Alan Fotoohi

Alan K Fotoohi

Anknuten till Forskning






- Introducing a simple and cost-effective RT-PCR protocol for detection of DPYD*2A polymorphism: the first study in Kurdish population. Salmani M, Ghaderi B, Fotoohi A, Omid-Shafa'at R, Vahabzadeh Z, Fotouhi O, Abdi M. Cancer Chemother Pharmacol. 2022 Nov;90(5):389-397. doi: 10.1007/s00280-022-04472-w. Epub 2022 Sep 9. PMID: 36083300


- CYP2D6 Genotype Predicts Plasma Concentrations of Tamoxifen Metabolites in Ethiopian Breast Cancer Patients. Ahmed JH, Makonnen E, Fotoohi A, Aseffa A, Howe R, Aklillu E. Cancers (Basel). 2019 Sep 12;11(9):1353. doi: 10.3390/cancers11091353.PMID: 31547390


Vitamin D Status and Association of VDR Genetic Polymorphism to Risk of Breast Cancer in Ethiopia. Ahmed JH, Makonnen E, Fotoohi A, Yimer G, Seifu D, Assefa M, Tigeneh W, Aseffa A, Howe R, Aklillu E. Nutrients. 2019 Jan 29;11(2):289. doi: 10.3390/nu11020289.PMID: 30699973

- CYP2J2∗7 Genotype Predicts Risk of Chemotherapy-Induced Hematologic Toxicity and Reduced Relative Dose Intensity in Ethiopian Breast Cancer Patients. Ahmed JH, Makonnen E, Yimer G, Seifu D, Bekele A, Assefa M, Aseffa A, Howe R, Fotoohi A, Hassan M, Aklillu E.Front Pharmacol. 2019 May 14;10:481. doi: 10.3389/fphar.2019.00481. eCollection 2019.PMID: 31139078


- Fotoohi AK, Karim H, Lafolie P, Pohanka A, Östervall J, Hatschek T, Vitols S. Pronounced Interindividual But Not Intraindividual Variation in Tamoxifen and Metabolite Levels in Plasma During Adjuvant Treatment of Women With Early Breast Cancer. Ther Drug Monit. 2016 Apr;38(2):239-45. doi: 10.1097/FTD.0000000000000257. PubMed PMID: 26485084.


- Karim H, Appell ML, Fotoohi A. Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Nov 15;939:80-5. doi: 10.1016/j.jchromb.2013.08.036. Epub 2013 Sep 14. PubMed PMID: 24113235.


- Karim H, Ghalali A, Lafolie P, Vitols S, Fotoohi AK. Differential role of thiopurine methyltransferase in the cytotoxic effects of 6-mercaptopurine and 6-thioguanine on human leukemia cells. Biochem Biophys Res Commun. 2013 Jul26;437(2):280-6. doi: 10.1016/j.bbrc.2013.06.067. Epub 2013 Jun 27. PubMed PMID: 23811272.


- Karim H, Bogason A, Bhuiyan H, Fotoohi AK, Lafolie P, Vitols S. Comparison of uptake mechanisms for anthracyclines in human leukemic cells. Curr Drug Deliv. 2013 Aug;10(4):404-12. PubMed PMID: 23062181.


- Karim H, Hashemi J, Larsson C, Moshfegh A, Fotoohi AK, Albertioni F. The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells. Biochem Biophys Res Commun. 2011 Jul 22;411(1):156-61. doi: 10.1016/j.bbrc.2011.06.120. Epub 2011 Jun 23. PubMed PMID: 21723252.


- Fotoohi AK, Melin AS. Painful pelvic joints induced by a levonorgestrel-releasing intrauterine system. J Obstet Gynaecol Res. 2010 Oct;36(5):1142-3. PubMed PMID: 21058450.


- Fotoohi AK, Coulthard SA, Albertioni F. Thiopurines: factors influencing toxicity and response. Biochem Pharmacol. 2010 May 1;79(9):1211-20. doi:10.1016/j.bcp.2010.01.006. Epub 2010 Jan 21. PubMed PMID: 20096268.


- Fotoohi AK, Assaraf YG, Moshfegh A, Hashemi J, Jansen G, Peters GJ, Larsson C, Albertioni F. Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7. doi: 10.1016/j.bcp.2008.12.026. Epub 2009 Jan 19. PubMed PMID: 19426680.


- Fotoohi AK, Albertioni F. Mechanisms of antifolate resistance and methotrexate efficacy in leukemia cells. Leuk Lymphoma. 2008 Mar;49(3):410-26. doi: 10.1080/10428190701824569. Review. PubMed PMID: 18297517.


- Fotoohi AK, Lindqvist M, Peterson C, Albertioni F. Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1039-44. PubMed PMID: 17065061.


- Fotoohi AK, Wrabel A, Moshfegh A, Peterson C, Albertioni F. Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside. Biochem Pharmacol. 2006 Sep 28;72(7):816-23. Epub 2006 Jul 20. PubMed PMID: 16859645.


- Fotoohi AK, Lindqvist M, Peterson C, Albertioni F. Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochem Biophys Res Commun. 2006 Apr 28;343(1):208-15. Epub 2006 Mar 3. PubMed PMID: 16530731.


- Fotoohi K, Skärby T, Söderhäll S, Peterson C, Albertioni F. Interference of 7-hydroxymethotrexate with the determination of methotrexate in plasma samples from children with acute lymphoblastic leukemia employing routine clinical assays. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Mar 25;817(2):139-44. PubMed PMID: 15686977.

Fotoohi K, Jansen G, Assaraf YG, Rothem L, Stark M, Kathmann I, Gregorczyk J, Peters GJ, Albertioni F. Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy. Blood. 2004 Dec 15;104(13):4194-201. Epub 2004 Aug 12. PubMed PMID: 15308564.


- Alan K Fotoohi. Pharmacological and molecular investigations on the mechanisms underlying resistance of human cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine. Doctoral thesis. From the Departmnet of Oncology-Pathology, Cancer Centrum Karolinska, Karolinska Indtitutet at Karolinska University Hospital, Solna, Stockholm, Sweden.


- RNA interference targeting thiopurine methyl transferase gene alter the effect of the 6-mercaptopurine in human leukaemia cells. Freidoun Albertioni, Alan K. Fotoohi, Jamileh Hashemi, Elham Hedayati and Catharina Larsson. American Society of Haematology 52nd annual meeting, 2011, USA. Abstract