Bruno Raposo

Bruno Raposo

Senior lab manager

E-post:
bruno.raposo@ki.se
Organisation:

Om mig

My name is Bruno Raposo and I am a senior immunologist with a working research experience at the academic level. I hold a PhD in Medical Science and have a pre-clinical research focus and vaccine development purpose. Praised presenting and mentoring skills, with expertise in animal models of autoimmunity, T and B cell immunity. On some of my free time I write a popular science column in a Portuguese newspaper:

  1. B. Raposo (March 2021); “Vacinas”; Jornal de Ferreira, Ferreira do Alentejo
  2. B. Raposo (June 2021); “Marte – o planeta vermelho”; Jornal de Ferreira, Ferreira do Alentejo
  3. B. Raposo (January 2022); “100 anos de insulina”; Jornal de Ferreira, Ferreira do Alentejo
  4. B. Raposo (June 2022); “O mito de um Super Sistema imunitário”; Jornal de Ferreira, Ferreira do Alentejo
  5. B. Raposo (accepted for publication, January 2023); “Ao porco o que é do porco”; Jornal de Ferreira, Ferreira do Alentejo

Forskningsbeskrivning

Publications

  1. B. Raposo, M. Afonso, L. Israelsson, H. Wähämaa, R. Stålesen, F. Wermeling, A. Hensvold, C. Grönwall, B. Réthi, L. Klareskog and V. Malmström; “Divergent and dominant anti-inflammatory effects of patient-derived anti-citrullinated protein antibodies (ACPA) in arthritis development” (2023); Annals of the Rheumatic Diseases, ahead of print
  2. V.S. Iyer, S.V. Boddul, A.K. Johnsson, B. Raposo, R.K. Sharma, Y. Shen, Z. Kasza, K.W. Lim, K. Chemin, G. Nilsson, V. Malmström, A.T. Phan and F. Wermeling (2022); ”Modulating T-cell activation with antisense oligonucleotides targeting lymphocyte cytosolic protein 2”; Journal of Autoimmunity, 131: 102857
  3. Y. Shen, L. Jiang, V. S. Iyer, B. Raposo, A. Dubnovitsky, S. V. Boddul, Z. Kasza, and F. Wermeling (2021); “A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system”; Comput. Struct. Biotechnol. J., 19: 5360
  4. S. Boddul, R.K. Sharma, A. Dubnovitsky, B. Raposo, C. Gerstner, Y. Shen, V.S. Iyer, Z. Kasza, W.W. Kwok, A. Winkler, L. Klareskog, V. Malmström, M. Bettini and F. Wermeling (2021); “In vitro and ex vivo functional characterization of human HLA-DRB1*04 restricted T cell receptors”; J. Transl. Immunol., 4: 100087
  5. G. Fernandez Lahore, B. Raposo, M. K. Lagerquist, C. Ohlsson, P. Sebatier, B. Xu, M. Aoun, J. R. James, X. Cai, R. A. Zubarev, K.S. Nandakumar and R. Holmdahl (2020); “Vitamin D3 receptor polymorphisms regulate T cells and T cell dependent inflammatory diseases”; Proc. Natl. Acad. Sci., 117: 24986
  6. S.K. Panda, G. Wigerblad, L. Jiang, Y. Jiménez-Andrade, V.S. Iyer, Y. Shen, S.V. Boddul, A.O. Guerreiro-Cacais, B. Raposo, Z. Kaska and F. Wermeling (2020); “IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints”; Proc. Natl. Acad. Sci., 117: 3103
  7. D. Vaartjes, K. S. Nandakumar, R. Holmdahl*, B. Raposo* (2018); “Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T cell-associated autoimmunity”; Immunology, 154: 683 – * authors contributed equally
  8. B. Raposo, P. Merky, C. Lundqvist, H. Yamada, V. Urbonaviciute, C. Niaudet, J. Viljanen, J. Kihlberg, B. Kyewski, O. Ekwall, R. Holmdahl, J. Bäcklund (2018); “T cells specific for post-translational modifications escape intrathymic tolerance induction”; Nature Communications, 9: 353
  9. B Raposo, D. Vaartjes, E. Ahlqvist, K.S. Nandakumar, R. Holmdahl (2015); “System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis”; Immunology, 146: 607
  10. B. Raposo, D. Dobritzsch, C. Ge, D. Ekman, B. Xu, I. Lindh, M. Förster, H. Uysal, K. S. Nandakumar, G. Schneider, R. Holmdahl (2014); “Epitope-specific antibody response is controlled by immunoglobulin VH polymorphisms”; The Journal of Experimental Medicine, 20: 3031
  11. T. Rodrigues-Sousa, A.F. Ladeirinha, R. Santiago, H. Carvalheiro, B. Raposo, A. Alarcão, A. Cabrita, R. Holmdahl, L. Carvalho, M.M. Souto-Carneiro (2014); “Deficient production of reactive oxygen species leads to severe chronic DSS-induced colitis in Ncf1/p47phox-mutant mice”; PLoS One; doi:10.1371/journal.pone.0097532
  12. M. Förster*, B. Raposo*, D. Ekman, D. Klaczkowska, M. Popovic, K.S. Nandakumar, T. Lindvall, M. Hultqvist, I. Teneva, M. Johannesson, E. Ahlqvist, R. Holmdahl (2012); “Genetic control of antibody production during collagen induced arthritis development in heterogeneous stock mice”; Arthritis & Rheumatism (presently Arthritis & Rheumatology), 64: 3594 – * authors contributed equally
  13. D. Klaczkowska*, B. Raposo* and K. S. Nandakumar (2011); “Heterogeneous stock mice are susceptible to encephalomyelitis and antibody-initiated arthritis but not to collagen- and G6PI-induced arthritis”; Scandinavian Journal of Immunology, 73: 46 – * authors contributed equally
  14. B. Raposo, P. Rodrigues-Santos, H. Carvalheiro, A. Água-Doce, L. Carvalho, J. Pereira da Silva, L. Graça, and M. M. Souto-Carneiro (2010); “Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis”; Arthritis & Rheumatism (presently Arthritis & Rheumatology), 62: 2953

Pedagogiska meriter

Research Mentor, training, supervision, guidance and scientific advisor

  •  Karolinska Institutet, Stockholm, Sweden
    • Master student M. Stoimenou, main supervisor, 3 months, 2021
    • Master student A. Angelopoulou, main supervisor, 6 months, Jul-Dec 2019
    • PhD student D. Vaartjes, co-supervisor, 2015-2018; PhD defense: June 2018
    • PhD student G. Fernández-Lahore, co-supervisor, 2014-2016
    • Master student G. Fernández-Lahore, main supervisor, 6 months, 2013-2014
    • Master student C. Heilmann, main supervisor, 6 months, 2013
    • Master student I. Mohammad, co-supervisor, 6 months, 2012
    • 3 undergraduate students, main supervisor, 3 months, 2010-2011
  • Harvard Medical School, Boston, USA
    • PhD student Z. Chen, co-supervisor, 2017-2019
    • PhD student R. Kochappan, co-supervisor, 2 months, 2018
    • MD PhD student M. Reinhart, principal supervisor, Sept 2017-Mar 2018; thesis to be defended by 2021 (University of Würzburg, Germany)
    • Undergraduate student A. Alavi, principal supervisor, 2 months, 2016

Teaching Assistant, lecturer and laboratory supervisor

  •  Karolinska Institutet, Stockholm, Sweden
    • 4th Workshop in Spectral Flow Cytometry, lecturer and instructor, Nov 2022
    • 3rd Workshop in Spectral Flow Cytometry, lecturer and instructor, April 2022
    • 2nd Workshop in Spectral Flow Cytometry, lecturer and instructor, Feb 2021
    • 1st Workshop in Spectral Flow Cytometry; lecturer and instructor; Nov 2020
    • PhD course #3187, “Basic Immunology”; lecturer and projector mentor; Academic year 2022-2023
    • PhD course #5229 “Basic Immunology”; lecturer and project mentor; Academic year 2020-21
    • PhD course #2302 “Basic Immunology”; lecturer and project mentor; Academic year 2019-20
    • PhD course #2532 “Multifactorial immune-mediated diseases – etiology and pathogenesis”, lecturer; Academic years 2013-14 / 2014-15
    • Biomedical program, course in “General and Organic Chemistry”, lecturer and laboratory supervisor; Academic years 2008/2009 to 2013/2014

Utbildning

Master in Biochemistry, University of Évora, 2006

PhD in Medical Sciences, Karolinska Institutet, 2012