Om mig
My name is Bruno Raposo and I am a senior immunologist with a working research experience at the academic level. I hold a PhD in Medical Science and have a pre-clinical research focus and vaccine development purpose. Praised presenting and mentoring skills, with expertise in animal models of autoimmunity, T and B cell immunity. On some of my free time I write a popular science column in a Portuguese newspaper:
- B. Raposo (March 2021); “Vacinas”; Jornal de Ferreira, Ferreira do Alentejo
- B. Raposo (June 2021); “Marte – o planeta vermelho”; Jornal de Ferreira, Ferreira do Alentejo
- B. Raposo (January 2022); “100 anos de insulina”; Jornal de Ferreira, Ferreira do Alentejo
- B. Raposo (June 2022); “O mito de um Super Sistema imunitário”; Jornal de Ferreira, Ferreira do Alentejo
- B. Raposo (accepted for publication, January 2023); “Ao porco o que é do porco”; Jornal de Ferreira, Ferreira do Alentejo
Forskningsbeskrivning
Publications
- B. Raposo, M. Afonso, L. Israelsson, H. Wähämaa, R. Stålesen, F. Wermeling, A. Hensvold, C. Grönwall, B. Réthi, L. Klareskog and V. Malmström; “Divergent and dominant anti-inflammatory effects of patient-derived anti-citrullinated protein antibodies (ACPA) in arthritis development” (2023); Annals of the Rheumatic Diseases, ahead of print
- V.S. Iyer, S.V. Boddul, A.K. Johnsson, B. Raposo, R.K. Sharma, Y. Shen, Z. Kasza, K.W. Lim, K. Chemin, G. Nilsson, V. Malmström, A.T. Phan and F. Wermeling (2022); ”Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2”; Journal of Autoimmunity, 131: 102857
- Y. Shen, L. Jiang, V. S. Iyer, B. Raposo, A. Dubnovitsky, S. V. Boddul, Z. Kasza, and F. Wermeling (2021); “A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system”; Comput. Struct. Biotechnol. J., 19: 5360
- S. Boddul, R.K. Sharma, A. Dubnovitsky, B. Raposo, C. Gerstner, Y. Shen, V.S. Iyer, Z. Kasza, W.W. Kwok, A. Winkler, L. Klareskog, V. Malmström, M. Bettini and F. Wermeling (2021); “In vitro and ex vivo functional characterization of human HLA-DRB1*04 restricted T cell receptors”; J. Transl. Immunol., 4: 100087
- G. Fernandez Lahore, B. Raposo, M. K. Lagerquist, C. Ohlsson, P. Sebatier, B. Xu, M. Aoun, J. R. James, X. Cai, R. A. Zubarev, K.S. Nandakumar and R. Holmdahl (2020); “Vitamin D3 receptor polymorphisms regulate T cells and T cell dependent inflammatory diseases”; Proc. Natl. Acad. Sci., 117: 24986
- S.K. Panda, G. Wigerblad, L. Jiang, Y. Jiménez-Andrade, V.S. Iyer, Y. Shen, S.V. Boddul, A.O. Guerreiro-Cacais, B. Raposo, Z. Kaska and F. Wermeling (2020); “IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints”; Proc. Natl. Acad. Sci., 117: 3103
- D. Vaartjes, K. S. Nandakumar, R. Holmdahl*, B. Raposo* (2018); “Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T cell-associated autoimmunity”; Immunology, 154: 683 – * authors contributed equally
- B. Raposo, P. Merky, C. Lundqvist, H. Yamada, V. Urbonaviciute, C. Niaudet, J. Viljanen, J. Kihlberg, B. Kyewski, O. Ekwall, R. Holmdahl, J. Bäcklund (2018); “T cells specific for post-translational modifications escape intrathymic tolerance induction”; Nature Communications, 9: 353
- B Raposo, D. Vaartjes, E. Ahlqvist, K.S. Nandakumar, R. Holmdahl (2015); “System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis”; Immunology, 146: 607
- B. Raposo, D. Dobritzsch, C. Ge, D. Ekman, B. Xu, I. Lindh, M. Förster, H. Uysal, K. S. Nandakumar, G. Schneider, R. Holmdahl (2014); “Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms”; The Journal of Experimental Medicine, 20: 3031
- T. Rodrigues-Sousa, A.F. Ladeirinha, R. Santiago, H. Carvalheiro, B. Raposo, A. Alarcão, A. Cabrita, R. Holmdahl, L. Carvalho, M.M. Souto-Carneiro (2014); “Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice”; PLoS One; doi:10.1371/journal.pone.0097532
- M. Förster*, B. Raposo*, D. Ekman, D. Klaczkowska, M. Popovic, K.S. Nandakumar, T. Lindvall, M. Hultqvist, I. Teneva, M. Johannesson, E. Ahlqvist, R. Holmdahl (2012); “Genetic control of antibody production during collagen induced arthritis development in heterogeneous stock mice”; Arthritis & Rheumatism (presently Arthritis & Rheumatology), 64: 3594 – * authors contributed equally
- D. Klaczkowska*, B. Raposo* and K. S. Nandakumar (2011); “Heterogeneous stock mice are susceptible to encephalomyelitis and antibody-initiated arthritis but not to collagen- and G6PI-induced arthritis”; Scandinavian Journal of Immunology, 73: 46 – * authors contributed equally
- B. Raposo, P. Rodrigues-Santos, H. Carvalheiro, A. Água-Doce, L. Carvalho, J. Pereira da Silva, L. Graça, and M. M. Souto-Carneiro (2010); “Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis”; Arthritis & Rheumatism (presently Arthritis & Rheumatology), 62: 2953
Pedagogiska meriter
Research Mentor, training, supervision, guidance and scientific advisor
- Karolinska Institutet, Stockholm, Sweden
- Master student M. Stoimenou, main supervisor, 3 months, 2021
- Master student A. Angelopoulou, main supervisor, 6 months, Jul-Dec 2019
- PhD student D. Vaartjes, co-supervisor, 2015-2018; PhD defense: June 2018
- PhD student G. Fernández-Lahore, co-supervisor, 2014-2016
- Master student G. Fernández-Lahore, main supervisor, 6 months, 2013-2014
- Master student C. Heilmann, main supervisor, 6 months, 2013
- Master student I. Mohammad, co-supervisor, 6 months, 2012
- 3 undergraduate students, main supervisor, 3 months, 2010-2011
- Harvard Medical School, Boston, USA
- PhD student Z. Chen, co-supervisor, 2017-2019
- PhD student R. Kochappan, co-supervisor, 2 months, 2018
- MD PhD student M. Reinhart, principal supervisor, Sept 2017-Mar 2018; thesis to be defended by 2021 (University of Würzburg, Germany)
- Undergraduate student A. Alavi, principal supervisor, 2 months, 2016
Teaching Assistant, lecturer and laboratory supervisor
- Karolinska Institutet, Stockholm, Sweden
- 4th Workshop in Spectral Flow Cytometry, lecturer and instructor, Nov 2022
- 3rd Workshop in Spectral Flow Cytometry, lecturer and instructor, April 2022
- 2nd Workshop in Spectral Flow Cytometry, lecturer and instructor, Feb 2021
- 1st Workshop in Spectral Flow Cytometry; lecturer and instructor; Nov 2020
- PhD course #3187, “Basic Immunology”; lecturer and projector mentor; Academic year 2022-2023
- PhD course #5229 “Basic Immunology”; lecturer and project mentor; Academic year 2020-21
- PhD course #2302 “Basic Immunology”; lecturer and project mentor; Academic year 2019-20
- PhD course #2532 “Multifactorial immune-mediated diseases – etiology and pathogenesis”, lecturer; Academic years 2013-14 / 2014-15
- Biomedical program, course in “General and Organic Chemistry”, lecturer and laboratory supervisor; Academic years 2008/2009 to 2013/2014
Utbildning
Master in Biochemistry, University of Évora, 2006
PhD in Medical Sciences, Karolinska Institutet, 2012