Bruno Raposo

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Journal article: JOINT BONE SPINE. 2023;90(6):105617

The diversity of anti-citrulline reactivity and ACPA-associated phenotypes.

Raposo B; Grönwall C
Article: KIDNEY INTERNATIONAL. 2023;103(5):973-985

Identification of proteinase 3 autoreactive CD4+T cells and their T-cell receptor repertoires in antineutrophil cytoplasmic antibody-associated vasculitis.

Sharma RK; Yoosuf N; Afonso M; Scheffschick A; Avik A; Bartoletti A; Horuluoglu B; Diaz Boada JS; Boddul SK; Jonasdottir AD; Lövström B; Brauner H; Raposo B; Chemin K; Bruchfeld A; Gunnarsson I; Malmström V
Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857

Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2.

Iyer VS; Boddul SV; Johnsson A-K; Raposo B; Sharma RK; Shen Y; Kasza Z; Lim KW; Chemin K; Nilsson G; Malmström V; Phan AT; Wermeling F
Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2021;19:5360-5370

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.

Shen Y; Jiang L; Iyer VS; Raposo B; Dubnovitsky A; Boddul SV; Kasza Z; Wermeling F
Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100087

In vitro and ex vivo functional characterization of human HLA-DRB1∗04 restricted T cell receptors.

Boddul SV; Sharma RK; Dubnovitsky A; Raposo B; Gerstner C; Shen Y; Iyer VS; Kasza Z; Kwok WW; Winkler AR; Klareskog L; Malmström V; Bettini M; Wermeling F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(40):24986-24997

Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.

Fernandez Lahore G; Raposo B; Lagerquist M; Ohlsson C; Sabatier P; Xu B; Aoun M; James J; Cai X; Zubarev RA; Nandakumar KS; Holmdahl R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):3103-3113

IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.

Panda SK; Wigerblad G; Jiang L; Jiménez-Andrade Y; Iyer VS; Shen Y; Boddul SV; Guerreiro-Cacais AO; Raposo B; Kasza Z; Wermeling F
Article: IMMUNOLOGY. 2018;154(4):683-694

Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T-cell-associated autoimmunity.

Vaartjes D; Nandakumar K-S; Holmdahl R; Raposo B
Article: NATURE COMMUNICATIONS. 2018;9(1):353

T cells specific for post-translational modifications escape intrathymic tolerance induction.

Raposo B; Merky P; Lundqvist C; Yamada H; Urbonaviciute V; Niaudet C; Viljanen J; Kihlberg J; Kyewski B; Ekwall O; Holmdahl R; Bäcklund J
Article: IMMUNOLOGY. 2015;146(4):607-617

System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis.

Raposo B; Vaartjes D; Ahlqvist E; Nandakumar K-S; Holmdahl R
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(3):405-411

Epitope-specific antibody response is controlled by immunoglobulin V(H) polymorphisms.

Raposo B; Dobritzsch D; Ge C; Ekman D; Xu B; Lindh I; Förster M; Uysal H; Nandakumar KS; Schneider G; Holmdahl R
Article: PLOS ONE. 2014;9(5):e97532

Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice.

Rodrigues-Sousa T; Ladeirinha AF; Santiago AR; Carvalheiro H; Raposo B; Alarcão A; Cabrita A; Holmdahl R; Carvalho L; Souto-Carneiro MM
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(11):3594-3603

Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice.

Förster M; Raposo B; Ekman D; Klaczkowska D; Popovic M; Nandakumar KS; Lindvall T; Hultqvist M; Teneva I; Johannesson M; Ahlqvist E; Holmdahl R
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(1):46-52

Heterogeneous stock mice are susceptible to encephalomyelitis and antibody-initiated arthritis but not to collagen- and G6PI-induced arthritis.

Klaczkowska D; Raposo B; Nandakumar KS
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(10):2953-2962

Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.

Raposo BR; Rodrigues-Santos P; Carvalheiro H; Agua-Doce AM; Carvalho L; Pereira da Silva JA; Graça L; Souto-Carneiro MM

Alla övriga publikationer

Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:214-215

HUMAN MONOCLONAL ANTIBODIES DERIVED FROM GINGIVAL TISSUE B CELLS BIND MALONDIALDEHYDE (MDA)-MODIFIED SELF-PROTEINS AND EXACERBATES ARTHRITIS - A NOVEL AUTOIMMUNE LINK BETWEEN INFLAMED GUMS AND JOINTS

Raposo B; De Vries C; Afonso MG; Sahlstrom P; Israelsson L; Stalesen R; Klareskog L; Malmstrom V; Rethi B; Gronwall C; Lundberg K
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:837.2-83837

PATIENT-DERIVED ACPA CLONES DISPLAY BOTH PRO- AND ANTI-INFLAMMATORY POTENTIAL IN VIVO

Raposo B; Afonso MG; Israelsson L; Stalesen R; Wahamaa H; Hansson M; Hensvold A; Wermeling F; Mueller D; Rethi B; Gronwall C; Klareskog L; Malmstrom V
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(5):724-726

Divergent and dominant anti-inflammatory effects of patient-derived anticitrullinated protein antibodies (ACPA) in arthritis development.

Raposo B; Afonso M; Israelsson L; Wähämaa H; Stålesen R; Wermeling F; Hensvold AH; Grönwall C; Rethi B; Klareskog L; Malmström V
Preprint: BIORXIV. 2022

Divergent and dominant anti-inflammatory effects of patient-derived anti-citrullinated protein antibodies (ACPA) in arthritis development

Raposo B; Afonso M; Israelsson L; Wähämaa H; Stålesen R; Wermeling F; Hensvold A; Grönwall C; Rethi B; Klareskog L; Malmström V
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:1

AUTOREACTIVE CD4+T CELLS AND THEIR TCR REPERTOIRE IN PR3-ANCA ASSOCIATED VASCULITIS

Kumar R; Yoosuf N; Bartoletti A; Avik A; Raposo B; Jonasdottir A; Lovstrom B; Chemin K; Bruchfeld A; Gunnarsson I; Malmstrom V
Preprint: BIORXIV. 2021

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system

Shen Y; Jiang L; Iyer VS; Raposo B; Boddul S; Kasza Z; Wermeling F
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;94(6)

Proteinase 3 reactive CD4+T cells and their TCR repertoire in ANCA associated vasculitis

Kumar R; Yoosuf N; Scheffschick A; Avik A; Bartoletti A; Raposo B; Boddul S; Jonasdottir A; Lovstrom B; Chemin K; Bruchfeld A; Gunnarsson I; Malmstrom V
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:131

Autoreactive CD4+T-cell phenotypes and TCR repertoires in ANCA associated vasculitis

Sharma RK; Yoosuf N; Bartoletti A; Avik A; Raposo B; Boddul SK; Jonasdottir AD; Lovstrom B; Chemin K; Bruchfeld A; Gunnarsson I; Malmstrom V
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:397

A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system

Shen Y; Jiang L; Iyer VS; Raposo B; Boddul SV; Kasza Z; Wermeling F
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):324

Non-coding variants promote vitamin D receptor expression in activated T cells and protect from GPI-induced arthritis

Fernandez-Lahore G; Raposo B; Marquina C; Aoun M; Lagerquist M; Holmdahl R
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:902

Increased salt exposure affects both lymphoid and myeloid effector functions, influencing antibody-induced arthritis but not autoimmunity

Vaartjes D; Raposo B; Nandakumar KS; Holmdahl R
Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46:807

T cells specific for posttranslational modifications escape negative selection in thymus

Raposo B; Merky P; Yamada H; Niaudet C; Urbonaviciute V; Pinto S; Kyewski B; Holmdahl R; Backlund J
Conference publication: JOURNAL OF IMMUNOLOGY. 2012;188:171.44

Genetic control of antibody production during collagen induced arthritis development in heterogeneous stock mice

Foerster M; Raposo B; Ekman D; Klaczkowska D; Popovic M; Selva NK; Lindvall T; Hultqvist M; Teneva I; Johannesson M; Ahlqvist E; Holmdahl R
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a55-A56

GENETIC INFLUENCE OF SPECIFIC ANTICOLLAGEN ANTIBODY PRODUCTION IN A MOUSE MODEL OF RHEUMATOID ARTHRITIS

Raposo B; Dobritzsch D; Uysal H; Ekman D; Holmdahl R
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a53-A54

GENETIC CONTROL OF ANTIBODY PRODUCTION DURING COLLAGEN INDUCED ARTHRITIS DEVELOPMENT IN HETEROGENEOUS STOCK MICE

Forster M; Raposo B; Ekman D; Klaczkowska D; Popovic M; Nandakumar KS; Ahlqvist E; Holmdahl R
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2010;69:a66

DISEASE AMELIORATION IN THE K/BXN MOUSE MODEL OF SPONTANEOUS CHRONIC ARTHRITIS AFTER CD8 T CELL DEPLETION

Raposo BR; Agua-Doce AM; Pereira da Silva JA; Graca L; Souto-Carneiro MM

Forskningsbidrag

POSITIONAL CLONING AND MOLECULAR PATHWAYS OF GENES ASSOCIATED WITH ARTHRITIS IN MICE

Fundação para a Ciência e Tecnologia

1 August 2008 - 31 July 2012
Utveckling av immunitet mot anti-citrulline in nässlemhinnan

Ulla och Gustaf af Uggla Stiftelse

Anställningar

Senior Lab Manager, Medicin, Solna, Karolinska Institutet, 2021-

Examina och utbildning

Medicine Doktorsexamen, Institutionen för medicinsk biokemi och biofysik, Karolinska Institutet, 2012

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI