Annika Karlsson

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: SCIENCE TRANSLATIONAL MEDICINE. 2023;15(704):eadg9452

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states.

Müller TR; Sekine T; Trubach D; Niessl J; Chen P; Bergman P; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Olofsson A; Amaya Hernandez SP; Gao Y; Cai C; Söderdahl G; Smith CIE; Österborg A; Loré K; Sällberg Chen M; Ljungman P; Ljunggren H-G; Karlsson AC; Saini SK; Aleman S; Buggert M
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):75.16

Anamnestic expansion of Omicron-reactive CD8 +T cells after booster SARS-CoV-2 mRNA vaccination across different immunocompromised states

Müller TR; Sekine T; Trubach D; Niessl J; Olofsson A; Gao Y; Cai C; Nowak P; Blennow O; Hansson L; Mielke S; Bergman P; Ljunggren H-G; Karlsson AC; Saini SK; Aleman S; Buggert M
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):75.20

Pre-existing SARS-CoV-2-reactive CD4 +T cells are established and highly functional in early childhood

Olofsson A; Humbert M; Niessl J; Hodcroft E; Gao Y; Sohlberg E; Malmberg K-J; Lund-Johansen F; Björkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(12):e2220320120

Functional SARS-CoV-2 cross-reactive CD4+ T cells established in early childhood decline with age.

Humbert M; Olofsson A; Wullimann D; Niessl J; Hodcroft EB; Cai C; Gao Y; Sohlberg E; Dyrdak R; Mikaeloff F; Neogi U; Albert J; Malmberg K-J; Lund-Johansen F; Aleman S; Björkhem-Bergman L; Jenmalm MC; Ljunggren H-G; Buggert M; Karlsson AC
Article: CELLS. 2022;11(19):3142

Hierarchical Clustering and Trajectory Analyses Reveal Viremia-Independent B-Cell Perturbations in HIV-2 Infection.

Johansson E; Kerkman PF; Scharf L; Lindman J; Szojka ZI; Månsson F; Biague A; Medstrand P; Norrgren H; Buggert M; Karlsson AC; Forsell MNE; Esbjörnsson J; Jansson M; The Swegub Core Group
Article: NATURE MEDICINE. 2022;28(3):472-476

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant.

Gao Y; Cai C; Grifoni A; Müller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Österborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren H-G; Karlsson AC; Sette A; Aleman S; Buggert M
Journal article: NATURE MEDICINE. 2022

Ancestral SARS-CoV-2-specific T cells cross-recognize Omicron

Gao Y; Cai C; Grifoni A; Müller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Österborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren H-G; Karlsson AC; Sette A; Aleman S; Buggert M
Article: SCIENCE IMMUNOLOGY. 2021;6(64):eabk0894

Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue.

Niessl J; Sekine T; Lange J; Konya V; Forkel M; Maric J; Rao A; Mazzurana L; Kokkinou E; Weigel W; Llewellyn-Lacey S; Hodcroft EB; Karlsson AC; Fehrm J; Sundman J; Price DA; Mjösberg J; Friberg D; Buggert M
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:744530

Inverted CD8 T-Cell Exhaustion and Co-Stimulation Marker Balance Differentiate Aviremic HIV-2-Infected From Seronegative Individuals.

Scharf L; Pedersen CB; Johansson E; Lindman J; Olsen LR; Buggert M; Wilhelmson S; Månsson F; Esbjörnsson J; Biague A; Medstrand P; Norrgren H; Karlsson AC; Jansson M; SWEGUB CORE Group
Article: SCIENCE IMMUNOLOGY. 2020;5(53):eabe8063

The known unknowns of T cell immunity to COVID-19.

Karlsson AC; Humbert M; Buggert M
Article: JOURNAL OF VIROLOGY. 2020;94(14):e02128-e02119

Delayed Expression of PD-1 and TIGIT on HIV-Specific CD8 T Cells in Untreated HLA-B*57:01 Individuals Followed from Early Infection.

Scharf L; Tauriainen J; Buggert M; Hartogensis W; Nolan DJ; Deeks SG; Salemi M; Hecht FM; Karlsson AC
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):453-465

Human Immunodeficiency Virus-Infected Women Have High Numbers of CD103-CD8+ T Cells Residing Close to the Basal Membrane of the Ectocervical Epithelium.

Gibbs A; Buggert M; Edfeldt G; Ranefall P; Introini A; Cheuk S; Martini E; Eidsmo L; Ball TB; Kimani J; Kaul R; Karlsson AC; Wählby C; Broliden K; Tjernlund A
Article: PLOS PATHOGENS. 2018;14(4):e1006973

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.

Buggert M; Nguyen S; McLane LM; Steblyanko M; Anikeeva N; Paquin-Proulx D; Del Rio Estrada PM; Ablanedo-Terrazas Y; Noyan K; Reuter MA; Demers K; Sandberg JK; Eller MA; Streeck H; Jansson M; Nowak P; Sönnerborg A; Canaday DH; Naji A; Wherry EJ; Robb ML; Deeks SG; Reyes-Teran G; Sykulev Y; Karlsson AC; Betts MR
Journal article: JOURNAL OF IMMUNOLOGY. 2017;198(1_Supplement):78.25

HIV-induced modifications of TIGIT expression impair CD8 T cell polyfunctionality

Scharf L; Tauriainen J; Frederiksen J; Naji A; Ljunggren H-G; Sönnerborg A; Lund O; Reyes-Terán G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Article: TRANSLATIONAL CANCER RESEARCH. 2017;6:S65-S67

Genetic footprints of T cell exhaustion

Buggert M; Tauriainen J; Karlsson AC
Article: SCIENTIFIC REPORTS. 2017;7:40354

Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.

Tauriainen J; Scharf L; Frederiksen J; Naji A; Ljunggren H-G; Sönnerborg A; Lund O; Reyes-Terán G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(1):91-106

Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency.

Abolhassani H; Edwards ESJ; Ikinciogullari A; Jing H; Borte S; Buggert M; Du L; Matsuda-Lennikov M; Romano R; Caridha R; Bade S; Zhang Y; Frederiksen J; Fang M; Bal SK; Haskologlu S; Dogu F; Tacyildiz N; Matthews HF; McElwee JJ; Gostick E; Price DA; Palendira U; Aghamohammadi A; Boisson B; Rezaei N; Karlsson AC; Lenardo MJ; Casanova J-L; Hammarström L; Tangye SG; Su HC; Pan-Hammarström Q
Article: AIDS. 2016;30(16):2415-2426

CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection.

Buggert M; Frederiksen J; Lund O; Betts MR; Biague A; Nielsen M; Tauriainen J; Norrgren H; Medstrand P; Karlsson AC; Jansson M; SWEGUB CORE group
Article: AIDS. 2016;30(11):1713-1722

Elevated levels of invariant natural killer T-cell and natural killer cell activation correlate with disease progression in HIV-1 and HIV-2 infections.

Bächle SM; Malone DFG; Buggert M; Karlsson AC; Isberg P-E; Biague AJ; Norrgren H; Medstrand P; Moll M; Sandberg JK; Jansson M; SWEGUB CORE group
Article: CLINICAL INFECTIOUS DISEASES. 2016;62(5):655-663

Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe.

Hofstra LM; Sauvageot N; Albert J; Alexiev I; Garcia F; Struck D; Van de Vijver DAMC; Åsjö B; Beshkov D; Coughlan S; Descamps D; Griskevicius A; Hamouda O; Horban A; Van Kasteren M; Kolupajeva T; Kostrikis LG; Liitsola K; Linka M; Mor O; Nielsen C; Otelea D; Paraskevis D; Paredes R; Poljak M; Puchhammer-Stöckl E; Sönnerborg A; Staneková D; Stanojevic M; Van Laethem K; Zazzi M; Zidovec Lepej S; Boucher CAB; Schmit J-C; Wensing AMJ; SPREAD Program; Puchhammer-Stockl E; Sarcletti M; Schmied B; Geit M; Balluch G; Vandamme A-M; Vercauteren J; Derdelinckx I; Sasse A; Bogaert M; Ceunen H; De Roo A; De Wit S; Echahidi F; Fransen K; Goffard J-C; Goubau P; Goudeseune E; Yombi J-C; Lacor P; Liesnard C; Moutschen M; Pierard D; Rens R; Schrooten Y; Vaira D; Vandekerckhove LPR; Van den Heuvel A; Van Der Gucht B; Van Ranst M; Van Wijngaerden E; Vandercam B; Vekemans M; Verhofstede C; Clumeck N; Van Laethem K; Beshkov D; Alexiev I; Lepej SZ; Begovac J; Kostrikis L; Demetriades I; Kousiappa I; Demetriou V; Hezka J; Linka M; Maly M; Machala L; Nielsen C; Jørgensen LB; Gerstoft J; Mathiesen L; Pedersen C; Nielsen H; Laursen A; Kvinesdal B; Liitsola K; Ristola M; Suni J; Sutinen J; Descamps D; Assoumou L; Castor G; Grude M; Flandre P; Storto A; Hamouda O; Kücherer C; Berg T; Braun P; Poggensee G; Däumer M; Eberle J; Heiken H; Kaiser R; Knechten H; Korn K; Müller H; Neifer S; Schmidt B; Walter H; Gunsenheimer-Bartmeyer B; Harrer T; Paraskevis D; Hatzakis A; Zavitsanou A; Vassilakis A; Lazanas M; Chini M; Lioni A; Sakka V; Kourkounti S; Paparizos V; Antoniadou A; Papadopoulos A; Poulakou G; Katsarolis I; Protopapas K; Chryssos G; Drimis S; Gargalianos P; Xylomenos G; Lourida G; Psichogiou M; Daikos GL; Sipsas NV; Kontos A; Gamaletsou MN; Koratzanis G; Sambatakou H; Mariolis H; Skoutelis A; Papastamopoulos V; Georgiou O; Panagopoulos P; Maltezos E; Coughlan S; De Gascun C; Byrne C; Duffy M; Bergin C; Reidy D; Farrell G; Lambert J; O'Connor E; Rochford A; Low J; Coakely P; O'Dea S; Hall W; Mor O; Levi I; Chemtob D; Grossman Z; Zazzi M; de Luca A; Balotta C; Riva C; Mussini C; Caramma I; Capetti A; Colombo MC; Rossi C; Prati F; Tramuto F; Vitale F; Ciccozzi M; Angarano G; Rezza G; Kolupajeva T; Vasins O; Griskevicius A; Lipnickiene V; Schmit JC; Struck D; Sauvageot N; Hemmer R; Arendt V; Michaux C; Staub T; Sequin-Devaux C; Wensing AMJ; Boucher CAB; van de Vijver DAMC; van Kessel A; van Bentum PHM; Brinkman K; Connell BJ; van der Ende ME; Hoepelman IM; van Kasteren M; Kuipers M; Langebeek N; Richter C; Santegoets RMWJ; Schrijnders-Gudde L; Schuurman R; van de Ven BJM; Åsjö B; Kran A-MB; Ormaasen V; Aavitsland P; Horban A; Stanczak JJ; Stanczak GP; Firlag-Burkacka E; Wiercinska-Drapalo A; Jablonowska E; Maolepsza E; Leszczyszyn-Pynka M; Szata W; Camacho R; Palma C; Borges F; Paixão T; Duque V; Araújo F; Otelea D; Paraschiv S; Tudor AM; Cernat R; Chiriac C; Dumitrescu F; Prisecariu LJ; Stanojevic M; Jevtovic D; Salemovic D; Stanekova D; Habekova M; Chabadová Z; Drobkova T; Bukovinova P; Shunnar A; Truska P; Poljak M; Lunar M; Babic D; Tomazic J; Vidmar L; Vovko T; Karner P; Garcia F; Paredes R; Monge S; Moreno S; Del Amo J; Asensi V; Sirvent JL; de Mendoza C; Delgado R; Gutiérrez F; Berenguer J; Garcia-Bujalance S; Stella N; de Los Santos I; Blanco JR; Dalmau D; Rivero M; Segura F; Elías MJP; Alvarez M; Chueca N; Rodríguez-Martín C; Vidal C; Palomares JC; Viciana I; Viciana P; Cordoba J; Aguilera A; Domingo P; Galindo MJ; Miralles C; Del Pozo MA; Ribera E; Iribarren JA; Ruiz L; de la Torre J; Vidal F; Clotet B; Albert J; Heidarian A; Aperia-Peipke K; Axelsson M; Mild M; Karlsson A; Sönnerborg A; Thalme A; Navér L; Bratt G; Karlsson A; Blaxhult A; Gisslén M; Svennerholm B; Bergbrant I; Björkman P; Säll C; Mellgren Å; Lindholm A; Kuylenstierna N; Montelius R; Azimi F; Johansson B; Carlsson M; Johansson E; Ljungberg B; Ekvall H; Strand A; Mäkitalo S; Öberg S; Holmblad P; Höfer M; Holmberg H; Josefson P; Ryding U
Journal article: PLOS ONE. 2016;11(7):e0160293

Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes.

Willberg CB; Garrison KE; Jones RB; Meiklejohn DA; Spotts G; Liegler TJ; Ostrowski MA; Karlsson AC; Hecht FM; Nixon DF
Article: BMC INFECTIOUS DISEASES. 2015;15:175

Virologic and immunologic failure, drug resistance and mortality during the first 24 months postpartum among HIV-infected women initiated on antiretroviral therapy for life in the Mitra plus Study, Dar es Salaam, Tanzania.

Ngarina M; Kilewo C; Karlsson K; Aboud S; Karlsson A; Marrone G; Leyna G; Ekström AM; Biberfeld G
Article: FRONTIERS IN IMMUNOLOGY. 2015;6:196

Single-Cell Characterization of in vitro Migration and Interaction Dynamics of T Cells Expanded with IL-2 and IL-7.

Tauriainen J; Gustafsson K; Göthlin M; Gertow J; Buggert M; Frisk TW; Karlsson AC; Uhlin M; Önfelt B
Article: PLOS ONE. 2015;10(9):e0137635

Multidimensional Clusters of CD4+ T Cell Dysfunction Are Primarily Associated with the CD4/CD8 Ratio in Chronic HIV Infection.

Frederiksen J; Buggert M; Noyan K; Nowak P; Sönnerborg A; Lund O; Karlsson AC
Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2014;85(11):969-977

NetFCM: a semi-automated web-based method for flow cytometry data analysis.

Frederiksen J; Buggert M; Karlsson AC; Lund O
Article: PLOS COMPUTATIONAL BIOLOGY. 2014;10(9):e1003830

Baseline CD4+ T cell counts correlates with HIV-1 synonymous rate in HLA-B*5701 subjects with different risk of disease progression.

Norström MM; Veras NM; Huang W; Proper MCF; Cook J; Hartogensis W; Hecht FM; Karlsson AC; Salemi M
Article: BMC INFECTIOUS DISEASES. 2014;14:407

Increase in transmitted resistance to non-nucleoside reverse transcriptase inhibitors among newly diagnosed HIV-1 infections in Europe.

Frentz D; Van de Vijver DAMC; Abecasis AB; Albert J; Hamouda O; Jørgensen LB; Kücherer C; Struck D; Schmit J-C; Vercauteren J; Åsjö B; Balotta C; Beshkov D; Camacho RJ; Clotet B; Coughlan S; Griskevicius A; Grossman Z; Horban A; Kolupajeva T; Korn K; Kostrikis LG; Liitsola K; Linka M; Nielsen C; Otelea D; Paraskevis D; Paredes R; Poljak M; Puchhammer-Stöckl E; Sönnerborg A; Stanekova D; Stanojevic M; Van Wijngaerden E; Wensing AMJ; Boucher CAB; SPREAD Programme
Article: PLOS PATHOGENS. 2014;10(7):e1004251

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.

Buggert M; Tauriainen J; Yamamoto T; Frederiksen J; Ivarsson MA; Michaëlsson J; Lund O; Hejdeman B; Jansson M; Sönnerborg A; Koup RA; Betts MR; Karlsson AC
Article: JOURNAL OF IMMUNOLOGY. 2014;192(10):4685-4696

Functional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progression.

Buggert M; Norström MM; Salemi M; Hecht FM; Karlsson AC
Article: JOURNAL OF IMMUNOLOGY. 2014;192(5):2099-2108

Multiparametric bioinformatics distinguish the CD4/CD8 ratio as a suitable laboratory predictor of combined T cell pathogenesis in HIV infection.

Buggert M; Frederiksen J; Noyan K; Svärd J; Barqasho B; Sönnerborg A; Lund O; Nowak P; Karlsson AC
Article: PLOS ONE. 2014;10(4):e0120787

Newly Exerted T Cell Pressures on Mutated Epitopes following Transmission Help Maintain Consensus HIV-1 Sequences.

Eriksson EM; Liegler T; Keh CE; Karlsson AC; Holditch SJ; Pilcher CD; Loeb L; Nixon DF; Hecht FM
Journal article: PLOS COMPUTATIONAL BIOLOGY. 2014;10(11)

Baseline CD4+ T Cell Counts Correlates inn HIV-1 Synonymous Rate in HLA-B*5701 Subjects with Different Risk of Disease Progression (vol 10, e1003830, 2014)

Karlsson AC
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2013;29(3):602-612

Targeting of conserved gag-epitopes in early HIV infection is associated with lower plasma viral load and slower CD4(+) T cell depletion.

Perez CL; Milush JM; Buggert M; Eriksson EM; Larsen MV; Liegler T; Hartogensis W; Bacchetti P; Lund O; Hecht FM; Nixon DF; Karlsson AC
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2012;28(11):1434-1443

Identification of conserved subdominant HIV Type 1 CD8(+) T Cell epitopes restricted within common HLA Supertypes for therapeutic HIV Type 1 vaccines.

Karlsson I; Kløverpris H; Jensen KJ; Stryhn A; Buus S; Karlsson A; Vinner L; Goulder P; Fomsgaard A
Article: JOURNAL OF VIROLOGY. 2012;86(18):9802-9816

Combination of immune and viral factors distinguishes low-risk versus high-risk HIV-1 disease progression in HLA-B*5701 subjects.

Norström MM; Buggert M; Tauriainen J; Hartogensis W; Prosperi MC; Wallet MA; Hecht FM; Salemi M; Karlsson AC
Article: PLOS ONE. 2012;7(3):e33484

Low prevalence of transmitted drug resistance in patients newly diagnosed with HIV-1 infection in Sweden 2003-2010.

Karlsson A; Björkman P; Bratt G; Ekvall H; Gisslén M; Sönnerborg A; Mild M; Albert J
Article: PLOS ONE. 2012;7(7):e39874

Characterization of HIV-specific CD4+ T cell responses against peptides selected with broad population and pathogen coverage.

Buggert M; Norström MM; Czarnecki C; Tupin E; Luo M; Gyllensten K; Sönnerborg A; Lundegaard C; Lund O; Nielsen M; Karlsson AC
Article: EVOLUTIONARY BIOINFORMATICS. 2012;8:261-269

PhyloTempo: A Set of R Scripts for Assessing and Visualizing Temporal Clustering in Genealogies Inferred from Serially Sampled Viral Sequences.

Norström MM; Prosperi MCF; Gray RR; Karlsson AC; Salemi M
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(10):1055-1059

Short communication: high prevalence of drug resistance in HIV type 1-infected children born in Honduras and Belize 2001 to 2004.

Parham L; de Rivera IL; Murillo W; Naver L; Largaespada N; Albert J; Karlsson AC
Article: HUMAN IMMUNOLOGY. 2010;71(7):733-735

Identification of HLA-DPA1*020107 in an individual of Ugandan descent.

Czarnecki C; Luo M; Brunham R; Broliden K; Karlsson AC; Plummer FA
Article: JOURNAL OF IMMUNOLOGY. 2010;184(9):5383-5391

Interdisciplinary analysis of HIV-specific CD8+ T cell responses against variant epitopes reveals restricted TCR promiscuity.

Hoof I; Pérez CL; Buggert M; Gustafsson RKL; Nielsen M; Lund O; Karlsson AC
Article: AIDS. 2010;24(7):969-974

Induction of systemic HIV-1-specific cellular immune responses by oral exposure in the uninfected partner of discordant couples.

Pérez CL; Hasselrot K; Bratt G; Broliden K; Karlsson AC
Article: PLOS ONE. 2010;5(4):e10249

Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.

Willberg CB; Garrison KE; Jones RB; Meiklejohn DA; Spotts G; Liegler TJ; Ostrowski MA; Karlsson AC; Hecht FM; Nixon DF
Article: HIV MEDICINE. 2010;11(2):95-103

Prevalence of drug resistance and importance of viral load measurements in Honduran HIV-infected patients failing antiretroviral treatment.

Murillo W; de Rivera IL; Parham L; Jovel E; Palou E; Karlsson AC; Albert J
Article: AIDS RESEARCH AND THERAPY. 2009;6:15

Reduction of the HIV-1 reservoir in resting CD4+ T-lymphocytes by high dosage intravenous immunoglobulin treatment: a proof-of-concept study.

Lindkvist A; Edén A; Norström MM; Gonzalez VD; Nilsson S; Svennerholm B; Karlsson AC; Sandberg JK; Sönnerborg A; Gisslén M
Article: JOURNAL OF IMMUNOLOGY. 2008;180(7):5092-5100

Broadly immunogenic HLA class I supertype-restricted elite CTL epitopes recognized in a diverse population infected with different HIV-1 subtypes.

Pérez CL; Larsen MV; Gustafsson R; Norström MM; Atlas A; Nixon DF; Nielsen M; Lund O; Karlsson AC
Article: JOURNAL OF VIROLOGY. 2007;81(20):11543-11548

Antiretroviral drug therapy alters the profile of human immunodeficiency virus type 1-specific T-cell responses and shifts the immunodominant cytotoxic T-lymphocyte response from Gag to Pol.

Karlsson AC; Chapman JM; Heiken BD; Hoh R; Kallas EG; Martin JN; Hecht FM; Deeks SG; Nixon DF
Article: PLOS ONE. 2007;2(2):e225

Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape.

Karlsson AC; Iversen AKN; Chapman JM; de Oliviera T; Spotts G; McMichael AJ; Davenport MP; Hecht FM; Nixon DF
Article: VIROLOGY. 2006;347(1):117-126

CD8 T cell effector maturation in HIV-1-infected children.

Jordan KA; Furlan SN; Gonzalez VD; Karlsson AC; Quigley MF; Deeks SG; Rosenberg MG; Nixon DF; Sandberg JK
Article: CLINICAL INFECTIOUS DISEASES. 2006;42(5):700-708

Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infection.

Hare CB; Pappalardo BL; Busch MP; Karlsson AC; Phelps BH; Alexander SS; Bentsen C; Ramstead CA; Nixon DF; Levy JA; Hecht FM
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2004;288(1-2):135-147

ELISPOT cell rescue.

Meiklejohn DA; Karlsson RK; Karlsson AC; Chapman JM; Nixon DF; Schweighardt B
Article: AIDS. 2004;18(7):981-989

Immunologic and virologic evolution during periods of intermittent and persistent low-level viremia.

Karlsson AC; Younger SR; Martin JN; Grossman Z; Sinclair E; Hunt PW; Hagos E; Nixon DF; Deeks SG
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2003;283(1-2):141-153

Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells.

Karlsson AC; Martin JN; Younger SR; Bredt BM; Epling L; Ronquillo R; Varma A; Deeks SG; McCune JM; Nixon DF; Sinclair E
Article: JOURNAL OF VIROLOGY. 2003;77(12):6743-6752

Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene.

Karlsson AC; Deeks SG; Barbour JD; Heiken BD; Younger SR; Hoh R; Lane M; Sällberg M; Ortiz GM; Demarest JF; Liegler T; Grant RM; Martin JN; Nixon DF
Article: HIV MEDICINE. 2002;3(1):1-11

The selection and evolution of viral quasispecies in HIV-1 infected children.

Nowak P; Karlsson AC; Naver L; Bohlin AB; Piasek A; Sönnerborg A
Article: JOURNAL OF INFECTIOUS DISEASES. 2001;184(11):1392-1401

Recent origin of human immunodeficiency virus type 1 variants in resting CD4+ T lymphocytes in untreated and suboptimally treated subjects.

Karlsson AC; Lindkvist A; Lindbäck S; Gaines H; Sönnerborg A
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2001;17(5):409-416

Initiation of therapy during primary HIV type 1 infection results in a continuous decay of proviral DNA and a highly restricted viral evolution.

Karlsson AC; Birk M; Lindbäck S; Gaines H; Mittler JE; Sönnerborg A
Article: AIDS. 2000;14(15):2333-2339

Diagnosis of primary HIV-1 infection and duration of follow-up after HIV exposure. Karolinska Institute Primary HIV Infection Study Group.

Lindbäck S; Thorstensson R; Karlsson AC; von Sydow M; Flamholc L; Blaxhult A; Sönnerborg A; Biberfeld G; Gaines H
Article: AIDS. 2000;14(15):2283-2291

Viral dynamics in primary HIV-1 infection. Karolinska Institutet Primary HIV Infection Study Group.

Lindbäck S; Karlsson AC; Mittler J; Blaxhult A; Carlsson M; Briheim G; Sönnerborg A; Gaines H
Article: JOURNAL OF VIROLOGY. 1999;73(7):6191-6196

Reappearance of founder virus sequence in human immunodeficiency virus type 1-infected patients.

Karlsson AC; Gaines H; Sällberg M; Lindbäck S; Sönnerborg A
Article: AIDS. 1998;12(8):839-847

Characterization of the viral population during primary HIV-1 infection.

Karlsson AC; Lindbäck S; Gaines H; Sönnerborg A
Visa fler

Alla övriga publikationer

Preprint: 2022;Research Square

Ancestral SARS-CoV-2-specific T cells cross-recognize Omicron (B.1.1.529)

Gao Y; Cai C; Grifoni A; Müller T; Niessl J; Olofsson A; Humbert M; Hansson L; Österborg A; Bergman P; Chen P; Olsson A; Sandberg J; Weiskopf D; Price D; Ljunggren H-G; Karlsson A; Sette A; Aleman S; Buggert M
Conference publication: JOURNAL OF CLINICAL IMMUNOLOGY. 2017;37(2):230

COMBINED IMMUNODEFICIENCY AND EPSTEIN-BARR VIRUS-INDUCED B CELL MALIGNANCY IN HUMANS WITH INHERITED CD70 DEFICIENCY

Jing H; Abolhassani H; Edwards ESJ; Ikinciogullari KA; Borte S; Buggert M; Du L; Lennikov M; Romano R; Caridha R; Bade S; Zhang Y; Frederiksen J; Fang M; Bal SK; Haskologlu S; Dogu F; Tacyildiz N; Matthews HF; McElwee JJ; Gostick E; Price DA; Palendira U; Aghamohammadi A; Boisson B; Rezaei N; Karlsson A; Lenardo MJ; Casanova J-L; Hammarstrom L; Tangye SG; Pan-Hammarstrom Q; Su HC
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):288-289

Increased numbers of CD103^-CD8⁺ T_RM cells in the cervical mucosa of HIV-infected women

Gibbs A; Buggert M; Edfeldt G; Ranefall P; Introini A; Cheuk S; Martini E; Eidsmo L; Hirbod T; Ball TB; Kimani J; Kaul R; Karlsson AC; Wahlby C; Broliden K; Tjernlund A
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):318

Modifications of TIGIT expression contribute to CD8 T cell exhaustion in chronic virus infection

Tauriainen J; Scharf L; Frederiksen J; Naji A; Ljunggren H-G; Sonnerborg A; Lund O; Reyes-Teran G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Conference publication: JOURNAL OF IMMUNOLOGY. 2017;198(1)

HIV-induced modifications of TIGIT expression impair CD8 T cell polyfunctionality

Scharf L; Tauriainen J; Frederiksen J; Naji A; Ljunggren H-G; Sonnerborg A; Lund O; Reyes-Teran G; Hecht FM; Deeks SG; Betts MR; Buggert M; Karlsson AC
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2016;32:307

Analysis of the Distribution of CD103 on CD8 T Cells in Blood and Genital Mucosa of HIV-infected Female Sex Workers

Gibbs A; Buggert M; Ranefall P; Introini A; Cheuk S; Eidsmo L; Hirbod T; Ball TB; Kimani J; Kaul R; Karlsson AC; Wahlby C; Broliden K; Tjernlund A
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(4):325

NetFCM: A Tool for Automated Flow Cytometric Data Analysis

Frederiksen J; Lund O; Buggert M; Karlsson A
Review: NEW MICROBIOLOGICA. 2012;35(2):101-111

Towards a new paradigm linking virus molecular evolution and pathogenesis: experimental design and phylodynamic inference.

Norström MM; Karlsson AC; Salemi M
Conference publication: ANTIVIRAL THERAPY. 2011;16:A139

Drug resistance in an MTCT programme in Honduras

Parham L; Lorenzana IJ; Albert J; Karlsson A
Conference publication: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2011;27(10):A88

Interdisciplinary Evaluation of Broadly-Reactive HLA Class II Restricted Epitopes Eliciting HIV-Specific CD4+T Cell Responses

Buggert M; Norstrom M; Lundegaard C; Lund O; Nielsen M; Karlsson AC
Conference publication: 2010;:658-659

PopCover

Lundegaard C; Buggert M; Karlsson A; Lund O; Perez C; Nielsen M
Meeting abstract: RETROVIROLOGY. 2009;6:p231

Induction of systemic HIV-1 specific cellular immune responses by oral exposure in exposed uninfected partner of discordant couples

Perez C; Hasselrot K; Broliden K; Karlsson A
Letter: LANCET. 2005;365(9475):1924-1925

Multidrug-resistant, dual-tropic HIV-1 and rapid progression.

Nixon DF; Deeks SG; Shacklett BL; Karlsson AC

Forskningsbidrag

Clinical and translational studies on cancer related fatigue in palliative care. Focus on vitamin D and the immune system.

Swedish Research Council

1 January 2023 - 31 December 2025
Cellular and molecular dynamics of antigen-specific T cells in HIV-treated children, pregnant women, and human cancer affecting immune function, development and health

Swedish Research Council

1 January 2021 - 31 December 2023
Molecular dynamics of T cell exhaustion in human viral infection and cancer affecting immune recovery and health

Swedish Research Council

1 January 2018 - 31 December 2020
A translational approach to link clinical, virological and immunological findings toward a functional cure for HIV

Swedish Research Council

1 January 2013 - 31 December 2017
The impact, role, and consequences of HIV-1 immune escape mutations on viral fitness, immune function, and clinical outcome

Swedish Research Council

1 January 2010 - 31 December 2012

Anställningar

Forskare, Laboratoriemedicin, Karolinska Institutet, 2011-

Examina och utbildning

Docent, Virologi, Karolinska Institutet, 2009
MEDICINE DOKTORSEXAMEN, Institutionen för laboratoriemedicin, Karolinska Institutet, 2000
LICENTIATEXAMEN, Institutionen för laboratoriemedicin, Karolinska Institutet, 1998

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