE; Foerster JR; Heckenlively JR; Othman MI; Vote BJ; Liang HH; Souzeau E; McAllister IL; Isaacs T; Hall J; Lake S; Mackey DA; Constable IJ; Craig JE; Kitchner TE; Yang Z; Su Z; Luo H; Chen D; Ouyang H; Flagg K; Lin D; Mao G; Ferreyra H; Stark K; von Strachwitz CN; Wolf A; Brandl C; Rudolph G; Olden M; Morrison MA; Morgan DJ; Schu M; Ahn J; Silvestri G; Tsironi EE; Park KH; Farrer LA; Orlin A; Brucker A; Li M; Curcio CA; Mohand-Saïd S; Sahel J-A; Audo I; Benchaboune M; Cree AJ; Rennie CA; Goverdhan SV; Grunin M; Hagbi-Levi S; Campochiaro P; Katsanis N; Holz FG; Blond F; Blanché H; Deleuze J-F; Igo RP; Truitt B; Peachey NS; Meuer SM; Myers CE; Moore EL; Klein R; Hauser MA; Postel EA; Courtenay MD; Schwartz SG; Kovach JL; Scott WK; Liew G; Tan AG; Gopinath B; Merriam JC; Smith RT; Khan JC; Shahid H; Moore AT; McGrath JA; Laux R; Brantley MA; Agarwal A; Ersoy L; Caramoy A; Langmann T; Saksens NTM; de Jong EK; Hoyng CB; Cain MS; Richardson AJ; Martin TM; Blangero J; Weeks DE; Dhillon B; van Duijn CM; Doheny KF; Romm J; Klaver CCW; Hayward C; Gorin MB; Klein ML; Baird PN; den Hollander AI; Fauser S; Yates JRW; Allikmets R; Wang JJ; Schaumberg DA; Klein BEK; Hagstrom SA; Chowers I; Lotery AJ; Léveillard T; Zhang K; Brilliant MH; Hewitt AW; Swaroop A; Chew EY; Pericak-Vance MA; DeAngelis M; Stambolian D; Haines JL; Iyengar SK; Weber BHF; Abecasis GR; Heid IM
Article: PLOS ONE. 2016;11(11):e0167181

Features of Age-Related Macular Degeneration in the General Adults and Their Dependency on Age, Sex, and Smoking: Results from the German KORA Study.

Brandl C; Breinlich V; Stark KJ; Enzinger S; Aßenmacher M; Olden M; Grassmann F; Graw J; Heier M; Peters A; Helbig H; Küchenhoff H; Weber BHF; Heid IM
Article: ANNUAL REVIEW OF VISION SCIENCE. 2015;1:73-96

What Does Genetics Tell Us About Age-Related Macular Degeneration?

Grassmann F; Ach T; Brandl C; Heid IM; Weber BHF
Article: HUMAN MOLECULAR GENETICS. 2015;24(22):6361-6373

Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.

Friedrich U; Datta S; Schubert T; Plössl K; Schneider M; Grassmann F; Fuchshofer R; Tiefenbach K-J; Längst G; Weber BHF
Journal article: BIOSPEKTRUM. 2015;21(7):703-705

Genetisches Risiko bei der altersabhängigen Makuladegeneration

Grassmann F; Loss J; Heid IM; Weber BHF
Article: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 2015;95(Pt B):194-202

The genetics of age-related macular degeneration (AMD)--Novel targets for designing treatment options?

Grassmann F; Fauser S; Weber BHF
Article: NEUROMOLECULAR MEDICINE. 2015;17(2):111-120

A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).

Grassmann F; Friedrich U; Fauser S; Schick T; Milenkovic A; Schulz HL; von Strachwitz CN; Bettecken T; Lichtner P; Meitinger T; Arend N; Wolf A; Haritoglou C; Rudolph G; Chakravarthy U; Silvestri G; McKay GJ; Freitag-Wolf S; Krawczak M; Smith RT; Merriam JC; Merriam JE; Allikmets R; Heid IM; Weber BHF
Article: BMC OPHTHALMOLOGY. 2015;15:18

Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy).

Grassmann F; Bergholz R; Mändl J; Jägle H; Ruether K; Weber BHF
Article: PLOS ONE. 2015;10(5):e0126636

Clinical and genetic factors associated with progression of geographic atrophy lesions in age-related macular degeneration.

Grassmann F; Fleckenstein M; Chew EY; Strunz T; Schmitz-Valckenberg S; Göbel AP; Klein ML; Ratnapriya R; Swaroop A; Holz FG; Weber BHF
Article: HUMAN MOLECULAR GENETICS. 2014;23(21):5827-5837

Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.

Ratnapriya R; Zhan X; Fariss RN; Branham KE; Zipprer D; Chakarova CF; Sergeev YV; Campos MM; Othman M; Friedman JS; Maminishkis A; Waseem NH; Brooks M; Rajasimha HK; Edwards AO; Lotery A; Klein BE; Truitt BJ; Li B; Schaumberg DA; Morgan DJ; Morrison MA; Souied E; Tsironi EE; Grassmann F; Fishman GA; Silvestri G; Scholl HPN; Kim IK; Ramke J; Tuo J; Merriam JE; Merriam JC; Park KH; Olson LM; Farrer LA; Johnson MP; Peachey NS; Lathrop M; Baron RV; Igo RP; Klein R; Hagstrom SA; Kamatani Y; Martin TM; Jiang Y; Conley Y; Sahel J-A; Zack DJ; Chan C-C; Pericak-Vance MA; Jacobson SG; Gorin MB; Klein ML; Allikmets R; Iyengar SK; Weber BH; Haines JL; Léveillard T; Deangelis MM; Stambolian D; Weeks DE; Bhattacharya SS; Chew EY; Heckenlively JR; Abecasis GR; Swaroop A
Article: NEUROMOLECULAR MEDICINE. 2014;16(3):551-564

In-depth characterisation of Retinal Pigment Epithelium (RPE) cells derived from human induced pluripotent stem cells (hiPSC).

Brandl C; Zimmermann SJ; Milenkovic VM; Rosendahl SMG; Grassmann F; Milenkovic A; Hehr U; Federlin M; Wetzel CH; Helbig H; Weber BHF
Article: DEUTSCHES ARZTEBLATT INTERNATIONAL. 2014;111(8):133-138

The role of the complement system in age-related macular degeneration.

Weber BHF; Charbel Issa P; Pauly D; Herrmann P; Grassmann F; Holz FG
Article: PLOS ONE. 2014;9(9):e107461

A circulating microrna profile is associated with late-stage neovascular age-related macular degeneration.

Grassmann F; Schoenberger PGA; Brandl C; Schick T; Hasler D; Meister G; Fleckenstein M; Lindner M; Helbig H; Fauser S; Weber BHF
Article: NATURE GENETICS. 2013;45(11):1375-1379

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.

Zhan X; Larson DE; Wang C; Koboldt DC; Sergeev YV; Fulton RS; Fulton LL; Fronick CC; Branham KE; Bragg-Gresham J; Jun G; Hu Y; Kang HM; Liu D; Othman M; Brooks M; Ratnapriya R; Boleda A; Grassmann F; von Strachwitz C; Olson LM; Buitendijk GHS; Hofman A; van Duijn CM; Cipriani V; Moore AT; Shahid H; Jiang Y; Conley YP; Morgan DJ; Kim IK; Johnson MP; Cantsilieris S; Richardson AJ; Guymer RH; Luo H; Ouyang H; Licht C; Pluthero FG; Zhang MM; Zhang K; Baird PN; Blangero J; Klein ML; Farrer LA; DeAngelis MM; Weeks DE; Gorin MB; Yates JRW; Klaver CCW; Pericak-Vance MA; Haines JL; Weber BHF; Wilson RK; Heckenlively JR; Chew EY; Stambolian D; Mardis ER; Swaroop A; Abecasis GR
Article: HUMAN MOLECULAR GENETICS. 2012;21(21):4573-4586

The retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in intermolecular protein interaction and microtubule association.

Zach F; Grassmann F; Langmann T; Sorusch N; Wolfrum U; Stöhr H
Article: PLOS ONE. 2012;7(5):e37979

Modelling the genetic risk in age-related macular degeneration.

Grassmann F; Fritsche LG; Keilhauer CN; Heid IM; Weber BHF
Article: MEDIZINISCHE GENETIK. 2011;23(3):377-384

How big are the small genetic risks?

Heid IM; Winkler TW; Grassmann F; Weber BHF
Article: JOURNAL OF INTEGRATIVE BIOINFORMATICS. 2011;8(1)

Key2Ann: a tool to process sequence sets by replacing database identifiers with a human-readable annotation.

Pürzer A; Grassmann F; Birzer D; Merkl R
Journal article: JOURNAL OF INTEGRATIVE BIOINFORMATICS. 2011;8(1):35-46

Key2Ann: a tool to process sequence sets by replacing database identifiers with a human-readable annotation

Pürzer A; Grassmann F; Birzer D; Merkl R
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Preprint: BIORXIV. 2023

The glucocorticoid receptor as a master regulator of Müller cell gliosis in the diabetic retina

Pfaller AM; Kaplan L; Carido M; Grassmann F; Díaz-Lezama N; Ghaseminejad F; Wunderlich KA; Glänzer S; Pannicke T; Weber BHF; Koch SF; Bonev B; Hauck SM; Grosche A
Preprint: RES SQ. 2023;RES SQ

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.

Morra A; Schreurs MAC; Andrulis IL; Anton-Culver H; Augustinsson A; Beckmann MW; Behrens S; Bojesen SE; Bolla MK; Brauch H; Broeks A; Buys SS; Camp NJ; Castelao JE; Cessna MH; Chang-Claude J; Chung WK; Collaborators N; Colonna SV; Couch FJ; Cox A; Cross SS; Czene K; Daly MB; Dennis J; Devilee P; Dörk T; Dunning AM; Dwek M; Easton DF; Eccles DM; Eriksson M; Evans DG; Fasching PA; Fehm TN; Figueroa JD; Flyger H; Gabrielson M; Gago-Dominguez M; García-Closas M; García-Sáenz JA; Genkinger J; Grassmann F; Gündert M; Hahnen E; Haiman CA; Hamann U; Harrington PA; Hartikainen JM; Hoppe R; Hopper JL; Houlston RS; Howell A; Investigators A; Investigators K; Jakubowska A; Janni W; Jernström H; John EM; Johnson N; Jones ME; Kristensen VN; Kurian AW; Lambrechts D; Marchand LL; Lindblom A; Lubiński J; Lux MP; Mannermaa A; Mavroudis D; Mulligan AM; Muranen TA; Nevanlinna H; Nevelsteen I; Neven P; Newman WG; Obi N; Offit K; Olshan AF; Park-Simon T-W; Patel AV; Peterlongo P; Phillips K-A; Plaseska-Karanfilska D; Polley EC; Presneau N; Pylkäs K; Rack B; Radice P; Rashid MU; Rhenius V; Robson M; Romero A; Saloustros E; Sawyer EJ; Schmutzler RK; Schuetze S; Scott C; Shah M; Smichkoska S; Southey MC; Tapper WJ; Teras LR; Tollenaar RAEM; Tomczyk K; Tomlinson I; Troester MA; Vachon CM; van Veen EM; Wang Q; Wendt C; Wildiers H; Winqvist R; Ziogas A; Hall P; Pharoah PDP; Adank MA; Hollestelle A; Schmidt MK; Hooning MJ
Preprint: MEDRXIV. 2021

The association between lymphocyte mitochondrial DNA abundance and Stroke: a combination of multivariable-adjusted survival and mendelian randomization analyses

Martens L; Luo J; Wermer M; van Dijk KW; Hägg S; Grassmann F; Noordam R; van Heemst D
Preprint: MEDRXIV. 2021

Risk of heart disease following breast cancer: results from a population-based cohort study

Yang H; Bhoo-Pathy N; Brand J; Hedayati E; Grassmann F; Zeng E; Bergh J; Bian W; Ludvigsson J; Hall P; Czene K
Preprint: BIORXIV. 2021

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans

McEwan AR; Hing B; Erickson JC; Turnbull Y; Delibegovic M; Grassmann F; MacKenzie A
Preprint: MEDRXIV. 2021

Low mitochondrial copy number drives atherogenic cardiovascular disease: evidence from prospective cohort analyses in the UK Biobank combined with Mendelian Randomization

Luo J; Noordam R; Jukema W; van Dijk KW; Hägg S; Grassmann F; Cessie SL; van Heemst D
Corrigendum: HUMAN GENETICS. 2021;140(6):863

Correction to: Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance.

Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Preprint: BIORXIV. 2020

Deciphering the genetic and epidemiological landscape of mitochondrial DNA abundance

Hägg S; Jylhävä J; Wang Y; Czene K; Grassmann F
Published conference paper: OPHTHALMOLOGY. 2020;127(2):186-195

Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial.

Liao DS; Grossi FV; El Mehdi D; Gerber MR; Brown DM; Heier JS; Wykoff CC; Singerman LJ; Abraham P; Grassmann F; Nuernberg P; Weber BHF; Deschatelets P; Kim RY; Chung CY; Ribeiro RM; Hamdani M; Rosenfeld PJ; Boyer DS; Slakter JS; Francois CG
Preprint: BIORXIV. 2019

Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Winkler TW; Grassmann F; Brandl C; Kiel C; Günther F; Strunz T; Weidner L; Zimmermann ME; Korb CA; Poplawski A; Schuster AK; Müller-Nurasyid M; Peters A; Rauscher FG; Elze T; Horn K; Scholz M; Cañadas-Garre M; McKnight AJ; Quinn N; Hogg RE; Küchenhoff H; Heid IM; Stark KJ; Weber BH
Conference publication: GLIA. 2019;67:E629

Glial cells shape the complement homeostasis the healthy and diseased murine retina

Pauly D; Agarwal D; Dana N; Schafer N; Grassmann F; Zhang NR; Gautam AK; Weber BHF; Hauck SM; Kim M; Curcio C; Stambolian D; Li M; Grosche A
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2019;60(9)

Towards comprehensive identification and functional characterization of deep-intronic ABCA4 variants in 1000 Stargardt disease cases

Khan M; Cornelis S; Valero MDP; Khan MI; Stohr H; Grassmann F; Steehouwer M; Hoischen A; Ayuso C; Ramesar R; Meunier IA; Defoort S; Weber BHF; Dhaenens C-M; Cremers FP
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2019;60(9)

An iPSC-derived RPE cell repository with high and low genetic AMD risk as model systems to study AMD pathology in vitro

Ploessl K; Lauer A; Kiel C; Brandl C; Grassmann F; Weber BHF
Preprint: BIORXIV. 2018

Cell type-specific complement expression from healthy and diseased retinae

Pauly D; Schäfer N; Grassmann F; Pfaller AM; Straub T; Weber BHF; Hauck SM; Grosche A
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2018;1074:247-255

Pleiotropic Effects of Risk Factors in Age-Related Macular Degeneration and Seemingly Unrelated Complex Diseases.

Kiel C; Weber BHF; Grassmann F
Review: MOLECULAR DIAGNOSIS & THERAPY. 2017;21(1):31-43

An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology.

Berber P; Grassmann F; Kiel C; Weber BHF
Review: JOURNAL OF CLINICAL MEDICINE. 2015;4(2):282-303

Tapping Stem Cells to Target AMD: Challenges and Prospects.

Brandl C; Grassmann F; Riolfi J; Weber BHF
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2014;801:291-300

Genetic risk models in age-related macular degeneration.

Grassmann F; Heid IM; Weber BHF

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