André Fisahn

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About me

I am an Associate Professor of Neuroscience at the Center for Alzheimer Research. After receiving my PhD in Neurophysiology from Oxford University (UK) in 1999 I underwent 4 years of postdoctoral training at the National Institutes of Health (USA). Since 2004 I am a principal investigator at the Karolinska Institute.

Research

The overall aim of our work is to help explain on a cellular, synaptic and network level the clinically-documented changes of rhythmic network activity caused by various brain disorders that result in cognitive decline and memory deficits in patients. We focus on functional network dynamics and mechanisms of neuronal synchronization in physiological conditions as well as in animal models of neurodegenerative and neuropsychiatric disorders with the aim to identify and validate potential targets for therapeutic intervention and restoration of cognitive function. Our core hypothesis postulates that changes to the electrical behavior of neurons and neuronal networks are the first functional impairments in disorders that lead to cognitive decline, and as such are a very reliable functional biomarker. Our work has shown that such functional changes far precede the accumulation of disease-typical classical biomarkers such as amyloid-beta in Alzheimer's disease or alpha-synuclein in Parkinson's disease. We are particularly interested in the role of fast-spiking interneurons, which experience action potential de-synchronization in disease assays very early on. We believe that rescuing this de-synchronization and restoring normal neuronal network function is the key to identify efficacious treatments for cognitive brain disorders.

Articles

Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585

Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease.

Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schröder B; Nilsson P; Tambaro S
Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545

Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity.

Isla AG; Balleza-Tapia H; Chu F; Chen G; Johansson J; Nilsson P; Fisahn A
Article: MOLECULAR PSYCHIATRY. 2023;28(6):2177-2188

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits.

Andrade-Talavera Y; Fisahn A; Rodríguez-Moreno A
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511

Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone.

Kumar R; Arroyo-García LE; Manchanda S; Adam L; Pizzirusso G; Biverstål H; Nilsson P; Fisahn A; Johansson J; Abelein A
Article: TRANSLATIONAL NEURODEGENERATION. 2023;12(1):6

Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer's disease.

Arroyo-García LE; Bachiller S; Ruiz R; Boza-Serrano A; Rodríguez-Moreno A; Deierborg T; Andrade-Talavera Y; Fisahn A
Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366

S100A9 amyloid growth and S100A9 fibril-induced impairment of gamma oscillations in area CA3 of mouse hippocampus ex vivo is prevented by Bri2 BRICHOS.

Andrade-Talavera Y; Chen G; Pansieri J; Arroyo-García LE; Toleikis Z; Smirnovas V; Johansson J; Morozova-Roche L; Fisahn A
Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue.

Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstål H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245

Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice.

Emre C; Arroyo-García LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514

Bri2 BRICHOS chaperone rescues impaired fast-spiking interneuron behavior and neuronal network dynamics in an AD mouse model in vitro.

Andrade-Talavera Y; Chen G; Kurudenkandy FR; Johansson J; Fisahn A
Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567

Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer's disease.

Arroyo-García LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212

Ablation of p75NTR signaling strengthens gamma-theta rhythm interaction and counteracts Aβ-induced degradation of neuronal dynamics in mouse hippocampus in vitro.

Andrade-Talavera Y; Balleza-Tapia H; Dolz-Gaitón P; Chen G; Johansson J; Fisahn A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(17):3711-3725

Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ-induced desynchronization of fast-spiking interneuron firing in an AD mouse model in vitro.

Andrade-Talavera Y; Arroyo-García LE; Chen G; Johansson J; Fisahn A
Article: NEUROPHARMACOLOGY. 2020;170:108070

Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations.

Narváez M; Andrade-Talavera Y; Valladolid-Acebes I; Fredriksson M; Siegele P; Hernandez-Sosa A; Fisahn A; Fuxe K; Borroto-Escuela DO
Article: HIPPOCAMPUS. 2020;30(2):101-113

Human cerebrospinal fluid promotes spontaneous gamma oscillations in the hippocampus in vitro.

Bjorefeldt A; Roshan F; Forsberg M; Zetterberg H; Hanse E; Fisahn A
Article: MOLECULAR NEUROBIOLOGY. 2020;57(2):1170-1185

Capsaicin-Induced Impairment of Functional Network Dynamics in Mouse Hippocampus via a TrpV1 Receptor-Independent Pathway: Putative Involvement of Na+/K+-ATPase.

Balleza-Tapia H; Dolz-Gaiton P; Andrade-Talavera Y; Fisahn A
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro.

Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstål H; Fisahn A; Abelein A; Johansson J
Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(3):1462-1477

Amyloid-β Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity.

Honcharenko D; Juneja A; Roshan F; Maity J; Galán-Acosta L; Biverstål H; Hjorth E; Johansson J; Fisahn A; Nilsson L; Strömberg R
Article: ELIFE. 2018;7:e37703

TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro.

Balleza-Tapia H; Crux S; Andrade-Talavera Y; Dolz-Gaiton P; Papadia D; Chen G; Johansson J; Fisahn A
Article: NATURE COMMUNICATIONS. 2017;8(1):2081

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state.

Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstål H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
Article: CELL REPORTS. 2017;20(9):2156-2168

Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition.

Wyeth MS; Pelkey KA; Yuan X; Vargish G; Johnston AD; Hunt S; Fang C; Abebe D; Mahadevan V; Fisahn A; Salter MW; McInnes RR; Chittajallu R; McBain CJ
Article: PSYCHONEUROENDOCRINOLOGY. 2017;82:46-50

Type 2 diabetes alters hippocampal gamma oscillations: A potential mechanism behind impaired cognition.

Lietzau G; Darsalia V; Pintana H; Östenson C-G; Nyström T; Fisahn A; Patrone C
Article: NEUROPHARMACOLOGY. 2017;118:13-25

Histamine induces KCNQ channel-dependent gamma oscillations in rat hippocampus via activation of the H1 receptor.

Andersson R; Galter D; Papadia D; Fisahn A
Article: TRANSLATIONAL PSYCHIATRY. 2017;7(4):e1088

The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism.

Masini D; Lopes-Aguiar C; Bonito-Oliva A; Papadia D; Andersson R; Fisahn A; Fisone G
Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704

Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila.

Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstål H; Crux S; Fisahn A; Presto J; Johansson J
Article: SCIENTIFIC REPORTS. 2016;6:18617

Hippocampal Transcriptome Profile of Persistent Memory Rescue in a Mouse Model of THRA1 Mutation-Mediated Resistance to Thyroid Hormone.

Wang Y; Fisahn A; Sinha I; Nguyen DP; Sterzenbach U; Lallemend F; Hadjab S
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2015;22(3):207-213

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.

Cohen SIA; Arosio P; Presto J; Kurudenkandy FR; Biverstal H; Dolfe L; Dunning C; Yang X; Frohm B; Vendruscolo M; Johansson J; Dobson CM; Fisahn A; Knowles TPJ; Linse S
Article: JOURNAL OF NEUROPHYSIOLOGY. 2015;113(3):971-980

Interconnection and synchronization of neuronal populations in the mouse medial septum/diagonal band of Broca.

Leão RN; Targino ZH; Colom LV; Fisahn A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2014;592(19):4187-4199

5-Hydroxytryptamine1A receptor-activation hyperpolarizes pyramidal cells and suppresses hippocampal gamma oscillations via Kir3 channel activation.

Johnston A; McBain CJ; Fisahn A
Article: ORGANIC & BIOMOLECULAR CHEMISTRY. 2014;12(34):6684-6693

Synthesis and evaluation of antineurotoxicity properties of an amyloid-β peptide targeting ligand containing a triamino acid.

Honcharenko D; Bose PP; Maity J; Kurudenkandy FR; Juneja A; Flöistrup E; Biverstål H; Johansson J; Nilsson L; Fisahn A; Strömberg R
Article: JOURNAL OF NEUROSCIENCE. 2014;34(34):11416-11425

Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation.

Kurudenkandy FR; Zilberter M; Biverstål H; Presto J; Honcharenko D; Strömberg R; Johansson J; Winblad B; Fisahn A
Article: NEUROBIOLOGY OF AGING. 2012;33(9):2046-2061

Medial septal dysfunction by Aβ-induced KCNQ channel-block in glutamatergic neurons.

Leão RN; Colom LV; Borgius L; Kiehn O; Fisahn A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(32):13118-13123

Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors.

Andersson RH; Johnston A; Herman PA; Winzer-Serhan UH; Karavanova I; Vullhorst D; Fisahn A; Buonanno A
Article: PLOS ONE. 2012;7(7):e40906

Dopamine D4 receptor activation increases hippocampal gamma oscillations by enhancing synchronization of fast-spiking interneurons.

Andersson R; Johnston A; Fisahn A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(41):17201-17206

TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.

Zheng K; An JJ; Yang F; Xu W; Xu Z-QD; Wu J; Hökfelt TGM; Fisahn A; Xu B; Lu B
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2011;34(7):1121-1130

Acoustic startle hypersensitivity in Mceph mice and its effect on hippocampal excitability.

Fisahn A; Lavebratt C; Canlon B
Article: PLOS ONE. 2010;5(11):e13833

A voltage-sensitive dye-based assay for the identification of differentiated neurons derived from embryonic neural stem cell cultures.

Leão RN; Reis A; Emirandetti A; Lewicka M; Hermanson O; Fisahn A
Article: NEUROPHARMACOLOGY. 2010;58(7):1130-1139

A mutant thyroid hormone receptor alpha1 alters hippocampal circuitry and reduces seizure susceptibility in mice.

Hadjab-Lallemend S; Wallis K; van Hogerlinden M; Dudazy S; Nordström K; Vennström B; Fisahn A
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(Pt 8):1241-1249

Histamine H3 receptor activation decreases kainate-induced hippocampal gamma oscillations in vitro by action potential desynchronization in pyramidal neurons.

Andersson R; Lindskog M; Fisahn A
Article: JOURNAL OF NEUROSCIENCE. 2009;29(42):13353-13364

Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro.

Leão RN; Tan HM; Fisahn A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(23):9191-9196

Alpha-helix targeting reduces amyloid-beta peptide toxicity.

Nerelius C; Sandegren A; Sargsyan H; Raunak R; Leijonmarck H; Chatterjee U; Fisahn A; Imarisio S; Lomas DA; Crowther DC; Strömberg R; Johansson J
Article: CEREBRAL CORTEX. 2009;19(3):612-618

Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia.

Fisahn A; Neddens J; Yan L; Buonanno A
Article: JOURNAL OF NEUROSCIENCE. 2008;28(8):1904-1915

Locomotor deficiencies and aberrant development of subtype-specific GABAergic interneurons caused by an unliganded thyroid hormone receptor alpha1.

Wallis K; Sjögren M; van Hogerlinden M; Silberberg G; Fisahn A; Nordström K; Larsson L; Westerblad H; Morreale de Escobar G; Shupliakov O; Vennström B
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2005;562(Pt 1):199-203

The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones.

Fisahn A; Heinemann SF; McBain CJ
Article: JOURNAL OF NEUROSCIENCE. 2004;24(43):9658-9668

Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations.

Fisahn A; Contractor A; Traub RD; Buhl EH; Heinemann SF; McBain CJ
Article: NEURON. 2002;33(4):615-624

Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents.

Fisahn A; Yamada M; Duttaroy A; Gan J-W; Deng C-X; McBain CJ; Wess J
Article: NEURON. 2001;31(5):831-840

Axo-axonal coupling. a novel mechanism for ultrafast neuronal communication.

Schmitz D; Schuchmann S; Fisahn A; Draguhn A; Buhl EH; Petrasch-Parwez E; Dermietzel R; Heinemann U; Traub RD
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12(11):4093-4106

A model of gamma-frequency network oscillations induced in the rat CA3 region by carbachol in vitro.

Traub RD; Bibbig A; Fisahn A; LeBeau FE; Whittington MA; Buhl EH
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1998;513 ( Pt 1)(Pt 1):117-126

Cholinergic activation and tonic excitation induce persistent gamma oscillations in mouse somatosensory cortex in vitro.

Buhl EH; Tamás G; Fisahn A
Article: NATURE. 1998;394(6689):186-189

Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro.

Fisahn A; Pike FG; Buhl EH; Paulsen O
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All other publications

Review: PROGRESS IN NEUROBIOLOGY. 2022;210:102213

Functionally-distinct pyramidal cell subpopulations during gamma oscillations in mouse hippocampal area CA3.

Balleza-Tapia H; Arroyo-García LE; Isla AG; Loera-Valencia R; Fisahn A
Review: EXPERIMENTAL NEUROLOGY. 2021;343:113743

Efficacy of preclinical pharmacological interventions against alterations of neuronal network oscillations in Alzheimer's disease: A systematic review.

Isla AG; Balleza-Tapia H; Fisahn A
Published paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2017;95(11):2195-2206

Chronic inhibition of brain glycolysis initiates epileptogenesis.

Samokhina E; Popova I; Malkov A; Ivanov AI; Papadia D; Osypov A; Molchanov M; Paskevich S; Fisahn A; Zilberter M; Zilberter Y
Letter: NATURE METHODS. 2015;12(7):595-596

Chemically defined, albumin-free human cardiomyocyte generation.

Lian X; Bao X; Zilberter M; Westman M; Fisahn A; Hsiao C; Hazeltine LB; Dunn KK; Kamp TJ; Palecek SP
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S246-S247

Histamine H3 receptor activation decreases gamma oscillation power and causes desynchronization of action potentials

Andersson R; Fisahn A; Lindskog M
Published paper: JOURNAL OF PHYSIOLOGY-LONDON. 2005;562(Pt 1):65-72

Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.

Fisahn A
Review: NATURE REVIEWS NEUROSCIENCE. 2001;2(1):11-23

Interneurons unbound.

McBain CJ; Fisahn A

Employments

Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2022-2025

Degrees and Education

Docent, Karolinska institutet, 2009

Supervisor

Daniela Papadia, Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies., https://openarchive.ki.se/xmlui/handle/10616/46338

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