Daniel Martinez Molina

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: NATURE CHEMICAL BIOLOGY. 2016;12(10):815-821

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.

Exell JC; Thompson MJ; Finger LD; Shaw SJ; Debreczeni J; Ward TA; McWhirter C; Siöberg CLB; Martinez Molina D; Abbott WM; Jones CD; Nissink JWM; Durant ST; Grasby JA
Article: NATURE COMMUNICATIONS. 2016;7:11040

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.

Almqvist H; Axelsson H; Jafari R; Dan C; Mateus A; Haraldsson M; Larsson A; Martinez Molina D; Artursson P; Lundbäck T; Nordlund P
Article: SCIENCE. 2014;346(6205):1255784

Tracking cancer drugs in living cells by thermal profiling of the proteome.

Savitski MM; Reinhard FBM; Franken H; Werner T; Savitski MF; Eberhard D; Martinez Molina D; Jafari R; Dovega RB; Klaeger S; Kuster B; Nordlund P; Bantscheff M; Drewes G
Article: NATURE PROTOCOLS. 2014;9(9):2100-2122

The cellular thermal shift assay for evaluating drug target interactions in cells.

Jafari R; Almqvist H; Axelsson H; Ignatushchenko M; Lundbäck T; Nordlund P; Martinez Molina D
Article: SCIENCE. 2013;341(6141):84-87

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

Martinez Molina D; Jafari R; Ignatushchenko M; Seki T; Larsson EA; Dan C; Sreekumar L; Cao Y; Nordlund P
Article: STRUCTURE. 2012;20(6):1062-1070

The Mycobacterium tuberculosis very-long-chain fatty acyl-CoA synthetase: structural basis for housing lipid substrates longer than the enzyme.

Andersson CS; Lundgren CAK; Magnúsdóttir A; Ge C; Wieslander A; Martinez Molina D; Högbom M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(52):40771-40776

Arginine 104 is a key catalytic residue in leukotriene C4 synthase.

Rinaldo-Matthis A; Wetterholm A; Martinez Molina D; Holm J; Niegowski D; Ohlson E; Nordlund P; Morgenstern R; Haeggström JZ
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;62(1):49-52

Expression and purification of the recombinant membrane protein YidC: a case study for increased stability and solubility.

Martinez Molina D; Lundbäck A-K; Niegowski D; Eshaghi S
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;60(1):1-6

High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris.

Wetterholm A; Martinez Molina D; Nordlund P; Eshaghi S; Haeggström JZ
Article: PROTEIN SCIENCE. 2008;17(4):673-680

Engineering membrane protein overproduction in Escherichia coli.

Martinez Molina D; Cornvik T; Eshaghi S; Haeggström JZ; Nordlund P; Sabet MI
Article: NATURE. 2007;448(7153):613-616

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase.

Martinez Molina D; Wetterholm A; Kohl A; McCarthy AA; Niegowski D; Ohlson E; Hammarberg T; Eshaghi S; Haeggström JZ; Nordlund P
Article: SCIENCE. 2006;313(5785):354-357

Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution.

Eshaghi S; Niegowski D; Kohl A; Martinez Molina D; Lesley SA; Nordlund P

Alla övriga publikationer

Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2016;56:141-161

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies.

Martinez Molina D; Nordlund P
Editorial comment: FUTURE MEDICINAL CHEMISTRY. 2015;7(8):975-978

CETSA: a target engagement assay with potential to transform drug discovery.

Jensen AJ; Martinez Molina D; Lundbäck T
Review: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2008;18(4):442-449

Catalysis within the lipid bilayer-structure and mechanism of the MAPEG family of integral membrane proteins.

Martinez Molina D; Eshaghi S; Nordlund P

Artiklar

Alla övriga publikationer

Nyheter från KI

Kalenderhändelser från KI