Erin Gabriel

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

* 2004 MA in Economics from McGill University
* 2012 PhD in Biostatistics from University of Washington

Forskningsbeskrivning

I am currently working on both methodological and applied research. My
methodological research covers several areas including machine learning for
time-to-event data, methods for vaccine research, including surrogate
evaluation and sieve analysis, as well as exact tests for challenge studies.
I am also interested in unique clinical trial designs. I assist with
statistical expertise in several fields of epidemiological and clinical
research including HIV, Malaria and prostate cancer.

Artiklar

Article: BIOSTATISTICS. 2023;24(4):1017-1030

Cross-direct effects in settings with two mediators.

Gabriel EE; Sjölander A; Follmann D; Sachs MC
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2023;118(544):2446-2453

Sharp Nonparametric Bounds for Decomposition Effects with Two Binary Mediators

Gabriel EE; Sachs MC; Sjolander A
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2023;118(541):684-692

Nonparametric Bounds for Causal Effects in Imperfect Randomized Experiments

Gabriel EE; Sjolander A; Sachs MC
Article: BIOMETRIKA. 2022;109(4):1101-1116

Sensitivity analysis for unmeasured confounding in the estimation of marginal causal effects

Ciocanea-Teodorescu I; Gabriel EE; Sjolander A
Article: BRITISH JOURNAL OF CANCER. 2022;127(9):1636-1641

Confidence bands in survival analysis.

Sachs MC; Brand A; Gabriel EE
Article: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION. 2022;117(538):939-950

Causal Bounds for Outcome-Dependent Sampling in Observational Studies

Gabriel EE; Sachs MC; Sjolander A
Article: ANNALS OF EPIDEMIOLOGY. 2022;66:1-4

Direct modeling of relative and absolute risks in register data: Mortality risk in sarcoidosis.

Gabriel EE; Arkema EV; Sachs MC
Article: JOURNAL OF STATISTICAL SOFTWARE. 2022;102(9):1-34

Event History Regression with Pseudo-Observations: Computational Approaches and an Implementation in R

Sachs MC; Gabriel EE
Article: MICROBIOLOGY SPECTRUM. 2021;9(2):e0054921-e00521

Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy.

Saccon E; Bandera A; Sciumè M; Mikaeloff F; Lashari AA; Aliberti S; Sachs MC; Billi F; Blasi F; Gabriel EE; Costantino G; De Roberto P; Krishnan S; Gori A; Peyvandi F; Scudeller L; Canetta C; Lorson CL; Valenti L; Singh K; Baldini L; Fracchiolla NS; COVID-19 Network Working Group,; Neogi U
Article: SEXUAL & REPRODUCTIVE HEALTHCARE. 2021;29:100622

Alcohol and illicit and non-medical prescription drug use before and during pregnancy in Stockholm, Sweden: A cross-sectional study.

Persson A; Lindmark S; Petersson K; Gabriel E; Thorsell M; Lindström K; Göransson M; Cardell G; Magnusson Å
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2021;190(9):1882-1889

Adjustment for Disease Severity in the Test-Negative Study Design.

Ciocănea-Teodorescu I; Nason M; Sjölander A; Gabriel EE
Article: STATISTICS IN MEDICINE. 2021;40(19):4185-4199

Prediction-driven pooled testing methods: Application to HIV treatment monitoring in Rakai, Uganda.

Brand A; May S; Hughes JP; Nakigozi G; Reynolds SJ; Gabriel EE
Article: ANNALS OF INTERNAL MEDICINE. 2021;174(8):1118-1125

A Deferred-Vaccination Design to Assess Durability of COVID-19 Vaccine Effect After the Placebo Group Is Vaccinated.

Follmann D; Fintzi J; Fay MP; Janes HE; Baden LR; El Sahly HM; Fleming TR; Mehrotra DV; Carpp LN; Juraska M; Benkeser D; Donnell D; Fong Y; Han S; Hirsch I; Huang Y; Huang Y; Hyrien O; Luedtke A; Carone M; Nason M; Vandebosch A; Zhou H; Cho I; Gabriel E; Kublin JG; Cohen MS; Corey L; Gilbert PB; Neuzil KM
Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(7):146221

Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice.

Healy SA; Anderson C; Swihart BJ; Mwakingwe A; Gabriel EE; Decederfelt H; Hobbs CV; Rausch KM; Zhu D; Muratova O; Herrera R; Scaria PV; MacDonald NJ; Lambert LE; Zaidi I; Coelho CH; Renn JP; Wu Y; Narum DL; Duffy PE
Article: TRANSFUSION. 2021;61(2):464-473

Frequent platelet donation is associated with lymphopenia and risk of infections: A nationwide cohort study.

Zhao J; Gabriel E; Norda R; Höglund P; Baden L; Diedrich BA; Marits P; Enoksson SL; Gansner JM; Kaufman R; Dickman PW; Edgren G
Article: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS. 2021;70(1):51-65

Stacked inverse probability of censoring weighted bagging: A case study in the InfCareHIV Register

Gonzalez Ginestet P; Kotalik A; Vock DM; Wolfson J; Gabriel EE
Article: JOURNAL OF CAUSAL INFERENCE. 2021;9(1):229-249

On the bias of adjusting for a non-differentially mismeasured discrete confounder

Pena JM; Balgi S; Sjolander A; Gabriel EE
Article: BIOMETRICS. 2020;76(4):1053-1063

A unified evaluation of differential vaccine efficacy.

Gabriel EE; Sachs MC; Follmann DA; Andersson TM-L
Article: SEXUAL & REPRODUCTIVE HEALTHCARE. 2020;25:100516

Potentially traumatic events, fear of childbirth and posttraumatic stress disorder during pregnancy in Stockholm, Sweden: A cross-sectional study.

Persson A; Lindmark S; Petersson K; Gabriel E; Thorsell M; Lindström K; Göransson M; Cardell G; Magnusson Å
Article: CLINICAL INFECTIOUS DISEASES. 2020;71(4):1017-1021

Adaptive Viral Load Monitoring Frequency to Facilitate Differentiated Care: A Modeling Study From Rakai, Uganda.

Ssempijja V; Nason M; Nakigozi G; Ndyanabo A; Gray R; Wawer M; Chang LW; Gabriel E; Quinn TC; Serwadda D; Reynolds SJ
Article: CLINICAL INFECTIOUS DISEASES. 2020;71(3):652-660

Prospective International Study of Incidence and Predictors of Immune Reconstitution Inflammatory Syndrome and Death in People Living With Human Immunodeficiency Virus and Severe Lymphopenia.

Sereti I; Sheikh V; Shaffer D; Phanuphak N; Gabriel E; Wang J; Nason MC; Roby G; Ngeno H; Kirui F; Pau A; Mican JM; Rupert A; Bishop R; Agan B; Chomchey N; Teeratakulpisarn N; Tansuphaswadikul S; Langat D; Kosgei J; French M; Ananworanich J; Sawe F
Article: AMERICAN STATISTICIAN. 2020;74(3):243-248

On Causal Inferences for Personalized Medicine: How Hidden Causal Assumptions Led to Erroneous Causal Claims About the D-Value.

Greenland S; Fay MP; Brittain EH; Shih JH; Follmann DA; Gabriel EE; Robins JM
Article: TRIALS. 2020;21(1):579

The ProBio trial: molecular biomarkers for advancing personalized treatment decision in patients with metastatic castration-resistant prostate cancer.

Crippa A; De Laere B; Discacciati A; Larsson B; Connor JT; Gabriel EE; Thellenberg C; Jänes E; Enblad G; Ullen A; Hjälm-Eriksson M; Oldenburg J; Ost P; Lindberg J; Eklund M; Grönberg H
Article: EPIDEMIOLOGY. 2020;31(3):359-364

Aim for Clinical Utility, Not Just Predictive Accuracy.

Sachs MC; Sjölander A; Gabriel EE
Article: BMC PREGNANCY AND CHILDBIRTH. 2020;20(1):225

Social concerns related to HIV status disclosure and participation in the prevention of mother-to-child transmission of HIV care among pregnant women in Kenya.

Nordberg B; Gabriel EE; Were E; Kaguiri E; Ekström AM; Kågesten A; Rautiainen S
Article: BIOSTATISTICS. 2020;21(2):e33-e46

Predictive cluster level surrogacy in the presence of interference.

Gabriel EE; Follmann DA
Article: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS. 2019;68(5):1431-1446

Ensemble prediction of time-to-event outcomes with competing risks: a case-study of surgical complications in Crohn's disease

Sachs MC; Discacciati A; Everhov AH; Olen O; Gabriel EE
Article: OPEN FORUM INFECTIOUS DISEASES. 2019;6(6):ofz246

A Phase I, Randomized, Controlled Clinical Study of CC-11050 in People Living With HIV With Suppressed Plasma Viremia on Antiretroviral Therapy (APHRODITE).

Boulougoura A; Gabriel E; Laidlaw E; Khetani V; Arakawa K; Higgins J; Rupert A; Gorelick RJ; Lumbard K; Pau A; Poole A; Kibiy A; Kumar P; Sereti I
Article: STATISTICS IN MEDICINE. 2019;38(7):1135-1146

Optimizing and evaluating biomarker combinations as trial-level general surrogates.

Gabriel EE; Sachs MC; Daniels MJ; Halloran ME
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1965

Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy.

Babu H; Ambikan AT; Gabriel EE; Svensson Akusjärvi S; Palaniappan AN; Sundaraj V; Mupanni NR; Sperk M; Cheedarla N; Sridhar R; Tripathy SP; Nowak P; Hanna LE; Neogi U
Article: STATISTICS IN MEDICINE. 2018;37(20):2923-2937

Causal estimands and confidence intervals associated with Wilcoxon-Mann-Whitney tests in randomized experiments.

Fay MP; Brittain EH; Shih JH; Follmann DA; Gabriel EE
Article: LANCET INFECTIOUS DISEASES. 2018;18(9):969-982

Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults.

Sagara I; Healy SA; Assadou MH; Gabriel EE; Kone M; Sissoko K; Tembine I; Guindo MA; Doucoure M; Niaré K; Dolo A; Rausch KM; Narum DL; Jones DL; MacDonald NJ; Zhu D; Mohan R; Muratova O; Baber I; Coulibaly MB; Fay MP; Anderson C; Wu Y; Traore SF; Doumbo OK; Duffy PE
Article: JCI INSIGHT. 2018;3(13):97880

Total body CD4+ T cell dynamics in treated and untreated SIV infection revealed by in vivo imaging.

Di Mascio M; Srinivasula S; Kim I; Duralde G; St Claire A; DeGrange P; St Claire M; Reimann KA; Gabriel EE; Carrasquillo J; Reba RC; Paik C; Lane HC
Article: BIOSTATISTICS. 2018;19(3):307-324

Evaluation and comparison of predictive individual-level general surrogates.

Gabriel EE; Sachs MC; Halloran ME
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018;98(6):1718-1721

Sulfamethoxazole Levels in HIV-Exposed Uninfected Ugandan Children.

Kasule J; Gabriel EE; Anok A; Neal J; Eastman RT; Penzak S; Newell K; Serwadda D; Duffy PE; Reynolds SJ; Hobbs CV
Article: STATISTICS IN MEDICINE. 2018;37(7):1047-1058

A boundary-optimized rejection region test for the two-sample binomial problem.

Gabriel EE; Nason M; Fay MP; Follmann DA
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2018;98(1):67-70

Prevalence of Asymptomatic Parasitemia and Gametocytemia in HIV-Infected Children on Differing Antiretroviral Therapy.

Hobbs CV; Gabriel EE; Kamthunzi P; Tegha G; Tauzie J; Li Y; Ilmet T; Artimovich E; Neal J; Hall T; Parikh S; Kirmse B; Jean-Philippe P; Chen J; Prescott WR; Palumbo P; Duffy PE; Borkowsky W; For The P S Study Team
Article: SCIENTIFIC REPORTS. 2017;7(1):14267

Hemoglobin variants shape the distribution of malaria parasites in human populations and their transmission potential.

Gonçalves BP; Sagara I; Coulibaly M; Wu Y; Assadou MH; Guindo A; Ellis RD; Diakite M; Gabriel E; Prevots DR; Doumbo OK; Duffy PE
Article: AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE. 2017;97(3):719-725

Optimizing Direct Membrane and Direct Skin Feeding Assays for Plasmodium falciparum Transmission-Blocking Vaccine Trials in Bancoumana, Mali.

Coulibaly MB; Gabriel EE; Sinaba Y; Sylla D; Sacko A; Sylla L; Coulibaly B; Hume JCC; Baber I; Assadou MH; Sagara I; Wu Y; Healy SA; Doumbo O; Traore SF; Duffy PE
Article: LANCET INFECTIOUS DISEASES. 2017;17(5):498-509

Safety and efficacy of PfSPZ Vaccine against Plasmodium falciparum via direct venous inoculation in healthy malaria-exposed adults in Mali: a randomised, double-blind phase 1 trial.

Sissoko MS; Healy SA; Katile A; Omaswa F; Zaidi I; Gabriel EE; Kamate B; Samake Y; Guindo MA; Dolo A; Niangaly A; Niaré K; Zeguime A; Sissoko K; Diallo H; Thera I; Ding K; Fay MP; O'Connell EM; Nutman TB; Wong-Madden S; Murshedkar T; Ruben AJ; Li M; Abebe Y; Manoj A; Gunasekera A; Chakravarty S; Sim BKL; Billingsley PF; James ER; Walther M; Richie TL; Hoffman SL; Doumbo O; Duffy PE
Article: JCI INSIGHT. 2017;2(4):e85687

HLA-DQ β1 alleles associated with Epstein-Barr virus (EBV) infectivity and EBV gp42 binding to cells.

Li Q; Bu W; Gabriel E; Aguilar F; Hoshino Y; Miyadera H; Hess C; Hornung RL; Roy A; Cohen JI
Article: PLOS ONE. 2017;12(11):e0187912

CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies.

Srinivasula S; Gabriel E; Kim I; DeGrange P; St Claire A; Mallow C; Donahue RE; Paik C; Lane HC; Di Mascio M
Article: BIOMETRICS. 2016;72(4):1046-1054

Comparing biomarkers as trial level general surrogates.

Gabriel EE; Daniels MJ; Halloran ME
Article: STATISTICS IN MEDICINE. 2016;35(24):4398-4412

Who really gets strep sore throat? Confounding and effect modification of a time-varying exposure on recurrent events.

Follmann D; Huang C-Y; Gabriel E
Article: BIOSTATISTICS. 2016;17(3):453-467

Augmented trial designs for evaluation of principal surrogates.

Gabriel EE; Follmann D
Article: PLOS ONE. 2016;11(2):e0147812

Pooled-Peptide Epitope Mapping Strategies Are Efficient and Highly Sensitive: An Evaluation of Methods for Identifying Human T Cell Epitope Specificities in Large-Scale HIV Vaccine Efficacy Trials.

Fiore-Gartland A; Manso BA; Friedrich DP; Gabriel EE; Finak G; Moodie Z; Hertz T; De Rosa SC; Frahm N; Gilbert PB; McElrath MJ
Article: PLOS ONE. 2016;11(10):e0163144

Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults.

Talaat KR; Ellis RD; Hurd J; Hentrich A; Gabriel E; Hynes NA; Rausch KM; Zhu D; Muratova O; Herrera R; Anderson C; Jones D; Aebig J; Brockley S; MacDonald NJ; Wang X; Fay MP; Healy SA; Durbin AP; Narum DL; Wu Y; Duffy PE
Article: PLOS ONE. 2016;11(12):e0165140

Malaria in HIV-Infected Children Receiving HIV Protease-Inhibitor- Compared with Non-Nucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy, IMPAACT P1068s, Substudy to P1060.

Hobbs CV; Gabriel EE; Kamthunzi P; Tegha G; Tauzie J; Petzold E; Barlow-Mosha L; Chi BH; Li Y; Ilmet T; Kirmse B; Neal J; Parikh S; Deygoo N; Jean Philippe P; Mofenson L; Prescott W; Chen J; Musoke P; Palumbo P; Duffy PE; Borkowsky W; P1068s Study Team
Article: JOURNAL OF CAUSAL INFERENCE. 2015;3(2):157-175

Surrogate Endpoint Evaluation: Principal Stratification Criteria and the Prentice Definition.

Gilbert PB; Gabriel EE; Huang Y; Chan ISF
Article: STATISTICS IN MEDICINE. 2015;34(3):381-395

Comparing and combining biomarkers as principal surrogates for time-to-event clinical endpoints.

Gabriel EE; Sachs MC; Gilbert PB
Article: JOURNAL OF INFECTIOUS DISEASES. 2014;210(10):1573-1581

Fold rise in antibody titers by measured by glycoprotein-based enzyme-linked immunosorbent assay is an excellent correlate of protection for a herpes zoster vaccine, demonstrated via the vaccine efficacy curve.

Gilbert PB; Gabriel EE; Miao X; Li X; Su S-C; Parrino J; Chan ISF
Article: BIOSTATISTICS. 2014;15(2):251-265

Evaluating principal surrogate endpoints with time-to-event data accounting for time-varying treatment efficacy.

Gabriel EE; Gilbert PB
Article: PLOS ONE. 2013;8(5):e64405

Superior control of HIV-1 replication by CD8+ T cells targeting conserved epitopes: implications for HIV vaccine design.

Kunwar P; Hawkins N; Dinges WL; Liu Y; Gabriel EE; Swan DA; Stevens CE; Maenza J; Collier AC; Mullins JI; Hertz T; Yu X; Horton H
Article: BLOOD. 2012;120(14):2836-2842

Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination.

Forthal DN; Gabriel EE; Wang A; Landucci G; Phan TB
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;382(1-2):117-128

Optimization and qualification of a multiplex bead array to assess cytokine and chemokine production by vaccine-specific cells.

Defawe OD; Fong Y; Vasilyeva E; Pickett M; Carter DK; Gabriel E; Rerks-Ngarm S; Nitayaphan S; Frahm N; McElrath MJ; De Rosa SC
Article: PLOS ONE. 2012;7(8):e43396

MRKAd5 HIV-1 Gag/Pol/Nef vaccine-induced T-cell responses inadequately predict distance of breakthrough HIV-1 sequences to the vaccine or viral load.

Janes H; Frahm N; DeCamp A; Rolland M; Gabriel E; Wolfson J; Hertz T; Kallas E; Goepfert P; Friedrich DP; Corey L; Mullins JI; McElrath MJ; Gilbert P
Article: STATISTICAL COMMUNICATIONS IN INFECTIOUS DISEASES. 2011;3(1):1037

A Sequential Phase 2b Trial Design for Evaluating Vaccine Efficacy and Immune Correlates for Multiple HIV Vaccine Regimens.

Gilbert PB; Grove D; Gabriel E; Huang Y; Gray G; Hammer SM; Buchbinder SP; Kublin J; Corey L; Self SG
Article: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. 2010;304(13):1455-1464

Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial.

Bulger EM; May S; Brasel KJ; Schreiber M; Kerby JD; Tisherman SA; Newgard C; Slutsky A; Coimbra R; Emerson S; Minei JP; Bardarson B; Kudenchuk P; Baker A; Christenson J; Idris A; Davis D; Fabian TC; Aufderheide TP; Callaway C; Williams C; Banek J; Vaillancourt C; van Heest R; Sopko G; Hata JS; Hoyt DB; ROC Investigators
Article: RESUSCITATION. 2010;81(2):155-162

Survival increases with CPR by Emergency Medical Services before defibrillation of out-of-hospital ventricular fibrillation or ventricular tachycardia: observations from the Resuscitation Outcomes Consortium.

Bradley SM; Gabriel EE; Aufderheide TP; Barnes R; Christenson J; Davis DP; Stiell IG; Nichol G; Resuscitation Outcomes Consortium Investigators
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Letter: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2021;190(10):2231-2232

ON THE USE OF NONPARAMETRIC BOUNDS FOR CAUSAL EFFECTS IN NULL RANDOMIZED TRIALS.

Gabriel EE; Sachs MC
Preprint: MEDRXIV. 2020;MEDRXIV

Assessing Durability of Vaccine Effect Following Blinded Crossover in COVID-19 Vaccine Efficacy Trials.

Follmann D; Fintzi J; Fay MP; Janes HE; Baden L; Sahly HE; Fleming TR; Mehrotra DV; Carpp LN; Juraska M; Benkeser D; Donnell D; Fong Y; Han S; Hirsch I; Huang Y; Huang Y; Hyrien O; Luedtke A; Carone M; Nason M; Vandebosch A; Zhou H; Cho I; Gabriel E; Kublin JG; Cohen MS; Corey L; Gilbert PB; Neuzil KM
Letter: STATISTICS IN MEDICINE. 2018;37(14):2303-2306

Response to letter by Antonio Martín Andrés on "A boundary-optimized rejection region test for the two-sample binomial problem".

Gabriel EE; Nason M; Fay MP; Follmann D
Editorial comment: R JOURNAL. 2016;8(2):277-292

An Introduction to Principal Surrogate Evaluation with the pseval Package.

Sachs MC; Gabriel EE
Review: VACCINE. 2016;34(48):5863-5870

Utilizing direct skin feeding assays for development of vaccines that interrupt malaria transmission: A systematic review of methods and case study.

Brickley EB; Coulibaly M; Gabriel EE; Healy SA; Hume JCC; Sagara I; Traore SF; Doumbo O; Duffy PE
Letter: JOURNAL OF INFECTIOUS DISEASES. 2015;212(9):1521-1523

Reply to Dunning.

Gilbert PB; Gabriel EE; Hudgens MG; Miao X; Li X; Su S-C; Parrino J; Chan ISF
Meeting abstract: RETROVIROLOGY. 2012;9:p260

Breadth or conservation score (CS): which is more important for HIV-1 T cell based vaccine immunogen design?

Kunwar P; Hawkins NR; Yu X; Liu Y; Collier A; Gabriel EE; Hertz T; Horton H

Anställningar

Anknuten till Forskning, Medicinsk epidemiologi och biostatistik, Karolinska Institutet, 2023-2026

Examina och utbildning

Docent, biostatistik, Karolinska Institutet, 2020

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