Christian Göritz

About me
Publications
Public outreach and news

About me

Principal Investigator
Fibrosis and Tissue Repair of the Central Nervous System
Fibroblast functions in blood flow regulation

Previous ERC Starting Grant (https://erc.europa.eu/)
Wallenberg Academy Fellow
(https://kaw.wallenberg.org/en/research/research-scarring-paving-way-new-treatments-spinal-cord-injuries)
Ming Wai Lau Centre for Reparative Medicine Fellow
(https://ki.se/en/research/ming-wai-lau-centre-for-reparative-medicine)

Director of StratRegen (https://ki.se/en/research/about-stratregen)

CV
Diploma in Biochemistry (FU Berlin)
PhD in Neuroscience (Max Planck / CNRS)
Postdoc on CNS Regeneration (Karolinska Institutet)

Research

Christian Göritz's group. [1]
[1] http://ki.se/en/cmb/christian-goritzs-group

Articles

Article: SCIENCE. 2024;383(6683):eade8064

Corpora cavernosa fibroblasts mediate penile erection.

Guimaraes EL; Dias DO; Hau WF; Julien A; Holl D; Garcia-Collado M; Savant S; Vågesjö E; Phillipson M; Jakobsson L; Göritz C
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20230675

CD163+ macrophages monitor enhanced permeability at the blood-dorsal root ganglion barrier.

Lund H; Hunt MA; Kurtović Z; Sandor K; Kägy PB; Fereydouni N; Julien A; Göritz C; Vazquez-Liebanas E; Andaloussi Mäe M; Jurczak A; Han J; Zhu K; Harris RA; Lampa J; Graversen JH; Etzerodt A; Haglund L; Yaksh TL; Svensson CI
Journal article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2023;325(6):c1415-c1420

Decoding fibrosis in the human central nervous system.

Holl D; Göritz C
Article: CELL REPORTS. 2022;38(9):110440

Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties.

Stenudd M; Sabelström H; Llorens-Bobadilla E; Zamboni M; Blom H; Brismar H; Zhang S; Basak O; Clevers H; Göritz C; Barnabé-Heider F; Frisén J
Article: NATURE COMMUNICATIONS. 2021;12(1):5501

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

Dias DO; Kalkitsas J; Kelahmetoglu Y; Estrada CP; Tatarishvili J; Holl D; Jansson L; Banitalebi S; Amiry-Moghaddam M; Ernst A; Huttner HB; Kokaia Z; Lindvall O; Brundin L; Frisén J; Göritz C
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(33):e2104119118

Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry.

Dorst MC; Díaz-Moreno M; Dias DO; Guimarães EL; Holl D; Kalkitsas J; Silberberg G; Göritz C
Article: FASEB JOURNAL. 2020;34(10):13978-13992

Circadian vulnerability of cisplatin-induced ototoxicity in the cochlea.

Tserga E; Moreno-Paublete R; Sarlus H; Björn E; Guimaraes E; Göritz C; Cederroth CR; Canlon B
Article: EMBO JOURNAL. 2018;37(9):e98280

Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.

Reichenbach B; Classon J; Aida T; Tanaka K; Genander M; Göritz C
Article: CELL. 2018;173(1):153-165.e22

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

Dias DO; Kim H; Holl D; Werne Solnestam B; Lundeberg J; Carlén M; Göritz C; Frisén J
Article: SCIENCE. 2014;346(6206):237-241

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.

Magnusson JP; Göritz C; Tatarishvili J; Dias DO; Smith EMK; Lindvall O; Kokaia Z; Frisén J
Article: NEURON. 2014;83(5):1085-1097

A transcriptional mechanism integrating inputs from extracellular signals to activate hippocampal stem cells.

Andersen J; Urbán N; Achimastou A; Ito A; Simic M; Ullom K; Martynoga B; Lebel M; Göritz C; Frisén J; Nakafuku M; Guillemot F
Article: SCIENCE. 2013;342(6158):637-640

Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice.

Sabelström H; Stenudd M; Réu P; Dias DO; Elfineh M; Zdunek S; Damberg P; Göritz C; Frisén J
Article: SCIENCE. 2011;333(6039):238-242

A pericyte origin of spinal cord scar tissue.

Göritz C; Dias DO; Tomilin N; Barbacid M; Shupliakov O; Frisén J
Article: MOLECULAR BIOLOGY OF THE CELL. 2011;22(11):1864-1877

In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements.

Raju CS; Fukuda N; López-Iglesias C; Göritz C; Visa N; Percipalle P
Article: CELL STEM CELL. 2010;7(6):730-743

EphB signaling controls lineage plasticity of adult neural stem cell niche cells.

Nomura T; Göritz C; Catchpole T; Henkemeyer M; Frisén J
Article: JOURNAL OF NEUROSCIENCE. 2010;30(41):13794-13807

RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.

Ehm O; Göritz C; Covic M; Schäffner I; Schwarz TJ; Karaca E; Kempkes B; Kremmer E; Pfrieger FW; Espinosa L; Bigas A; Giachino C; Taylor V; Frisén J; Lie DC
Article: CELL STEM CELL. 2010;7(4):470-482

Origin of new glial cells in intact and injured adult spinal cord.

Barnabé-Heider F; Göritz C; Sabelström H; Takebayashi H; Pfrieger FW; Meletis K; Frisén J
Article: NATURE NEUROSCIENCE. 2009;12(3):259-267

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.

Carlén M; Meletis K; Göritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabé-Heider F; Yeung MSY; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisén J
Article: MOLECULAR BIOLOGY OF THE CELL. 2008;19(7):3008-3019

In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences.

Raju CS; Göritz C; Nord Y; Hermanson O; López-Iglesias C; Visa N; Castelo-Branco G; Percipalle P
Article: GLIA. 2007;55(15):1565-1576

Transgenic mice for conditional gene manipulation in astroglial cells.

Slezak M; Göritz C; Niemiec A; Frisén J; Chambon P; Metzger D; Pfrieger FW
Article: GLIA. 2007;55(11):1108-1122

Glia-induced neuronal differentiation by transcriptional regulation.

Göritz C; Thiebaut R; Tessier L-H; Nieweg K; Moehle C; Buard I; Dupont J-L; Schurgers LJ; Schmitz G; Pfrieger FW
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2005;29(2):190-201

Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron.

Goritz C; Mauch DH; Pfrieger FW
Article: JOURNAL OF PHYSIOLOGY PARIS. 2002;96(3-4):257-263

Role of glia-derived cholesterol in synaptogenesis: new revelations in the synapse-glia affair.

Göritz C; Mauch DH; Nägler K; Pfrieger FW
Article: SCIENCE. 2001;294(5545):1354-1357

CNS synaptogenesis promoted by glia-derived cholesterol.

Mauch DH; Nägler K; Schumacher S; Göritz C; Müller EC; Otto A; Pfrieger FW
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All other publications

Preprint: BIORXIV. 2023

A network of CD163⁺macrophages monitors enhanced permeability at the blood-dorsal root ganglion barrier

Lund H; Hunt M; Kurtovic Z; Sandor K; Fereydouni N; Julien A; Göritz C; Han J; Zhu K; Harris R; Lampa J; Haglund L; Yaksh T; Svensson C
Preprint: RESEARCH SQUARE. 2022

Macrophages support healing of ischemic injury by transdifferentiating towards mural cells and adopting functions important for vascular support

Parv K; Hidalgo CH; Xu F; Amoedo-Leite C; Giraud A; Holl D; Seignez C; Goeritz C; Christoffersson G; Phillipson M
Preprint: BIORXIV. 2020

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

Dias DO; Kalkitsas J; Kelahmetoglu Y; Estrada CP; Tatarishvili J; Ernst A; Huttner HB; Kokaia Z; Lindvall O; Brundin L; Frisén J; Göritz C
Conference publication: GLIA. 2019;67:E38

Mechanisms of fibrotic scarring and axon regeneration

Goritz C
Review: MATRIX BIOLOGY. 2018;68-69:561-570

Fibrotic scarring following lesions to the central nervous system.

Dias DO; Göritz C
Conference publication: GLIA. 2017;65:E53-E54

Attenuation of pericyte-derived fibrosis promotes axonal regeneration and functional recovery following CNS injury

Goritz C
Conference publication: GLIA. 2017;65:E534-E535

Attenuation of pericyte-derived scarring promotes axonal regeneration and functional recovery following spinal cord injury

Dias DO; Kim H; Holl D; Solnestam BW; Lundeberg J; Carlen M; Frisen J; Goritz C
Editorial comment: CELL STEM CELL. 2012;10(6):657-659

Neural stem cells and neurogenesis in the adult.

Göritz C; Frisén J
Conference publication: CHEMISTRY AND PHYSICS OF LIPIDS. 2005;136(2):134

Cholesterol biosynthesis and its regulation in neurons and glial cells

Nieweg K; Goritz C; Pfrieger FW
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2001;12:378A

Identification of a glia-derived factor promoting synaptogenesis

Mauch D; Nagler K; Schumacher S; Goritz C; Muller EC; Otto A; Pfrieger FW

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