Curtis Cai

About me
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Public outreach and news

About me

Interested in the study of tissue-specific distribution and functionality of T cells in humans.
- Postdoctoral researcher in the group of Marcus Buggert, 2021 - current.
- SSMF Postdoctoral Grant (Svenska Sällskapet för Medicinsk Forskning), 2023 - current.
- Doctor of Philosophy (Ph.D.). School of Medical Sciences, Faculty of Medicine, University of New South Wales, Australia, 2017 - 2021. Thesis titled: Characterising CD8+ T cell responses in HCV infection at the single-cell level

Research

Immunologist studying T cell biology, SARS-CoV-2 immunity, and the cutting edge of human immunology. My work uses techniques including multicolour flow cytometry, spatial transcriptomics, and single-cell RNA-sequencing.

Articles

Article: SCIENCE IMMUNOLOGY. 2023;8(90):eadh0687

SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19.

Cai C; Gao Y; Adamo S; Rivera-Ballesteros O; Hansson L; Österborg A; Bergman P; Sandberg JK; Ljunggren H-G; Björkström NK; Strålin K; Llewellyn-Lacey S; Price DA; Qin C; Grifoni A; Weiskopf D; Wherry EJ; Sette A; Aleman S; Buggert M
Journal article: NATURE COMMUNICATIONS. 2023;14(1):7767

CAR+ and CAR- T cells share a differentiation trajectory into an NK-like subset after CD19 CAR T cell infusion in patients with B cell malignancies.

Louie RHY; Cai C; Samir J; Singh M; Deveson IW; Ferguson JM; Amos TG; McGuire HM; Gowrishankar K; Adikari T; Balderas R; Bonomi M; Ruella M; Bishop D; Gottlieb D; Blyth E; Micklethwaite K; Luciani F
Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states.

Müller TR; Sekine T; Trubach D; Niessl J; Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Olofsson A; Amaya Hernandez SP; Gao Y; Cai C; Söderdahl G; Smith CIE; Österborg A; Loré K; Sällberg Chen M; Ljungman P; Ljunggren H-G; Karlsson AC; Saini SK; Aleman S; Buggert M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(12):e2220320120

Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age.

Humbert M; Olofsson A; Wullimann D; Niessl J; Hodcroft EB; Cai C; Gao Y; Sohlberg E; Dyrdak R; Mikaeloff F; Neogi U; Albert J; Malmberg K-J; Lund-Johansen F; Aleman S; Björkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Journal article: NATURE COMMUNICATIONS. 2022;13(1):7543

Identification of human progenitors of exhausted CD8+ T cells associated with elevated IFN-γ response in early phase of viral infection.

Cai C; Samir J; Pirozyan MR; Adikari TN; Gupta M; Leung P; Hughes B; Van der Byl W; Rizzetto S; Elthala A; Keoshkerian E; Palgen J-L; Peters T; Nguyen THO; Louie R; Kedzierska K; Gaudieri S; Bull RA; Lloyd AR; Luciani F
Article: IMMUNITY. 2022;55(9):1732-1746.e5

Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination.

Gao Y; Cai C; Wullimann D; Niessl J; Rivera-Ballesteros O; Chen P; Lange J; Cuapio A; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Perez-Potti A; Sekine T; Müller TR; Boulouis C; Kammann T; Parrot T; Muvva JR; Sobkowiak M; Healy K; Bogdanovic G; Muschiol S; Söderdahl G; Österborg A; Hellgren F; Grifoni A; Weiskopf D; Sette A; Loré K; Sällberg Chen M; Ljungman P; Sandberg JK; Smith CIE; Bergman P; Ljunggren H-G; Aleman S; Buggert M
Article: NATURE MEDICINE. 2022;28(3):472-476

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant.

Gao Y; Cai C; Grifoni A; Müller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Österborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren H-G; Karlsson AC; Sette A; Aleman S; Buggert M
Journal article: BLOOD. 2021;138(16):1391-1405

Investigation of product-derived lymphoma following infusion of piggyBac-modified CD19 chimeric antigen receptor T cells.

Micklethwaite KP; Gowrishankar K; Gloss BS; Li Z; Street JA; Moezzi L; Mach MA; Sutrave G; Clancy LE; Bishop DC; Louie RHY; Cai C; Foox J; MacKay M; Sedlazeck FJ; Blombery P; Mason CE; Luciani F; Gottlieb DJ; Blyth E
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51(7):1732-1747

Human CD8 T-stem cell memory subsets phenotypic and functional characterization are defined by expression of CD122 or CXCR3.

Zhao Y; Cai C; Samir J; Palgen J-L; Keoshkerian E; Li H; Bull RA; Luciani F; An H; Lloyd AR
Journal article: BIOINFORMATICS. 2018;34(16):2846-2847

B-cell receptor reconstruction from single-cell RNA-seq with VDJPuzzle.

Rizzetto S; Koppstein DNP; Samir J; Singh M; Reed JH; Cai CH; Lloyd AR; Eltahla AA; Goodnow CC; Luciani F
Journal article: JOURNAL OF PROTEOME RESEARCH. 2015;14(12):5038-5047

Proteogenomic Discovery of a Small, Novel Protein in Yeast Reveals a Strategy for the Detection of Unannotated Short Open Reading Frames.

Yagoub D; Tay AP; Chen Z; Hamey JJ; Cai C; Chia SZ; Hart-Smith G; Wilkins MR

All other publications

Book chapter: METHODS IN MOLECULAR BIOLOGY. 2019;p. 155-205

Single-Cell Transcriptome Analysis of T Cells.

Van Der Byl W; Rizzetto S; Samir J; Cai C; Eltahla AA; Luciani F

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